Phytochemical and Pharmacological Evaluation of Ampelocissus Latifolia
Journal name: Ancient Science of Life
Original article title: Phytochemical and Pharmacological Evaluation of Ampelocissus Latifolia
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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Mrs. C.T. Tamilarasi, U. Subasin, Mr. S. Kavimani, Mr. B Jaykar
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Phytochemical and Pharmacological Evaluation of Ampelocissus Latifolia
Year: 2000
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
Ampelocissus latifolia, a plant from the Vitaceae family, has been traditionally used for various medicinal purposes, including the treatment of snake bites, dysentery, and muscular pains. This study focuses on the phytochemical and pharmacological evaluation of different extracts from its roots, stems, and leaves. The investigation includes the extraction of the plant using solvents such as acetone, chloroform, and alcohol, and aims to characterize its chemical constituents as well as assess its safety and anti-inflammatory properties.
Phytochemical and Pharmacological Assessment
The research presents significant findings regarding the phytochemical screening of Ampelocissus latifolia. The study revealed the presence of various phytochemicals, including alkaloids, carbohydrates, and tannins in the acetone, chloroform, and alcoholic extracts. Acute toxicity studies determined the lethal dose (LD50) for these extracts, indicating they were safe up to a maximum dose of 500 mg/kg, as no mortality or adverse behavioral changes were observed in the test animals. Furthermore, the anti-inflammatory activity was assessed using a carrageenan-induced paw edema model, where it was found that the acetone extract exhibited a percentage inhibition of edema comparable to that of the standard anti-inflammatory drug indomethacin.
Conclusion
The findings of the study suggest that Ampelocissus latifolia possesses notable anti-inflammatory properties potentially linked to its effects on the release of inflammatory mediators such as histamine, kinin, and prostaglandins. The results support the traditional use of this plant in herbal medicine and indicate its potential as an effective natural anti-inflammatory agent. By demonstrating its safety and efficacy, this research lays the groundwork for further studies and applications in herbal pharmacology.
FAQ section (important questions/answers):
What is the main objective of the Ampelocissus latifolia study?
The study aims to evaluate the phytochemical properties and pharmacological activities, especially focusing on anti-inflammatory effects of various extracts of Ampelocissus latifolia.
What extracts of Ampelocissus latifolia were tested?
The extracts tested were acetone, chloroform, and alcoholic extracts, which were analyzed for their phyto-chemical constituents and evaluated for their safety and anti-inflammatory activity.
What was the significant finding related to anti-inflammatory activity?
The study found that acetone extract exhibited the highest anti-inflammatory activity, with a percentage inhibition of edema of 51.1%, similar to that of indomethacin, a known anti-inflammatory drug.
What safety levels were observed during the toxicity studies?
The toxicity studies indicated that the extracts were safe at doses up to 500 mg/kg, with no observed mortality or significant behavioral changes in the tested animals.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Phytochemical and Pharmacological Evaluation of Ampelocissus Latifolia”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Edema (Oedema):
Edema refers to the accumulation of fluid in tissues, leading to swelling. In the context of the study, it is a crucial parameter for assessing the anti-inflammatory activity of Ampelocissus latifolia. The extent of edema induced by carrageenin in experimental rats offers insights into the efficacy of various extracts in mitigating inflammation.
2) Phytochemical:
Phytochemicals are bioactive compounds found in plants that contribute to their medicinal properties. The study's focus on phytochemical screening of Ampelocissus latifolia reveals the presence of beneficial compounds such as alkaloids and tannins, which can influence therapeutic outcomes and underscore the plant's potential in traditional medicine.
3) Water:
Water plays a vital role in extracting phytochemicals from plant materials during the preparation of various extracts. In this study, water-soluble constituents are analyzed to evaluate their therapeutic potential. Understanding the solubility of active compounds in water aids in optimizing extraction methods for enhanced pharmacological efficacy.
4) Drug:
A drug is a substance used for medical treatment, aiming to cure, mitigate, or prevent disease. In this research, the extracts of Ampelocissus latifolia are studied as potential drugs for their anti-inflammatory effects, paralleling pharmaceutical agents like indomethacin, thereby contributing to discussions about herbal alternatives in medicine.
5) Pharmacological:
Pharmacological studies focus on the effects of compounds on biological systems. The research evaluates the pharmacological properties of Ampelocissus latifolia, particularly its anti-inflammatory action. This helps bridge the gap between traditional herbal medicine and modern pharmacology, providing empirical evidence for the therapeutic use of the plant extracts.
6) Flavonoid:
Flavonoids are a class of plant secondary metabolites known for their antioxidant and anti-inflammatory properties. The presence of flavonoids in the extracts of Ampelocissus latifolia may significantly contribute to the observed pharmacological effects. Analyzing these compounds enhances our understanding of the plant's potential in treating inflammation and other ailments.
7) Activity:
In this context, activity refers to the biological efficacy of Ampelocissus latifolia extracts in combating inflammation and edema formation. The study measures anti-inflammatory activity through experimental models, showing how these extracts can alter physiological responses, highlighting their therapeutic promise in managing inflammatory conditions.
8) Inflammation:
Inflammation is a complex biological response to harmful stimuli, which can lead to tissue damage. The research centers on the inflammatory response induced by carrageenin in rats, providing a model to evaluate the anti-inflammatory properties of plant extracts. Understanding inflammation mechanisms aids in developing effective treatments using herbal remedies.
9) Discussion:
Discussion in scientific papers analyzes results, interprets findings, and compares them to existing literature. In this study, the discussion section elucidates the significance of the anti-inflammatory effects of Ampelocissus latifolia extracts, drawing connections between phytochemical properties and biological activities, thus enriching the understanding of the plant's medicinal potential.
10) Substance:
A substance is a form of matter with a particular chemical composition, which may possess therapeutic properties. The study examines the active substances in Ampelocissus latifolia extracts that contribute to anti-inflammatory effects, emphasizing the importance of identifying specific compounds responsible for their pharmacological activities in herbal medicine.
11) Toxicity:
Toxicity pertains to the adverse effects of substances on biological systems. The study includes acute toxicity assessments of Ampelocissus latifolia extracts, determining safe dosage levels. Evaluating toxicity ensures that the therapeutic use of plant extracts does not result in harmful side effects, which is critical for their application in medicine.
12) Science (Scientific):
Science is the systematic study of the structure and behavior of the physical and natural world through observation and experimentation. This research exemplifies the application of scientific methods to explore the phytochemical and pharmacological properties of plants, thus providing a foundation for evidence-based herbal medicine.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Phytochemical and Pharmacological Evaluation of Ampelocissus Latifolia’. Further sources in the context of Science might help you critically compare this page with similair documents:
Preliminary phytochemical screening, Phytochemical screening, Acetone extract, Pharmacological studies, Chloroform extract, Percentage inhibition, Significant antiinflammatory activity, Mortality observation, Animal groups, Physiochemical standards, Alcohol extract, Behavioural changes.