Accelerated stability studies of a polyherbal preparation (eazmovr) capsule
Journal name: Ancient Science of Life
Original article title: Accelerated stability studies of a polyherbal preparation (eazmovr) capsule
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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S.K. Chauhan, A. Tyagi, B. Singh, S. Agarwal
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Accelerated stability studies of a polyherbal preparation (eazmovr) capsule
Year: 1999
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
The study investigated the accelerated stability of Eazmov capsule, a polyherbal preparation used for its analgesic, anti-inflammatory, antiarthritic, and immune-modulating properties. Conducted under high temperature and humidity conditions (45°C and 75% relative humidity), the analysis spanned a period of six months, focusing on various organoleptic and physical characteristics, as well as the assay of active plant ingredients like Glycyrrhizin, β-Sitosterol, and Kutkin. This information is critical for determining the shelf life of the product, defined as the duration in which it retains at least 90% of its active ingredients under recommended storage conditions.
Stability Analysis of Active Ingredients
The assessment of the stability of active ingredients showed that their concentrations remained consistent within acceptable limits throughout the study period. Specifically, the changes in the quantifiable components of Eazmov were maintained within 90% of their initial amounts, indicating a strong stability profile. The evaluation was carried out using High-Performance Thin-Layer Chromatography (HPTLC) to analyze the retention of key active compounds during the accelerated testing. The consistency in organoleptic characteristics and physical parameters supported these findings, enunciating that Eazmov exhibits notable stability even when subjected to accelerated degradation conditions.
Conclusion
In conclusion, the results of the accelerated stability study suggest that Eazmov capsules retain their chemical integrity and efficacy for more than three years when stored at room temperature, based on findings from the six-month accelerated tests. While the current data is promising, the authors also acknowledge that real-time stability studies are ongoing to further substantiate these claims. The research underscores the importance of rigorous stability testing in herbal formulations, given the complexity and variability of their biological active components.
FAQ section (important questions/answers):
What was the purpose of the stability study on Eazmov capsules?
The study aimed to evaluate the stability of Eazmov capsules under accelerated conditions over six months, focusing on maintaining the integrity of active ingredients and organoleptic characteristics to establish an expected shelf life.
What conditions were the Eazmov capsules exposed to during testing?
The capsules were stored at 45°C and at 40°C with 75% relative humidity. These conditions were used to simulate accelerated degradation for stability testing.
How were the active ingredients in Eazmov capsules assessed?
Active ingredients like Kutkin, Glycyrrhizin, and β-Sitosterol were quantified using High-Performance Thin-Layer Chromatography (HPTLC) and Gas Chromatography methods to evaluate their stability over time.
What were the findings regarding the stability of Eazmov capsules?
The study found that Eazmov capsules remained stable, retaining more than 90% of their initial active ingredients after six months, suggesting they could remain stable at room temperature for over three years.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Accelerated stability studies of a polyherbal preparation (eazmovr) capsule”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Gelatin:
Gelatin refers to a substance derived from collagen, commonly used in the production of capsules like the Eazmov capsule. In the context of this stability study, gelatin serves as the outer layer of the hard capsule, ensuring protection and containment of the herbal ingredients, which is vital for maintaining product integrity during storage and testing.
2) Water:
Water is a crucial solvent used in the experimental procedures for preparing extracts of the herbal ingredients found in Eazmov capsules. Its role in dissolving and extracting active compounds, such as glycyrrhizin and kutkin, is essential for analyzing the stability and efficacy of the polyherbal formulation under accelerated conditions of temperature and humidity.
3) Drug:
The term 'drug' refers to the Eazmov capsule itself, which acts therapeutically to provide analgesic, anti-inflammatory, and immune-modulating effects. This study assesses the stability of the formulation under different conditions to ensure that the drug retains its efficacy and safety over its anticipated shelf life, thereby meeting pharmacological standards.
4) Glycyrrhiza glabra:
Glycyrrhiza glabra, commonly known as licorice, is one of the primary herbal ingredients in Eazmov capsules. It is noted for its active compound, glycyrrhizin, which has anti-inflammatory properties. Understanding its stability during storage is critical for confirming the Eazmov formulation's effectiveness as a herbal drug, especially in accelerated conditions.
5) Cyperus rotundus:
Cyperus rotundus, or nutgrass, is another important herbal component of the Eazmov formulation, contributing to its overall therapeutic effects. The presence of β-sitosterol, an active compound obtained from this plant, is analyzed during stability testing to ensure that its levels remain consistent throughout the product's shelf life under varying environmental conditions.
6) Tinospora cordifolia:
Tinospora cordifolia, known for its medicinal properties, is included in Eazmov for its immune-modulating effects. The stability study assesses how this ingredient behaves under accelerated conditions, which is essential to determine if its beneficial properties are preserved over time, ensuring the formulation's desired health benefits are maintained.
7) Zingiber officinale:
Zingiber officinale, or ginger, is included in the Eazmov capsules for its anti-inflammatory and digestive benefits. During the stability study, it is crucial to monitor the consistency of its active compounds under accelerated storage conditions, ensuring that the formulation retains its therapeutic efficacy throughout its expected shelf life.
8) Discussion:
The discussion section critically evaluates the findings of the stability study, interpreting the results related to the stability of Eazmov capsules. It highlights the implications of the data collected and provides insights into the efficacy and reliability of the formula, stressing the need for further real-time studies to validate the accelerated test results.
9) Science (Scientific):
Science in this context refers to the scientific methodologies employed in conducting the stability study of the Eazmov capsules. It encompasses the experimental design, analysis of active ingredients, and the use of HPTLC fingerprinting to ascertain the formulation's stability, underpinning the importance of rigorous scientific research in herbal medicine development.
10) Reason:
Reason pertains to the rationale behind conducting the stability study of Eazmov capsules. The intent is to determine how the herbal formulation maintains its efficacy over time and under stress conditions, allowing manufacturers to assign a reliable shelf life and ensuring that consumers receive a safe and effective product.
11) Post:
Post in this context refers to the geographic location involving the research team, specifically the R&D center in Saharanpur, India. It implies where the study and formulation development took place, and may reflect the cultural and regional significance of the herbal ingredients utilized in Eazmov's composition, underpinning the product's tradition of use in local medicine.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Accelerated stability studies of a polyherbal preparation (eazmovr) capsule’. Further sources in the context of Science might help you critically compare this page with similair documents:
Shelf life, Organoleptic characteristics, Active ingredient, Accelerated stability studies, Physical parameter, Relative humidity, Evaluation parameter, Visual assessment, HPTLC finger printing.