Biochemical effects of plantain juice on normal and stone-forming rats.

| Posted in: Science

Journal name: Ancient Science of Life
Original article title: Biochemical effects in normal and stone forming rats treated with the ripe kernel juice of plantain (musa paradisiaca)
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

V. Kalpana Devi, R. Baskar, P. Varalakshmi


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: Biochemical effects in normal and stone forming rats treated with the ripe kernel juice of plantain (musa paradisiaca)

Year: 1993

Copyright (license): CC BY-NC-SA


Download the PDF file of the original publication


Summary of article contents:

Introduction

Urinary lithiasis, a prevalent condition characterized by the aggregation of crystalline substances like oxalate, calcium, and phosphate within the urinary tract, poses significant health challenges. Traditional remedies in countries like India often accompany contemporary medical and surgical treatments for urolithiasis, which can lead to renal damage. The study investigates the ripe kernel juice of Musa paradisiaca as a potential treatment for calcium oxalate stone formation in experimental rat models, assessing its effects on biochemical parameters associated with lithogenesis.

Biochemical Effects of Kernel Juice on Stone Formation

The research highlights the elevated activities of oxalate synthesizing enzymes, namely glycollic acid oxidase (GAO) and lactate dehydrogenase (LDH), in stone-forming rats, which contributes to increased oxalate levels in urine. Through the administration of Musa paradisiaca kernel juice, a notable reduction in both these enzyme activities and the levels of urinary stone-forming constituents (oxalate, calcium, and phosphorus) was observed. The extract treatment not only mitigated the elevated synthesis of these components in the liver and kidneys but also normalized urinary enzyme activities indicating nephron cell integrity. This suggests an antilithic action of the kernel juice, reinforcing its traditional use among rural populations for managing urinary stones.

Conclusion

The study concludes that the ripe kernel juice of Musa paradisiaca exhibits beneficial biochemical effects in regulating stone formation in experimental models. By decreasing the synthesis of oxalate and the activities of the associated synthesizing enzymes, the kernel extract presents a promising avenue for non-toxic interventions in urinary stone disease. Future research is encouraged to evaluate the effectiveness of this natural remedy in human subjects, potentially validating and enhancing traditional medicine approaches alongside modern treatments.

FAQ section (important questions/answers):

What is the effect of Musa paradisiaca kernel juice on rats?

The study shows that Musa paradisiaca kernel juice reduces oxalate levels and the activities of oxalate synthesizing enzymes in experimental urolithiatic rats, suggesting its potential antilithic properties.

How were the calcium oxalate stones induced in the rats?

Calcium oxalate stones were induced by feeding rats a diet mixed with 3% sodium glucollate for 30 days to promote lithiasis.

What urinary components were measured in the study?

Levels of oxalate, calcium, and phosphorus in urine and kidneys were measured to assess the stone-forming constituents in both control and experimental rats.

What enzymes were analyzed in the kidneys of the rats?

Enzymes analyzed included glycolic acid oxidase (GAO) and lactate dehydrogenase (LDH), which are involved in oxalate synthesis and were significantly altered in stone-forming rats.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Biochemical effects of plantain juice on normal and stone-forming rats.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Activity:
Activity refers to the level of biochemical functions or reactions occurring within an organism, especially concerning enzyme functions in this study. In the context of the research, the term specifically pertains to enzyme levels such as glyoxylate oxidase, lactate dehydrogenase, and urinary enzymes measured to evaluate the effect of Musa paradisiaca kernel juice on stone-forming rats.

2) Musha (Musa, Musā, Mūṣā, Muṣā, Musá):
Musa is a genus of flowering plants that includes bananas and plantains. The relevance of this word lies in its association with Musa paradisiaca, the plant studied for its potential antilithic properties. Researchers explored its ripe kernel juice as a natural remedy against urinary stone formation in rats, highlighting its traditional medicinal use.

3) Diet:
Diet denotes the specific food consumed by test subjects, crucial for inducing and studying the formation of kidney stones in the experiment. The experimental diet mixed with sodium glycollate aimed to simulate conditions leading to the development of stones, helping researchers analyze subsequent biochemical effects and the impact of Musa paradisiaca extract.

