Antiulcer activity of Amlapitta Mishran suspension in rats: A pilot study
Journal name: Ancient Science of Life
Original article title: Antiulcer activity of Amlapitta Mishran suspension in rats: A pilot study
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Sampath K. Vemula, Mukesh B. Chawada, Kapil S. Thakur, Mahesh K. Vahalia
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Antiulcer activity of Amlapitta Mishran suspension in rats: A pilot study
Year: 2012
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Amlapitta Mishran is a polyherbal Ayurvedic formulation traditionally utilized for treating acidity and gastric ulcers. This study investigates its antiulcer activity, particularly against ulcers induced by non-steroidal anti-inflammatory drugs (NSAIDs) in a rat model. Gastric and duodenal ulcers represent a significant global health issue, often resulting from an imbalance between aggressive factors, such as gastric acid, and protective factors like mucus secretion. The aim of this research is to provide scientific validation for the traditional use of Amlapitta Mishran in managing gastric ulcers, especially considering the limitations of current therapeutic options.
Efficacy of Amlapitta Mishran
The study demonstrated that Amlapitta Mishran exhibits a dose-dependent antiulcer effect on NSAID-induced ulcers in rats. Male Wistar rats received Amlapitta Mishran at two different doses alongside indomethacin, a commonly used NSAID. The results indicated a significant reduction in both the total number of ulcers and ulcer index when compared to the control group. Furthermore, the percentage inhibition of ulceration was notably higher in the groups treated with Amlapitta Mishran compared to those receiving just the NSAID. This suggests that the gastroprotective effects of Amlapitta Mishran may be linked to its ability to enhance mucus secretion in the stomach, potentially mediated by prostaglandin synthesis.
Conclusion
The findings of this study support the traditional use of Amlapitta Mishran for the management of gastric ulcers, highlighting its potential as a viable herbal alternative in antiulcer therapy. The significant reduction in ulcer formation associated with Amlapitta Mishran treatment underscores its efficacy and aligns with the Ayurvedic perspective on using herbal formulations to address gastric disorders. Future research should continue to explore the mechanistic pathways through which Amlapitta Mishran exerts its gastroprotective effects, potentially leading to new therapeutic approaches for ulcer management that minimize the side effects associated with conventional medications.
FAQ section (important questions/answers):
What is the purpose of the study on Amlapitta Mishran?
The study aims to evaluate the antiulcer activity of Amlapitta Mishran suspension on NSAID-induced ulcers in a rat model, confirming its traditional use in treating gastric ulcers.
How was the antiulcer activity of Amlapitta Mishran tested?
The activity was tested by administering indomethacin to induce ulcers in rats, followed by treatment with different doses of Amlapitta Mishran to compare its effectiveness.
What were the key findings regarding Amlapitta Mishran's effectiveness?
The results showed that Amlapitta Mishran significantly reduced the total number of ulcers and ulcer index, indicating its dose-dependent gastroprotective effect.
What traditional uses does Amlapitta Mishran have?
Amlapitta Mishran is a poly-herbal Ayurvedic formulation traditionally used for treating acidity and gastric ulcers, with scientific evaluation supporting its therapeutic claims.
Other Health Sciences Concepts:
Discover the significance of concepts within the article: ‘Antiulcer activity of Amlapitta Mishran suspension in rats: A pilot study’. Further sources in the context of Health Sciences might help you critically compare this page with similair documents:
Ayurvedic system, Reactive oxygen species, Institutional animal ethics committee, Ulcer index, Non steroidal anti inflammatory drug, Prostaglandin synthesis, Percentage inhibition, Antiulcer activity, Standard diet, Gastrointestinal health, Indomethacin induced ulcer, Experimental animal, Wistar rat, Gastroprotective effect, Gastric lesions, Plastic cages.