ANTIFERTILITY EFFECT OF LINDENBERGIA INDICA (70% EtOH) EXTRACT

| Posted in: Science

Journal name: Ancient Science of Life
Original article title: ANTIFERTILITY EFFECT OF LINDENBERGIA INDICA (70% EtOH) EXTRACT
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Ashok Purohit, Surendra K. Vyas


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: ANTIFERTILITY EFFECT OF LINDENBERGIA INDICA (70% EtOH) EXTRACT

Year: 2003

Copyright (license): CC BY-NC-SA


Download the PDF file of the original publication


Summary of article contents:

Introduction

The study investigates the antifertility effects of Lindenbergia indica, a herb from the Scrophulariaceae family, on female rats. Known locally as “Pindru,” this plant has been utilized traditionally for various ailments, but its impact on reproduction had not been previously explored. The research aimed to determine the potential of a 70% ethanol extract of Lindenbergia indica as an oral contraceptive by observing its effects on fertility and the lipid profile of treated rats.

Impact on Lipid Profile and Fertility

Oral administration of Lindenbergia indica extract at dosages of 500 mg/kg and 1000 mg/kg resulted in significant reductions in serum cholesterol, HDL-cholesterol, triglycerides, and phospholipids, implying that the extract disrupts normal lipid metabolism and synthesis. The observed decline in estrogen levels, attributed to decreased cholesterol—a precursor for steroid hormone production—indicates that the extract interferes with Oogenesis. Ultimately, the extract demonstrated a negative fertility outcome of 90–100% in the treated groups, suggesting a strong association between lipid profile changes and reduced reproductive capabilities in the female rats.

Conclusion

The findings of this study indicate that the 70% ethanol extract of Lindenbergia indica effectively diminishes Oogenesis and estrogen levels, thereby leading to significant antifertility effects in female rats. The reduction in crucial lipid components in the serum further supports the idea of hormonal disruption as a mechanism for its contraceptive properties. This research potentially paves the way for developing a herbal contraceptive agent, highlighting the need for further investigation into its safety and efficacy in humans.

FAQ section (important questions/answers):

What is the main focus of the study on Lindenbergia indica?

The study investigates the antifertility effects of 70% EtOH extract of Lindenbergia indica in female rats, exploring its potential as an oral contraceptive agent by assessing effects on hormone levels and fertility.

What were the main findings regarding lipid levels in rats?

The treatment with Lindenbergia indica resulted in significant reductions in serum cholesterol, HDL-cholesterol, triglycerides, and phospholipids, indicating a potential impact on metabolic processes related to reproductive functions.

How did Lindenbergia indica affect fertility in female rats?

The study observed a 90-100% negative fertility outcome in treated rats, suggesting that the extract inhibits oogenesis and depletes estrogen levels, leading to reproductive impairment.

What methods were used to assess the effects of the extract?

The research involved oral administration of the extract, monitoring estrus cycles through vaginal smears, and performing laparotomies post-treatment to evaluate implantation sites and serum lipid profiles.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “ANTIFERTILITY EFFECT OF LINDENBERGIA INDICA (70% EtOH) EXTRACT”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Discussion:
Discussion refers to the section of research where findings are interpreted and contextualized within the broader scope of existing knowledge. It allows for the elaboration on the results presented, addressing implications, limitations, and connections to previous studies, thereby advancing understanding of the studied phenomenon—in this case, the antifertility effects of Lindenbergia indica.

2) Zoology:
Zoology is the branch of biology that studies animals, covering their structure, function, behavior, and evolution. In this study, it is relevant as the research focuses on the reproductive physiology of female rats, contributing to understanding ecological and evolutionary patterns related to reproduction and fertility effects induced by plant extracts.

3) Science (Scientific):
Science is the systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions about the universe. This study illustrates the scientific method through hypothesis testing regarding the antifertility effects of Lindenbergia indica, contributing to empirical knowledge within biological and medical research.

4) Cancer:
Cancer is a group of diseases characterized by uncontrolled cell growth. The relevance in this study lies in the mention of terpenoids from Lindenbergia indica that have shown cytotoxicity against human cancer cell lines, suggesting potential therapeutic properties of the plant beyond antireproductive effects, possibly informing future cancer research.

5) Water:
Water is a crucial solvent in biological systems, essential for various physiological functions. In this study, water is indirectly relevant as the rats were maintained with water ad libitum, ensuring proper hydration, which impacts metabolism, absorption of nutrients, and overall health, critical for reliable experimental outcomes.

6) Blood:
Blood is a vital fluid that transports oxygen, nutrients, and hormones to cells and removes waste products. In this study, blood samples were collected to assess serum lipid profiles, highlighting its role in understanding metabolic changes and physiological impacts of the Lindenbergia indica extract on female reproductive health.

7) Diet:
Diet refers to the sum of food consumed by an organism. In this research, the rats were maintained on a standard diet, which is essential for ensuring that any observed effects from the Lindenbergia indica extract are attributed to the treatment itself, and not due to variations in nutritional intake.

8) Drug:
A drug is a substance used for medical purposes, particularly to diagnose, cure, or prevent diseases. The study investigates the potential of Lindenbergia indica extract as an oral contraceptive, positioning it as a candidate drug for fertility regulation, which has implications for reproductive health management in humans.

Other Science Concepts:

[back to top]

Discover the significance of concepts within the article: ‘ANTIFERTILITY EFFECT OF LINDENBERGIA INDICA (70% EtOH) EXTRACT’. Further sources in the context of Science might help you critically compare this page with similair documents:

Significant reduction, Female rat, Serum cholesterol, Serum lipid profile, Chronic Bronchitis, Oral feeding, Oogenesis, Ancient Science of life, Alkaloids and terpenoids, Fertility test.

Like what you read? Consider supporting this website: