Anti-inflammatory activity of dodonaea viscose
Journal name: Ancient Science of Life
Original article title: Anti-inflammatory activity of dodonaea viscose
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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N. Mahadevan, Sama Venkatesh, B. Suresh
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Anti-inflammatory activity of dodonaea viscose
Year: 1998
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
Dodonaea viscose, Linn, a plant commonly found in the Nilgiris district of Tamil Nadu, is utilized by the local tribes as a traditional remedy for fractures and inflammation. Recognizing its folkloric use, the study aimed to explore the anti-inflammatory activity of the leaves of Dodonaea viscose through experimental methods. The research involved collecting the plant material and preparing various extracts, notably using methanol, to assess their efficacy in mitigating inflammation induced by carrageenin in Wistar albino rats.
Anti-inflammatory Activity of Dodonaea Viscose
The study employed the carrageenin-induced paw edema method to evaluate the anti-inflammatory effects of the methanolic extract and its various fractions (chloroform, ethyl acetate, and n-butanol). The results indicated that both the methanolic extract and the chloroform fraction exhibited significant anti-inflammatory activity, particularly noticeable at the 180-minute mark post-administration. The percentage protection against inflammation provided by the methanolic extract was 50%, while the chloroform fraction offered 46%, in comparison to the positive control, Ibuprofen, which demonstrated a protection rate of 73.07%. These findings highlight the potential therapeutic benefits of Dodonaea viscose for inflammatory conditions.
Conclusion
The research concludes that Dodonaea viscose possesses substantial anti-inflammatory properties, corroborating the traditional use of this plant in treating inflammation-related ailments. The significant activity exhibited by the methanolic extract and the chloroform fraction suggests that further exploration and validation of this plant's components could lead to the development of natural anti-inflammatory agents. Additionally, the qualitative phytochemical analysis indicated the presence of various bioactive compounds, such as steroids and flavonoids, which may contribute to the observed therapeutic effects.
FAQ section (important questions/answers):
What is the traditional use of Dodonaea viscose among Nilgiris tribals?
Dodonaea viscose is traditionally used by Nilgiris tribals for treating bone fractures and joint sprains, as they believe the leaves, when made into a paste with groundnut oil, promote quick healing.
How was the anti-inflammatory activity of Dodonaea viscose tested?
The anti-inflammatory activity was tested using the carrageenin-induced paw edema method in Wistar albino rats, where the extracts were administered and the swelling measured over time.
What extracts from Dodonaea viscose were studied for anti-inflammatory effects?
The study focused on the methanolic extract and its fractions, including chloroform, ethyl acetate, and n-butanol, to evaluate their anti-inflammatory properties using various tests.
What were the results of the anti-inflammatory activity tests?
The methanolic extract and chloroform fraction showed significant anti-inflammatory activity, with 50% and 46% protection at 180 minutes post-carrageenin administration, respectively, indicating their potential medicinal value.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Anti-inflammatory activity of dodonaea viscose”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
Activity refers to the biological effects or actions of a substance, in this context, the anti-inflammatory effects demonstrated by Dodonaea viscose. The study investigates this activity through experimental methods, particularly measuring the paw edema response in rats, thus quantifying the plant's medicinal potential.
2) Edema (Oedema):
Edema is the swelling caused by excess fluid trapped in the body's tissues, often resulting from inflammation or injury. In this research, edema is induced by carrageenin in rats to evaluate the anti-inflammatory effects of Dodonaea viscose by measuring the extent of swelling.
3) Flavonoid:
Flavonoids are a class of phytochemicals known for their antioxidant and anti-inflammatory properties. Their presence in the Dodonaea viscose extracts indicates potential health benefits, contributing to the plant's traditional use in treating injuries and inflammation, as explored in the qualitative analysis.
4) Liquor:
In the context of this study, 'liquor' refers to the mother liquor obtained during the extraction process of the plant's leaves. This liquid contains dissolved substances from the plant material, which are subsequently fractionated to isolate specific compounds for further analysis of their pharmacological effects.
5) Water:
Water is a crucial solvent used in the extraction process of Dodonaea viscose. After the methanolic extract is obtained, it is suspended in distilled water to facilitate further fractionation. Water serves as an essential medium for assessing the plant's bioactive compounds and their therapeutic activities.
6) Inflammation:
Inflammation is the body's response to injury or harmful stimuli, characterized by redness, swelling, heat, and pain. This research aims to evaluate the anti-inflammatory effects of Dodonaea viscose, based on traditional claims of its efficacy in treating inflammation related to fractures and sprains.
7) Medicine:
Medicine refers to the science and practice of diagnosing, treating, and preventing diseases, often using substances derived from plants, like Dodonaea viscose. This study contributes to understanding its potential medicinal properties and validates traditional uses as therapeutic interventions for inflammation.
8) Drug:
A drug is any chemical substance used in the diagnosis, treatment, or prevention of disease. In this study, the extracts of Dodonaea viscose, particularly the methanolic extract, are evaluated for their potential as anti-inflammatory agents, akin to conventional pharmaceutical drugs.
9) Phytochemical:
Phytochemicals are bioactive compounds found in plants that have health-promoting properties. The qualitative analysis of Dodonaea viscose identifies several phytochemicals, including flavonoids and saponins, which may contribute to the plant's traditional medicinal uses and its demonstrated anti-inflammatory activity.
10) Discussion:
Discussion refers to the section of the research where results are interpreted and analyzed. This part evaluates the significance of findings regarding the anti-inflammatory activity of Dodonaea viscose, comparing it to known standards like Ibuprofen and examining the implications for herbal medicine.
11) Science (Scientific):
Science is the systematic study of the natural world through observation and experimentation. This research exemplifies scientific inquiry by employing controlled methods to assess the medicinal properties of Dodonaea viscose, thus bridging traditional knowledge with evidence-based findings in pharmacology.
12) Sama (Śama, Sāmā, Sāma, Shama, Samā):
Sama refers to one of the researchers involved in the study, along with Mahadevan and Suresh. Their collaboration underscores the importance of scientific teamwork in conducting comprehensive research to explore the pharmacological properties of traditional medicinal plants like Dodonaea viscose.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Anti-inflammatory activity of dodonaea viscose’. Further sources in the context of Science might help you critically compare this page with similair documents:
Traditional medicine, Anti-inflammatory activity, Ethanol extraction, Methanolic extract, Qualitative phytochemical analysis, Carrageenin induced paw edema, Percentage protection, Fractionated extracts, Wistar albino rat.