Effect of Pedalium murex on Ethylene Glycol-Induced Urolithiasis
Journal name: Ancient Science of Life
Original article title: EFFECT OF ETHANOLIC FRUIT EXTRACT OF Pedalium murex Linn. IN ETHYLENE GLYCOL INDUCED UROLITHIASIS IN MALE WISTAR ALBINO RATS
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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K. S. Ananta Teepa, R Kokilavani, A Balakrishnan, K Gurusamy
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: EFFECT OF ETHANOLIC FRUIT EXTRACT OF Pedalium murex Linn. IN ETHYLENE GLYCOL INDUCED UROLITHIASIS IN MALE WISTAR ALBINO RATS
Year: 2010
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
Urolithiasis, also known as urinary stones or calculi, is a condition characterized by the formation of calcifications in the urinary system, particularly the kidneys. These stones can lead to various health issues, including hematuria and renal failure due to crystal deposits and tissue damage. This study investigates the antiurolithiatic properties of the ethanolic fruit extract of Pedalium murex Linn. in male Wistar albino rats subjected to ethylene glycol-induced urolithiasis. Past studies have demonstrated the use of ethylene glycol to induce kidney stone formation in laboratory animals, which allows researchers to evaluate potential treatments effectively.
Protective Effects of Pedalium murex
The results demonstrated that the fruit extract of Pedalium murex effectively mitigated the adverse effects caused by ethylene glycol intoxication in rats. Significant increases in liver and kidney markers—specifically enzymes such as ACP, ALP, AST, and ALT—were observed in ethylene glycol-intoxicated rats, indicating damage to renal and hepatic cells. However, the administration of the fruit extract led to a marked restoration of these enzyme levels to near-normal, suggesting a protective effect against cellular damage. Moreover, the study noted that the extract prevented crystal retention in tissues, highlighting its potential as a natural remedy in managing urolithiasis. The efficacy of the extract was comparable to that of thiazide, a standard drug used for treating kidney stones, pointing towards its significant therapeutic promise.
Conclusion
In conclusion, this investigation into the ethanolic fruit extract of Pedalium murex indicates its potent antiurolithiatic and hepato-nephroprotective activities. The findings suggest that this herbal extract could be a viable alternative or complement to conventional pharmacological treatments for urolithiasis due to its ability to restore damaged organ function and prevent further crystallization within the kidneys. Future research is encouraged to further elucidate the underlying mechanisms of action and potential clinical applications of this plant in treating kidney stone disease.
FAQ section (important questions/answers):
What is urolithiasis and how does it affect health?
Urolithiasis, or urinary calculi, involves the formation of stones in the urinary system, primarily the kidneys. It may cause pain, hematuria, proteinuria, and renal failure due to obstruction and damage to urinary tract tissues.
How was the ethanolic extract of Pedalium murex prepared?
Fruits of Pedalium murex were washed, shade dried, and powdered. A 100g powder was soaked in 500 ml of 99% ethanol overnight, filtered, and the residue was dried, yielding an 18g crude extract for therapeutic evaluation.
What effects did Pedalium murex have on kidney function?
The extract reduced elevated levels of liver and kidney markers in ethylene glycol intoxicated rats, indicating protective effects on renal tissues and prevention of crystal retention, thereby potentially mitigating urolithiasis conditions.
How did the ethanolic extract compare to conventional treatments?
The effects of Pedalium murex extract were comparable to the standard drug thiazide, suggesting its potential as an effective antiurolithiatic agent and hepato-nephroprotective remedy in managing kidney stones.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Effect of Pedalium murex on Ethylene Glycol-Induced Urolithiasis”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
A drug refers to a substance used to diagnose, treat, or prevent disease. In the context of the study, thiazide is mentioned as a standard drug for treating kidney stones, highlighting its role in managing urolithiasis alongside herbal remedies like Pedalium murex. This emphasizes the importance of pharmacological interventions in medical treatments.
2) Activity:
Activity often denotes the efficacy or function of a substance, particularly in scientific studies. Here, it pertains to the antiurolithiatic (preventing or treating kidney stones) activity of the ethanolic extract of Pedalium murex. Understanding such activity is crucial for developing effective herbal medicines and their integration into health care.
