Study on the concept on sodhana with special reference to visopavisas

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Journal name: Ancient Science of Life
Original article title: Study on the concept on sodhana with special reference to visopavisas
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Author:

Damodar Joshi, V. Nagaraju


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: Study on the concept on sodhana with special reference to visopavisas

Year: 1988

Copyright (license): CC BY-NC-SA


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Summary of article contents:

Introduction

The article presents a study on the concept of 'Sodhana,' a crucial pharmaceutical process in Ayurveda aimed at the purification and detoxification of various drugs to reduce their toxicity and enhance their therapeutic properties. The origins of 'Sodhana' can be traced back to ancient texts like 'Caraka Samhita,' although extensive procedures for its application primarily developed during the era of 'Rasa Shastra.' The necessity for purification is especially critical for drugs categorized as 'visopavisa,' which, due to their toxic nature, require comprehensive protocols to mitigate harmful effects and amplify medicinal benefits.

Importance of 'Sodhana' in Toxicity Reduction

The study emphasizes the efficacy of 'Sodhana' in minimizing toxicity levels of drugs from the 'visopavisa' category, which includes potent substances that can induce distress and adverse reactions. Through various techniques such as soaking in cow’s urine, boiling in milk, and other processing methods, 'Sodhana' treatment effectively elevates the lethal dose (LD50) of these drugs, making them safer for therapeutic use. Experimental findings documented in the research show that specific treatments can significantly alter the toxicological profiles of individual substances. For example, the processing of 'Vatsanabha' led to a notable reduction in cardiac toxicity and enhancement of anti-inflammatory properties, illustrating the critical relationship between the purification processes and the enhancement of medicinal effects.

Conclusion

The study concludes that the application of 'Sodhana' not only reduces the toxicity of Ayurvedic drugs, thereby increasing their LD50 levels but also can potentiate certain therapeutic actions. The variations in the effectiveness of different purification methods highlight the nuanced approach required in traditional medicine to maximize health benefits while minimizing adverse effects. This reinforces the significance of 'Sodhana' as an essential practice in Ayurveda, ensuring the safe use of 'visopavisa' drugs in clinical settings.

FAQ section (important questions/answers):

What is the purpose of the Ayurvedic process 'Sodhana'?

'Sodhana' aims to purify and detoxicate drugs, reducing their toxicity and enhancing their pharmacotherapeutic properties for safer and more effective use in treatments.

What are the properties of 'Visa' and 'Upavisa' substances?

'Visa' substances cause distress in the body and are highly toxic, while 'Upavisa' are less potent sub-poisons, both requiring careful handling in Ayurveda.

Which procedures are common for 'Sodhana' treatment of drugs?

Common 'Sodhana' procedures include soaking in cow's urine, boiling in milk, frying, maceration, and washing to eliminate toxins and enhance therapeutic effects.

How effective is 'Sodhana' in reducing drug toxicity?

Studies show 'Sodhana' significantly reduces toxicity, evidenced by increased LD50 levels and altered pharmacological actions, improving the safety and efficacy of various drugs.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Study on the concept on sodhana with special reference to visopavisas”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
In the context of Ayurveda, 'drug' refers to substances used for therapeutic purposes. The article discusses the purification processes (Sodhana) necessary for drugs, particularly those categorized as 'Visopavisa' which may have toxic properties and require specific treatments to minimize adverse effects and enhance therapeutic efficacy.

2) Shodhana (Śodhana, Sodhana):
'Sodhana' is a critical pharmaceutical process in Ayurveda aimed at purifying or detoxifying drugs. It employs various methods to reduce toxic content in 'Visopavisa' drugs, thereby potentiating therapeutic properties and ensuring safer use in medical practices, as highlighted through various studies and traditional texts referenced in the paper.

3) Visha (Viśa, Visa, Viṣa, Viṣā, Vīśa):
'Visa' is defined as a substance causing distress or harm to the body, being particularly virulent. The article categorizes substances with destructive properties under this term, emphasizing the importance of understanding and detoxifying them through processes like 'Sodhana' before clinical use in Ayurveda.

4) Milk:
In Ayurvedic practice, 'milk' serves as a medium for various purification processes of toxic drugs. The article mentions its role in 'Sodhana' treatments for substances like Vatsanabha and Kupilu, demonstrating how different methods using milk can significantly lower the toxicity levels of toxic herbs.

