Arogya vardhii bati and anand bhairava ras, two amoebicidal ayurvedic drugs
Journal name: Ancient Science of Life
Original article title: Arogya vardhii bati and anand bhairava ras, two amoebicidal ayurvedic drugs
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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S.C. Shukla, E. Chakraborty, Geeta Tewari, S.R. Das
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Arogya vardhii bati and anand bhairava ras, two amoebicidal ayurvedic drugs
Year: 1990
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
The study investigates the effectiveness of two Ayurvedic preparations, Arogya Vardhini Bati (AVB) and Anand Bhairava Ras (ABR), in treating amoebiasis caused by the parasite Entamoeba histolytica. Historically, Ayurvedic treatments have been employed for parasitic diseases, but empirical evidence confirming their efficacy through scientific experimentation has been limited. This research seeks to ascertain the amoebicidal properties of AVB and ABR through both in vitro and in vivo methodologies using animal models, specifically rats and golden hamsters.
In Vitro and In Vivo Efficacy
The study demonstrated the amoebicidal activity of both AVB and ABR at a concentration of 500 µg/ml in vitro, effectively eliminating the trophozoites of E. histolytica. In vivo testing showed that a dosage of 200 mg/kg for five days could cure intestinal amoebiasis in rats, although only a 50% cure rate was achievable. Conversely, lower dosages of 50 mg/kg proved ineffective. The control groups showed significant rates of caecal ulceration in rats and hepatic amoebiasis in hamsters, emphasizing the comparative effectiveness of the Ayurvedic treatments.
Conclusion
This study represents a pivotal effort in validating the traditional use of Arogya Vardhini Bati and Anand Bhairava Ras in treating amoebiasis, marking the first systematic research confirming their effectiveness against this parasitic infection in laboratory animals. The findings lend empirical support to the historical claims within Ayurvedic medicine regarding the treatment of amoebic infections, suggesting a potential avenue for therapeutic applications in human health regarding amoebiasis management.
FAQ section (important questions/answers):
What are Arogya Vardhini Bati and Anand Bhairava Ras?
Arogya Vardhini Bati (AVB) and Anand Bhairava Ras (ABR) are two Ayurvedic preparations used for treating amoebiasis, an intestinal infection caused by the protozoan Entamoeba histolytica. They have shown potential amoebicidal activity in both in vitro and in vivo studies.
What experimental results were found with these Ayurvedic drugs?
Both AVB and ABR exhibited amoebicidal effects at 500 µg/ml in vitro. In vivo studies showed a cure for intestinal amoebiasis in rats with a 200 mg/kg dosage for five days, achieving 50% effectiveness.
How were the drugs tested for effectiveness?
The effectiveness was tested using animal models, specifically albino rats and golden hamsters. Trophozoites of Entamoeba histolytica were injected into the animals, and the drugs were administered orally to assess their curative impacts.
What is the significance of these findings?
The findings confirm the efficacy of Arogya Vardhini Bati and Anand Bhairava Ras against amoebiasis, reinforcing their traditional use in Ayurvedic medicine. This study marks a pivotal step in validating the use of these remedies for humans.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Arogya vardhii bati and anand bhairava ras, two amoebicidal ayurvedic drugs”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
The keyword 'Drug' refers to the therapeutic substances tested in the study. Arogya Vardhini Bati (AVB) and Anand Bhairava Ras (ABR) are Ayurvedic formulations with potential amoebicidal properties. Understanding their effects on amoebiasis is essential for validating traditional medicine's role in treating parasitic infections in humans.
2) Bhairava:
The term 'Bhairava' is integral to the name Anand Bhairava Ras, an Ayurvedic formulation. In Hindu tradition, Bhairava represents a form of Lord Shiva and signifies transformation and power. This indicates that the formulation harnesses potent medicinal qualities, possibly attributed to its spiritual significance in ancient healing practices.
3) Arogya (Ārogya):
The word 'Arogya' translates to 'health' or 'well-being' in Sanskrit. In the context of Arogya Vardhini Bati, it suggests a focus on promoting health and curing ailments. Its name underscores the Ayurvedic tradition's holistic approach, emphasizing the importance of restoring balance and health through natural remedies.
4) Bati (Bāṭī, Batī, Baṭī):
The term 'Bati' refers to a form of Ayurvedic preparation typically used in traditional medicine. It indicates a solid internal medicine, often in tablet form. In Arogya Vardhini Bati, 'Bati' underscores the formulation's role in treating health conditions traditionally, particularly in the context of intestinal amoebiasis.
5) Activity:
The term 'Activity' in the study refers to the effectiveness of the drugs against amoebic pathogens. Both AVB and ABR showed amoebicidal activity, indicating their capacity to kill or inhibit the growth of infectious amoebae. This term is crucial for assessing the pharmacological efficacy of these traditional Ayurvedic drugs.
6) Bhasma (Bhasman):
The word 'Bhasma' denotes a calcined substance used in Ayurveda, implying a therapeutic action. In AVB, various Bhasmas (mercury, sulphur, Lauha, and Abhra) suggest a mineral-based approach to healing. This showcases the traditional belief in using processed metals and minerals to enhance therapeutic properties and effectiveness.
7) Rice (Ṛce):
The inclusion of 'Rice' in the diet of experimental animals indicates the nutritional foundation necessary for maintaining health during the study. Additionally, rice starch was noted as a component in the amoeba inoculum used in the experiments, emphasizing the need for proper nutrition in evaluating drug effects.
