Anti-ulcer activity of leucas aspera spreng
Journal name: Ancient Science of Life
Original article title: Anti-ulcer activity of leucas aspera spreng
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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M. Kannappa Reddy, S. Viswanathan, P. Thiugnanasambhantham, Lalitha Kameshwaran
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Anti-ulcer activity of leucas aspera spreng
Year: 1992
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
The study investigates the anti-ulcer activity of Leucas aspera, a plant used in Indian traditional medicine for various ailments. Previous research has indicated its anti-inflammatory and analgesic properties. The current study aims to explore its potential in reducing gastric acid secretion and ulcer formation, further examining its effectiveness through two experimental models in rats: Shay rat ulcers and aspirin-induced ulcers.
Antisecretory Activity of Leucas Aspera
The results indicated that the alcoholic extract of Leucas aspera (ALA) significantly reduced gastric secretion and ulcer scores in treated rats compared to controls. In the Shay rat model, treatment with ALA at doses of 100 and 200 mg/kg resulted in lower volumes of gastric secretion and reduced free and total acidity, mirroring the effects of cimetidine, a known anti-ulcer medication. Furthermore, in the aspirin-induced ulcer model, ALA treatment also led to a marked decrease in the ulcer score at higher dosages. This suggests that ALA possesses strong antisecretory properties, likely due to its influence on histamine release from mast cells, which may play a critical role in ulcer development.
Conclusion
The findings of this study provide compelling evidence that Leucas aspera has significant anti-ulcer activity, which may be attributed to its antisecretory effects and protective action on the gastric mucosa. This dual action is unique, as most compounds with analgesic and anti-inflammatory effects typically induce gastric ulcers. The results merit further investigation into the mechanisms underlying these effects and highlight the potential therapeutic applications of Leucas aspera in the treatment of gastric ulcers.
FAQ section (important questions/answers):
What was the focus of the study on Leucas aspera?
The study investigated the anti-ulcer effect of the alcoholic extract of Leucas aspera in rats, assessing reductions in gastric secretion and ulcer scores using two experimental models.
What methods were used to induce ulcers in rats?
Ulcers were induced using the Shay rat ulcer method and through aspirin administration. The study measured gastric secretion and ulcer scores after treatment with Leucas aspera.
What were the main findings regarding the extract's effects?
The results showed that the extract significantly reduced gastric secretion volume and ulcer scores in both experimental models, indicating potent antisecretory and anti-ulcer activity.
What possible mechanisms were suggested for Leucas aspera's effects?
The anti-ulcer effects may be due to a combination of antisecretory activity and protective effects on gastric mucosa, possibly related to inhibition of histamine release from mast cells.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Anti-ulcer activity of leucas aspera spreng”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Ulcer:
An ulcer is a sore that can develop on the lining of the stomach, leading to pain and discomfort. In the context of this study, ulcers are significant as the research investigates the anti-ulcer effects of Leucas aspera, a plant traditionally believed to aid in healing ulcers. Understanding ulcer formation is essential for exploring treatment options.
2) Activity:
Activity in this context refers to the biological effects or interactions of a substance, particularly the anti-ulcer activity of the alcoholic extract of Leucas aspera. The study highlights how this activity impacts gastric secretion, acidity, and ulcer scores in experimental models, showcasing the extract's potential therapeutic role.
3) Water:
Water is crucial as a solvent in pharmacological experiments. The alcoholic extract of Leucas aspera was suspended in distilled water, which serves as a vehicle for administering the extract to the rats. Additionally, hydration is essential for the overall health of the animals used in the study.
4) Pharmacological:
Pharmacological pertains to the study of how drugs interact with biological systems. This research focuses on the pharmacological properties of Leucas aspera, specifically evaluating its anti-ulcer effects. Understanding these properties contributes to the broader field of drug development and the search for effective treatments for ulcers.
5) Pharmacology:
Pharmacology is the branch of medicine that studies drugs and their effects on the body. This study contributes to pharmacology by investigating the anti-ulcer potential of a natural extract, demonstrating how traditional remedies can be assessed scientifically, enriching knowledge about therapeutics derived from plants.
6) Discussion:
The discussion section of a research paper interprets results, provides insights, and contextualizes findings within existing literature. In this study, it evaluates the anti-ulcer activity of the extract, comparing it to known treatments like cimetidine, and offers explanations for the mechanisms behind the observed effects.
7) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing illness. This study on Leucas aspera aligns with traditional and modern medicinal practices, exploring how plant-based therapies can be scientifically validated to improve medical treatment options, particularly for gastrointestinal disorders like ulcers.
8) Science (Scientific):
Science refers to the systematic pursuit of knowledge, involving observation, experimentation, and analysis. This study exemplifies the scientific method by rigorously assessing the effects of Leucas aspera, contributing to our understanding of its medicinal properties and its potential role in treating ulcers within a scientific framework.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Anti-ulcer activity of leucas aspera spreng’. Further sources in the context of Science might help you critically compare this page with similair documents:
Leucas aspera, Anti-inflammatory activity, Analgesic effect, Pharmacological testing, Anti-ulcer activity, Total acidity, Free acidity, Alcoholic extract, Acid Secretion, Gastric mucosa, Mucosal Protection, Aspirin-induced ulcer, Ulcer score.