Study of Brāhmī Ghṛta and piracetam in amnesia
Journal name: Ancient Science of Life
Original article title: Study of Brāhmī Ghṛta and piracetam in amnesia
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Kapil Deo Yadav, K. R. C. Reddy, Vikas Kumar
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Study of Brāhmī Ghṛta and piracetam in amnesia
Year: 2012
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
The study evaluated the effects of Brāhmī Ghṛta, an Ayurvedic formulation, in comparison to the standard drug piracetam, on amnesia induced by scopolamine in Charles Foster rats. Aiming to explore potential treatments for cognitive disorders, the research highlights the significance of herbal remedies in mental health, referencing traditional knowledge from Ayurvedic texts. The formulation of Brāhmī Ghṛta combines several herbal ingredients known for their neuroprotective effects, and the study investigates their ability to reverse scopolamine-induced cognitive deficits.
Antiamnesic Effects of Brāhmī Ghṛta
The primary finding of the study was that both Brāhmī Ghṛta and piracetam significantly antagonized the effects of scopolamine, demonstrating their potential as antiamnesic agents. Through various tests—such as the elevated plus maze, passive avoidance, and active avoidance tests—the researchers observed that treated rats showed improved memory retention and learning capabilities compared to control groups. Notably, there was no significant difference in the effectiveness of Brāhmī Ghṛta and piracetam, suggesting that Brāhmī Ghṛta might act through mechanisms similar to those of cholinergic drugs, which are known to enhance cognitive function.
Conclusion
The study concludes that Brāhmī Ghṛta is an effective herbal alternative for mitigating cognitive impairments related to amnesia, showing comparable efficacy to piracetam. This finding positions Brāhmī Ghṛta as a valuable option in Ayurvedic medicine for addressing learning and memory disorders. The results encourage further exploration of traditional herbal formulations, underscoring their relevance in contemporary therapeutic contexts for mental health issues.
FAQ section (important questions/answers):
What was the objective of the study on Brāhmī Ghṛta?
The objective was to compare the effects of Brāhmī Ghṛta with piracetam in treating amnesia induced by scopolamine in rats.
What methodology was used to evaluate antiamnesic activity?
Antiamnesic activity was evaluated through modified elevated plus maze, passive avoidance, and active avoidance tests after administering scopolamine and treatments to rats.
What were the results of treating rats with Brāhmī Ghṛta?
Both dosages of Brāhmī Ghṛta significantly reversed scopolamine-induced amnesia, showing similar effectiveness to the standard drug, piracetam.
What conclusions were drawn from the study's findings?
The study concluded that both Brāhmī Ghṛta and piracetam antagonized scopolamine's effects, indicating that Brāhmī Ghṛta may be effective in treating learning and memory disorders.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Study of Brāhmī Ghṛta and piracetam in amnesia”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Brahmi:
[see source text or glossary: #Brāhmī#] is an herb known for its potential cognitive benefits and its role in treating mental disorders, specifically as a key ingredient in Brāhmī Ghṛta, as it is derived from the plant Bacopa monnieri, which aligns with the principles of Āyurveda.
2) Ghrita (Ghrta):
[see source text or glossary: #Ghrita#] is the alternate Sanskrit term referring to medicinal Ghee, emphasizing its importance in the preparation of therapeutic formulations such as Brāhmī Ghṛta for cognitive benefit.
3) Brahmighrita (Brahmighrta, Brahmi-ghrita):
[see source text or glossary: #Brāhmī-ghṛta#] is a specific formulation combining Brāhmī with Ghṛta, used to support cognitive functions and combat amnesia, demonstrating significant effectiveness against the impacts of scopolamine in scientific studies.
4) Drug:
[see source text or glossary: #Drug#] in the context of the study refers to substances like piracetam, which are used as references to evaluate the efficacy of herbal formulations like Brāhmī Ghṛta, especially in enhancing memory and combating amnesia.
5) Ghi (Ghee):
[see source text or glossary: #Ghee#] represents the traditional clarified butter used in Āyurvedic medicine, acting as a vehicle for various herbal treatments, including Brāhmī Ghṛta, and providing beneficial fats that support mental health.
6) Ayurveda (Ayus-veda):
[see source text or glossary: #Ayurveda#] is the holistic system of medicine that encompasses various treatments, including herbal formulations like Brāhmī Ghṛta, to promote mental health and well-being.
7) Science (Scientific):
[see source text or glossary: #Science#] in this context pertains to the methodical study of the effects of substances like Brāhmī Ghṛta and piracetam on mental disorders through rigorous experimentation and statistical analysis, bridging traditional practices with modern validation.
