Investigation and anti-inflammatory screening of Capsicum and Hemidesmus.

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Journal name: Ancient Science of Life
Original article title: Physico-Phytochemical investigation and Anti-inflammatory screening of Capsicum annum L. and Hemidesmus indicus (Linn.) R. Br
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:

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Author:

K. Vijayalakshmi, R. Shyamala, V. Thirumurugan, M. Sethuraman, S. Rajan, Shrishailappa Badami, Pulok K. Mukherjee


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: Physico-Phytochemical investigation and Anti-inflammatory screening of Capsicum annum L. and Hemidesmus indicus (Linn.) R. Br

Year: 2010

Copyright (license): CC BY-NC-SA


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Summary of article contents:

Introduction

Capsicum annum L. (commonly known as chili) and Hemidesmus indicus (Linn.) R.Br. (known as Sariba or Nannari) are two medicinal plants widely used in Tamil Nadu for treating various ailments within traditional medicine systems. The hydroalcoholic extracts of these plants have been evaluated for their anti-inflammatory properties using the carrageenan-induced hind paw edema model in rats. The study aimed to assess the efficacy of these extracts, comparing their effect with a standard anti-inflammatory drug, indomethacin, while also conducting preliminary physico-phytochemical analyses.

The Significance of Anti-Inflammatory Activity

The anti-inflammatory activity of the hydroalcoholic extracts showcased promising outcomes, particularly for Hemidesmus indicus, which demonstrated a superior anti-inflammatory effect compared to Capsicum annum. Inflammation is characterized by a biphasic response, with the initial phase involving the release of substances such as histamine and serotonin, followed by persistent edema due to kinin-like substances and prostaglandins. The results indicate both plant extracts exhibit significant anti-inflammatory action at a dose of 100 mg/kg body weight, leading to a notable reduction in paw edema. However, the overall efficacy of the extracts was found to be less than that of the standard drug indomethacin, suggesting the need for further studies on various doses and different inflammation models to fully comprehend their therapeutic potential.

Conclusion

The findings of the study highlight the traditional medicinal value of Capsicum annum L. and Hemidesmus indicus (Linn.) R.Br. in treating inflammatory conditions. Both plants revealed significant anti-inflammatory activity, validating their use in ethnic medicine and underscoring the need for extensive research to ascertain their potential as alternative therapeutic options. The preliminary physico-phytochemical analysis provided foundational data on the composition of these extracts, which can guide future investigations aimed at exploring their full pharmacological profiles and possible applications in modern medicine.

FAQ section (important questions/answers):

What are the traditional uses of Capsicum annum L. and Hemidesmus indicus?

Capsicum annum L. is used for treating various conditions, including skin problems and urinary issues, while Hemidesmus indicus is used for inflammatory conditions, asthma, and skin diseases in traditional medicine practices in Tamil Nadu.

What was the method used to evaluate anti-inflammatory activity?

The study assessed anti-inflammatory activity using a carrageenan-induced hind paw edema model in rats, comparing the effects of hydroalcoholic extracts from both plants with a standard drug (Indomethacin).

What results were found regarding the anti-inflammatory activity of the extracts?

The hydroalcoholic extracts of Capsicum annum L. and Hemidesmus indicus demonstrated significant anti-inflammatory activity, with Hemidesmus indicus showing stronger effects than Capsicum annum in the tested model.

What are the physical and phytochemical characteristics of the studied plants?

Both plants exhibited rough texture. Capsicum annum L. fruits were yellow with a hot taste, while Hemidesmus indicus roots were light green and aromatic, containing various phytochemicals like glycosides and saponins.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Investigation and anti-inflammatory screening of Capsicum and Hemidesmus.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Phytochemical:
Phytochemicals are chemical compounds produced by plants, which have biological significance and are often investigated for their medicinal properties. The relevance in this study comes from examining compounds found in Capsicum annum and Hemidesmus indicus to identify anti-inflammatory activities and other health effects.

