Effect of Syzygium calophyllifolium on liver enzymes in diabetic rats.
Journal name: Ancient Science of Life
Original article title: Effect of Syzygium calophyllifolium Walp. seed extract on transaminases and phosphatases in alloxan induced diabetic rats
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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K. Gurusamy, R Kokilavani, K. S. Ananta Teepa
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Effect of Syzygium calophyllifolium Walp. seed extract on transaminases and phosphatases in alloxan induced diabetic rats
Year: 2007
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
Diabetes mellitus is characterized by hyperglycemia due to either insufficient insulin secretion or impaired insulin action. The disorder leads to severe complications, such as cardiovascular issues, retinopathy, and nephropathy, when left untreated. Traditional medicines have employed various hypoglycemic plants for diabetes management. The study investigated the antidiabetic effects of Syzygium calophyllifolium Walp. seed extract in alloxan-induced diabetic rats, focusing on its impact on serum and tissue enzyme activities.
Impact of Syzygium Calophyllifolium Seed Extract on Enzyme Levels
The research revealed that alloxan-induced diabetic rats exhibited significant elevations in serum markers such as aspartate transaminase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH), acid phosphatase (ACP), and alkaline phosphatase (ALP). These enzyme increases are indicative of tissue injury often associated with diabetes. However, oral administration of S. calophyllifolium seed extract restored these enzyme levels to near-normal conditions. Notably, the untreated rats demonstrated no significant changes in their enzyme levels, highlighting the extract's potential protective role against oxidative damage caused by diabetes-related metabolic derangements.
Conclusion
The findings of this study underline the potent antidiabetic properties of S. calophyllifolium seed extract, suggesting it may serve as a beneficial therapeutic option for managing diabetes. The observed reversal of enzyme levels towards normalcy following treatment indicates the extract's ability to mitigate metabolic disturbances associated with alloxan-induced diabetes. The study opens avenues for further exploration into the molecular mechanisms underlying these effects and the potential development of herbal-based treatments for diabetes.
FAQ section (important questions/answers):
What is the effect of Syzygium calophyllifolium on diabetic rats?
The aqueous seed extract of Syzygium calophyllifolium has been shown to reverse elevated enzyme activities associated with diabetes in alloxan-induced diabetic rats, suggesting its antidiabetic properties.
How was the experiment conducted with diabetic rats?
Male albino rats were induced with diabetes using alloxan. They were then divided into groups, with one group receiving S. calophyllifolium seed extract orally for 30 days to assess its effects.
What measurements were taken to assess the treatment's effectiveness?
The study measured serum and tissue activities of various enzymes, including AST, ALT, LDH, ACP, and ALP, to evaluate the biochemical effects of the treatment in both control and diabetic groups.
What conclusions were drawn from the S. calophyllifolium study?
The results suggest that S. calophyllifolium has a significant antidiabetic effect, as it normalized enzyme levels in diabetic rats, indicating potential therapeutic value.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Effect of Syzygium calophyllifolium on liver enzymes in diabetic rats.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Blood:
In this study, blood is crucial as it serves as the medium to assess enzyme levels such as AST, ALT, and LDH. These transaminases are vital indicators of liver and kidney function, particularly in the context of diabetes-related tissue damage and metabolic disturbances. Monitoring blood parameters allows researchers to evaluate the efficacy of the treatment with S. calophyllifolium seed extract.
2) Drug:
The term drug refers to the S. calophyllifolium seed extract investigated for its antidiabetic properties. In pharmacological research, understanding how this herbal extract acts on biological systems is essential for determining its therapeutic potential. The study aims to elucidate its impact on enzyme activity in diabetic rats, offering insights into alternative treatments for diabetes.
3) Diet:
In this research, diet pertains to the controlled feeding of the experimental rats. A standard diet is crucial to ensure consistent nutrition during the study while assessing the effects of S. calophyllifolium extract. This controlled dietary context helps isolate the extract's effects on enzyme levels from other variables, allowing for valid conclusions to be drawn.
4) Activity:
Activity in this context signifies the levels of enzymatic reactions measured in the serum, liver, and kidney samples. The term is significant in evaluating the biochemical effects induced by alloxan-induced diabetes and the subsequent recovery observed after administration of S. calophyllifolium. Analyzing enzyme activity provides insights into the biological impact and efficacy of the treatment.
5) Science (Scientific):
Science refers to the methodical study of natural phenomena through observation and experimentation. In this research, scientific principles are applied to understand the biochemical changes occurring due to diabetes and the potential therapeutic effects of S. calophyllifolium. This systematic approach allows for a rigorous evaluation of traditional medicine through modern scientific lenses.
