Comparative study of anti-inflammatory effects of two Premna leaves.

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Journal name: Ancient Science of Life
Original article title: A comparative experimental evaluation of anti-inflammatory activity of Premna obtusifolia Linn and Premna latifolia Roxb leaves in Charles foster rats
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:

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Author:

Harshitha Kumari, P. Shrikanth, Chaithra, Reshmi Pushpan, K. Nishteswar


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: A comparative experimental evaluation of anti-inflammatory activity of Premna obtusifolia Linn and Premna latifolia Roxb leaves in Charles foster rats

Year: 2011

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

The study evaluates the anti-inflammatory properties of the leaves from two species of Premna, namely Premna obtusifolia and Premna latifolia, in a controlled laboratory setting using Charles Foster rats. Both species are recognized as sources of the classical Ayurvedic drug Agnimantha, which is traditionally utilized for various inflammatory conditions. The experiments aimed to assess the efficacy of leaf extracts against carrageenan-induced edema, commonly used to model inflammation in research. The results indicated that both species possessed notable anti-inflammatory effects, with P. latifolia demonstrating superior activity compared to P. obtusifolia.

Efficacy and Mechanism of Action

The significant reduction in paw edema observed in the study suggests that P. latifolia exhibits rapid and effective anti-inflammatory activity, notably suppressing the initial phase of inflammation triggered by histamine and prostaglandin-like substances. While P. obtusifolia showed effectiveness primarily in the later phase, the findings point towards P. latifolia’s ability to inhibit various mediators of inflammation, potentially supporting its use as an alternative to conventional anti-inflammatory treatments such as indomethacin. The presence of bioactive compounds in these plant leaves, including flavonoids and alkaloids, suggests that these may be responsible for the observed pharmacological effects, indicating a promising area for future research on their applications in Ayurvedic treatments.

Conclusion

In conclusion, the study underscores the potential of Premna obtusifolia and Premna latifolia as effective anti-inflammatory agents, with a strong indication that the leaves may serve as viable substitutes for the more traditionally utilized roots in Ayurvedic medicine. The favorable results from the leaf extracts could encourage further investigation into the therapeutic capabilities of these and other parts of the plants, aiming for a more sustainable approach to harvesting and using medicinal plants. Recognizing the significant anti-inflammatory properties of both species could lead to enhanced treatment options for inflammatory disorders while respecting traditional Ayurvedic practices.

FAQ section (important questions/answers):

What was the purpose of the study on Premna leaves?

The study aimed to evaluate the anti-inflammatory activity of leaves from two species of Premna, specifically Premna obtusifolia and Premna latifolia, using a carrageenan-induced rat paw edema model.

Which Premna species showed superior anti-inflammatory effects?

Premna latifolia demonstrated better anti-inflammatory activity compared to Premna obtusifolia, particularly in terms of onset and effectiveness in reducing edema.

What methodology was used for evaluating anti-inflammatory activity?

The anti-inflammatory activity was assessed by measuring paw edema in rats after administering carrageenan, with the treatments given an hour prior to the injection.

What were the implications of the study's findings?

The study supports the potential of using Premna leaves as a substitute for roots in Ayurvedic formulations due to their significant anti-inflammatory properties.

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Discover the significance of concepts within the article: ‘Comparative study of anti-inflammatory effects of two Premna leaves.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Anti-inflammatory activity, Phytochemical analysis, Animal Ethics Committee, Leaf decoction, Carrageenan-induced edema, Anti-inflammatory drug, Plant part substitution.

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