Serum enzyme and glycoprotein changes in fibrosarcoma and panchakavvyam.
Journal name: Ancient Science of Life
Original article title: Changes observed in serum marker enzymes and plasma glycoproteins in fibrosarcoma and in treatment with an indigenous drug “panchakavvyam” in rats
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
K. Kumar, P. Sachidanandam
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Changes observed in serum marker enzymes and plasma glycoproteins in fibrosarcoma and in treatment with an indigenous drug “panchakavvyam” in rats
Year: 1991
Copyright (license): CC BY-NC-SA
Download the PDF file of the original publication
Summary of article contents:
Introduction
This study investigates the changes in serum marker enzymes and plasma glycoproteins in rats affected by fibrosarcoma and the potential therapeutic effects of an indigenous drug, “Panchakavvyam.” Drawing from ancient Vedic literature, Panchakavvyam is noted for its anticarcinogenic properties. The research aimed to evaluate how this drug affects enzymatic levels associated with malignancy and to provide a detailed analysis of histopathological alterations in tumor tissues following treatment.
Effects of Panchakavvyam on Enzymatic Changes
The results indicated significant alterations in enzyme levels between the control group, the untreated tumor group, and the drug-treated group. Specifically, lactate dehydrogenase (LDH) levels were elevated in the untreated group, correlating with the presence of fibrosarcoma, whereas treatment with Panchakavvyam led to a notable reduction in LDH levels, suggesting improved metabolic balance and possible regression of the tumor. Additionally, alkaline phosphatase levels, typically associated with cellular membrane integrity, were also reduced in the drug-treated group, implying a potential healing mechanism triggered by the drug. The plasma glycoprotein levels, including hexose, hexosamine, and sialic acid, demonstrated significant increases in the untreated group, which decreased upon administration of Panchakavvyam, further supporting its therapeutic potential by restoring normal physiological conditions in damaged cells.
Conclusion
In summary, the administration of Panchakavvyam in fibrosarcoma-afflicted rats resulted in a significant reduction of key serum enzymes and plasma glycoproteins linked with tumor burden, alongside observable histopathological improvements in the tumor tissue. These findings suggest that Panchakavvyam may possess valid anticarcinogenic properties and could contribute to the management of cancer through biochemical and regenerative mechanisms. Future investigations on the drug’s efficacy and mechanisms of action could establish it as a beneficial adjunct therapy in cancer treatment.
FAQ section (important questions/answers):
What is the indigenous drug 'Panchakavvyam' used for?
'Panchakavvyam' is an indigenous preparation with reported anticarcinogenic properties, used in ancient Indian rituals. In this study, it was administered to rats with fibrosarcoma to evaluate its effects on tumor progression and enzyme levels.
How was fibrosarcoma induced in the experimental rats?
Fibrosarcoma was induced by subcutaneously injecting a 10% suspension of cancerous cells into the axillary region of Wistar strain male rats, which were then monitored for tumor development.
What significant changes were observed in enzyme levels?
The administration of 'Panchakavvyam' resulted in significant reductions in lactate dehydrogenase and alkaline phosphatase levels in serum compared to untreated cancer-bearing groups, indicating its potential therapeutic effects.
What were the histopathological findings in this study?
Histopathological examination revealed marked regenerative changes in the tumor tissues of drug-treated animals compared to untreated rats, suggesting that 'Panchakavvyam' may support tissue repair and combat malignancy.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Serum enzyme and glycoprotein changes in fibrosarcoma and panchakavvyam.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
The term 'drug' refers to a substance used for therapeutic purposes. In this study, 'Panchakavvyam' serves as a pivotal agent believed to possess anticarcinogenic properties, demonstrating its potential in treating fibrosarcoma in rats. The examination of its effects on enzyme levels underscores its medicinal relevance.
2) Cancer:
Cancer denotes a group of diseases characterized by uncontrolled cell division. This paper specifically discusses fibrosarcoma, a malignant tumor. Understanding cancer's biology is crucial for evaluating treatment efficacy, including interventions like 'Panchakavvyam', which may alter biochemical markers and histopathological outcomes in cancerous tissues.
3) Activity:
Activity in this context relates to the enzymatic and metabolic functions within the biological systems of the rats. The study measures the activity levels of specific enzymes, such as lactate dehydrogenase, as indicators of malignancy and the effect of 'Panchakavvyam', providing insights into its biochemical impact.
4) Blood:
Blood serves as a critical medium for transporting nutrients, waste, and signaling molecules, including enzymes mentioned in the study. The analysis of serum enzyme levels reflects systemic changes due to tumor presence and treatment. It highlights the relationship between systemic health and localized tumor conditions.
5) Transformation (Transform, Transforming):
Transformation refers to the process wherein normal cells change into cancerous cells, which in the study is examined through the lens of neoplastic changes. Understanding this transformation is fundamental to the study’s objectives, as it correlates with enzyme release and the efficacy of treatment modalities like 'Panchakavvyam'.
6) Discussion:
Discussion in the paper allows the authors to interpret their findings and connect them to existing knowledge. It facilitates a critical evaluation of the results related to enzyme and glycoprotein levels, leading to broader implications about treatment efficacy and suggesting future research directions.
7) Inference:
Inference denotes the logical conclusions drawn from the experimental data. The study’s findings about the effects of 'Panchakavvyam' on enzyme and glycoprotein levels provide inferences regarding its potential anticarcinogenic properties, contributing to a deeper understanding of its role in cancer management and treatment strategies.
8) Medicine:
Medicine encompasses the scientific field dedicated to the treatment and prevention of diseases. In this study, the exploration of 'Panchakavvyam' contributes to the understanding of traditional medicine in combating fibrosarcoma, highlighting the merge of indigenous practices with contemporary biomedical research.
9) Science (Scientific):
Science represents the systematic study of the natural world through observation and experimentation. This research contributes to the scientific understanding of cancer biology and treatment by employing empirical methods to assess the biochemical and histopathological impacts of 'Panchakavvyam' on tumor-bearing rats.
10) Repair:
'Repair' in this context refers to the biological processes aimed at healing damaged tissues. The reduction in enzyme levels and favorable histopathological changes observed in the drug-treated group suggest that 'Panchakavvyam' may facilitate repair mechanisms, thereby improving the prognosis in fibrosarcoma cases.
11) Water:
Water is an essential component of biological systems, influencing various physiological processes, including metabolism and nutrient transport. Although not directly examined in the study, it underlies the overall health and management of the experimental animals, reflecting the importance of maintaining hydration in research settings.
12) Veda (Vedā):
Vedic refers to the ancient texts of Indian scriptures that include profound knowledge on health and medicinal practices. The study of 'Panchakavvyam', rooted in Vedic literature, emphasizes the significance of traditional Indian medicine and its potential applications in contemporary cancer treatment and research.
13) Diet:
Diet signifies the food and drink consumed by the rats in the study, which impacts their overall health and metabolic responses. The standard pellet diet provided to the animals ensures a controlled environment for evaluating the efficacy of 'Panchakavvyam' on fibrosarcoma and related markers.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Serum enzyme and glycoprotein changes in fibrosarcoma and panchakavvyam.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Chronic stage, Statistical evaluation, Biochemical analysis, Experimental period, Control animals, Glycoprotein, Ancient Science of life, Indigenous Drug, Colony forming unit, Histopathological change, Sialic acid, Neoplastic transformation, Serum level, Marker enzyme, Fibrosarcoma, Tumor tissue.
Concepts being referred in other categories, contexts and sources.