Immunomodulatory activity of Āmalaki Rasāyana: An experimental evaluation
Journal name: Ancient Science of Life
Original article title: Immunomodulatory activity of Āmalaki Rasāyana: An experimental evaluation
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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Jignesh Rajani, B.K. Ashok, Galib, B.J. Patgiri, P.K. Prajapati, B. Ravishankar
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Immunomodulatory activity of Āmalaki Rasāyana: An experimental evaluation
Year: 2012
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
The Ayurvedic system of medicine is recognized for its potential to enhance the body’s natural immunity, a principle encapsulated in the concept of Vyādhi Kṣamatva. One notable medicinal plant within this tradition is Āmalaki (Emblica officinalis), which is classified as a Rasāyana drug known for its beneficial effects on health. Previous studies have highlighted the antioxidant and immunomodulatory properties of crude extracts of Āmalaki, but there has been limited research on Āmalaki Rasāyana, which is specifically prepared through traditional methods involving multiple levigations, or Bhāvanas. This study aimed to assess the immunomodulatory activity of two formulations of Āmalaki Rasāyana—prepared using 7 and 21 levigations, respectively—against cyclophosphamide-induced immunosuppression in rats.
Immunomodulatory Activity of Āmalaki Rasāyana
The experimental design involved administering the two formulations, referred to as AR7 (7 Bhāvanas) and AR21 (21 Bhāvanas), to Wistar rats subjected to immunosuppression via cyclophosphamide. The results indicated that Āmalaki Rasāyana exhibits significant immunostimulatory effects and moderate cytoprotective activities, with AR21 demonstrating a superior profile in both regards. Specifically, AR21 effectively mitigated body weight loss and restored organ weight in the thymus and kidney, which supports its potential nephroprotective properties. Furthermore, in terms of antibody response measured through hemagglutination titer, both formulations showed improvement compared to the cyclophosphamide control group, although the vehicle control group exhibited the most significant immune enhancement.
Conclusion
The findings highlight the substantial immunostimulatory and cytoprotective effects of Āmalaki Rasāyana, particularly the formulation prepared with 21 Bhāvanas, which proved more effective than its 7 Bhāvanas counterpart. This suggests that the preparation method significantly influences the pharmacological activity of Āmalaki Rasāyana. Therefore, for optimal immunomodulatory and protective outcomes against agents that induce immunosuppression, it is recommended to utilize the formulation involving multiple levigations. These results not only contribute to the validation of traditional Ayurvedic practices but also open avenues for further research on the therapeutic applications of Āmalaki in contemporary medicine.
FAQ section (important questions/answers):
What is the main medicinal plant studied in this research?
The research primarily focuses on Āmalaki, known scientifically as Emblica officinalis, which is recognized for its potential immunomodulatory activities and antioxidant properties within the Ayurvedic framework.
What were the two formulations of Āmalaki Rasāyana evaluated?
The study assessed two formulations of Āmalaki Rasāyana: AR7, prepared using 7 Bhāvanas, and AR21, prepared with 21 Bhāvanas, to compare their immunomodulatory effects against cyclophosphamide-induced immunosuppression in rats.
What significant findings were reported regarding AR21?
AR21 demonstrated better immunostimulant and cytoprotective activities compared to AR7, effectively addressing cyclophosphamide-induced weight loss and enhancing hematological parameters, indicating its therapeutic potential in enhancing immunity.
What were the primary methods used to analyze the data?
The data were analyzed using one-way ANOVA with Dunnett's multiple t-test to compare groups. Significant findings were indicated by a p-value less than 0.05, ensuring statistical reliability in results.
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Bhavana, Statistical analysis, Amalaki Rasayana, Gujarat Ayurved University, Immunomodulatory activity, Animal Ethics Committee, Wistar strain albino rats, Histopathological studies, Hemagglutination titer, Pharmacognosy laboratory, Serum biochemical parameters, Cytoprotective activity, Dose fixation, Body weight reduction, Department of Rasashastra and Bhaishajya Kalpana, Spleen and thymus, Cyclophosphamide induced changes.