Antioxidant and antibacterial effects of Xanthium strumarium extracts
Journal name: Ancient Science of Life
Original article title: In-vitro antioxidant and antibacterial activities of Xanthium strumarium L. extracts on methicillin-susceptible and methicillin-resistant Staphylococcus aureus
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Javad Sharifi Rad, Seyedeh Mahsan Hoseini Alfatemi, Majid Sharifi Rad, Marcello Iriti
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: In-vitro antioxidant and antibacterial activities of Xanthium strumarium L. extracts on methicillin-susceptible and methicillin-resistant Staphylococcus aureus
Year: 2013
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
The emergence of antibiotic-resistant strains of pathogens, particularly Staphylococcus aureus, has become a significant challenge in modern medicine. Staphylococcus aureus is responsible for a wide range of infections, and its resistance to antibiotics has limited treatment options. This study investigates the antioxidant and antimicrobial activities of methanolic extracts of Xanthium strumarium L. leaves against both methicillin-susceptible (MSSA) and methicillin-resistant (MRSA) strains of Staphylococcus aureus. The aim is to evaluate the potential health benefits of this plant traditionally used in folk remedies around the world.
Antioxidant and Antimicrobial Potency of Xanthium strumarium***
The research findings revealed that the methanolic extract of Xanthium strumarium L. demonstrated significant antioxidant capabilities as evidenced by its antioxidant activity and DPPH radical scavenging capacity, with lower IC₅₀ values indicating higher effectiveness. Furthermore, the study found that the extract was more effective against MSSA compared to MRSA, demonstrating inhibitory zones of 26.0 mm and 20.0 mm, respectively, at the highest concentration tested. The observed activities are attributed to the presence of various phytochemicals, such as phenolic acids and flavonoids, which are known for their health-promoting properties.
Conclusion
The results of this study support the traditional use of Xanthium strumarium as a folk remedy, confirming its potential as a source of natural antimicrobial and antioxidant agents. The potent antibacterial activity against both MSSA and MRSA, alongside its antioxidant properties, highlights the relevance of this plant in addressing oxidative stress-related diseases and antibiotic resistance. Further exploration of its phytochemical profile could unlock new therapeutic applications and contribute to the development of alternatives to synthetic antibiotics.
FAQ section (important questions/answers):
What plant was studied for its antioxidant and antibacterial activities?
The study investigated the methanolic extract of Xanthium strumarium L. leaves, focusing on its antioxidant and antibacterial effects against both methicillin-susceptible and methicillin-resistant Staphylococcus aureus.
What significant activities were observed in Xanthium strumarium extracts?
The methanol extract exhibited notable antioxidant activity with IC50 values of 0.02 mg/mL for radical scavenging. It also showed antibacterial activity, being more effective against methicillin-susceptible Staphylococcus aureus than methicillin-resistant strains.
How were the antioxidant and antibacterial activities measured in the study?
Antioxidant activity was measured using the paired diene method and DPPH radical scavenging assay. The antibacterial activity was assessed using the disc diffusion method on various Staphylococcus aureus strains.
What are the implications of the study's findings?
The findings support the traditional use of Xanthium strumarium as a folk remedy, emphasizing its potential medicinal properties for treating infections and diseases associated with oxidative stress.
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Medicinal plant, Natural remedies, Antioxidant activity, Phytochemical screening, Anti-inflammatory activities, Neuroprotective activity, Oxidative stress, Traditional use, Disc diffusion method, Antibacterial activities, IC50 value, DPPH free radical, Antiradical activity, Methicillin resistant Staphylococcus aureus, 1,1-diphenyl-2-picrylhydrazyl, Antiallergic activities, Chemical constituent, Biochemical test, Antifungal activities, Xanthium strumarium L., In vitro antioxidant, Microbial strains, Clinical infections, Folklore remedies, Phytosterol, Healthcare institutions, Methicillin-susceptible Staphylococcus aureus.