Free radicals in ayurveda

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Journal name: Ancient Science of Life
Original article title: Free radicals in ayurveda
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:

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Author:

Yamini B. Tripathi


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: Free radicals in ayurveda

Year: 1998

Copyright (license): CC BY-NC-SA


Download the PDF file of the original publication


Summary of article contents:

Introduction

The article by Yamini B. Tripathi explores the relationship between free radicals and the principles of Ayurveda, particularly focusing on the concepts of body humors (Vata, Pitta, and Kapha) and their connection to diseases mediated by free radicals. It discusses how both ancient Ayurvedic philosophy and modern scientific understanding recognize an imbalance—whether it be within body humors or through oxidative stress—as a key factor in the onset of various diseases. The article highlights the significance of free radicals in biological systems, their production through metabolic processes, and the damage they can inflict on cellular structures, leading to conditions like arthritis, diabetes, and neurodegenerative diseases.

The Role of Free Radicals in Disease

One key concept presented in the article is the harmful impact of free radicals on human health. Free radicals are defined as reactive molecules with unpaired electrons, formed during metabolic processes, particularly within the mitochondria. Their production can occur accidentally or as a consequence of oxidative stress and exposure to exogenous factors like pollution or radiation. They initiate chain reactions that result in cellular damage, lipid peroxidation, and disruptions in cellular functions, ultimately leading to various pathological conditions. Particularly, conditions such as rheumatoid arthritis and diabetes have been linked to free radical activity, emphasizing the need for effective management and a deeper understanding of these reactive species' paths and impacts on health.

Conclusion

In conclusion, tripathi's article merges the ancient wisdom of Ayurveda with modern biochemical principles to advance our understanding of health and disease. It argues that while Ayurveda provides holistic approaches to treat imbalances in body humors, modern science underscores the necessity of addressing oxidative stress and free radicals in disease management. This synthesis of knowledge suggests that Ayurvedic practices, particularly those involving Rasayana drugs (which can act as antioxidants), may offer valuable insights and therapeutic avenues for combating diseases associated with free radical damage. Ultimately, understanding and integrating both perspectives can enhance the effectiveness of treatments and promote overall health.

FAQ section (important questions/answers):

What is the role of free radicals in diseases?

Free radicals are involved in over 50 diseases, contributing to conditions like rheumatoid arthritis, cancer, and neurodegenerative diseases. They cause cellular damage by attacking lipids, nucleic acids, and proteins, leading to various health complications.

How does Ayurveda correlate with modern free radical research?

Ayurveda's concept of health revolves around the balance of three body humours (Vata, Pitta, Kapha). Similar to modern findings, imbalances in these humours can lead to excess free radical production, linking ancient wisdom with contemporary biochemical understandings.

What are antioxidants and their significance in health?

Antioxidants lower free radical levels in the body, thus protecting cells from oxidative damage. They come from various sources, including plants, and play critical roles in disease prevention and promoting overall health by preventing cellular damage.

How do Rasayana drugs relate to modern antioxidants?

Rasayana drugs in Ayurveda are known to vitalize cells and enhance health, paralleling the role of antioxidants in modern medicine, which aim to prevent oxidative stress by lowering free radical levels and supporting overall well-being.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Free radicals in ayurveda”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Ayurveda (Āyurveda, Ayus-veda):
Ayurveda is a traditional Indian system of medicine that emphasizes holistic healing and balance among body, mind, and environment. It is based on the concepts of body humors (doshas), vital energies (prana), and the significance of herbs and natural remedies, aiming for the prevention and treatment of diseases through lifestyle and dietary adjustments.

2) Medicine:
Medicine refers to the science and practice of diagnosing, treating, and preventing illnesses. In Ayurveda, it encompasses various approaches, including herbal treatments, diet, and lifestyle changes, aimed at restoring balance in the body and mind. Ayurveda views medicine as an integral part of maintaining holistic health.

3) Drug:
A drug is a substance used for medical treatment, especially to diagnose, cure, or prevent disease. In the context of Ayurveda, drugs include herbal formulations that not only address symptoms but also aim to restore underlying imbalances, acting on the body's physiology more holistically than conventional pharmaceuticals.

4) Rasayana (Rasa-ayana, Rasāyana, Rāsāyana):
Rasayana in Ayurveda refers to a category of rejuvenative therapies designed to enhance longevity, vitality, and overall health. These treatments aim to optimize bodily functions, improve metabolic pathways, and potentially prevent age-related disorders by revitalizing tissues (dhatus) and promoting the smooth flow of energy (prana) throughout the body.

