A study of psoriasis and the healing property of a new chemical compound
Journal name: Ancient Science of Life
Original article title: A study of psoriasis and the healing property of a new chemical compound
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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P. R. Mahapatra
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: A study of psoriasis and the healing property of a new chemical compound
Year: 1988
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
This study conducted by P.R. Mahapatra explores psoriasis, a persistent skin condition characterized by scaly, erythematous lesions that can be resistant to treatment and often follows a chronic pattern of remissions and exacerbations. Psoriasis affects a significant portion of the global population, with a prevalence of about 1-3% regardless of gender or age. The cause of psoriasis remains largely unknown despite extensive research, though genetic factors are acknowledged. The ancient Indian medical literature provides insights into the disease, classifying it among seven major skin diseases (Sapta Maha Kustha) and detailing prevention and treatment methods rooted in Ayurveda.
The Healing Properties of a New Chemical Compound
In this study, a new therapeutic compound derived from Haritala (Orpiment), Parada (Mercury), and Palasha Bhasma is evaluated for its effectiveness in treating psoriasis. Traditional Indian medicine attributes a spectrum of healing properties to these ingredients, with Haritala recognized for its broad action against skin ailments and Parada noted for restoring balance among the body's three doshas (Vata, Pitta, Kapha). The experimental trials involved five psoriasis patients who took the compound for six weeks, resulting in significant healing without side effects. This underscores the compound's potential in achieving remission of psoriasis by addressing the underlying pathological processes through restoration of the body's internal balance.
Conclusion
The findings from the study suggest that the newly developed compound shows promise as an effective oral treatment for psoriasis, capable of being administered at home and without the severe side effects often associated with conventional therapies. This represents a significant advancement, especially in regions with limited access to modern healthcare facilities. By improving the methodology of preparation and refining the components used, the therapeutic efficacy can be enhanced, potentially offering a viable alternative to address the large unmet needs of psoriasis patients, particularly in India where the disorder is commonly observed. The research advocates for the compound as not only a treatment for psoriasis but possibly a broader healing agent for various skin ailments.
FAQ section (important questions/answers):
What is psoriasis and how common is it globally?
Psoriasis is a common skin disease characterized by scaly, erythematous lesions. It affects about 1% to 3% of the global population, with no significant differences in incidence between males and females.
What are the main causes of psoriasis according to ancient Indian science?
Ancient Indian science attributes psoriasis to various factors including improper dietary combinations, suppression of bodily urges, and lifestyle choices that disturb the balance of the body’s three humors (Vata, Pitta, Kapha), leading to skin diseases.
What chemical compound was studied for psoriasis treatment?
The compound studied is made from Haritala (Orpiment), Parada (Mercury), and Palasha Bhasma, evaluated for its healing properties in psoriasis by addressing the underlying pathological factors.
What were the trial results for the psoriasis treatment compound?
In a trial with five patients, the compound was well tolerated, showed no side effects, and resulted in marked improvement of skin lesions, with healthy skin replacement observed at the end of the six-week treatment period.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “A study of psoriasis and the healing property of a new chemical compound”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Kushtha (Kuṣṭha):
Kustha refers to a historical classification in ancient Indian medicine, particularly within Ayurveda, encompassing various skin diseases, including psoriasis. It is described in Ayurvedic texts, indicating a multifactorial origin influenced by imbalances in body doshas (humors). Kustha's significance lies in its representation of a broader understanding of dermatological conditions in traditional medicine.
2) Haritala (Haritāla, Hari-tala):
Haritala, known as Arsenic trisulfide (AS2S3), is a mineral used in traditional Indian medicine. It is recognized for its healing properties, particularly in treating skin ailments. In the context of the study, Haritala contributes to the formulation that supports the therapeutic approach against psoriasis, showcasing ancient medicinal practices.
3) Science (Scientific):
Scientific refers to an empirical approach grounded in observation and experimentation. The study seeks to bridge traditional Ayurvedic practices with scientific validation, showcasing how ancient remedies can be integrated into modern medical frameworks through rigorous evaluation and testing.
4) Parada (Pārādā, Pārada, Pāradā, Parādā):
Parada, or mercury, plays a crucial role in Ayurvedic medicine. It is revered for its therapeutic effects, particularly its ability to restore balance among the body’s doshas. In the discussed formulation, Parada is one of the primary ingredients, offering its rejuvenating properties against skin diseases, notably psoriasis.
5) Ayurveda (Āyurveda, Ayus-veda):
Ayurveda is a traditional system of medicine that originated in ancient India. It emphasizes holistic health through balancing the body's three doshas—Vata, Pitta, and Kapha. The study illustrates how Ayurvedic principles guide the understanding of psoriasis and its treatments, integrating ancient wisdom with modern scientific exploration.
6) Medicine:
In this context, medicine refers to the substances and practices used to cure or alleviate diseases. The study explores a novel compound developed from ancient ingredients aimed at treating psoriasis. It demonstrates how traditional ingredients can be re-conceptualized and adapted for contemporary medicinal use.
7) Rasa (Rasā, Rasha):
Rasa, meaning 'essence' or 'taste' in Sanskrit, can refer to both the therapeutic essence of herbal formulations as well as the alchemical processes in Ayurveda. The study discusses Rasa's relevance in developing compounds with medicinal properties, emphasizing the importance of traditional teachings in modern drug formulation.
8) Tridosha (Tridoṣa, Tri-dosha):
Tridosha constitutes the three fundamental energies—Vata, Pitta, and Kapha—identified in Ayurvedic medicine. These doshas regulate physiological functions, and their imbalance is believed to lead to health issues such as psoriasis. The article employs this concept to explain the multifactorial nature of psoriasis and its treatment strategies.
9) Tantra (Tantrā, Tamtra, Tantrism):
Tantra often refers to traditional texts or systems within Ayurveda that guide medicinal practices and formulations. In the paper, Rasa Tantras encompass the alchemical processes essential for purifying and preparing medicinal compounds. The relevance of tantra underscores the systematic approach in the ancient healing practices.
10) Toxicity:
Toxicity pertains to the harmful effects of substances on living organisms. The study emphasizes the safety and non-toxicity of the experimental compound developed from traditional ingredients. Highlighting the absence of adverse effects illustrates the potential of ancient remedies to contribute positively to modern medicinal practices.
11) Nidana (Nidāna):
Nidana signifies diagnosis in Ayurveda. It encompasses the understanding of various diseases and their underlying causes. The term is pivotal in the context of the study, as it relates to identifying psoriasis’s unique characteristics and symptoms, thereby enabling appropriate treatment through holistic approaches.
12) Palasha (Palāśa, Palāsa, Palasa, Palāśā, Pālāśa, Pala-asha):
Palasha, or the ash derived from the Butea monosperma tree, plays a role in the formulation due to its medicinal properties. The study mentions Palasha to emphasize the importance of ancient ingredients, underscoring their therapeutic value in contemporary treatments for psoriasis.
13) Kapha:
Kapha is one of the three doshas in Ayurveda associated with stability, structure, and moisture. An imbalance in Kapha can lead to various diseases, including skin disorders like psoriasis. The research discusses how the compound aims to re-establish balance among doshas, focusing on restoring Kapha’s harmony.
14) Patra (Pātra):
Patra represents 'leaves' or 'covering' within Sanskrit, denoting the principle of protection or preparation in medicine. In this context, 'Patra Haritala' refers to the specific type of Haritala used in the study, highlighting the significance of selecting quality sources for effective medicinal formulation.
15) Vata (Vāṭa, Vaṭa, Vāta, Vaṭā):
Vata, one of the doshas in Ayurveda, represents the elements of air and space, governing movement and communication within the body. Its imbalance can contribute to skin diseases such as psoriasis. The study uses this concept to explain how the compound corrects Vata to restore health.
16) Drug:
Drug refers to a substance used for medical treatment. In this research, the term reflects the compound developed from traditional ingredients aimed at treating psoriasis. This indicates a convergence of ancient practices with modern principles in drug development and therapeutic use.
17) Butea monosperma:
Butea monosperma, commonly known as Palasa, is a medicinal tree whose elements are incorporated into Ayurvedic formulations. It possesses various therapeutic properties, and its role in the healing compound highlights the significance of plant-based remedies in treating skin conditions like psoriasis.
18) Madhavanidana (Mādhavanidāna, Madhava-nidana):
Madhavanidana is another essential Ayurvedic text that elaborates on the understanding and treatment of various ailments, particularly skin diseases. It serves as a reference in the study, grounding modern research within the rich historical context of Ayurvedic practice regarding psoriasis.
19) Rasayana (Rasa-ayana, Rasāyana, Rāsāyana):
Rasayana refers to the rejuvenative and anti-aging aspects of Ayurvedic treatment. It highlights the use of specific compounds to restore bodily functions and promote longevity. The studied compound includes Rasayana principles, suggesting its potential for revitalizing the skin and overall health.
20) Krishna (Kṛṣṇā, Kṛṣṇa):
Krishna often signifies the divine and is a name historically associated with wisdom and knowledge in Indian culture. In Ayurvedic texts, references to Krishna may be metaphorical, representing the pursuit of holistic understanding and the application of timeless wisdom in health and medicine.
21) Quality:
Quality pertains to the effectiveness and safety of medicinal compounds. In the study, the purification and preparation processes are essential to ensuring a high-quality product. Emphasizing quality underlines the commitment to producing effective treatments based on ancient Ayurvedic practices.
22) Bhasma (Bhasman):
Bhasma refers to the calcined form of substances in Ayurvedic medicine, often utilized in formulations for their therapeutic benefits. The study references Bhasma in discussing the transformation of minerals into healing compounds, showcasing an integral aspect of traditional Indian alchemy.
23) Sidhma (Sidhmā):
Sidhma represents a classification of skin diseases in Ayurveda, closely related to diseases like psoriasis. Mentioning Sidhma in the study highlights the alignment of ancient knowledge with modern understanding, as it offers insights into the characteristics and treatment approaches for skin conditions.
24) Dosha (Dosa, Doṣa, Dosā, Doṣā, Ḍosā):
Dosha refers to the three fundamental energies in Ayurveda—Vata, Pitta, and Kapha. They are essential for understanding body constitution and disease pathology. The study emphasizes the role of doshas in diagnosing and treating psoriasis, illustrating the fundamental principles of Ayurvedic medicine.
25) Pitta (Pītta, Piṭṭā):
Pitta is one of the three doshas responsible for metabolism, transformation, and digestion. An imbalance in Pitta can lead to inflammatory skin conditions like psoriasis. The research addresses how the compound seeks to restore balance among doshas, underscoring Pitta’s relevance in treatment strategies.
26) Diet:
Diet refers to the food and nutrition regimen crucial in Ayurveda for maintaining health and balance among doshas. The study emphasizes dietary considerations for preventing psoriasis flare-ups, linking proper nutrition to overall well-being and chronic disease management.
27) Milk:
Milk is often viewed as a nourishing food in Ayurveda; however, it is also noted to be potentially incompatible with certain food items like non-vegetarian products. The mention of milk in dietary contexts reflects the need for careful food combinations to prevent disruptions in bodily balance and health.
28) Rasaratnakara (Rasaratnākara, Rasa-ratnakara):
Rasaratnakara is a significant text in Indian alchemy detailing the preparation and medicinal use of minerals. Its inclusion signifies the study’s reliance on established Ayurvedic knowledge, underscoring the academic foundation for the development of the therapeutic compound aimed at treating psoriasis.
29) Riddhikhanda (Ṛddhikhaṇḍa, Riddhi-khanda):
Riddhi-khanda refers to a section within an Ayurvedic text that elaborates on medicinal formulations and practices. Its mention highlights the historical context from which the therapeutic compound is derived, emphasizing the importance of ancient wisdom applied to modern treatment solutions.
30) Ashtasamskara (Aṣṭasaṃskāra, Ashta-samskara):
Astasamskara encompasses the eight specific processes prescribed in Ayurveda for purifying materials, particularly minerals like mercury. This concept is relevant in the study as it underscores the meticulous approach required to detoxify substances before formulation, ensuring their safety and efficacy for medical use.
31) Purification:
Purification is the process of cleansing substances from impurities, crucial in Ayurveda for achieving therapeutic efficacy. The study highlights purification methods to ensure that traditional ingredients are rendered safe and potent for healing, illustrating the importance of quality control in medicine.
32) Rasahridaya (Rasahṛdaya):
Rasahridaya is an important text in Ayurvedic alchemy that deals with the essence and applications of various medicinal substances. Its reference in the study illustrates the foundational knowledge that informs the preparation and use of the compound aimed at treating psoriasis.
33) Nityanatha (Nityanātha):
Nityanatha is often attributed to authorship of key Ayurvedic texts. His contributions to medicine and treatments inform many practices within the field. Mention of Nityanatha signifies the scholarly tradition of Ayurveda, linking the study to deeper historical and philosophical insights.
34) Discussion:
Discussion refers to the analytical deliberation on findings and interpretations derived from research. In this paper, discussions focus on assessing the implications of the compound's healing properties for psoriasis treatment, providing insights into its operational mechanisms and therapeutic potential.
35) Vadikhanda (Vādikhaṇḍa, Vadi-khanda):
Vadikhanda represents a section within Rashayana texts that elaborates on medicinal practices. Its reference illustrates the scope of Ayurvedic knowledge available to enhance the understanding of treatment methods reported in the study, enriching the contextual depth of the research.
36) Mahapatra (Maha-patra, Mahāpatrā, Mahāpātra, Mahāpatra):
Mahapatra is the last name of the author, P.R. Mahapatra, who conducted the study and authored the paper. Understanding the researcher's background and expertise brings credibility to the findings presented, establishing a personal connection to the scholarly work on psoriasis treatment.
37) Samnipata (Sannipāta, Saṃnipāta, Sannipata):
Sannipata denotes a state of coexistence of all three doshas—Vata, Pitta, and Kapha—resulting from certain imbalances within the body. The study references this concept to explain the complexity of conditions like psoriasis, stressing the importance of addressing all doshas in treatment strategies.
38) Substance:
Substance indicates the ingredients or materials used in formulation. The study intricately discusses various substances including Haritala, Parada, and Palasa as they create the therapeutic compound. An understanding of these substances is essential for recognizing their medicinal properties and potential effects in treatment.
39) Nighantu (Nighaṇṭu, Nighamtu):
Nighantu refers to a glossary of medicinal plants and ingredients used in Ayurveda. This term emphasizes the integration of traditional knowledge with modern practices, as the research involves identifying and utilizing ancient ingredients that possess therapeutic properties for treating psoriasis.
40) Niyamana (Niyāmana):
Niyamana represents a regulatory or controlling process in Ayurveda, aimed at enhancing the stability and potency of medicinal substances. This concept is relevant for ensuring the effectiveness and safety of the compound discussed in the study, showcasing traditional methods of formulation and preparation.
41) Samskara (Saṃskāra):
Samskara refers to the processes of transformation and refinement applied to substances in Ayurveda to prepare them for medicinal use. The study highlights various samskaras as crucial steps for purifying and enhancing the therapeutic potential of traditional ingredients.
42) Rasayoga (Rasa-yoga):
Rasayoga refers to the science of preparing traditional medicines, particularly those involving metals and minerals. It encompasses methodologies that ensure the safe and effective use of such compounds. The study draws upon Rasayoga principles to substantiate its methods for developing the therapeutic compound.
43) Mokshana (Mokṣaṇa):
Mokshana indicates a purification technique involving the removal of harmful substances, often through bleeding in Ayurveda. It plays a role in detoxifying the body, and its mention underlines the holistic approach in Ayurvedic medicine for restoring balance and health, especially in chronic conditions like psoriasis.
44) Rasendra (Rasa-indra):
Rasendra signifies the expertise in alchemy and mineralogy within Ayurveda. This term underlines the significance of traditional Indian knowledge concerning the properties of minerals used in medicine, fostering a connection to ancient wisdom that informs contemporary practices as discussed in the study.
45) Vomiting:
Vomiting represents a bodily reaction that Ayurveda perceives as significant. It indicates an imbalance and the need for cleansing procedures. Its mention highlights certain dietary guidelines to avoid suppression of natural urges, pointing out the holistic view towards health management in Ayurvedic practice.
46) Activity:
Activity encompasses both physical and mental actions that contribute to an individual's health. The study allows participants to engage in their normal activities while on medication, emphasizing the practicality of the proposed treatment regime and its potential to improve quality of life.
47) Vitiation (Vitiated):
Vitiated denotes a state of disturbance or imbalance within the body's doshas. The study emphasizes the necessity to address vitiated states to treat conditions like psoriasis effectively, reinforcing the fundamental Ayurvedic principle of restoring homeostasis for optimal health.
48) Rudhira:
Rudhira refers to blood in Ayurvedic terminology. It plays a vital role in the understanding of body composition and health. The study acknowledges various body fluids—including rudhira—in relation to the pathological changes associated with psoriasis, highlighting the interconnectedness of bodily functions.
49) Kshudra (Kṣudrā):
Kshudra refers to minor skin diseases within the Ayurvedic classification of kustha. The distinction is significant in understanding the broad spectrum of skin disorders treated in Ayurveda. It provides context for the study, illustrating how psoriasis fits within traditional frameworks of skin diseases.
50) Vriksha (Vṛkṣa, Vṛkṣā):
Vriksha means tree in Sanskrit and signifies the importance of plant-based resources in traditional medicine. The study discusses the use of Palasa (Butea monosperma) in the compound, underscoring the role of botanical sources in effective psoriasis treatment and their historical significance in Ayurveda.
51) Mandala (Maṇḍala, Maṇḍalā, Mamdala):
Mandala, in the context of Ayurveda, refers to a classification system for diseases or their symptoms. The study correlates psoriasis to the Mandala Kustha category, which aids in contextualizing the disorder within traditional frameworks, allowing for a comprehensive understanding of its nature.
52) Leprosy:
Leprosy, often linked historically to skin diseases, is referenced in Ayurvedic texts as a comparative study condition. The inclusion emphasizes the antiquity of psoriasis as a recognized ailment in ancient Indian medicine, framing the contemporary study within a broader historical context of skin disorders.
53) Siddha (Siddhā):
Siddha is related to perfected knowledge or accomplishment in Ayurveda, often linked to specific remedies and practices. It highlights the aspirational aspect of Ayurvedic medicine, connecting the ancient texts' teachings with the therapeutic applications in treating chronic skin diseases like psoriasis.
54) Riddhi (Ṛddhī, Ṛddhi):
Riddhi translates to prosperity or success in Sanskrit, indicating a positive outcome in health and well-being. Its mention connects to the study's goal of successfully treating psoriasis through the developed compound, aiming for improved health and quality of life for patients.
55) Dushya (Dūṣya, Dūśya):
Dushya refers to the 'elements or tissues affected by diseases' in Ayurveda. Understanding dushya is crucial in treating disorders as it helps to identify areas needing intervention. The study's focus includes the perturbation of dushya in relation to psoriasis, reinforcing the holistic approach of Ayurvedic treatment.
56) Baddha (Baddhā):
Baddha refers to a condition of being bound or tied; it indicates an altered state of substances in Ayurveda. The term's context in the study reflects efforts aimed at making the compound heat stable and effective against disorders like psoriasis, emphasizing the refinement processes.
57) Lasika (Lasikā, Lāsikā, Lasīkā, Lāsika):
Lasika refers to lymph in Ayurvedic terminology, signifying one of the substances involved in maintaining bodily functions. Its mention in the study indicates an understanding of the interconnectedness of bodily fluids and their implications for dermatological health, particularly in the context of psoriasis.
58) Sharman (Śarma, Sarmā, Sarma, Sharma, Śarman):
Sharma is a common surname often associated with scholars in Indian culture. In the context of the study, it represents the legacy of Ayurvedic practitioners who contribute to the literature and understanding of therapeutic practices, establishing a continuum of knowledge supporting the research.
59) Reason:
Reason denotes the rationale behind understanding and addressing health issues. The study articulates a compelling rationale for using traditional ingredients in treating psoriasis, merging ancient wisdom with a modern scientific approach to emphasize the potential for innovation in medical treatment.
60) Khanda (Khaṇḍa, Khamda, Khāṃda):
Khanda refers to a section or chapter within Ayurvedic texts. Its inclusion in the study illustrates the diverse range of sources contributing to Ayurvedic wisdom, linking back to the foundational knowledge of treatments discussed in relation to psoriasis.
61) Phlegm:
Phlegm corresponds to Kapha dosha in Ayurveda, which governs moisture and stability. An imbalance in Kapha can lead to various health issues, including skin diseases. The term’s mention reinforces the importance of balancing phlegm for effective treatment and underscores Ayurveda's holistic principles.
62) Mukta (Muktā):
Mookta refers to a purified substance, often related to detoxified components in Ayurveda. It’s important because the study emphasizes the detoxification methods applied to ingredients like mercury, highlighting the necessity of ensuring safety and efficacy in developing compounds for medical use.
63) Panca (Pancan, Pañca, Pañcan, Pamca, Pañcāṉ):
Pancha means 'five' in Sanskrit, often referring to the five foundational elements in Ayurveda that compose the body and universe. The mention of Pancha highlights the interconnectedness of these elements and their balancing roles in the holistic treatment approaches within Ayurvedic medicine.
64) Karma (Karman, Kārma):
Karma refers to action or processes in Ayurveda that lead to medicinal effects. It signifies the deliberate steps taken to ensure the safety and efficacy of formulations. The study underscores the significance of karma in developing effective treatments based on ancient knowledge.
65) Tejas (Tejās, Tējas):
Tejas represents the fiery aspect of the Pitta dosha, associated with transformation and metabolism. Its mention illustrates the role of metabolic processes in the context of psoriasis, emphasizing the importance of balancing this dosha for skin health and overall well-being.
66) Mamsa (Maṃsa, Māṃsa, Mamsha):
Mamsa translates to flesh or muscle in Ayurvedic terminology, referring to one of the core tissues. The study recognizes the relevance of mamsa in the context of healing skin disorders like psoriasis, underpinning the holistic approach that considers all bodily aspects in treatment.
67) Bhava (Bhāva):
Bhava translates to essence or state of being and refers to the overall constitution in Ayurveda. It represents the fundamental principles guiding diagnosis and treatment, linking emotional states and physical health. This concept is critical for understanding holistic health in the context of treating psoriasis.
68) Krimi (Kṛmi, Kṛmī):
Krimi refers to parasites or worms in Ayurvedic terminology, often linked to various health conditions. Their mention indicates the awareness of potential external factors affecting skin health. The study reflects an understanding of comprehensive health, recognizing all influences on conditions like psoriasis.
69) Water:
Water is foundational to life and holds significance in Ayurveda as a hydrating and detoxifying agent. The reference to water illustrates its role in maintaining balance within the body and preventing disturbances that could lead to skin diseases like psoriasis.
70) Blood:
Blood, or rudhira, is an essential fluid in Ayurveda, vital for sustaining life and function. Recognizing its importance in the context of psoriasis treatment signifies the interconnectedness of bodily systems and the holistic approach of Ayurveda in restoring health.
71) Mica:
Mica is a naturally occurring mineral often associated with other minerals in traditional healing practices. Its reference in the study suggests a connection to the geological aspects of medicinal ingredients, emphasizing the relevance of mineral sourcing in creating effective Ayurvedic formulations.
72) Mala (Māla, Mālā, Māḻā, Māḷa, Maḻa):
Mala refers to impurities or waste products in the body concerning Ayurvedic understanding. Its mention highlights the importance of detoxification processes in treatment methodologies, underlining the necessity of purification to promote health and combat conditions like psoriasis.
73) Soil:
Soil represents the earth's material, which is foundational to plant growth and the sourcing of herbal ingredients in medicine. The mention of soil connects to the origin of plant-based treatments in Ayurveda, reflecting the importance of natural elements in developing effective medicinal compounds.
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