5) Gomutra (Gomūtra, Go-mutra):
Gomutra, or cow's urine, is utilized in 'Sodhana' processes for its reputed purifying properties. The article outlines its application in various purification techniques, showing its effectiveness in detoxifying 'Visopavisa' drugs like Datura and Vatsanabha, which are known for their pharmacologically active yet toxic components.

6) Rasa (Rasā, Rasha):
'Rasa' relates to the essence or extractiveness of substances, particularly in the context of 'Rasa Shastra,' the traditional Indian alchemical and medicinal chemistry. The term encompasses the medicinal qualities attributed to drugs, which are focal in discussions about purification and enhancing therapeutic benefits in Ayurvedic texts.

7) Upavisha (Upaviṣā, Upaviṣa):
'Upavisa' refers to substances considered sub-poisons, which are less virulent compared to 'Visa'. The article details the classifications and how these less toxic materials still require purification processes to mitigate adverse effects before therapeutic use, ensuring safety in Ayurvedic practices.

8) Toxicity:
'Toxicity' is a central theme in the paper, addressing the harmful effects some drugs may have when unpurified. The discussion highlights how 'Sodhana' treatments play a vital role in minimizing toxicity, which is critically important for drugs with potent pharmacological actions like Vatsanabha and Kupilu.

9) Bhavana (Bhāvanā, Bhāvana, Bha-vana):
'Bhavana' in Ayurvedic pharmacology refers to the process of maceration or triturating a drug with a liquid medium. This article references 'Bhavana' among other purification methods that enhance the efficacy and bioavailability of drugs, particularly those considered toxic in their raw forms.

10) Caraka (Cāraka, Cārāka):
Referring to the ancient Ayurvedic physician Caraka, whose texts form a foundation for Ayurvedic medicine. Caraka's classifications and, particularly his discussions on 'Sodhana' and detoxification, are referenced in the context of ensuring safe therapeutic applications of various drugs, especially those with toxic properties.

11) Godugdha:
'Godugdha' is treated cow's milk used in various 'Sodhana' processes. The article describes how milk enhances the safety and effectiveness of certain toxic drugs by reducing their toxicity, and illustrates its application in studies focused on Vatsanabha and other potent substances.

12) Kopana:
'Kopana' refers to the action of aggravating the doshas (basic bodily humors) in Ayurvedic terms. Understanding the potential for drugs to provoke 'Kopana' underlines the importance of purification to prevent adverse health effects, especially with 'Visopavisa' drugs that can disrupt balance.

13) Ghi (Ghī, Ghee):
'Ghee', a clarified butter used in Ayurvedic preparations, is also included in 'Sodhana' processes. Discussions in the text reveal how ghee interacts with or alters the toxicity and therapeutic actions of certain drugs, highlighting its significance as a vehicle in Ayurvedic medicine.

14) Pharmacological:
The term 'pharmacological' relates to the study of the effects of drugs on biological systems. The article draws a correlation between 'Sodhana' treatments and their impact on improving medicinal effects while minimizing toxic outcomes, emphasizing the importance of pharmacological analysis in traditional practices.

15) Vatsanabha (Vatsanābha, Vatsa-nabha):
'Vatsanabha', a highly toxic herb, is extensively discussed in the context of its detoxification via 'Sodhana'. The article highlights empirical findings demonstrating how different purification processes can significantly enhance its safety profile while preserving or enhancing its therapeutic effects.

16) Sthavara (Sthāvara):
'Sthavara' refers to stationary substances, specifically minerals or certain plants, in Ayurvedic terminology. The article classifies various toxic sources, indicating that 'Sodhana' is crucial for these entities due to their potential danger, illustrating the depth of classification in Ayurveda.

17) Kanjika (Kañjika, Kāñjika, Kañjikā, Kāñjikā, Kāñjīka, Kamjika):
'Kanjika' is an Ayurvedic preparation often used as a medium in purification processes. The text outlines its roles in reducing toxicity through specific treatments, showcasing the diverse methods available within Ayurvedic practices to ensure the safe application of various drugs.