5) Toxicity:
Toxicity refers to the degree to which a substance can harm living organisms. In Ayurveda, understanding toxicity is crucial for identifying how certain foods or chemicals can disrupt the balance of doshas (Vata, Pitta, Kapha) and hinder overall health, leading to illnesses that necessitate appropriate herbal treatment and detoxification strategies.

6) Rubia cordifolia:
Rubia cordifolia, known as Indian madder, is an important medicinal plant in Ayurveda praised for its various health benefits. Its extracts are recognized for antioxidant properties, potentially aiding in the management of free radical-mediated diseases while also supporting detoxification and restoration of body balance as per Ayurvedic principles.

7) Activity:
Activity refers to the biological or therapeutic actions exerted by substances, particularly in medical treatments. In Ayurveda, the activity of herbs and formulations is analyzed to understand how they interact with the body, targeting specific dosha imbalances and promoting healing and balance in physiological functions.

8) Science (Scientific):
Scientific approaches in Ayurveda involve research and validation of ancient practices through empirical studies, focusing on the efficacy and safety of herbal treatments. This bridge encourages a deeper understanding of Ayurvedic remedies, aligning traditional therapeutic practices with modern scientific principles, enhancing their acceptance in contemporary medicine.

9) Accumulation (Accumulating, Accumulate):
Accumulate denotes the gradual gathering of substances, such as toxins or imbalances in the body. In Ayurveda, accumulation can result from lifestyle factors, causing disruptions in dosha equilibrium. Treatment strategies focus on detoxifying the body to remove excess substances and restore health while preventing further accumulation of harmful elements.

10) Sharman (Śarma, Sarmā, Sarma, Sharma, Śarman):
Sharma is a common surname in India and is often associated with scholars and practitioners in fields like Ayurveda. In the context of this article, references to Sharma indicate contributions or research findings related to Ayurvedic principles, highlighting the integration of traditional wisdom and contemporary scientific inquiry in health care.

11) Agni:
Agni, meaning digestion or metabolic fire in Ayurveda, is essential for bio-transformation in the body. It plays a role in digesting food, absorbing nutrients, and eliminating waste. Proper functioning of Agni is critical for maintaining health, as imbalances can lead to disease, directly linking to overall vitality and wellness.

12) Vata (Vāṭa, Vaṭa, Vāta, Vaṭā):
Vata is one of the three doshas in Ayurveda, representing the elements of air and space. It governs movement, communication, and biological activities within the body. An imbalance in Vata can lead to various disorders; thus, treatment focuses on restoring balance through dietary changes, lifestyle modifications, and herbal remedies.

13) Rheumatoid arthritis:
Rheumatoid arthritis is a chronic inflammatory disease characterized by immune-mediated joint damage and systemic effects. In Ayurveda, it is understood as a condition resulting from imbalances, particularly involving the doshas. Targeted treatments may include herbal medicine and therapies that aim to reduce inflammation and restore joint function.

14) Phytochemical:
Phytochemicals are bioactive compounds found in plants, recognized for their health-promoting properties. Their consumption is integral in Ayurveda, where many remedies rely on phytochemicals for therapeutic effects. Research continues to explore their roles in fighting free radicals, supporting immune response, and preventing chronic diseases.

15) Channel:
Channel refers to pathways in the body through which energy, nutrients, and information flow. In Ayurveda, ensuring the proper function of srotas (channels) is vital for transporting vital substances, removing waste, and maintaining balance. Blocked or altered channels can lead to disease, emphasizing the need for detoxification and restoration.

16) Dosha (Dosa, Doṣa, Dosā, Doṣā, Ḍosā):
Dosha denotes the three fundamental energies (Vata, Pitta, Kapha) governing physiological and psychological functions in Ayurveda. Each dosha encompasses specific qualities and functions, and health is viewed through the lens of their balance. Understanding a person's dosha constitution is essential for diagnosing and implementing individualized treatment plans.

17) Pitta (Pītta, Piṭṭā):
Pitta is one of the three doshas in Ayurveda that embodies fire and water elements. It governs digestion, metabolism, and the transformation of nutrients within the body. Imbalances in Pitta can lead to inflammatory conditions and digestive issues; treatment often involves cooling and calming approaches to restore harmony.

18) Kapha:
Kapha is another of the three doshas in Ayurveda, characterized by earth and water elements. It governs structure, stability, and lubrication in the body. When Kapha dosha is imbalanced, it may lead to ailments associated with excess weight, sluggishness, and congestion, necessitating treatment focused on detoxification and stimulation.

19) Water:
Water is a fundamental element in Ayurveda, representing fluidity, nourishment, and cleansing properties vital for health. It is involved in the balance of doshas, supporting various physiological functions. Proper hydration and the consumption of fluids are essential for maintaining Agni, facilitating digestion, and promoting overall well-being.

