BRONCHODILATOR EFFECT OF ALCOHOLIC EXTRACT OF Euphorbia hirta linn

| Posted in: Science Health Sciences

Journal name: Ancient Science of Life
Original article title: BRONCHODILATOR EFFECT OF ALCOHOLIC EXTRACT OF Euphorbia hirta linn
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

S. Karpagam Kumara Sundari, C T. Kumarappan, A. Jaswanth, R Valarmathy


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: BRONCHODILATOR EFFECT OF ALCOHOLIC EXTRACT OF Euphorbia hirta linn

Year: 2004

Copyright (license): CC BY-NC-SA


Download the PDF file of the original publication


Summary of article contents:

Introduction

The study investigates the bronchodilator effect of the alcoholic extract of Euphorbia hirta Linn, a plant commonly used in traditional Indian medicine for the treatment of asthma and bronchitis. Bronchial asthma is characterized by airway obstruction due to hypersensitivity reactions mediated by various chemical substances. The research aims to evaluate the protective effects of E. hirta against histamine-induced bronchoconstriction using a model involving guinea pigs, with a focus on assessing the effectiveness of different doses of the extract.

Efficacy of Euphorbia Hirta on Bronchoconstriction

The results showed a dose-dependent bronchodilator effect of Euphorbia hirta, with the maximum efficacy observed at a dosage of 200 mg/kg, which significantly increased the mean exposition time post-treatment compared to pre-treatment results (P < 0.001). The study recorded percentage protection values of 19.93%, 43.08%, and 80.66% for the doses of 50 mg/kg, 100 mg/kg, and 200 mg/kg, respectively. In contrast, the standard antihistamine drug Promethazine offered 100% protection against bronchoconstriction. This highlights the potential of E. hirta as a herbal alternative for managing asthma symptoms, possibly due to its antiallergic properties.

Conclusion

The findings of this study provide evidence supporting the use of Euphorbia hirta as a natural bronchodilator, demonstrating its effectiveness in alleviating histamine-induced bronchoconstriction. The increasing protection afforded by higher doses suggests that further exploration into its active compounds could lead to the development of novel anti-asthmatic therapies. This research opens avenues for further studies to validate the traditional use of herbal medicines in treating respiratory ailments and to identify the active principles responsible for their therapeutic actions.

FAQ section (important questions/answers):

What is the bronchodilator effect of Euphorbia hirta?

Euphorbia hirta Linn exhibits a dose-dependent bronchodilator effect against histamine-induced bronchoconstriction, particularly at 200 mg/kg, showing significant improvement.

How was the study on Euphorbia hirta conducted?

The study was conducted using guinea pigs exposed to histamine aerosol. Different doses of the extract were administered, and exposition times were measured to assess protective effects.

What does the study suggest about Euphorbia hirta?

The findings indicate that Euphorbia hirta has potential as an anti-asthmatic agent, inhibiting bronchospasm and suggesting an H1 blocking effect.

What comparison was made in the bronchodilator study?

The effects of Euphorbia hirta were compared with the known anti-histaminic drug Promethazine, which provided complete protection, demonstrating E. hirta's efficacy at varying doses.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “BRONCHODILATOR EFFECT OF ALCOHOLIC EXTRACT OF Euphorbia hirta linn”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Science (Scientific):
Scientific refers to knowledge that is based on the systematic study of natural phenomena. The term underscores the study's aim to provide empirically validated results regarding the effects of Euphorbia hirta. Employing rigorous testing and analysis, the research aims to contribute to the body of scientific literature on traditional medicinal plants.

2) Post:
Post in this context refers to the period after an initial treatment or intervention. The study involves measuring the bronchodilator effects of Euphorbia hirta after administration, comparing the 'post' treatment outcomes to 'pre' treatment baselines. This differential analysis helps determine the effectiveness of the extract in countering histamine-induced bronchoconstriction.

3) Drug:
A drug is a substance intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease. This research discusses the potential of Euphorbia hirta as a natural drug, assessing its pharmacological properties against traditional antihistaminic drugs such as Promethazine, thereby exploring its therapeutic efficacy in treating bronchial conditions.

4) Medicine:
Medicine is the science and practice of diagnosing, treating, and preventing illness. This study falls within the domain of alternative medicine, highlighting the use of herbal extracts like Euphorbia hirta in managing conditions like asthma. It emphasizes the link between traditional medicinal practices and modern scientific validation.

5) Activity:
Activity in this research pertains to the biological effects exhibited by Euphorbia hirta, specifically its bronchodilator activity. The study quantitatively assesses how varying doses of the extract affect the response to histamine challenge, demonstrating the extract's potential therapeutic benefits through measured pharmacological effects.