3) Science (Scientific):
Scientific pertains to disciplined methods of inquiry and empirical research. The experiments conducted in this study align with scientific methodology, providing structured evidence to ascertain the efficacy of herbal treatments. Scientific validation is essential for establishing trust and acceptance of alternative therapies in conventional medical practices.
4) Water:
Water is fundamental for life and serves as a medium in biological processes. In the experiment, ethylene glycol was diluted in drinking water to induce kidney stones in rats. Its relevance is critical as hydration status and fluid intake directly influence urinary composition and the formation of stones in the urinary tract.
5) Medicine:
Medicine refers to the science and practice of diagnosing, treating, and preventing illness. The study combines modern pharmaceutical approaches with traditional herbal medicine, emphasizing the necessity of integrating both for effective treatment strategies. Understanding the medicinal properties of plant extracts enhances the potential for new therapeutic developments.
6) Blood:
Blood is vital for transporting nutrients, oxygen, and waste products throughout the body. In this study, blood samples were analyzed for biochemical markers of liver and kidney function, revealing the impact of ethylene glycol toxicity and the potential protective effects of Pedalium murex. This relationship aids in assessing health status and monitoring therapies.
7) Diet:
Diet is crucial as it influences health and disease states. The rats were fed a standard pelleted diet, ensuring consistency in nutrition during the experiment. Understanding dietary impacts is essential when researching the effects of herbal treatments on health, as dietary components can modulate drug effects and health outcomes.
8) Toxicity:
Toxicity refers to the degree a substance can harm living organisms. The study investigates the toxicity of ethylene glycol, demonstrating its detrimental effects on kidney and liver function in rats. Exploring toxicity levels is critical in assessing safety and efficacy in potential treatments derived from herbal sources.
9) Botany:
Botany is the branch of biology that studies plants. It plays a key role in the research, providing the scientific basis for identifying and utilizing Pedalium murex as an herbal remedy. Understanding plant properties contributes to the knowledge of their applications in medicine, promoting the investigation of plant-derived compounds.
10) Wolf:
Wolf likely refers to F. Wolf, a researcher cited within the study. References to previous works are essential for grounding the current investigation's findings in established literature. This enhances the credibility of the research by contextualizing it within existing knowledge and contributing to the scientific discourse.
11) Discussion:
Discussion involves analyzing and interpreting findings in the context of existing literature. In the study, the discussion section draws conclusions from data comparing the effects of Pedalium murex to known treatments, highlighting its potential benefits. This critical evaluation is essential for conveying the implications of the research outcomes.
12) Ananta (Anamta):
Ananta refers to the first author of the study, highlighting the contributions of various researchers. Acknowledging individual contributors is essential in academic research, ensuring proper attribution for innovative findings and allowing for the dissemination of knowledge through their recognized work within the scientific community.
13) Latta:
Latha is another author mentioned, emphasizing the collaborative nature of scientific research. Each author's contributions are vital for the study's success, showcasing diverse expertise that enriches the research findings. Collaboration among researchers enhances the depth and breadth of investigations into complex medical issues.
14) Cina:
China is referenced as a country where herbal medicines are commonly used. This highlights the global acceptance and reliance on herbal therapies in various cultures, reinforcing the importance of examining plant-based treatments. Understanding cross-cultural practices can inform modern medical approaches and broaden therapeutic options in diverse populations.
15) Post:
Post likely refers to post-experimental analysis, discussing outcomes and implications after the study. Post-analysis considerations are crucial for conveying the study's relevance, recommending further research directions, and applying findings to practical therapeutic approaches. Such discussions advance knowledge and are important for the continual progression of medical science.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Effect of Pedalium murex on Ethylene Glycol-Induced Urolithiasis’. Further sources in the context of Science might help you critically compare this page with similair documents:
Scientific investigation, Urinary system, Toxicity studies, Animal Ethics Committee, Pedalium murex Linn., Ethanol extract, Shade-dried, Calcium oxalate stone, Metabolic Acidosis, Biochemical marker, Marker enzyme, Animal breeding centre, Herbarium collection, Standard drug thiazide, Crystal retention, Marker enzyme activities, Acclimatized to laboratory condition, Hepatic cell, Renal tissue.