8) Zingiber officinale:
Zingiber officinale, or ginger, is a component in Anand Bhairava Ras. It is valued in Ayurveda for its anti-inflammatory and digestive properties. This indicates the formulation's holistic strategy in addressing infections by assisting in overall digestive health, thus providing a supportive role in treating amoebiasis.
9) Piper longum:
Piper longum, known as long pepper, is another ingredient in Anand Bhairava Ras. It is used for its potential to enhance digestion and bioavailability of other ingredients. This addition highlights the Ayurvedic philosophy of synergistically enhancing therapeutic effects and therapeutic potency, particularly in combating infections.
10) Commiphora mukul:
Commiphora mukul, known as guggul, is utilized for its medicinal properties, particularly in metabolism regulation and anti-inflammatory actions. Its incorporation in Arogya Vardhini Bati reflects Ayurveda's focus on using natural resins for healing, reinforcing the formulation's role in managing amoebiasis effectively and holistically.
11) Tamrabhasma (Tāmrabhasma, Tamra-bhasma):
Tamra-bhasma refers to the calcined form of copper with reputed medicinal properties in Ayurveda. Its presence in Arogya Vardhini Bati indicates the traditional practice of using minerals for their therapeutic qualities, particularly for enhancing immune response and supporting health in the face of infections like amoebiasis.
12) Lauhabhasma (Lauha-bhasma):
Lauha-bhasma is the processed form of iron in Ayurvedic treatments, used for its various health benefits, particularly in anemia and improving general health. Its role in Arogya Vardhini Bati suggests a significance in bolstering the body’s defenses against parasitic infections like amoebiasis, enhancing overall efficacy.
13) Inflammation:
Inflammation refers to the body's response to infection or injury, and it is critical in the context of amoebiasis. The study evaluated the effect of therapies on inflammation changes in infected systems. Understanding inflammation patterns is essential for assessing drug efficacy in treating diseases caused by Entamoeba histolytica.
14) Discussion:
The 'Discussion' section encapsulates the interpretation of experimental results. It provides insights into the implications of using traditional Ayurvedic drugs like AVB and ABR in modern therapeutic practices. By analyzing findings, it emphasizes the significance of confirming traditional claims through scientific experimentation in treating amoebiasis.
15) Triphala (Triphalā, Tri-phala):
Triphala, a traditional herbal formulation consisting of three fruits, is often known for its detoxifying and digestive benefits. Although not directly mentioned in the studied drugs, its significance lies in the Ayurvedic tradition’s focus on holistic health and supporting overall gut function, likely paralleling the study's intentions.
16) Incision:
The term 'Incision' refers to the surgical procedure used to expose the peritoneum during hamster experiments. This technique is vital for introducing the amoebe inoculum effectively. Understanding surgical methods utilized in experiments is crucial for evaluating the replicability and precision of the study's findings in laboratory models.
17) Science (Scientific):
The keyword 'Science' signifies the systematic study and validation of traditional claims made by Ayurvedic practices. The research utilizes scientific methods to evaluate the efficacy of Ayurvedic drugs, underscoring the importance of merging ancient traditional knowledge with contemporary scientific investigation to understand therapeutic potentials thoroughly.
18) Shukla (Śukla, Śuklā, Suklā, Sukla):
Shukla refers to one of the authors of the research, S.C. Shukla. As a contributing scientist, his role in conducting the study highlights the collaboration between traditional medicine and modern research methodologies, promoting a deeper understanding of how Ayurvedic formulations can play a role in contemporary therapeutic applications.
19) Tamra (Tāmra, Tāmrā):
Tamra, which refers to copper in Ayurvedic medicine, is critical in formulations like Arogya Vardhini Bati. Its therapeutic applications, particularly in enhancing healing properties, highlight the intrinsic value of metals in traditional practices. Studying such components is essential for appreciating their roles in treating amoebic infections.
20) Lauha:
Lauha is another term for iron in Ayurvedic texts, representing its significance in health and healing. Its inclusion in Arogya Vardhini Bati emphasizes the historical use of iron compounds in treating various ailments, showcasing how traditional medicine incorporates metals for their restorative and therapeutic properties.
21) Abhra (Ābhra):
Abhra denotes mica in Ayurvedic medicine, which is believed to have rejuvenating properties. Its role in Arogya Vardhini Bati suggests an intention to harness its therapeutic potential for enhancing health or aiding in recovery from conditions like amoebiasis, thereby integrating ancient wisdom into modern applications.
22) Borax:
Borax, mentioned in Anand Bhairava Ras, is a mineral known for its antiseptic and anti-inflammatory properties. Its inclusion reflects the practice of utilizing naturally occurring substances for their medicinal effects, reinforcing the idea that Ayurvedic formulations are designed to address multiple aspects of infections like amoebiasis effectively.
23) Lemon:
Lemon refers to the citrus fruit used in the preparation of Anand Bhairava Ras. Its inclusion might indicate its role in enhancing flavor or potentially its acidic properties, which can facilitate digestion and microbial control, aligning with the Ayurvedic philosophy of incorporating natural ingredients for health benefits.
24) Diet:
The term 'Diet' refers to the nutritional regimen provided to experimental animals, which is vital for overall health during the study. Proper diet supports the immune response and recovery during infection, indicating a holistic approach in research assessing the effectiveness of Ayurvedic formulations in treating amoebiasis.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Arogya vardhii bati and anand bhairava ras, two amoebicidal ayurvedic drugs’. Further sources in the context of Science might help you critically compare this page with similair documents:
In vitro, Animal experimentation, Effective dose, In vivo, Intestinal Amoebiasis.