Clinical evaluation of dhatrilauha in parinamasula

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Journal name: Ancient Science of Life
Original article title: Clinical evaluation of dhatrilauha in parinamasula
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:

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Author:

P.K. Gupta, K.P. Shukla, J.P. Gupta


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: Clinical evaluation of dhatrilauha in parinamasula

Year: 1998

Copyright (license): CC BY-NC-SA


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Summary of article contents:

Introduction

Parinamashoola is a common clinical issue prevalent in daily medical practice, comparable to non-ulcer dyspepsia and peptic ulcer disease. The increasing incidence of this condition may be attributed to modern stressors related to urbanization and lifestyle changes. The herbomineral compound Dhatrilauha, utilized in Ayurveda for managing Parinamashoola, was the focus of a clinical study aimed at scientifically evaluating its efficacy. This study involved a total of 30 patients who were divided into two groups: one receiving Dhatrilauha and the other receiving ranitidine, a modern medication, for a duration of six weeks.

Efficacy of Dhatrilauha

The clinical study assessed the efficacy of Dhatrilauha based on various parameters, including symptoms like pain in the abdomen, nausea, and heartburn, along with radiological and endoscopic results. Outcomes were recorded using a grading system, with significant improvement observed in the trial group compared to the control group, particularly in terms of abdominal pain relief and symptom reduction. Notably, the trial drug demonstrated promising results, with an 82% net response showing good to excellent clinical improvement in Non-Ulcer Dyspepsia patients and similar outcomes for those with peptic ulcers. The ingredients of Dhatrilauha, including Amalaki, Yashtimadhu, and Lauha Bhasma, contributed to its potential actions of cytoprotection, mucosal resistance enhancement, and prokinetic effects.

Conclusion

The present study confirmed the efficacy of Dhatrilauha in managing Parinamashoola, illustrating its benefits in treating both peptic ulcers and non-ulcer dyspepsia. The results suggest that Dhatrilauha is a valuable alternative to conventional drugs like ranitidine, especially given its wide acceptance in Ayurvedic practices. As symptoms were significantly alleviated, the study advocates for further exploration into the long-term effects and clinical applications of Dhatrilauha, emphasizing the need for ongoing research in Ayurvedic treatments and their integration into modern medicine.

FAQ section (important questions/answers):

What is Parinamashoola and how is it classified?

Parinamashoola is a common clinical condition described in Ayurvedic texts. It resembles non-ulcer dyspepsia and peptic ulcer disease, commonly affecting individuals due to modern lifestyle stresses and strains.

What is Dhatrilauha and its application?

Dhatrilauha is a herbomineral Ayurvedic compound used for managing Parinamashoola. It consists of Amalaki, Yashtimadhu, and Lauha Bhasma, known for their efficacy in treating symptoms associated with gastrointestinal issues.

How were the clinical trials conducted for Dhatrilauha?

The study involved 30 patients divided into two groups. One group received Dhatrilauha, while the control group was administered ranitidine. Clinical, radiological, and endoscopic evaluations were performed to assess efficacy.

What were the results of the Dhatrilauha study?

The study showed promising results for Dhatrilauha in treating Parinamashoola, indicating significant clinical improvements in symptoms such as abdominal pain, heartburn, and nausea, although results varied when compared to ranitidine.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Clinical evaluation of dhatrilauha in parinamasula”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Ulcer:
An ulcer is a sore that develops on the lining of the digestive tract, frequently observed in conditions like peptic ulcer disease. In the context of this study, ulcers are significant as they are one of the primary clinical concerns being evaluated for treatment efficacy, particularly for peptic ulcer disease.

2) Drug:
A drug is a substance used for medical treatment that alters physiological functions. In the study, drugs (Dhatrilauha and ranitidine) are tested for their effectiveness in alleviating symptoms of parinamashoola, highlighting their therapeutic potential in traditional and modern medicine.

3) Dhatrilauha (Dhātrīlauha, Dhatri-lauha):
Dhatri-lauha is a variation of Dhatrilauha, reinforcing its relevance in Ayurvedic treatments. The term highlights the blend of traditional knowledge with modern research in evaluating its effectiveness on gastrointestinal conditions.

4) Edema (Oedema):
Oedema refers to swelling caused by excess fluid trapped in the body's tissues. In the study, oedema is a notable symptom in endoscopic evaluations, specifically in conditions related to ulcers and gastritis, making it essential for assessing treatment effectiveness.

5) Lauha:
Lauha, or iron, is an important ingredient in Ayurvedic medicines like Dhatrilauha, known for its hematinic properties. Its role in promoting blood health and its potential benefits in digestive issues highlights its relevance in Ayurvedic therapeutic practices.

6) Science (Scientific):
Science is the study of the structure and behavior of the physical and natural world through observation and experiment. This study embodies a scientific approach by investigating a traditional Ayurvedic treatment through methods like clinical trials and statistical evaluation.

7) Vomiting:
Vomiting, the act of expelling stomach contents, is a common symptom of gastrointestinal disorders such as parinamashoola. The study evaluates the frequency and significance of vomiting in patients as an indicator of treatment response to Dhatrilauha and ranitidine.

8) Lauhabhasma (Lauha-bhasma):
Lauha-bhasma is a purified form of iron used in various Ayurvedic formulations. Its use in Dhatrilauha underscores its significance in enhancing therapeutic effects, particularly in addressing conditions associated with digestion and blood health.

9) Amalaki (Āmalakī, Āmalaki):
Amalaki, or Indian gooseberry, is a key ingredient in Dhatrilauha, known for its antioxidant and anti-inflammatory properties. Its inclusion signifies its recognized role in supporting digestive health and enhancing the efficacy of herbal formulations in Ayurveda.

10) Kaphaja:
Kaphaja refers to a constitution characterized by the predominance of Kapha dosha according to Ayurvedic principles. Understanding a patient's constitution helps tailor treatments in Ayurveda, and this study analyzes the prevalence of Kaphaja in patients with parinamashoola.

11) Prakriti (Prakṛti):
Prakrti denotes an individual's biological constitution or inherent nature in Ayurveda, influencing health and disease susceptibility. This study observes the relationship between Prakrti and peptic disorders, aiding in personalized treatment strategies.

12) Bhasma (Bhasman):
Bhasma refers to the calcined ash of metals, used in Ayurvedic medicine for its therapeutic properties. Lauha-bhasma in Dhatrilauha contributes to its healing effects, emphasizing the significance of proper preparation and dosage in treatment.

13) Pitta (Pītta, Piṭṭā):
Pitta, one of the three doshas in Ayurveda, embodies metabolic functions and is associated with heat and digestion. In the study, understanding the role of Pitta is crucial for comprehending the nature of parinamashoola and tailoring treatments.

14) Deha:
Deha translates to 'body' in Ayurvedic context, encompassing physical structure and constitution. The study examines how various physical characteristics, or Deha Prakrti, influence the prevalence of parinamashoola among patients, linking body constitution to gastrointestinal disorders.

15) Shri (Śri, Śrī, Śṝ, Sṛ, Sṝ):
Shri is an honorific prefix often used in Indian languages, showing respect. In clinical texts, its inclusion often refers to esteemed figures in Ayurveda, signifying their contributions to the study and practice of traditional medicine.

16) Vata (Vāṭa, Vaṭa, Vāta, Vaṭā):
Vata is another dosha in Ayurveda, associated with movement and dynamism. Its imbalance can lead to various health issues, including digestive disorders. The study looks at Vata's role in the manifestation of parinamashoola in patients.

17) Vidyotini (Vidyotinī):
Vidyotini is a commentary that enriches Ayurvedic texts with explanations and interpretations. References to Vidyotini in this study provide a deeper understanding of the principles underlying treatments and their significance in contemporary clinical settings.

18) Dhatri (Dhātrī, Dhātṛ, Dhātri):
Dhatri means 'nurturer' or 'mother' in Sanskrit. In Ayurvedic terms, it emphasizes the nourishing aspect of herbs like Amalaki, and may denote the nurturing effects of formulations like Dhatrilauha on the digestive system.

19) Nausea:
Nausea is the sensation of needing to vomit, a common symptom in various gastrointestinal disorders. In this study, nausea is examined in the context of its resolution following treatment with Dhatrilauha, emphasizing its importance in clinical assessment.

20) Gupta (Guptā):
Gupta is a surname commonly found in India, here likely referring to one of the authors or contributors to the study. This underscores the collaborative nature of research and the importance of regional historical contributions to Ayurveda.

21) Blood:
Blood is vital in the context of health, representing life and vitality. In this study, the blood-related properties of Lauha (iron) in Dhatrilauha are critical for understanding its potential benefits for patients with digestive disorders.

22) Caraka-samhita (Caraka-saṃhitā):
Caraka-samhita is an ancient Ayurvedic text that serves as a foundational guide for practitioners. The study references this text to anchor its understanding of traditional treatments and concepts related to gastric disorders in contemporary practice.

23) Yashtimadhu (Yaṣṭimadhu, Yashti-madhu, Yaṣṭīmadhu):
Yashtimadhu, or Licorice, is an important herb in Ayurveda known for its soothing and anti-inflammatory properties. Its inclusion in Dhatrilauha highlights its role in treating digestive ailments and supports the formulation's therapeutic efficacy.

24) Shrikantha (Śrīkaṇṭha, Shri-kantha, Shrikamtha):
Shri-kantha, likely referring to an author or commentator, signifies the respect attributed to contributors and the traditions of Ayurvedic literature. The term enhances the credibility and scholarly nature of the research presented.

25) Discussion:
The discussion section is critical in research as it interprets results and places them in the context of existing knowledge. This aspect of the study allows for exploration of findings related to Dhatrilauha's efficacy compared to modern medicine.

26) Siddhanta (Siddhānta, Siddha-anta, Siddhamta):
Siddhanta refers to principles or theories in Ayurvedic science. This term underlines the foundational concepts guiding the treatment approaches and evaluations discussed in the study, emphasizing the theoretical underpinnings of Ayurvedic practices.

27) Liquorice (Licorice):
Liquorice is another term for Yashtimadhu and is crucial in Ayurvedic formulations for its therapeutic properties. Its presence in Dhatrilauha highlights its importance in enhancing the formula's effectiveness against gastrointestinal disturbances.

28) Ayurveda (Āyurveda, Ayus-veda):
Ayurveda is an ancient system of medicine originating from India, emphasizing holistic health approaches. The study exemplifies Ayurveda's enduring relevance by investigating modern scientific evaluations of its treatments, particularly for digestive disorders.

29) Medicine:
Medicine refers to the science and practice of diagnosing, treating, and preventing disease. This study bridges traditional Ayurvedic practices with modern medical standards, exemplifying the integration of ancient wisdom with contemporary health care.

30) Samhita (Saṃhitā, Saṃhita):
Samhita denotes collected texts or treatises in Ayurveda, proposing foundational knowledge. The term emphasizes the importance of classical texts in informing current practices and validating the treatment protocols examined in the study.

31) Quality:
Quality pertains to the standard of something, indicating its effectiveness and reliability. In the study, the quality of the drug Dhatrilauha and its components is assessed through scientific methods, linking traditional knowledge with contemporary evaluation.

32) Caraka (Cāraka, Cārāka):
Caraka refers to a key figure in Ayurvedic medicine, notable for his contributions to the Caraka-samhita. His influence underscores the relevance of traditional practices and texts in evaluating treatments for modern health issues.

33) Shukla (Śukla, Śuklā, Suklā, Sukla):
Shukla, often a surname in Indian culture, here likely refers to an author or contributor. Including such names means recognizing the collaborative efforts involved in contributing to the understanding and evaluation of Ayurvedic treatments.

34) Ambika (Aṃbikā, Ambikā):
Ambika may refer to Ambika Dutta Shastri, a notable commentator in Ayurvedic literature. Recognizing his contributions reassures the blend of modern interpretations with ancient texts, reinforcing the framework within which the study is set.

35) Kantha (Kaṇṭha, Kamtha):
Kantha refers to voice, speech, or a figure. In the context of Ayurvedic commentary, it signifies authoritative interpretations and verbal traditions that have shaped the understanding of health and disease in classical texts.

36) Vatika (vaṭikā, Vātīka, Vātika, Vaṭika, Vatikā, Vātikā):
Vatika refers to a constitution characterized by the predominance of Vata dosha. This classification aids in understanding patient symptoms in the study and highlights Ayurveda's individualized approach to treatment based on body constitution.

37) Thirst:
Thirst indicates the body's signal for hydration, often related to digestive health. In the study, managing symptoms like thirst is important for comprehensive treatment of digestive disorders, affecting overall patient well-being.

38) Water:
Water is essential for life and plays a crucial role in maintaining bodily functions. It is particularly relevant in Ayurveda for digestion and detoxification, and its relationship with symptomatic relief in patients is an implied concern of this study.

39) Honey:
Honey is often used in Ayurvedic formulations for its therapeutic and soothing properties. In the study, honey acts as a medium for administering Dhatrilauha, enhancing patient compliance and enjoyment of the treatment.

40) Diet:
Diet encompasses the nutritional intake of individuals, significantly influencing health. The study examines dietary habits in relation to parinamashoola, emphasizing the importance of diet in both causation and management of gastrointestinal disorders.

41) Post:
Post refers to the time following treatment. The evaluation of outcomes post-treatment in the study is critical for assessing the efficacy and long-term implications of Dhatrilauha versus modern medicinal approaches.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Clinical evaluation of dhatrilauha in parinamasula’. Further sources in the context of Science might help you critically compare this page with similair documents:

Dhatrilauha, Statistical analysis, Symptomatic relief, Peptic ulcer, Clinical evaluation, Treatment duration, Significant improvement, Ayurvedic text, Demographic Profile, Non-ulcer dyspepsia, Clinical profile, Radiological examination, Parinamashoola, Demographic incidence, Endoscopic examination, Efficacy of drug, Ranitidine.

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