Pharmacological studies on Aglaia roxburghiana var. beddomei leaves

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Journal name: Ancient Science of Life
Original article title: Pharmacological investigations on aglaia roxburghiana (w. &.a) miq. var. beddomei leaves
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:

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Author:

S. Janaki, S. Vijayasekaran, R. Bima Rao


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: Pharmacological investigations on aglaia roxburghiana (w. &.a) miq. var. beddomei leaves

Year: 1998

Copyright (license): CC BY-NC-SA


Download the PDF file of the original publication


Summary of article contents:

Introduction

Aglaia roxburghiana (W. & A) Miq. Var. beddomei, known for its traditional use in Ayurveda, has been investigated for its pharmacological properties, particularly focusing on its leaves. This study aimed to evaluate the anti-inflammatory, analgesic, and protective effects of the ethanolic extract of the leaves on various biological systems. Traditional claims suggest that this plant can remedy conditions like inflammation, skin diseases, and abdominal pain. The study seeks to substantiate these claims by analyzing the extract's effects on inflammation and possible underlying mechanisms, including mast cell stabilization and histamine receptor blockage.

Anti-Inflammatory Activity

The conducted experiments demonstrated significant anti-inflammatory effects of the ethanolic extract on both acute and chronic models of inflammation. In acute studies, the extract significantly reduced paw edema in carrageenan-induced inflammatory conditions, comparable to the effects of ibuprofen. Chronic inflammation assessments revealed that the extract also reduced weights of cotton pellets implanted in rats, which serves as an indicator of chronic inflammatory response. In addition to this, the extract showed a capability to inhibit mast cell degranulation in vitro, suggesting that it may stabilize mast cells and obstruct histamine-mediated responses. These findings indicate that compounds present in the extract may exert their effects through mechanisms that involve modulation of immune responses.

Conclusion

The results of this investigation reinforce the validity of traditional medicinal assertions regarding Aglaia roxburghiana in the treatment of inflammatory disorders. Despite the absence of analgesic effects, the extract showcased a notable capacity to alleviate inflammation through multiple pathways. The presence of various phytoconstituents such as alkaloids, triterpenes, and steroids in the leaves may contribute to its therapeutic profile. Future studies may further elucidate specific compounds responsible for these effects and assess their potential in clinical settings, thereby enhancing our understanding of the plant's pharmacological significance.

FAQ section (important questions/answers):

What is the purpose of the study on Aglaia roxburghiana?

The study aims to evaluate the pharmacological activities of Aglaia roxburghiana leaves, particularly their anti-inflammatory effects and safety through various experimental models.

What kind of activities were observed from the ethanolic extract?

The ethanolic extract exhibited significant anti-inflammatory activity, showed no acute toxicity, and displayed effects on mast cell degranulation and histamine-induced contractions in guinea pig ileum.

How was the extract prepared for the experiments conducted?

The leaves were extracted using the cold percolation method with 90% alcohol, yielding a suspension used in various animal experiments to assess its pharmacological effects.

What were the main findings regarding the analgesic effects of the extract?

The extract did not show significant analgesic activity in acetic acid-induced writhing in mice compared to morphine, indicating limitations in its pain-relieving properties.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Pharmacological studies on Aglaia roxburghiana var. beddomei leaves”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Activity:
Activity refers to the effects or benefits that a substance, like an extract from a plant, has on biological systems. In the study, the activity of the Aglaia roxburghiana leaves was evaluated in terms of its anti-inflammatory effects, which are crucial in pharmacological research to justify its traditional uses.

2) Inflammation:
Inflammation is a biological response to harmful stimuli, such as pathogens or injury, often characterized by redness, swelling, and pain. The research focuses on the anti-inflammatory activity of the Aglaia roxburghiana extract, suggesting its potential therapeutic benefits in treating conditions associated with inflammation, a common ailment.

3) Ulcer:
An ulcer is a sore that develops on the lining of the stomach or intestines, often due to excessive acid or infection. In the pharmacological evaluation, the effect of the Aglaia roxburghiana extract on gastric ulcers was studied, emphasizing its relevance in digestive health and medicinal therapies.

4) Edema (Oedema):
Oedema refers to swelling caused by excess fluid trapped in body tissues, commonly resulting from inflammation. The research examined the extract's effect on carrageenin-induced paw oedema in rats, validating its traditional claim as an anti-inflammatory remedy and contributing to understanding fluid dynamics in biological systems.

5) Pharmacology:
Pharmacology is the study of how drugs interact with biological systems, encompassing drug action, effects, and therapeutic uses. This study of the Aglaia roxburghiana extract falls within pharmacology, evaluating its efficacy, safety, and mechanisms of action, expanding the field of natural product research.

6) Ayurveda (Āyurveda, Ayus-veda):
Ayurveda is a traditional Indian system of medicine that emphasizes natural remedies and holistic wellness. The investigation of Aglaia roxburghiana, a plant utilized in Ayurveda for various ailments, connects modern scientific research with traditional practices, validating ancient knowledge through pharmacological methods.

7) Toxicity:
Toxicity refers to the degree to which a substance can harm living organisms. The study assessed the safety of the Aglaia roxburghiana extract through acute toxicity tests, a fundamental aspect of pharmacological research that determines safe dosage levels and potential adverse effects before therapeutic use.

8) Drug:
A drug is a substance used for diagnosis, treatment, or prevention of disease. The research on the Aglaia roxburghiana extract explores its potential as a natural drug, contributing to the development of pharmacological agents derived from traditional medicines and supporting the search for new therapeutic compounds.

9) Science (Scientific):
Scientific pertains to the methodological approach rooted in empirical evidence and reproducibility. The investigation of the Aglaia roxburghiana extract embodies scientific rigor, applying established pharmacological techniques to substantiate traditional uses, and fostering a deeper understanding of medicinal plant properties.

10) Bhavaprakashanighantu (Bhāvaprakāśanighaṇṭu, Bhavaprakasha-nighantu):
The Bhavaprakasha-nighantu is a classical text in Ayurveda outlining medicinal plants and their uses. The mention of this text reflects the historical significance and systematic approach of herbal medicine in India, highlighting the foundational knowledge that informs contemporary pharmacological studies like the one on Aglaia roxburghiana.

11) Pharmacological:
Pharmacological pertains to the interactions and effects of drugs within biological systems. This study's focus on the pharmacological properties of Aglaia roxburghiana extracts demonstrates the integration of modern scientific techniques to investigate traditional medicines, underscoring the need for evidence-based validation of herbal remedies.

12) Discussion:
Discussion in scientific research involves analyzing and interpreting results, placing findings in context. In the study of Aglaia roxburghiana, the discussion evaluates traditional claims against experimental evidence, exploring potential mechanisms of action and setting the stage for future research directions in pharmacology.

13) Nighantu (Nighaṇṭu, Nighamtu):
Nighantu refers to ancient texts cataloging medicinal plants and their therapeutic applications. The mention of Nighantu in the context of Aglaia roxburghiana indicates the importance of historical medicinal literature in guiding contemporary pharmacological research, bridging traditional practices with modern medicinal understanding.

14) Priyangu (Priyaṅgu, Priyaṃgu, Priyamgu):
Priyangu is the traditional name for Aglaia roxburghiana in Ayurvedic texts, emphasizing its classification and medicinal significance. Understanding the traditional nomenclature aids researchers in linking ethnobotanical knowledge with pharmacological studies, allowing for a comprehensive exploration of the plant's medicinal properties.

15) Leprosy:
Leprosy, an infectious disease caused by Mycobacterium leprae, leads to skin lesions and nerve damage. The traditional use of Aglaia roxburghiana in treating skin diseases like leprosy underscores the need for pharmacological validation of its historical medicinal claims and efficacy in addressing chronic conditions.

16) Sharada (Śāradā, Śārada, Śaradā, Sāradā, Sārada, Sarada, Sara-da):
Sarada refers to a historical figure associated with the knowledge of medicinal plants and Ayurveda. His contributions highlight the cultural heritage of herbal medicine in India, which informs pharmacological research on plants like Aglaia roxburghiana and connects modern studies to traditional wisdom.

17) Patra (Pātra):
Patra means 'leaf' in Sanskrit, highlighting the part of the plant utilized in traditional medicine. The focus on the leaves of Aglaia roxburghiana in the study emphasizes the importance of specific plant components in pharmacological investigations and their potential therapeutic applications.

18) Vidya (Vidyā):
Vidya translates to 'knowledge' or 'science' in Sanskrit. In the context of Ayurveda and pharmacological studies, it reflects the rich knowledge base established over centuries regarding medicinal plants and their use in healthcare, bridging ancient wisdom with contemporary scientific inquiry.

19) Water:
Water serves as a solvent and medium for botanical extractions in pharmacological studies. In this research on Aglaia roxburghiana, techniques like cold percolation utilize water-based methods to extract bioactive compounds, highlighting water's essential role in isolating and evaluating plant-derived therapeutic agents.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Pharmacological studies on Aglaia roxburghiana var. beddomei leaves’. Further sources in the context of Science might help you critically compare this page with similair documents:

Dysentery, Statistical analysis, Anti-inflammatory activity, Acute toxicity, Analgesic activity, Ethanolic extract, Pyloric ligation, Gastric secretion, Pharmacological investigation, Chronic study, Histamine Receptors.

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