Evaluation of anti-inflammatory and antioxidant activity of Chyavana drink.
Journal name: Ancient Science of Life
Original article title: Evaluation of anti-inflammatory and anti oxidant activity of a poly herbal formulation - Chyavana drink
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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K. Poornima, Haseeb Koya Thangal, S. Karpagavalli
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Evaluation of anti-inflammatory and anti oxidant activity of a poly herbal formulation - Chyavana drink
Year: 2008
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
The study investigates the anti-inflammatory and antioxidant properties of a polyherbal formulation known as Chyavana drink, composed of 39 different medicinal plants. The escalating global reliance on herbal medicine, as estimated by the WHO, emphasizes its significance in primary healthcare, especially in managing inflammatory conditions. Rheumatoid arthritis serves as a pertinent example, where plant-based drugs have been used to mitigate inflammation and oxidative stress, which are damaging to body cells. This research aims to substantiate the efficacy of Chyavana drink in alleviating inflammation and promoting antioxidant activity.
Antioxidant Activity Measurement
A critical finding of the study is the evaluation of Chyavana drink's antioxidant activity through various in vitro assays. The DPPH radical scavenging activity assay revealed that the formulation effectively scavenged free radicals, achieving a remarkable 94% inhibition at a concentration of 1000 µg/ml, with an IC50 value of 38.83 µg/ml. Additional tests demonstrated that the formulation's reducing power increased with higher concentrations, indicating strong antioxidant potential. Furthermore, the total phenolic content of the Chyavana drink was substantial, correlating with its antioxidant capabilities; phenolics are known for their role in preventing age-related diseases by scavenging free radicals.
Conclusion
In summary, Chyavana drink has shown significant anti-inflammatory effects comparable to established drugs, alongside robust antioxidant activity, making it a valuable candidate for natural therapeutic interventions. The presence of various phytochemicals supports its multifaceted medicinal properties, particularly in addressing inflammatory diseases like rheumatoid arthritis. This study underscores the potential of Chyavana drink in traditional medicine and provides a foundation for further research into its mechanisms and benefits in promoting health and wellness.
FAQ section (important questions/answers):
What is the purpose of the study on Chyavana drink?
The study aimed to evaluate the anti-inflammatory and antioxidant activities of the poly herbal formulation known as Chyavana drink, comparing its effectiveness to a known anti-inflammatory drug using experimental animal models.
How was inflammation induced in the study's rats?
Inflammation in the albino rats was induced by injecting 0.2 ml of 3% carrageenan into the right hind paw, allowing researchers to measure the resultant edema and test the effectiveness of the Chyavana drink.
What methods were used to assess antioxidant activity?
Antioxidant activity was assessed through various in vitro methods, including DPPH radical scavenging activity, reducing power tests, and phenolic content estimation, which indicated the formulation's capacity to inhibit free radicals.
What were the main findings regarding Chyavana drink's effects?
The study found that Chyavana drink exhibited significant anti-inflammatory activity and potent antioxidant effects, demonstrating a high percentage of free radical scavenging ability and supporting its traditional medicinal claims.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Evaluation of anti-inflammatory and antioxidant activity of Chyavana drink.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
Activity refers to the effectiveness or potency of a substance, in this case, the anti-inflammatory and antioxidant effects of the 'Chyavana drink'. These activities are measured through specific experiments where changes, such as reducing inflammation or scavenging free radicals, are observed and quantified, thus demonstrating the health benefits of the formulation.
2) Phytochemical:
Phytochemicals are bioactive compounds found in plants, which have health-enhancing properties. In the study, the presence of phytochemicals in 'Chyavana drink' was evaluated, as they contribute to its medicinal effects, such as antioxidant and anti-inflammatory activities. Understanding these compounds helps in recognizing the formulation's therapeutic potential.
3) Inflammation:
Inflammation is a biological response to harmful stimuli, characterized by swelling, redness, heat, and pain. In the study, inflammation was induced in rats to evaluate the effectiveness of 'Chyavana drink' in alleviating these symptoms. This response is critical in understanding the formulation's potential in treating inflammatory conditions.
4) Medicine:
Medicine refers to substances used to treat or prevent diseases. The research aimed at evaluating a herbal formulation, 'Chyavana drink', which is rooted in traditional practices. Understanding its medicinal properties, particularly against inflammation and oxidative stress, emphasizes the relevance of herbal formulations in contemporary medical applications.
5) Edema (Oedema):
Edema refers to the accumulation of fluid in tissues, causing swelling, particularly after inflammation. In the study, edema was measured in rats' hind paws after carrageenan induction. The reduction in edema in test subjects signifies the anti-inflammatory effectiveness of 'Chyavana drink', showcasing its therapeutic relevance.
6) Drug:
A drug is a chemical substance used to treat, cure, prevent, or diagnose a disease. 'Chyavana drink' is assessed for its potential as a natural drug, providing an herbal alternative to synthetic medications. Evaluating its efficacy helps in understanding how traditional formulations can play a role in modern healthcare.
7) Rheumatoid arthritis:
Rheumatoid arthritis is a chronic inflammatory disorder that affects joints, leading to pain and disability. The study highlights the potential of 'Chyavana drink' in managing rheumatoid arthritis symptoms. Insights into its effects on inflammation provide evidence for its use in complementary therapeutic strategies for this condition.
8) Discussion:
Discussion in scientific research involves interpreting results, comparing them with existing literature, and evaluating implications. In this study, the discussion section analyzes the findings related to 'Chyavana drink's' anti-inflammatory and antioxidant activities. It also contextualizes the results within the broader scope of herbal medicine.
9) Flavonoid:
Flavonoids are a group of phytochemicals known for their antioxidant properties. The study’s phytochemical analysis examined the presence of flavonoids in 'Chyavana drink'. These compounds are significant in understanding the formulation’s health benefits, particularly in combating oxidative stress and enhancing overall efficacy as a herbal remedy.
10) Science (Scientific):
Science is the systematic study of the structure and behavior of the physical and natural world through observation and experimentation. The research conducted on 'Chyavana drink' embodies the principles of science, as it adopts a methodological approach to evaluate the formulation’s anti-inflammatory and antioxidant properties, contributing to evidence-based medicine.
11) Latta:
Latha appears to be a contributor or author associated with the study of 'Chyavana drink'. The presence of individuals in a research context emphasizes collaboration in scientific inquiry. Their contributions add credibility to the findings and signify the importance of teamwork in advancing knowledge in herbal medicine.
12) Hand:
In this context, 'hand' could refer to the practical aspect of conducting experiments or preparing herbal formulations. It highlights the skill and care involved in scientific research, indicating that proper techniques in handling materials and subjects are vital for obtaining reliable results in the study of 'Chyavana drink'.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Evaluation of anti-inflammatory and antioxidant activity of Chyavana drink.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Control group, Treatment group, Anti-inflammatory activity, Antioxidant activity, Phytochemical screening, Herbal formulation, Oxidative stress, Phenolic content, Reducing power, DPPH radical scavenging activity, Carrageenan, In vitro method, Free Radical, Polymorphonuclear leucocyte.