8) Mental disorder:
[see source text or glossary: #Mental disorder#] encompasses various conditions affecting cognitive functions, such as depression and anxiety, which studies like the one on Brāhmī Ghṛta aim to treat and understand through both traditional Āyurvedic and modern scientific methods.
9) Activity:
[see source text or glossary: #Activity#] often refers to the behavioral or physiological processes affected by treatments like Brāhmī Ghṛta, specifically regarding how they influenced the learning and memory activities in experimental models of amnesia.
10) Rasashastra (Rasa-shastra, Rasasastra):
[see source text or glossary: #Rasa-shastra#] is a branch of Āyurveda focused on the study of metallic and herbal compounds, providing a scientific basis for the use of substances like Brāhmī in treatments for mental health and cognitive enhancement.
11) Depression:
[see source text or glossary: #Depression#] is a common mental disorder addressed within Āyurveda, with herbal remedies including Brāhmī Ghṛta utilized for their potential to improve mood and cognitive functions, alongside lifestyle modifications.
12) Shastra (Sastra):
[see source text or glossary: #Shastra#] means 'scripture' or 'treatise' in the context of Āyurveda, where it refers to the extensive knowledge system governing the use of substances like Brāhmī in promoting mental health and wellness.
13) Anxiety:
[see source text or glossary: #Anxiety#] is another mental health condition that may be addressed via treatments like Brāhmī Ghṛta according to Āyurveda, focusing on restoring balance through natural remedies and lifestyle alterations.
14) Kushtha (Kustha):
[see source text or glossary: #Kuṣṭha#] refers to a condition mentioned in Āyurveda, linked with mental disturbances and characteristics of various disorders, which can benefit from formulations involving herbs like Brāhmī.
15) Kalka:
[see source text or glossary: #Kalka#] denotes a paste made from herbal components in Āyurvedic medicine, used in the preparation of formulations like Brāhmī Ghṛta, aiding in the therapeutic enhancement of mental health treatments.
16) Blood:
[see source text or glossary: #Blood#] is significant in Āyurvedic philosophy and science, as it plays a crucial role in the distribution of nutrients and medicinal substances in the body, including those from herbal formulations like Brāhmī Ghṛta.
17) Rasa (Rasha):
[see source text or glossary: #Rasa#] refers to 'taste' and is also linked to the essence and medicinal properties of substances in Āyurveda, particularly in relation to their effects on mental health when included in treatments.
18) Vaca:
[see source text or glossary: #Vacā#] is a significant herb (Acorus calamus) used in formulations like Brāhmī Ghṛta for its cognitive-enhancing properties, particularly beneficial in addressing cognitive impairments.
19) Shankhapushpi (Sankhapuspi, Samkhapuspi):
[see source text or glossary: #Śaṅkhapuṣpī#] is another herb included in Brāhmī Ghṛta, recognized for its role in supporting mental clarity and functions in the context of Āyurvedic treatments for memory and learning.
20) Training:
[see source text or glossary: #Training#] in the study context refers to the behavioral conditioning process for the rats used to evaluate memory and learning, illustrating how treatments like Brāhmī Ghṛta can impact these activities.
21) Water:
[see source text or glossary: #Water#] is fundamental for all living beings and plays an essential role in delivering nutrients and medicines within the body, including the fluid formulations in Āyurveda.
22) Acorus calamus:
[see source text or glossary: #Acorus calamus#] is the scientific name for the herb Vacā, used in Brāhmī Ghṛta for its potential benefits in enhancing cognitive functions and combating mental disorders.
23) Puranaghrita (Puranaghrta, Purana-ghrita):
[see source text or glossary: #Purāṇa-ghṛta#] refers to aged or traditionally prepared ghee, often regarded as more potent in medicinal properties and used in the preparation of formulations like Brāhmī Ghṛta.
24) Murchana (Murcchana):
[see source text or glossary: #Mūrcchanā#] is a specific preparatory process in Āyurveda used to enhance the efficacy of Ghṛta, which can impact the quality and effectiveness of Brāhmī Ghṛta in treating mental disorders.
25) Medicine:
[see source text or glossary: #Medicine#] encompasses all remedies, including herbal preparations like Brāhmī Ghṛta, that are utilized within Āyurveda to improve health, particularly in the realm of mental health.
26) Dravya:
[see source text or glossary: #Dravya#] refers to substances used in Āyurveda, including the herbs and compounds found in Brāhmī Ghṛta, vital for their therapeutic properties in addressing mental health.
27) Purana:
[see source text or glossary: #Purāṇa#] denotes the aged aspect of substances, particularly Ghee, in Āyurveda that often enhances its medicinal effectiveness in treatments like Brāhmī Ghṛta.