6) Bronchial asthma:
Bronchial asthma is a chronic condition characterized by the inflammation and narrowing of airways, leading to breathing difficulties. The relevance of this term in the research anchors the study's objective: to explore new, potentially safer therapeutic options derived from plants to manage or alleviate the symptoms of asthma effectively.

7) Pharmacology:
Pharmacology is the branch of medicine that deals with the study of drugs, their effects, and mechanisms of action. This research is deeply rooted in pharmacology, as it investigates the efficacy and safety of a natural herbal extract, Euphorbia hirta, in modulating bronchoconstriction and reviewing drug interactions at a pharmacological level.

8) Water:
Water is essential in biological systems and is mentioned as a solvent in the preparation of Euphorbia hirta extracts. In pharmacological studies, water serves as the medium for administration and impacts the solubility and bioavailability of the active compounds, thus influencing the extract’s therapeutic efficacy in the experimental setup.

9) Benincasa hispida:
Benincasa hispida, known as winter melon, is evaluated in another study referenced within the document. Comparative studies involving its effects on bronchospasm highlight the breadth of medicinal plants explored for treating respiratory issues. Including alternate plants suggests a wider context for developing herbal remedies alongside Euphorbia hirta.

10) Pharmacological:
Pharmacological pertains to the branch of medicine that studies the effects and modes of action of drugs. This term denotes the study's focus on understanding how Euphorbia hirta functions at a biochemical level to provide relief from bronchoconstriction, including potential interactions with histamine receptors or other mediators involved in asthma.

11) Inflammation:
Inflammation is a biological response to harmful stimuli, often a key factor in conditions like asthma. Mentioning inflammation emphasizes the underlying mechanisms of bronchial asthma being studied, and how the effectiveness of Euphorbia hirta may correlate with its ability to alleviate inflammatory responses in the respiratory pathways.

12) Discussion:
Discussion refers to the section of the study where results are interpreted, contextualized, and linked to existing knowledge. This section is critical for understanding the implications of the findings regarding Euphorbia hirta’s efficacy as a bronchodilator and exploring recommendations for future research and therapeutic applications.

13) Sundari (Sundarī, Sumdari):
Sundari refers to one of the contributing researchers in the study. This term highlights the collaborative nature of scientific research, illustrating how outputs are the culmination of many individuals’ expertise and efforts. Acknowledging individual contributors is customary and points to the academic rigor behind the findings.

14) Allergy:
Allergy is a hypersensitive response by the immune system to foreign substances, often leading to symptoms like those seen in asthma. This term's relevance stems from the study's aim to address the therapeutic potential of Euphorbia hirta in managing allergic reactions and bronchial asthma, which are closely interrelated.

15) Shukla (Śukla, Śuklā, Suklā, Sukla):
Shukla refers to one of the cited researchers, acknowledging their contribution to related pharmacological studies. This reflects the depth of peer-reviewed literature that informs the current research, emphasizing the importance of building upon existing knowledge and recognizing the influences of previous works on current findings.

16) Botany:
Botany is the scientific study of plants. The mention of botany in this research context underscores the importance of understanding plant sources, their properties, and their potential applications in medicine. This relationship highlights how traditional knowledge intersects with botanical research in developing modern therapeutic strategies.

17) Kumara (Kumāra, Kumārā):
Kumara refers to one of the authors of the study, emphasizing individual contributions to research. It signifies the importance of collaboration among academic professionals in the fields of pharmacology and herbal medicine and underscores the collective effort involved in advancing scientific knowledge in these domains.

18) Gupta (Guptā):
Gupta, like other author names mentioned, represents a contributor to the study. Each name signifies the collaborative effort inherent in scientific research, reflecting the diverse expertise needed to investigate and validate the medicinal properties of plants like Euphorbia hirta, ultimately contributing to future therapeutic applications.

19) Glass:
In this context, glass refers to the type of nebuliser used in the histamine aerosol tests. The use of glass equipment emphasizes the standards of precision and safety in scientific experiments, showing the importance of using appropriate materials to ensure reliable and reproducible results in pharmacological testing.

Other Health Sciences Concepts:

[back to top]

Discover the significance of concepts within the article: ‘BRONCHODILATOR EFFECT OF ALCOHOLIC EXTRACT OF Euphorbia hirta linn’. Further sources in the context of Health Sciences might help you critically compare this page with similair documents:

Bronchial asthma, Active principle, Ayurvedic system of medicine, Traditional literature, Student's t test, Protective effect, Alcoholic extract, Dose-dependent effect, Euphorbia hirta Linn, Bronchodilator effect, Promethazine hydrochloride, Chemical mediators.

Let's grow together!

I humbly request your help to keep doing what I do best: provide the world with unbiased sources, definitions and images. Your donation direclty influences the quality and quantity of knowledge, wisdom and spiritual insight the world is exposed to.

Let's make the world a better place together!

Like what you read? Help to become even better: