Antifertility effects of Curcuma longa with serum biochemistry focus.
Journal name: Ancient Science of Life
Original article title: ANTIFERTILITY EFFICACY OF CURCUMA LONGA (50% E to H EXTRACT) WITH SPECIAL REFERANCE TO SERUM BIOCHEMISTRY and FERTILITY TEST
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Ashok Purohit
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: ANTIFERTILITY EFFICACY OF CURCUMA LONGA (50% E to H EXTRACT) WITH SPECIAL REFERANCE TO SERUM BIOCHEMISTRY and FERTILITY TEST
Year: 1999
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
The study focuses on the antifertility efficacy of Curcuma longa, commonly known as "Haldi," through its 50% ethanol extract on male rats. Conducted by Ashok Purohit at J.N.V University, the research aimed to evaluate the effects of this extract on serum biochemistry and fertility. Previous studies indicated the contraceptive potential of Curcuma longa, but this investigation specifically examines its influence on biochemical parameters, such as lipid profile and liver enzyme activity, alongside fertility outcomes.
Impact on Serum Biochemistry
One important aspect of the study is the significant alteration in serum biochemical parameters due to the administration of Curcuma longa extract. Findings revealed notable reductions in serum cholesterol, HDL cholesterol, phospholipids, and triglycerides in treated rats compared to the control group. Specifically, the treatment group displayed an 80% negative fertility rate, indicating a substantial inhibition of spermatogenesis and a decrease in androgen levels. The diminished cholesterol levels may lead to impaired biosynthesis of steroid hormones crucial for male fertility, supporting the hypothesis that Curcuma longa exhibits antispermatogenic properties.
Conclusion
In summary, the oral administration of Curcuma longa extract significantly affects the serum biochemistry and reproductive capacity of male rats, suggesting its potential as an antifertility agent. The observed reductions in key serum lipids, combined with the negative fertility outcomes, highlight the extract's role in disrupting spermatogenesis and androgen production. Overall, these findings underscore the need for further research to explore the mechanisms of action and potential applications of Curcuma longa in reproductive health and contraception.
FAQ section (important questions/answers):
What was the main focus of Ashok Purohit's study on Curcuma longa?
The study aimed to assess the ant fertility efficacy of Curcuma longa extract, particularly its effects on serum biochemistry and fertility in male rats.
What significant effects did Curcuma longa extract have on serum biochemistry?
Curcuma longa extract led to a significant reduction in serum cholesterol, triglycerides, and phospholipids, indicating its impact on lipid metabolism in treated male rats.
What were the fertility test results after administering Curcuma longa extract?
The fertility tests showed an 80% negative result, indicating a significant arrest of spermatogenesis and depletion of androgen levels in the treated male rats.
How were the male rats treated in the study?
Twenty mature male Swiss albino rats received 1 gm/kg body weight of 50% EtOH extract of Curcuma longa orally for 60 days.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Antifertility effects of Curcuma longa with serum biochemistry focus.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Curcuma longa:
Curcuma longa, commonly known as turmeric or 'Haldi', is a perennial herb belonging to the Zingiberaceae family. Its active component, curcumin, has gained attention for its potential medicinal properties, including antifertility effects observed in male rats. This study assesses its impact on serum biochemistry and fertility.
2) Azadirachta indica:
Azadirachta indica, also known as neem, is a tree native to India. It is recognized for its various medicinal properties. The paper references neem's antispermatogenic efficacy, highlighting the broader context of herbal remedies being investigated for their effects on fertility and reproductive health.
3) Pharmacological:
Pharmacological refers to the branch of medicine concerned with the uses, effects, and modes of action of drugs. The relevance lies in understanding the biological impacts of substances like Curcuma longa on metabolism and hormonal regulation, illustrating the therapeutic potential and risks related to herbal extracts in reproduction.
4) Discussion:
The discussion section of a scientific paper interprets results and places them in context. In this study, it elaborates on how reduced serum cholesterol and lipids correlate with fertility impairment in male rats treated with Curcuma longa, helping to understand the broader implications of the findings.
5) Zoology:
Zoology is the scientific study of animals, their physiology, behavior, and reproduction. The research conducted by Ashok Purohit falls under this domain, focusing on the reproductive physiology of male rats and contributing to our understanding of how certain botanical extracts affect animal health and reproduction.
6) Science (Scientific):
Science is a systematic enterprise that builds and organizes knowledge about the universe through testable explanations and predictions. This study exemplifies scientific inquiry by exploring the effects of Curcuma longa on serum biochemistry and fertility, contributing to the broader knowledge of reproductive health.
7) Methane:
Methane is a colorless, odorless greenhouse gas predominantly created from the decomposition of organic matter. It is not directly related to the study but reflects the complexity of biochemical interactions. The reference to 'diferuloyl methane' as an active compound in Curcuma longa highlights the significance of chemical structures in biological activity.
8) Garlic:
Garlic, known for its health benefits, is mentioned in the context of herbal treatments for various health conditions. Its inclusion indicates the growing interest in natural remedies alongside curcumin, emphasizing the role of dietary substances in modulating physiology and possibly affecting fertility.
9) Gupta (Guptā):
Gupta refers to one of the authors cited in the references, specifically R.N. Chopra, J.C. Gupta, and G.S. Chopra, who researched the pharmacological actions of Curcuma longa. The acknowledgment of prior work strengthens the credibility of the current study by situating it within an established body of research.
10) Water:
Water is essential for all living organisms and plays a critical role in biological functions. Within the context of this study, the availability of water ad libitum for the rats ensures that the effects observed are due to the curcuma treatment rather than hydration status, maintaining experimental validity.
11) Blood:
Blood serves as a medium for transporting nutrients, hormones, and waste products in the body. The study's investigation into serum biochemistry, including cholesterol and triglycerides, emphasizes its importance in assessing the physiological effects of Curcuma longa on overall health and fertility in male rats.
12) Neem:
Neem, or Azadirachta indica, is noted for its therapeutic properties, particularly its antifertility effects. Its mention alongside Curcuma longa reflects the broader inquiry into traditional medicinal plants for reproductive health, suggesting various natural substances may influence fertility and hormonal balance in animals.
13) Diet:
Diet refers to the food and drink habitually consumed by an organism. The control of diet in this study ensures that the impact of Curcuma longa on fertility parameters can be accurately assessed, illustrating how dietary choices play a crucial role in research outcomes and health indicators.
Other Health Sciences Concepts:
Discover the significance of concepts within the article: ‘Antifertility effects of Curcuma longa with serum biochemistry focus.’. Further sources in the context of Health Sciences might help you critically compare this page with similair documents:
Curcuma longa, Control group, Experimental group, Serum Biochemistry, Serum cholesterol, Oral feeding, Serum glutamic-oxaloacetic transaminase (SGOT), Standard diet, Serum Glutamic Pyruvic Transaminase (SGPT), Reproductive physiology, Antifertility efficacy, Fertility test, Androgen level.