2) Inflammation:
Inflammation is a biological response to harmful stimuli such as pathogens or injuries, involving immune cells and molecular mediators. It plays a crucial role in host defense and is characterized by redness, heat, swelling, and pain. This study explores natural remedies that may help mitigate inflammation.

3) Activity:
Activity refers to the functional effect or biological response elicited by a substance, especially in therapeutic contexts. In this study, it relates to the anti-inflammatory effects demonstrated by the hydroalcoholic extracts of Capsicum annum and Hemidesmus indicus on induced paw edema in rats.

4) Drug:
A drug is a biological agent capable of producing a therapeutic effect or altering physiological functions. The study compares the anti-inflammatory properties of natural extracts from plants with that of a standard drug, Indomethacin, to evaluate their efficacy and potential use in traditional medicine.

5) Edema (Oedema):
Oedema is another term for edema, describing the swelling caused by excess fluid in tissues. The study utilizes the term to indicate the specific type of swelling induced in the hind paws of rats for evaluating anti-inflammatory activity, recognizing its clinical significance.

6) Water:
Water is a universal solvent and essential for various biochemical processes. In the context of this study, it is used as a solvent to extract medicinal compounds from the plant materials, allowing for the analysis of their chemical properties and biological activities.

7) Science (Scientific):
Science is a systematic enterprise that builds and organizes knowledge through observation and experimentation. This study employs scientific methods to investigate the anti-inflammatory properties and phytochemical composition of two traditional medicinal plants, contributing to the field of ethnomedicine.

8) Pharmacology:
Pharmacology is the branch of medicine that deals with the study of drugs, their effects, mechanisms, and therapeutic uses. This research investigates the pharmacological effects of plant extracts on inflammation, providing insights into their potential applications as alternative therapies in medicine.

9) Substance:
A substance refers to any material with a definite composition and specific properties. In this study, it pertains to the various phytochemicals and extracts derived from plants being tested for their anti-inflammatory activity, contributing to understanding natural remedies.

10) Flavonoid:
Flavonoids are a class of plant secondary metabolites known for their antioxidant and anti-inflammatory properties. The study notes the absence of flavonoids in the examined plants, which could inform discussions on their therapeutic potential and the characteristics of the tested extracts.

11) Medicine:
Medicine is the science and practice of diagnosing, treating, and preventing disease. This study contributes to medicinal knowledge by evaluating traditional remedies derived from plants, fostering a better understanding of their roles in healthcare and potential integration into modern medical practices.

12) Vitiation (Vitiated):
Vitiated refers to a state of deterioration or imbalance in health conditions traditionally described in herbal medicine. In this study, it is used to denote the ailments that G. annum and H. indicus aim to address in traditional Indian herbal practices.

13) Aroma (A-roma):
Aroma describes the distinctive scent or fragrance of a substance, particularly food or plants. The study mentions the pleasant aroma of Hemidesmus indicus, adding sensory characteristics to its medicinal profile and representing an important aspect of its ethnomedicinal use.

14) Hand:
Hand in this context may generally refer to the manual handling or processing of plants and samples in the laboratory. It's essential for preparing, extracting, or analyzing the plant materials that are fundamental to the study's investigative methods.

15) Burning sensation:
Burning sensation is often indicative of inflammation or irritation in tissues. This study relates the burning sensation associated with certain ailments to the therapeutic properties of the plant extracts, aiming to demonstrate their effectiveness against such discomforts.

16) Discussion:
Discussion in scholarly work refers to the analysis and interpretation of results obtained from research. In this study, the discussion section critically evaluates the findings related to anti-inflammatory activity, phytochemical properties, and potential implications for alternative medicine.

17) Shyamala (Syamala):
Shyamala refers to one of the researchers involved in the study. Mentioning individual contributions in research reports emphasizes collaborative efforts within the academic community and recognizes the roles of various scientists in the project's development.

18) Toxicity:
Toxicity denotes the degree to which a substance can harm living organisms. In the context of this study, understanding the toxicity of plant extracts is crucial for establishing their safety profiles and potential adverse effects when developed for medicinal use.

