Standardisation studies on some mercurials of siddha system*

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Journal name: Ancient Science of Life
Original article title: Standardisation studies on some mercurials of siddha system*
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:

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Author:

A. Saraswathy, Sankari Rajagopal, Girija Mohan


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: Standardisation studies on some mercurials of siddha system*

Year: 1993

Copyright (license): CC BY-NC-SA


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Summary of article contents:

Introduction

The study conducted on four mercurial drugs from the Siddha system of medicine—Ilinkaccenturam No. 1, Canta Cantirotayam, Kowri Cintamani Centuram, and Cati Campirakkulampu—aimed to establish chemical standards for these formulations. The Siddha system's materia medica comprises diverse drugs, including those derived from plants, metals, minerals, and animal products. Mercury, referred to as 'Iracam' within this system, plays a significant role in various medicinal formulations, exhibiting properties such as blood purification and nervous system benefits. The research involved thorough chemical analysis and standardization of these mercurial formulations to provide concrete data and parameters for quality control.

Chemical Composition and Standardization of Canta Cantirotayam

One noteworthy aspect of this study is the detailed examination of Canta Cantirotayam, a formulation containing active ingredients such as Calomel (Mercurous chloride) and Curcuma longa L. (turmeric). The analysis demonstrated a composition featuring 16.24% mercury and 10.8% borax along with the presence of curcumin, isolated from the formulation at a concentration of 0.5%. Curcumin was confirmed through thin-layer chromatography with a melting point of 183°C, highlighting its importance as an active component. This information is crucial for establishing standards, as the presence of curcumin alongside the quantifiable mercury content can serve as parameters for quality assurance and pharmaceutical regulation within Siddha medicine.

Conclusion

The findings from the analysis of the four mercurial formulations underscore the importance of rigorous chemical examination and standardization in traditional medicine. These studies not only shed light on the quantitative aspects of key ingredients such as mercury and curcumin but also reinforce the compatibility and safety profiles of these compounds within the Siddha system. Therefore, the established parameters provide a foundational framework for quality control, setting the stage for further research and validation of similar formulations. The recognition of such traditional remedies within a scientific context could lead to broader acceptance and utilization in modern herbal medicine.

FAQ section (important questions/answers):

What are the main mercurial drugs analyzed in this study?

The study analyzes four mercurial drugs: Ilinkaccenturam No.1, Canta Cantirotayam, Kowri Cintamani Centuram, and Cati Campirakkulampu, focusing on their chemical properties for standardization purposes.

What is the significance of mercury in Siddha medicine?

In Siddha medicine, mercury, or 'Iracam,' is considered beneficial for its roles as a blood purifier, carminative, antiseptic, nervine tonic, memory promoter, and rejuvenator, despite its potential toxicity.

How were the formulations in this study prepared?

The formulations were prepared according to classical Siddha texts, with specific purification methods for the metals and minerals involved, ensuring the authenticity and efficacy of the preparations.

What method was used to isolate curcumin from the formulations?

Curcumin was isolated from the MeOH extract of cantacantirotayam using column chromatography over silica gel, followed by thin-layer chromatography (TLC) to confirm its presence in the formulation.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Standardisation studies on some mercurials of siddha system*”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
In the context of Siddha medicine, a 'Drug' refers to any substance used for therapeutic purposes. The document details various mercurial compounds used in Siddha practices, highlighting the importance of chemical analysis in ensuring safety and efficacy of these materials in traditional healing methods.

2) Siddha (Siddhā):
'Siddha' refers to a traditional system of medicine originating from Tamil Nadu, India. It incorporates a combination of herbal and metallic formulations, emphasizing the spiritual aspect of healing. The standardisation studies conducted aim to provide a scientific basis for Siddha treatments and enhance their acceptance in contemporary medicine.

3) Medicine:
'Medicine' encompasses the science and practice of diagnosing, treating, and preventing diseases. In this context, Siddha medicine involves the use of natural substances, including mercurial compounds, which are analyzed to set quality standards. This effort bridges traditional practices with modern scientific methodologies.

