Anti-atherogenic Action of “Cardipro” - A Herbal Proprietary Formulation
Journal name: Ancient Science of Life
Original article title: Anti-atherogenic Action of “Cardipro” - A Herbal Proprietary Formulation
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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S. Chatterjee, A.T. Rao, S.N Das, S.K. Agrawal
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Anti-atherogenic Action of “Cardipro” - A Herbal Proprietary Formulation
Year: 2001
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
Atherosclerosis, characterized by the buildup of lipids and plaque in arterial walls, poses a significant risk for cardiovascular diseases, which are leading causes of mortality globally. The study aimed to assess the anti-atherogenic properties of Cardipro, a polyherbal cardiotonic formulation composed mainly of extracts from Terminalia arjuna, Ocimum sanctum, Boerhaavia diffusa, Emblica officinalis, and Withania somnifera. Previous research highlighted Cardipro’s potential in cardiovascular health, demonstrating positive effects on cardiac function and lipid profiles. This study specifically investigates Cardipro's ability to mitigate atherosclerosis in adult Wistar albino rats subjected to a high-cholesterol diet.
Lipid Profile Modulation
The examination of lipid profiles revealed that cholesterol-fed rats exhibited significantly elevated levels of total lipids, cholesterol, low-density lipoproteins (LDL), very low-density lipoproteins (VLDL), and triglycerides compared to healthy controls. In contrast, treatment with Cardipro notably reduced these lipid levels, particularly in rats receiving the higher dose of 50 mg/kg. Histopathological analyses of the aorta corroborated these findings, revealing a marked reduction in cholesterol accumulation and atherosclerotic changes in the Cardipro-treated groups. The absence of microthrombi and calcium deposits in the arterial tissues from these rats further underscored Cardipro's beneficial effects on maintaining vascular health and preventing atherogenesis.
Conclusion
The study concludes that Cardipro demonstrates significant anti-atherogenic activity, illustrated by improved lipid profiles and reduced pathological changes in aortic tissues of cholesterol-fed rats. These results suggest that the herbal formulation could be a valuable adjunct in managing atherosclerosis and associated cardiovascular issues. Although the precise mechanisms of action warrant further investigation, the promising outcomes indicate that Cardipro may offer a natural therapeutic option for patients suffering from hyperlipidemia and related cardiovascular disorders. Accordingly, larger clinical trials are recommended to validate these findings in human populations.
FAQ section (important questions/answers):
What is the primary purpose of the Cardipro study?
The study aimed to determine the anti-atherogenic effects of Cardipro, a poly herbal cardiotonic formulation containing standardized extracts from multiple plants, in Wistar albino rats.
How was the effectiveness of Cardipro measured in the study?
Effectiveness was measured by evaluating blood lipid profiles, including total lipids, cholesterol, and triglycerides, and comparing these levels in Cardipro-treated rats against untreated cholesterol-fed rats.
What were the key findings related to blood lipid levels?
Cardipro significantly reduced total lipids, cholesterol, LDL, VLDL, and triglycerides in cholesterol-fed rats, indicating strong anti-atherogenic properties and potential benefits for treating high cholesterol levels.
What further studies are recommended based on the findings?
The study recommends conducting large-scale clinical trials on hyperlipidemic patients to further validate Cardipro's efficacy in managing atherosclerosis and associated cardiac issues.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Anti-atherogenic Action of “Cardipro” - A Herbal Proprietary Formulation”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Blood:
Blood is a vital fluid that carries oxygen and nutrients to cells while removing waste products. In the context of this study, the authors examine how Cardipro influences blood component levels, such as total lipids, cholesterol, and triglycerides, crucial in understanding atherosclerosis and cardiovascular health.
2) Arjuna:
Arjuna refers to Terminalia arjuna, a tree whose bark is traditionally used in Ayurvedic medicine. Its extracts are a significant part of Cardipro and are implicated in reducing cholesterol levels and improving cardiovascular health. Its relevance in the study highlights its potential anti-atherogenic properties.
3) Activity:
Activity in this context refers to the biological effects or pharmacological actions of Cardipro and its constituents. The study evaluates various activities, focusing on the formulation's ability to reduce lipid accumulation and improve cardiovascular parameters, ultimately contributing to its anti-atherogenic profile.
4) Salt (Salty):
Salt, specifically referring to calcium salts in this study, is linked to atherosclerosis. The deposition of calcium in blood vessels is a significant pathological feature of the disease. The authors report that Cardipro prevents this deposition, suggesting a protective mechanism against atherosclerotic changes in aortic tissues.
5) Emblica officinalis:
Emblica officinalis, also known as Amla, is a key ingredient in Cardipro known for its antioxidant properties. This herb may aid in lowering cholesterol levels and enhancing the body’s metabolic processes. Its inclusion underscores the formulation's holistic approach to managing cardiovascular health.
6) Ocimum sanctum:
Ocimum sanctum, commonly known as Holy Basil or Tulsi, is a prominent herb in traditional medicine. Its extracts in Cardipro may contribute to the formulation's cardioprotective effects, which include reducing cholesterol levels and improving overall lipoprotein profiles, important for cardiovascular health.
7) Terminalia arjuna:
Terminalia arjuna is a tree widely referenced in Ayurvedic practices and used in Cardipro for its health benefits. Its extracts are known for their ability to improve heart function, lower cholesterol, and combat the adverse effects associated with atherosclerosis, making it vital in the study's context.
8) Accumulation (Accumulating, Accumulate):
Accumulation refers to the buildup of lipids and cholesterol in blood vessels, a significant factor in atherosclerosis. The study discusses how Cardipro effectively reduces this accumulation, thus mitigating risks of vascular complications and providing insight into treatments for hyperlipidemia.
9) Depression:
Depression in the context of this study refers to the physical and pathological changes observed in the aortic tissues of cholesterol-fed rats. These changes were used to evaluate the protective effects of Cardipro, observing less severe depression in treated groups compared to untreated controls.
10) Science (Scientific):
Science is the systematic study of the natural world through observation and experimentation. The research presented here applies scientific methods to evaluate Cardipro's effects on blood lipid profiles and atherosclerosis, contributing to the broader medical understanding of herbal remedies in cardiovascular health.
11) Water:
Water in this study is used as a solvent for administering Cardipro to experimental rats. The choice of distilled water for dissolving the formulation emphasizes purity in the experimental setup, ensuring that observed effects can be attributed directly to the formulation's herbal components.
12) Withania somnifera:
Withania somnifera, also known as Ashwagandha, is included in Cardipro for its adaptogenic and cardiovascular benefits. The study may highlight its role in reducing stress and improving overall heart health, ultimately contributing to the formulation's efficacy against atherosclerosis and related disorders.
13) Pharmacological:
Pharmacological relates to the study of drug interactions and their effects on biological systems. The study evaluates the pharmacological actions of Cardipro in modulating lipid levels and controlling atherogenesis, providing insights into potential alternative therapies for cardiovascular diseases.
14) Pharmacology:
Pharmacology is the branch of science that studies the interactions between drugs and biological systems. This study contributes to pharmacology by investigating Cardipro's effects on cardiovascular health, offering evidence for its applications in managing lipid profiles and preventing atherosclerosis.
15) Discussion:
Discussion refers to the part of the study where the authors interpret their findings and relate them to existing literature. This section provides critical insights into the efficacy of Cardipro, linking experimental outcomes to broader implications for herbal treatments in cardiovascular health.
16) Swelling:
Swelling often indicates an inflammation or pathological change, such as seen in the aortic tissues of untreated rats. The study describes how treatment with Cardipro resulted in less swelling and pathological damage, suggesting its role in countering the effects of cholesterol-induced vascular injury.
17) Shaila (Śaila):
Shaila likely refers to a researcher or study that provided evidence regarding the effects of T. arjuna on plasma cholesterol levels. Her findings contribute to the understanding of herbal constituents in Cardipro and their potential in managing cardiac health, linking prior research to current findings.
18) Drug:
Drug in this context refers to Cardipro as a formulation comprising multiple herbal constituents with therapeutic potential. The study assesses its effectiveness as a natural alternative or adjunct to conventional medicines in the treatment of atherosclerosis and associated cardiovascular complications.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Anti-atherogenic Action of “Cardipro” - A Herbal Proprietary Formulation’. Further sources in the context of Science might help you critically compare this page with similair documents:
Emblica officinalis, Withania somnifera, Ocimum sanctum, Terminalia arjuna, Cholesterol, Clinical trial, Hyperlipidaemia, Atherosclerosis, Lipid profile, High-density lipoprotein, Low-density lipoprotein, Very low density lipoprotein, Histopathological examination, Risk factor, Triglyceride, Boerhaavia diffusa, Pharmacological means.