20) Blood:
Blood in Ayurveda symbolizes vitality and nourishment, critical for sustaining life and health. It is associated with Kapha dosha due to its nourishing aspects. Understanding blood health involves addressing metabolic processes and maintaining the balance of nutrients and energies that support systemic and organ functions, highlighting its vital role in wellness.

21) Diet:
Diet, or ahara in Ayurveda, refers to the food and nutrition consumed to maintain health. It is integral for balancing the doshas, enhancing Agni, and supporting overall well-being. Ayurveda emphasizes personalized dietary practices tailored to individuals' unique constitutions, conditions, and lifestyle, reinforcing the connection between nutrition and health.

22) Hand:
Hand can symbolize interaction, care, and healing in many contexts, including Ayurveda where practitioners utilize hands-on methods for treatment. Various therapeutic techniques, such as massages and energy work, involve the hands to facilitate healing, promote balance, and enhance the efficacy of herbal remedies and holistic health practices.

23) Post:
Post can denote a position in time or order, possibly referring to follow-up actions in treatment regimens or changes in health after interventions. In Ayurveda, the post-treatment phase is crucial for understanding the effectiveness of therapies and making necessary adjustments to continue fostering balance and health.

24) Prana (Prāṇā, Prāṇa, Praṇa, Prāṇ, Pran):
Pran is the vital life force in Ayurveda, essential for sustaining health and vitality. It represents breath and energy, governing all physiological functions. The management of Pran through practices like yoga and meditation is key for maintaining dosha balance, mental clarity, and overall well-being, promoting resilience against diseases.

25) Nardostachys jatamansi (Nardostachys jatamamsi):
Nardostachys jatamansi, known as spikenard, is a revered medicinal plant in Ayurveda recognized for its calming and balancing effects. It has potential antioxidant properties, making it valuable in combating oxidative stress. Its inclusion in Ayurvedic formulations aims to promote mental clarity and emotional stability while supporting overall health.

26) Pharmacological:
Pharmacological aspects explore the interactions and effects of substances within biological systems. In Ayurveda, understanding the pharmacological basis of herbal treatments enhances their credibility through scientific validation, revealing how traditional remedies work at the biochemical level to restore balance, alleviate diseases, and support overall health and wellness.

27) Malnutrition:
Malnutrition encompasses deficiencies or imbalances in nutrient intake, leading to health complications. In Ayurveda, it is understood that malnutrition disrupts dosha equilibrium and overall health. Addressing malnutrition through proper dietary practices and herbal supplementation is vital for restoring balance, improving resilience against diseases, and enhancing bodily functions.

28) Saptadhatu (Saptadhātu, Sapta-dhatu, Saptan-dhatu):
Sapta-dhatu refers to the seven fundamental tissues in Ayurveda: plasma, blood, muscle, fat, bones, nerve, and reproductive tissues. Maintaining the health of these dhatus is crucial for overall well-being. Ayurvedic treatments aim to nourish and revitalize each dhatu, promoting systemic health and fostering recovery from illnesses.

29) Mithyayoga (Mithyāyoga, Mithya-yoga):
Mithyayoga denotes the improper use or balance of elements within the body as per Ayurvedic principles. It signifies excess or inadequate practices that lead to health complications. Recognizing and rectifying Mithyayoga is fundamental for achieving balance among the doshas and restoring optimal health through tailored dietary and lifestyle strategies.

30) Similarity:
Similarity highlights the parallels between Ayurvedic principles and modern scientific understanding, particularly in recognizing the roles of antioxidants and rejuvenative therapies. Establishing such correspondences enriches the validation of traditional knowledge, demonstrating that age-old remedies may have empirical support through contemporary research, thus enhancing their application in health care.

31) Depression:
Depression is a complex mental health condition characterized by persistent low mood and disinterest in activities. In Ayurveda, depression may relate to imbalances in doshas, particularly Vata. Treatment often involves herbal therapies, dietary adjustments, and lifestyle modifications designed to stabilize mood and restore mental and emotional well-being.

32) Substance:
Substance refers to any chemical compound or herbal material that may impact physiological functions. In Ayurveda, substances include various herbs and dietary components that possess therapeutic properties. Understanding their roles within the body aids in developing formulations for disease management and promoting overall health by restoring balance among doshas.

33) Flavonoid:
Flavonoids are a diverse group of phytochemicals known for their antioxidant properties. In Ayurveda, many herbal remedies incorporate flavonoid-rich plants due to their potential health benefits. Their ability to neutralize free radicals and mitigate oxidative stress supports the rationale behind using specific herbs to prevent and treat various diseases.

34) Pesticide:
Pesticides are chemicals used in agriculture to control pests but can pose health risks if accumulated in the body. In Ayurveda, awareness of the potential toxicity of pesticides informs dietary choices and emphasizes the importance of consuming organic, natural products to maintain health and prevent exposure to harmful substances that can disrupt dosha balance.

35) Samhita (Saṃhitā, Saṃhita):
Samhita refers to ancient texts that compile knowledge, particularly in Ayurveda. They serve as foundational references for understanding traditional practices, medicinal formulations, and philosophical principles. These texts guide practitioners in diagnosing and treating ailments based on the holistic framework established over centuries, ensuring the continuity of Ayurvedic wisdom and practices.

36) Atiyoga:
Atiyoga indicates the excess or overuse of practices, substances, or elements that can lead to health imbalances according to Ayurveda. Identifying and correcting Atiyoga is essential for achieving dosha balance. Ayurvedic treatments focus on moderation and tailoring lifestyle choices to prevent excesses and promote optimal health and well-being.

37) Hygiene (Hygienic):
Hygiene encompasses practices that ensure cleanliness and health, critical for disease prevention. In Ayurveda, maintaining proper hygiene supports overall well-being by preventing the accumulation of toxins and imbalances within the body. It encompasses not only physical cleanliness but also psychological and spiritual practices to promote holistic health.

38) Anxiety:
Anxiety is a mental health condition characterized by excessive worry and apprehension. In Ayurveda, anxiety may stem from imbalances in Vata dosha. Therapeutic approaches often include herbal remedies, lifestyle changes, and relaxation techniques aimed at calming the mind and restoring balance, ultimately improving overall mental health and resilience.

39) Vaidya:
Vaidya refers to a practitioner or physician of Ayurveda, knowledgeable in traditional healing methods. Vaidyas play a crucial role in diagnosing ailments, prescribing herbal regimens, and offering lifestyle advice tailored to individual needs. Their expertise is vital for ensuring holistic health and aligning treatments with the principles of Ayurveda.

40) Dharma (Dharmā, Dhārma):
Dharma is a complex term denoting duty, righteousness, and moral values. In Ayurveda, adhering to one's dharma informs healthful practices and choices—both personal and social. It emphasizes that living in accordance with dharma can contribute to mental and physical well-being, promoting overall life balance and health.

41) Yamini (Yāminī, Yāmiṉi):
Yamini is a personal name, likely referencing the author of the article. The inclusion of personal contributions enriches the discourse on Ayurveda by providing empirical studies and observations that validate ancient practices. It underscores the importance of individual research efforts in bridging traditional knowledge with contemporary scientific inquiry.

42) Srotas (Śrotas, Shrotas):
Srotas are channels or pathways in Ayurveda that facilitate the flow of substances, energy, and nutrition throughout the body. Proper functioning of srotas is crucial for health, as blockages or imbalances can lead to diseases. Treatments often aim to restore the patency of srotas, enhancing physical and metabolic processes.

43) Repair:
Repair refers to the body's ability to heal and restore damage, crucial for maintaining health. In Ayurveda, strategies for repair focus on promoting the body's natural healing mechanisms through nutrition, herbal therapies, and lifestyle adjustments. This process aims to rejuvenate tissues, restore balance, and achieve optimal physiological function.

44) Psyche:
Psyche refers to the mind or soul within the context of Ayurveda, where mental health is interlinked with physical well-being. Ayurveda emphasizes the balance of mental, emotional, and spiritual dimensions as foundational for overall health. Understanding and addressing psychological factors are essential for holistic treatment and promoting resilience against disease.

45) Dhatu (Dhātu):
Dhatu signifies the fundamental tissues in Ayurveda essential for sustaining life. Each dhatu corresponds to specific biological functions and impacts overall health. Treatments often focus on nourishing and rejuvenating these tissues through dietary practices and herbal remedies, emphasizing the interconnectedness of dhatus in achieving balance and vitality.

46) Worry (Worried, Worrying):
Worry represents anxious concern or distress, which can impact mental and physical health. In Ayurveda, excessive worry may disrupt Vata dosha, leading to physiological imbalances. Effective treatments focus on stress management through herbal support, lifestyle adjustments, and practices aimed at calming the mind and restoring a sense of tranquility.

47) Curd:
Curd, a dairy product, holds significance in Ayurveda as a nutritious food that may balance Vata and Pitta doshas when consumed appropriately. It provides essential nutrients and aids digestion when included in a balanced diet. Curd is considered beneficial for overall health and is often utilized in Ayurvedic dietary recommendations.

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