4) Borax:
'Borax' is a naturally occurring mineral, identified as sodium borate. In Siddha formulations, it serves both as a therapeutic agent and a stabilizing compound. Its inclusion in formulations signifies the integration of mineral-based remedies that are believed to enhance the efficacy of other ingredients.

5) Cintamani (Cintāmaṇi, Cintāmanī, Cinta-mani, Cimtamani):
'Cintamani' refers to specific formulations in Siddha practice, which often include mercury as a central ingredient. These formulations are noted for their purported health benefits, including rejuvenation and purification. The research underscores the need for standardisation and safety monitoring of these traditional compounds.

6) Curcuma longa:
'Curcuma longa', commonly known as turmeric, is a well-studied herb revered in Siddha and other traditional medicines for its anti-inflammatory and antioxidant properties. The research highlights its inclusion in formulations along with the extraction of curcumin, its active compound, underlining its therapeutic relevance.

7) Ocimum sanctum:
'Ocimum sanctum', also known as holy basil or tulsi, is a revered plant in Ayurveda and Siddha medicine. It is acknowledged for its adaptogenic and therapeutic properties. Its incorporation into formulations signifies a blend of herbal and mineral medicine aimed at holistic healing.

8) Purification:
'Purification' refers to essential processes undertaken to prepare metallic and mineral substances for medicinal use in the Siddha system. It ensures the removal of impurities and toxic elements, thus enhancing the safety and efficacy of the final medicinal formulations analyzed in the study.

9) Discussion:
'Discussion' in research entails analyzing results, comparing findings, and interpreting their significance. The document provides a platform for examining the analytical data gathered from Siddha formulations, aiming to establish reliable standards that can be utilized in quality control and further studies.

10) Turmeric:
'Turmeric' is recognized for its significant medicinal properties, particularly its active compound, curcumin. In Siddha formulations, it serves as both a therapeutic agent and a coloring substance. Its analysis within the context of standards provides a reliable basis for its inclusion in traditional remedies.

11) Science (Scientific):
'Science' encompasses systematic study and application of knowledge through observation and experimentation. The standardisation studies on Siddha formulations exemplify the application of scientific methods in traditional medicine, facilitating a better understanding of herbal and mercurial drugs within a modern context.

12) Girija (Giri-ja):
'Girija' is a co-author of the study. The inclusion of the author’s name signifies the collaborative nature of scientific research. Contributions from various researchers enhance the depth and credibility of the work, which aims to standardize traditional formulations in Siddha medicine.

13) Blood:
'Blood' is crucial in Siddha medicine, where mercurial compounds are believed to facilitate purification and rejuvenation. The reference to blood emphasizes the foundational aspects of health and wellness in therapeutic interventions, demonstrating the potential impact of these formulations on overall health.

14) Coral (Cōral):
'Coral' relates to the Siddha categorization of materials used in medicines. It is noted for its mineral content, reinforcing the classification of 'Thathupporutkal' used within Mercurial drugs, demonstrating the intertwining of natural elements in traditional healing practices.

15) Tara (Tārā, Tāra):
'Thara' is a term related to alloys in the context of Siddha medicine. This highlights the practice of incorporating metals and their derivatives into formulations, underpinning the historical and cultural significance of metallic substances in traditional therapeutics.

16) Mica:
'Mica' is recognized as a compatible material with mercury in Siddha medicine. This signifies the nuanced understanding of mineral interactions and their influence on therapeutic efficacy. Its role underscores the importance of context-specific knowledge in the formulation of traditional remedies.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Standardisation studies on some mercurials of siddha system*’. Further sources in the context of Science might help you critically compare this page with similair documents:

Active principle, Standard method, Materia medica, Cinnabar, Physico-chemical parameters, Moisture content, Chemical analysis, TLC, Qualitative test, Siddha system of medicine, Loss on ignition, Physico-chemical standards, Formulation ingredients, Analytical values, Calomel.

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