28) Vikara:
[see source text or glossary: #Vikāra#] indicates 'disorder or disturbance' in Sanskrit, directly relating to mental disorders that formulations like Brāhmī Ghṛta are designed to alleviate according to Āyurvedic principles.
29) Unmada:
[see source text or glossary: #Unmāda#] refers to insanity or severe mental disturbance in Āyurvedic terms, which treatments like Brāhmī Ghṛta can potentially address through their cognitive-enhancing properties.
30) Medhya:
[see source text or glossary: #Medhya#] describes substances in Āyurveda that promote intellect and memory, a quality attributed to the ingredients of Brāhmī Ghṛta used to enhance cognitive function.
31) Shukra (Sukra):
[see source text or glossary: #Śukra#] denotes bodily essence or reproductive tissue in Āyurvedic medicine, which can be influenced by certain herbal formulations, potentially linking to overall mental health.
32) Diet:
[see source text or glossary: #Diet#] signifies the importance of nutritional intake within Āyurveda, impacting both physical and mental health, and is an integral part of treatment protocols including those with Brāhmī Ghṛta.
33) Zingiber officinale:
[see source text or glossary: #Zingiber officinale#] is ginger, recognized within Āyurveda for its various health benefits, often used in the dietary context to promote overall wellness including mental clarity.
34) Mental health:
[see source text or glossary: #Mental health#] encapsulates emotional and psychological well-being, directly addressed by treatments like Brāhmī Ghṛta aimed at supporting cognitive functions and alleviating disorders.
35) Shukradhatu (Sukradhatu, Shukra-dhatu):
[see source text or glossary: #Śukra-dhātu#] is a term that relates to reproductive tissue in Āyurvedic medicine, which can be affected by the quality of herbs used in formulations targeting mental disorders.
36) Nagakesara (Nagakeshara, Naga-kesara):
[see source text or glossary: #Nāgakesara#] corresponds to a flower used in certain Āyurvedic preparations, contributing to the potential therapeutic effects of formulations like Brāhmī Ghṛta in mental health treatment.
37) Perception:
[see source text or glossary: #Perception#] in the context of mental health relates to the cognitive processes affected by treatments like Brāhmī Ghṛta, which aims to enhance clarity of thought and understanding.
38) Discussion:
[see source text or glossary: #Discussion#] in research papers includes analyzing the findings from studies involving Brāhmī Ghṛta, showcasing its effects on mental disorders and exploring traditional medicine's relevance in contemporary science.
39) Vibhitaki:
[see source text or glossary: #Vibhītakī#] is a component known in Āyurveda for its medicinal properties, potentially contributing to the effectiveness of formulations aimed at enhancing cognitive functions like those in Brāhmī Ghṛta.
40) Matulunga (Matulumga, Matulamga):
[see source text or glossary: #Mātuluṅga#] is a type of fruit used in traditional medicine; when applied in formulations, it helps improve overall mental and physical health, pertinent to the preparation of Brāhmī Ghṛta.
41) Murcchita:
[see source text or glossary: #Mūrcchita#] describes the process of preparing medicated Ghee like Brāhmī Ghṛta, establishing its potency and efficacy in treating cognitive impairments and supporting mental health.
42) Substance:
[see source text or glossary: #Substance#] refers to any material used in treatments like Brāhmī Ghṛta, highlighting the importance of active ingredients that affect mental health outcomes.
43) Apasmara:
[see source text or glossary: #Apasmāra#] signifies epilepsy in Āyurvedic literature, emphasizing the need for effective treatments like Brāhmī Ghṛta aimed at stabilizing mental health and cognitive clarity.
44) Haritaki:
[see source text or glossary: #Harītakī#] refers to a well-known herb in Āyurveda used for its health benefits, contributing to formulations including Brāhmī Ghṛta which aim to enhance cognitive functions.
45) Vagbhata:
[see source text or glossary: #Vāgbhaṭa#] is one of the ancient Āyurvedic scholars, whose texts outline the principles of using substances like Brāhmī in mental health treatments, further scientific understanding of their applications.
46) Aushadhi (Ausadhi, Aushadhin, Ausadhin):
[see source text or glossary: #Aushadhi#] refers to medicinal herbs in Āyurveda, which are crucial in preparing formulations like Brāhmī Ghṛta intended for cognitive enhancement and treatment of mental disorders.
47) Epilepsy:
[see source text or glossary: #Epilepsy#] is a neurological disorder addressed within Āyurveda using formulations such as Brāhmī Ghṛta to help regulate brain function and reduce symptoms related to cognitive impairment.
48) Amalaki:
[see source text or glossary: #Āmalakī#] is an Ayurvedic herb used in the preparation of various medicines; it plays a role in enhancing the effects of formulations like Brāhmī Ghṛta on mental clarity and wellness.
49) Svarasa (Sva-rasa):
[see source text or glossary: #Svarasa#] translates to juice or essence, crucial in the preparation of herbal medicines like Brāhmī Ghṛta, which focus on delivering active ingredients effectively for mental health benefits.
50) Kaphaja:
[see source text or glossary: #Kaphaja#] refers to a type of disorder influenced by the Kapha dosha in Āyurveda, which may be treated with formulations like Brāhmī Ghṛta aimed at restoring balance and improving mental health.
51) Brahman:
[see source text or glossary: #Brahman#] is associated with ultimate consciousness in Āyurvedic philosophy, symbolizing the high spiritual aim of formulations like Brāhmī Ghṛta, which seek to enhance overall mental well-being.
52) Haridra:
[see source text or glossary: #Haridrā#] signifies turmeric in Āyurveda, which can enhance Brāhmī Ghṛta's properties, showcasing a blend of herbs aimed at enhancing mental clarity and wellness.
53) Channel:
[see source text or glossary: #Channel#] relates to the pathways in the body through which nutrients and medicines travel, crucial in understanding how substances like Brāhmī Ghṛta affect mental health conditions.
54) Quality:
[see source text or glossary: #Quality#] refers to the effectiveness and properties of formulations like Brāhmī Ghṛta, emphasizing the importance of high-quality ingredients in achieving therapeutic aims in mental health.
55) Mantra (Mamtra):
[see source text or glossary: #Mantra#] are sacred chants in Āyurveda, sometimes combined with treatments like Brāhmī Ghṛta to enhance the healing process and promote better mental health through spiritual resonance.
56) Caraka:
[see source text or glossary: #Caraka#] is one of the foundational figures in Āyurveda, whose teachings guide the use of remedies like Brāhmī for treating mental health conditions and enhancing cognitive functions.
57) Skandha (Skamdha, Skamda):
[see source text or glossary: #Skanda#] relates to specific conditions or entities within Ayurvedic texts, connecting to treatments such as Brāhmī Ghṛta that seek to address cognitive imbalances.
58) Bitter:
[see source text or glossary: #Bitter#] is a taste associated with many herbs used in Āyurveda that can stimulate digestive and cognitive functions, relevant to the properties of ingredients in Brāhmī Ghṛta.
59) Reason:
[see source text or glossary: #Reason#] underlines the rationale for selecting particular herbs and formulations like Brāhmī Ghṛta for mental health treatments, grounded in both traditional knowledge and scientific evidence.
60) Pitta:
[see source text or glossary: #Pitta#] denotes one of the three doshas in Āyurveda, influencing mental and physical health, where treatments like Brāhmī Ghṛta may address imbalances contributing to mental disorders.
61) Sneha:
[see source text or glossary: #Sneha#] signifies the concept of unctuousness in Āyurveda, crucial to understanding how formulations like Brāhmī Ghṛta are absorbed and utilized to treat mental health effectively.
62) Varti (Vartin):
[see source text or glossary: #Varti#] refers to the wick-like shape characteristic of Ghee preparations in Āyurveda, emphasizing the unique texture and form of medicinal Ghee like Brāhmī Ghṛta which aims to treat mental health issues.
63) Nasya (Nashya):
[see source text or glossary: #Nasya#] is a method of administration in Āyurveda, involving the nasal application of substances like Brāhmī Ghṛta, utilized for direct effects on cognitive functions and overall mental wellness.
64) Dhatu:
[see source text or glossary: #Dhātu#] refers to the bodily tissues in Āyurveda, signifying the importance of nourishing all bodily systems, including those influencing mental health, through the use of restorative herbs like those in Brāhmī Ghṛta.
65) Vata:
[see source text or glossary: #Vāta#] is the dosha associated with movement and metabolism, which can contribute to various mental disorders; treatments like Brāhmī Ghṛta can help to balance this dosha to promote mental wellness.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Study of Brahmi Ghrta and piracetam in amnesia’. Further sources in the context of Science might help you critically compare this page with similair documents:
Brahmighrita, Medicated ghee, Central nervous system, Institutional Animal Ethical committee, Bacopa monnieri, Passive avoidance test, Learning and memory activity, Active avoidance test, Elevated plus maze test, Lipid Soluble Drugs, Scopolamine-induced amnesia, Snehapaka process, Institute of Medical Sciences, Antiamnesic activity, Psychotropic drug, Manasa vikara, Calmodulin.