6) Water:
Water is the solvent used in preparation of the aqueous extract of S. calophyllifolium seeds for this study. Its role as a medium for extracting phytochemicals is essential, as it influences the availability and efficacy of the active compounds present in the seeds. The use of distilled water ensures that the extract is free from any contaminants.
7) Trigonella foenum-graecum:
Trigonella foenum-graecum, also known as fenugreek, is referenced as another plant studied for its hypoglycemic effects. By comparing data and findings from other studies involving this plant, the research contextualizes the significance of S. calophyllifolium in traditional medicine and its potential benefits in managing diabetes-related complications, further supporting the search for alternative treatments.
8) Pharmacology:
Pharmacology encompasses the study of drug actions and interactions within biological systems. In this research, pharmacology is used to evaluate the antidiabetic effects of S.calophyllifolium seed extract. Understanding the biochemical pathways affected by this herbal extract aids in discerning its therapeutic potential and mechanisms of action on diabetes and related enzyme activities.
9) Discussion:
Discussion refers to the section in scientific papers where results are analyzed and interpreted. In this study, the discussion section contextualizes findings regarding the enzyme activities in alloxan-induced diabetic rats. It connects observed data to existing literature, emphasizing the efficacy of S.calophyllifolium as an antidiabetic agent and suggesting future research directions.
10) Ayurveda (Āyurveda, Ayus-veda):
Ayurveda symbolizes the traditional Indian system of medicine that often utilizes herbal remedies, including plants like S. calophyllifolium. This study's context nods to the historical significance of Ayurveda in managing diabetes, underscoring the importance of exploring herbal treatments through modern scientific methodologies to validate and potentially integrate traditional practices.
11) Medicine:
Medicine in this text relates to the practice of treating and preventing diseases. The research evaluates S. calophyllifolium's role as a potential medicinal agent against diabetes. By bridging traditional practices and scientific inquiry, this study contributes to a broader understanding of how herbal medicines can complement modern healthcare strategies in diabetes management.
12) Ananta (Ānanta, Anantā, Anamta, Āṉanta):
Ananta refers to K. S. Ananta Teepa, one of the authors involved in the study. The contributions of individual researchers are essential for the completeness and credibility of scientific work. Their expertise guides experimental design, data analysis, and interpretation of results, fostering collaboration that enriches the research outcomes.
13) Salin (Sālin, Shalin, Śālin):
Shalin could refer to Shalin A. from the references, indicating prior studies associated with diabetes and herbal treatments. Recognizing contributions from other researchers helps establish a broader scientific context within which the current study operates. It illustrates the continuing dialogue in the field regarding the evaluation of herbal substances.
14) Sharman (Śarma, Sarmā, Sarma, Sharma, Śarman):
Sharma references one of the authors, R. Sharma, who contributed to the broader research landscape associated with diabetes and herbal remedies. Including multiple researchers enriches scientific exploration, illustrating collaborative efforts to enhance understanding of diabetes treatment options through investigating natural products and their effects.
15) Botany:
Botany is the scientific study of plants, crucial for this research that involves S. calophyllifolium. Understanding the botanical characteristics, chemical composition, and traditional uses of this plant informs its potential applications in medicine. Botanists often authenticate and identify plants, ensuring the validity of the herbal extracts used in pharmacological studies.
16) Gupta (Guptā):
Gupta, identified in the references, likely refers to one of the authors contributing to the understanding of diabetes and herbal medicines. Highlighting such associations within the study underscores the collaborative nature of scientific research while acknowledging the body's collective knowledge that continually informs and guides individual research endeavors.
17) Latta (Laṭṭā):
Latha is mentioned as a contributor to research in the context of diabetes and herbal studies. Recognizing the roles of various researchers in this scientific investigation acknowledges the importance of diverse expertise and perspectives that enhance research quality, creating a richer context for understanding the implications and potential benefits of herbal treatments.
Other Health Sciences Concepts:
Discover the significance of concepts within the article: ‘Effect of Syzygium calophyllifolium on liver enzymes in diabetic rats.’. Further sources in the context of Health Sciences might help you critically compare this page with similair documents:
Traditional medicine, Statistical analysis, Control group, Oral administration, Experimental setup, Hyperglycemia, Biochemical analysis, Serum marker enzymes, Herbal drug treatment, Potent antidiabetic activity, Diabetic Condition, Alloxan induced diabetic rat, Liver and kidney samples, Herbal practices.