Bioefficiency of Indigofera tinctoria on isoniazid hepatotoxicity
Journal name: Ancient Science of Life
Original article title: Bioefficiency of indigogera tinctoria linn. on isoniazid induced hepatotoxicity in albinorats
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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M. Chitra, N. Muthusudha, R. Sasikala
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Bioefficiency of indigogera tinctoria linn. on isoniazid induced hepatotoxicity in albinorats
Year: 2003
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
The study conducted by M. Chitra, N. Muthusudha, and R. Sasikala explores the hepatoprotective effects of Indigofera tinctoria Linn. against isoniazid-induced hepatotoxicity in albino rats. Isoniazid is commonly used to treat tuberculosis but can cause liver toxicity even at low doses. The aim of the research was to evaluate the efficacy of the leaf extract of Indigofera tinctoria in reversing liver damage caused by isoniazid. The plant, used traditionally for various health issues, including liver ailments, was investigated through a controlled study involving multiple dosage levels administered to different groups of rats over 15 days.
Hepatoprotective Efficacy of Indigofera tinctoria
The findings of the study reveal that administration of Indigofera tinctoria leaf extract significantly mitigated the biochemical alterations induced by isoniazid toxicity. Biochemical markers such as serum levels of AST, ALT, ALP, total bilirubin, and total protein were measured during the course of the experiment. Rats treated with Indigofera tinctoria, particularly at higher doses, demonstrated significant improvements in these parameters, indicating restored liver function. The restoration of these markers suggests that the extract may promote hepatocyte regeneration and reduce liver enzyme leakage into the bloodstream, thereby alleviating the damage caused by isoniazid. Despite the observed benefits, the precise mechanisms underlying the protective effects remain unclear and warrant further investigation.
Conclusion
The research highlights the potential of Indigofera tinctoria as a natural treatment option for combating isoniazid-induced hepatotoxicity. The plant demonstrates considerable hepatoprotective effects, as evidenced by its ability to normalize abnormal biochemical levels in affected rats. Future studies are recommended to explore the mechanisms of action and long-term effects of Indigofera tinctoria, which could enhance our understanding of its therapeutic benefits and contribute to the development of effective treatments for liver diseases with minimal side effects. The authors express their gratitude to the institutions and individuals who supported their research efforts.
FAQ section (important questions/answers):
What is the purpose of the study on Indigofera tinctoria?
The study aims to evaluate the hepatoprotective effects of Indigofera tinctoria leaf extract against isoniazid-induced hepatotoxicity in albino rats, focusing on its potential to reverse liver damage.
How was Indigofera tinctoria administered in the study?
Indigofera tinctoria leaf extract was administered orally to rats in two doses: 5 ml/kg and 10 ml/kg of body weight, alongside isoniazid treatment, to assess its protective efficacy against liver damage.
What changes were observed in biochemical parameters after treatment?
After treatment with Indigofera tinctoria, levels of AST, ALT, ALP, and total bilirubin returned to normal, indicating significant protection against liver damage caused by isoniazid.
What are the implications of this study's findings?
The findings suggest that Indigofera tinctoria has hepatoprotective properties, potentially helping in the management of liver diseases without significant side effects, warranting further long-term studies for deeper insights.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Bioefficiency of Indigofera tinctoria on isoniazid hepatotoxicity”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Indigofera tinctoria:
Indigofera tinctoria, commonly known as indigo or true indigo, is a plant widely studied for its potential hepatoprotective properties. The leaf extract of this plant has shown effectiveness in reversing liver damage induced by isoniazid, a common antitubercular drug, thus highlighting its relevance in natural therapeutic interventions for liver health.
2) Tuberculosis:
Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis, primarily affecting the lungs. The standard treatment for TB often includes isoniazid. However, the drug can induce liver toxicity, which emphasizes the need for protective agents, like extracts from Indigofera tinctoria, to mitigate these adverse effects.
3) Toxicity:
Toxicity refers to the degree to which a substance can harm biological systems. In the context of this study, isoniazid is known to cause toxicity, particularly hepatotoxicity, which necessitates the evaluation of protective substances like Indigofera tinctoria to alleviate the toxic effects on the liver in experimental models.
4) Activity:
Activity in this context refers to the biological effects and efficacy of Indigofera tinctoria against liver damage. The study investigates its protective activity by measuring changes in serum biochemical markers, indicating how effectively the plant extract can counteract the liver enzyme alterations induced by isoniazid administration.
5) Science (Scientific):
Science provides the methodological framework for understanding biological interactions and therapeutic effects in controlled studies. This research exemplifies the scientific approach in pharmacology, using experimental methods to assess the hepatoprotective effects of Indigofera tinctoria, contributing to the broader field of medicinal plant research and pharmacotherapy.
6) Water:
Water serves as a solvent and medium in the experimental setup. For this study, it is used to ensure the delivery of the various treatments to the rats. The control group received water, highlighting the importance of comparing the effects of treatments against a baseline without any active intervention.
7) Blood:
Blood is a crucial medium for evaluating the biochemical effects of treatments as it transports enzymes, proteins, and metabolites throughout the body. Serum biochemical parameters measured in the blood, such as AST, ALT, and bilirubin levels, provide insights into liver function and the extent of hepatoprotection offered by Indigofera tinctoria.
8) Insect poison (Insect venom):
The mention of venomous insects highlights the traditional uses of Indigofera tinctoria in folk medicine, where it is applied to alleviate pain from bites. This underscores the multifaceted applications of the plant and its historical significance in managing not only liver ailments but also other health issues caused by envenomation.
9) Discussion:
Discussion refers to the section where results are interpreted, contextualized, and implications are drawn. In this study, the discussion elaborates on the significance of the findings regarding Indigofera tinctoria's hepatoprotective effects and prompts further exploration into its mechanisms of action and potential clinical applications in treating drug-induced hepatotoxicity.
10) Medicine:
Medicine relates to the field dedicated to diagnosing, treating, and preventing illnesses. The study's focus on natural plant extracts like Indigofera tinctoria contributes to integrative medicine, combining traditional and modern medical practices, especially pertinent for liver ailments often exacerbated by pharmaceutical interventions like isoniazid.
11) Insect:
Insects represent a broader category that informs the study’s traditional applications of Indigofera tinctoria. The ability of the plant to alleviate pain from insect bites enhances its profile as a versatile herbal remedy and further suggests its potential for other therapeutic uses, including anti-inflammatory properties.
12) Diet:
Diet refers to the nutritional regimen provided to the experimental rats. Standard pellet diet ensures the animals receive a balanced nutritional foundation, critical for the validity of the results. Proper dietary control is essential in animal studies to ensure that observed effects are attributable to the treatments and not other dietary variables.
13) Drug:
The term drug signifies substances used for medical treatment, notably isoniazid in this study, which is essential for TB treatment but poses risks of hepatotoxicity. Understanding the drug's effects and the potential of Indigofera tinctoria as a protective agent underscores the critical interaction between pharmacology and herbal remedies.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Bioefficiency of Indigofera tinctoria on isoniazid hepatotoxicity’. Further sources in the context of Science might help you critically compare this page with similair documents:
Control group, Clinical management, Mechanism of action, Serum total protein, Hepatoprotective efficacy, Hepatic Dysfunction, Biochemical parameter, Isoniazid induced hepatotoxicity, Albino rat, Indigofera tinctoria Linn.