4) Musa paradisiaca:
Musa paradisiaca, or the plantain, is the specific species investigated in this study. It holds traditional significance for treating urinary stones. The research assessed the biochemical impact of its ripe kernel juice on stone-forming rats, demonstrating its potential efficacy and contributing to the body of knowledge on alternative medicine for urolithiasis.

5) Water:
Water, often seen as a fundamental requirement for living organisms, represents the control condition in the experiment where it served as a placebo. The study used water for hydration in control groups to ensure all rats received identical care except for the treatment with Musa paradisiaca extract, helping attribute any changes specifically to the treatment.

6) Science (Scientific):
Scientific indicates a systematic and evidence-based approach to knowledge creation. The research into Musa paradisiaca's effects is grounded in rigorous biochemical analysis, providing credibility to traditional claims. The scientific method enables the investigation of herbal remedies, aligning ancient practices with contemporary biomedical understanding, particularly in treating conditions such as urolithiasis.

7) Drug:
Drug refers to any chemical substance intended for use in the treatment of disease. In this study, the ripe kernel juice of Musa paradisiaca is examined for its antilithic properties. The interaction of this 'drug' (herbal extract) with pathophysiological mechanisms of urolithiasis provides insights into alternative therapeutic approaches.

8) Inflammation:
Inflammation is a biological response to harmful stimuli such as pathogens or injury. This study notes elevated activity of certain urinary enzymes in stone-forming rats, indicating potential inflammatory processes at play. Understanding inflammation helps elucidate pathology associated with urinary stone disease, linking tissue damage and enzymatic changes to stone formation.

9) Discussion:
Discussion refers to the section in the research paper where the implications of the findings are interpreted. It evaluates the significance of data regarding enzymatic changes and the efficacy of Musa paradisiaca in preventing stone formation. This section contextualizes observations, suggesting further research avenues and rationalizing the results obtained.

10) Medicine:
Medicine pertains to the science of diagnosing, treating, and preventing disease. This research contributes to medical knowledge by evaluating the antilithic properties of Musa paradisiaca. Such studies bridge traditional herbal remedies with modern therapeutic strategies, potentially leading to novel, less invasive treatment options for conditions like urinary stone disease.

11) Jayanti (Jayantī, Jayamti):
Jayanthi appears to refer to an author or researcher associated with the study or previous literature on related topics. Mentioning researchers provides credibility and acknowledges contributions in the field, establishing a connection between the current research findings on Musa paradisiaca and established scientific discourse.

12) Kalpana (Kalpanā):
Kalpana likely references one of the researchers involved in the study. Acknowledging individuals in published research highlights collaboration and contributions to scientific discovery. It draws attention to the specialized expertise needed to conduct such investigations into the biochemical effects of Musa paradisiaca on urolithiasis.

13) Shubha (Śubhā, Śubha, Subha, Subhā):
Subha may refer to another researcher or previous studies in the literature. Recognition of past contributions or ongoing research efforts in the area of urolithiasis underscores the collaborative nature of scientific inquiry. It also aids in tracing the lineage of ideas and findings that inform the current research.

14) Devi (Devī):
Devi is likely a reference to one of the authors involved in the research or significant figures in related studies on Musa paradisiaca and its effects. Identifying researchers gives context and credibility to the study, emphasizing their roles in contributing to the understanding of alternative medicine in treating kidney stones.

Other Science Concepts:

[back to top]

Discover the significance of concepts within the article: ‘Biochemical effects of plantain juice on normal and stone-forming rats.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Traditional medicine, Crystalluria, Lactate dehydrogenase, Calcium oxalate stone, Urinary lithiasis, Gamma Glutamyl Transferase, Crystalline component, Alkaline phosphatase activity, Metabolic cage, Biochemical Effect.

Let's grow together!

I humbly request your help to keep doing what I do best: provide the world with unbiased sources, definitions and images. Your donation direclty influences the quality and quantity of knowledge, wisdom and spiritual insight the world is exposed to.

Let's make the world a better place together!

Like what you read? Consider supporting this website: