EVALUATION OF WOUND HEALING ACTIVITY OF FLAVONOIDS FROM IPOMOEA CARNEA Jacq
Journal name: Ancient Science of Life
Original article title: EVALUATION OF WOUND HEALING ACTIVITY OF FLAVONOIDS FROM IPOMOEA CARNEA Jacq
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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S Ambiga, R Narayanan, Durga Gowri, D Sukumar, S Madhavan
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: EVALUATION OF WOUND HEALING ACTIVITY OF FLAVONOIDS FROM IPOMOEA CARNEA Jacq
Year: 2007
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
Flavonoids, a group of polyphenolic compounds found in numerous plants, have shown various health benefits, including medicinal applications. These compounds contribute to the pigmentation of plants and play vital roles in human health. The study primarily focuses on the extraction and evaluation of flavonoids from the flowers of Ipomoea carnea, a plant known for its healing properties, particularly its wound-healing activity. The research examines the effects of specific flavonoids, namely Kaempferol and Kaempferol-3-O-β-D-glucoside, on wound healing in male Wistar rats through several experimental models including excision and incision wound models.
Healing Efficacy of Flavonoids
The study demonstrated that both isolated compounds from Ipomoea carnea significantly enhanced wound healing compared to control groups. In the incision wound model, rats treated with Kaempferol-3-O-β-D-glucoside exhibited a notable increase in skin-breaking strength and collagen content, indicating improved healing. Similarly, in the excision wound model, the treated groups showed faster wound closure rates and higher protein content in granulation tissues. The histopathological analysis further revealed increased collagen deposition and fibroblast activity in the treated groups, affirming the efficacy of these flavonoids in promoting wound recovery.
Conclusion
The findings from the evaluation of flavonoids from Ipomoea carnea highlight their significant potential as natural wound-healing agents, comparable to the standard drug sulphathiazole. Both Kaempferol and Kaempferol-3-O-β-D-glucoside not only accelerated healing processes but also enhanced collagen turnover, critical for tissue repair. This study reinforces the medicinal value of plant-derived flavonoids, warranting further exploration for their therapeutic applications in wound management and other potential health benefits.
FAQ section (important questions/answers):
What is the focus of the study on Ipomoea carnea?
The study evaluates the wound healing activity of flavonoids extracted from the flowers of Ipomoea carnea using various wound models on male Wistar rats.
Which flavonoids were isolated from Ipomoea carnea?
The isolated flavonoids include Kaempferol and Kaempferol-3-O-β-D-glucoside, which were tested for their effectiveness in promoting wound healing.
What methods were used to assess wound healing activity?
Wound healing activity was assessed using excision and incision wound models, measuring parameters like wound closure, epithelialisation time, collagen content, and granulation tissue weight.
How did the flavonoids compare to the control group?
The flavonoids demonstrated significant wound healing activity, outperforming the control group and showing results comparable to the reference standard, sulphathiazole.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “EVALUATION OF WOUND HEALING ACTIVITY OF FLAVONOIDS FROM IPOMOEA CARNEA Jacq”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
Activity refers to the capability of a substance or compound to produce a biological effect. In the context of this study, it specifically pertains to the wound healing properties of flavonoids extracted from Ipomoea carnea. Evaluating the activity helps understand how effective these compounds are in promoting wound repair mechanisms.
2) Flavonoid:
Flavonoids are a class of naturally occurring polyphenolic compounds known for their antioxidant properties and various health benefits. They are abundant in plants, contributing to the colors of flowers and fruits. In this context, flavonoids from Ipomoea carnea are being studied for their potential wound healing effects.
3) Incision:
Incision refers to a surgical cut made in the skin or flesh, often used in experiments to study wound healing. In the research, an incision wound model is employed to observe how the extracts of Ipomoea carnea affect the healing process, specifically measuring parameters like skin-breaking strength.
4) Drug:
In this research, 'drug' denotes the compounds derived from Ipomoea carnea, specifically Kaempferol and Kaempferol-3-O-β-D-glucoside, which are being tested for their therapeutic effects. Understanding the role of these 'drugs' in wound healing is critical in evaluating their potential as natural treatments for improving recovery.
5) Edema (Oedema):
Edema refers to swelling caused by excess fluid trapping in your body's tissues. In the context of wound healing, it is an important indicative symptom that may affect the healing process. The study investigates how treatments with Ipomoea carnea extracts impact tissue edema around healing wounds.
6) Water:
Water is essential for various biological processes, including wound healing. It facilitates cellular functions, nutrient transportation, and waste removal. This study indirectly relates to water through the aqueous extracts of Ipomoea carnea, which are utilized to evaluate their efficacy in promoting healing in wound models.
7) Sugar:
In this context, sugar refers to the glycosylation seen in compounds like Kaempferol-3-O-β-D-glucoside. Sugars can influence the solubility and bioavailability of flavonoids, impacting their effectiveness in biological activities. The research aims to understand how these sugar-conjugated flavonoids contribute to the wound healing process.
8) Blood:
Blood plays a vital role in wound healing by supplying oxygen and nutrients necessary for tissue repair. It also contains various cells involved in the inflammatory response and immune defense. This study may explore how treatments with Ipomoea carnea extracts affect blood parameters relevant to the healing process.
9) Pharmacological:
Pharmacological relates to the effects and mechanisms of drugs on biological systems. In this study, the pharmacological properties of the flavonoid extracts from Ipomoea carnea are examined in the context of their wound healing activities, offering insight into their potential therapeutic applications and mechanisms of action.
10) Discussion:
Discussion refers to the section in scientific research where results are interpreted, implications are drawn, and the significance of the findings is addressed. In this study, the discussion would integrate the implications of the observed wound healing effects of Ipomoea carnea extracts, comparing them to existing treatments.
11) Accumulation (Accumulating, Accumulate):
To accumulate means to gather or build up over time. In the biological context of the study, it may refer to the process by which beneficial compounds like flavonoids build up in tissues or cells, leading to enhanced wound healing and other therapeutic effects when applied over a period.
12) Toxicity:
Toxicity refers to the degree to which a substance can harm living organisms. Understanding the toxicity of the extracts from Ipomoea carnea is crucial, as it ensures that the wound healing compounds are safe for use. The study includes toxicity assessments to evaluate the safety profile of the tested compounds.
13) Science (Scientific):
Science encompasses the systematic study of the structure and behavior of the physical and natural world through observation and experimentation. This research embodies scientific inquiry into the medicinal properties of flavonoids, contributing to the broader understanding of plant-based therapies in wound management.
14) Diet:
Diet relates to the types and amounts of food consumed by an organism. In this study, the diet of the laboratory rats is controlled to avoid confounding factors in the wound healing experiments. Proper diet ensures that results reflect the effects of the compounds from Ipomoea carnea rather than nutritional variances.
15) Post:
Post refers to the duration following an event. In this study, it likely indicates post-wound application of the flavonoid extracts and how they contribute to the healing process over time. Monitoring post-treatment outcomes is essential to gauge the effectiveness and time course of the healing response.
Other Science Concepts:
Discover the significance of concepts within the article: ‘EVALUATION OF WOUND HEALING ACTIVITY OF FLAVONOIDS FROM IPOMOEA CARNEA Jacq’. Further sources in the context of Science might help you critically compare this page with similair documents:
Ipomoea carnea, Granulation tissue, Wound healing activity, Lipid peroxidation, Histopathological study, Acute toxicity study, Kaempferol, Mesenchymal cells, Collagen deposition, Hydroxyproline content, Excision wound model, Incision wound model.