19) Swelling:
Swelling is the result of edema and is a key clinical sign of inflammation. It is monitored in the study to assess the effectiveness of the tested extracts in reducing inflammation, ultimately aiming to provide relief from related health issues.

20) Debility:
Debility indicates a state of physical weakness or incapacity, often associated with illness or chronic conditions. The study acknowledges the therapeutic potential of explored plants in alleviating symptoms of debility related to various inflammatory and health issues.

21) Epilepsy:
Epilepsy is a neurological disorder characterized by recurrent seizures. As part of discussing the medicinal uses of Hemidesmus indicus, its potential application in treating various health issues, including epilepsy, underscores the diverse therapeutic claims associated with traditional plant remedies.

22) Nannari:
Nannari is the local name for Hemidesmus indicus in Tamil, highlighting its cultural significance and regional use in traditional medicine. This identification connects the plant to its ethnomedical applications and local practices in India.

23) Pungent:
Pungent refers to a strong, sharp taste or smell, often associated with certain spices and medicinal plants. The pungency of Capsicum annum contributes to its traditional uses in medicine, emphasizing the sensory properties that may play a role in its health benefits.

24) Leprosy:
Leprosy is a chronic infectious disease that affects the skin and nerves. This study mentions that the roots of Hemidesmus indicus may be useful in treating leprosy, indicating the historical medicinal uses of the plant within traditional healing practices.

25) Emerald:
Emerald refers to a location in The Nilgiris where plant specimens were collected for the study. It underscores the geographical context of the research, linking the findings to local biodiversity and traditional practices in the herbal medicine of that area.

26) Coconut (Cocoanut):
Coconut is often tied to various traditional remedies and practices, including utilizing coconut oil for medicinal purposes. While the study primarily focuses on Capsicum annum and Hemidesmus indicus, the cultural significance of coconut is relevant to broader ethnobotanical discussions.

27) Botany:
Botany is the scientific study of plants, including their physiology, structure, genetics, and ecology. The relevance in this study lies in understanding the botanical characteristics of Capsicum annum and Hemidesmus indicus to support chemotaxonomy and research in traditional drug discovery.

28) Shariba (Sariba):
Sariba is the Sanskrit name for Hemidesmus indicus, reflecting its historical and cultural associations within Indian traditional medicine. The use of local names connects the plant to its ethnomedicinal heritage and highlights the importance of cultural context in herbal therapy.

29) Pitta:
Pitta is a term from Ayurvedic medicine describing a type of energy in the body associated with heat and metabolism. The study connects Hemidesmus indicus's properties to balancing Pitta dosha, underlining the holistic approach in traditional Indian medicinal systems.

30) Kapha:
Kapha represents another dosha in Ayurvedic medicine, associated with water and earth elements, suggesting stability and structure. The study acknowledges the role of Hemidesmus indicus in alleviating Kapha imbalances, linking the plant’s usage to traditional health practices of wellness and balance.

31) Honey:
Honey is often used in traditional medicine for its soothing properties and as a vehicle for herbal extracts. In this study, honey's potential in enhancing the therapeutic effects of Capsicum annum fruit powder underscores its relevance in traditional practices.

32) Mundi (Mundin, Mumdi):
Mundi refers to a specific geographic region from where ethnomedicinal plants were sourced for research. Recognizing regional biodiversity is essential for assessing traditional healing practices and understanding the cultural significance tied to the use of local flora.

Other Health Sciences Concepts:

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Discover the significance of concepts within the article: ‘Investigation and anti-inflammatory screening of Capsicum and Hemidesmus.’. Further sources in the context of Health Sciences might help you critically compare this page with similair documents:

Hemidesmus indicus, Coconut oil, Anti-inflammatory activity, Ethnomedicine, Organoleptic properties, Extractive value, Biphasic event, Anti-ulcerogenic, Tropical and temperate regions, Albino rat, Tissue inflammation, Research data, Phytochemical constituent.

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