18) Prakasha (Prakāśa, Prākāśa):
'Prakasa' indicates clarity or manifestation and in the medical context refers to the clear understanding and application of Ayurvedic practices. The article emphasizes the evolution of knowledge concerning 'Visa' and 'Upavisa' over time, showcasing the growing recognition of toxic plants.

19) Sthavaravisha (Sthāvaraviṣa, Sthavara-visha):
'Sthavara-visa' identifies poisons derived from mineral or plant sources, highlighting the importance of 'Sodhana' to mitigate their toxic effects. The classification of these potent substances emphasizes their significance in Ayurvedic practices and the need for safety in treatments.

20) Sukshma (Sūkṣma, Sūkṣmā, Shukshma, Śūkṣma):
'Suksma' translates to subtle or fine and refers to the quality of certain drugs. The article discusses how the subtle properties of drugs categorized under 'Visa' can contribute to their toxic nature, necessitating detailed purification processes for safe usage.

21) Tikshna (Tīkṣṇā, Tīkṣṇa):
'Tiksna' describes drugs that are sharp or penetrating in nature, often associated with toxicity in Ayurveda. The text emphasizes the need for 'Sodhana' processes to neutralize such sharp properties, thus ensuring that these potent drugs can be safely integrated into therapeutic regimens.

22) Vikasin (Vikāsin, Vikāśin, Vikāṣin, Vikasi, Vikashin):
'Vikasi' means the property of spreading or disseminating throughout the body, which can be relevant for poisonous substances. The article emphasizes how understanding such properties in 'Visa' drugs necessitates purification before administration to avoid harmful systemic effects.

23) Ushna (Uṣṇa, Uṣṇā):
'Usna' indicates a hot property in terms of drug action. In the context of toxic herbs, the article highlights that such heat-producing drugs require 'Sodhana' to reduce their intense effects, underscoring the necessary precautions for handling 'Visopavisa' materials.

24) Ayurvedaprakasha (Āyurvedaprakāśa, Ayurveda-prakasha):
'Ayurveda-prakasa' refers to a classical Ayurvedic text that catalogs various drugs and their properties. In the article, it is referenced to show the historical developments and classifications that have shaped the understanding of toxic substances and their management through 'Sodhana.'

25) Rasarnava (Rasārṇava):
'Rasarnava' is one of the early texts in Rasa Shastra that delineates the classifications of poisonous substances like 'Visa' and 'Upavisa'. The article refers to this text to illustrate the foundational knowledge in the classification and detoxification processes that continue to influence modern practices.

26) Ayurveda (Āyurveda, Ayus-veda):
'Ayurveda' is the ancient Indian system of medicine that emphasizes holistic health and well-being. This article highlights its focus on the detoxification of toxic substances through processes like 'Sodhana' and its relevance in today's therapeutic applications.

27) Rasendra (Rasa-indra):
Referring to texts that focus on Rasa Shastra, 'Rasendra' texts cover the properties and uses of metals and minerals in Ayurveda. The relevance of these texts in discussing 'Visa' and 'Upavisa' is evident in their contribution to understanding these substances' effects and purification needs.

28) Activity:
'Activity' in this context refers to the pharmacological effects or actions of various drugs discussed. The paper sheds light on how different purification treatments can either alter or enhance the activities of potentially toxic drugs, reflecting the dynamic nature of Ayurvedic formulations.

29) Babbula (Babbūla):
'Babbula' refers to a specific herbal substance under consideration for 'Sodhana' processes. The article includes examples of how such substances are handled and treated in Ayurveda, emphasizing the need to mitigate their toxic properties before clinical usage.

30) Vyavayi (Vyavāyī):
'Vyavayi' represents the property of dispersion and is associated with how toxins can spread throughout the body. The paper emphasizes the importance of understanding these properties in 'Visa' substances to initiate appropriate detoxifying measures through 'Sodhana.'

31) Visada (Viṣāda, Visāda, Visāda, Viśada, Vishada, Viṣada, Visha-da):
'Visada' implies a state of sadness or distress caused by toxins. The article describes how certain drugs classified as 'Visa' can induce such effects, justifying the necessity for purification processes to prevent adverse emotional and physiological outcomes.

32) Sharman (Śarma, Sarmā, Sarma, Sharma, Śarman):
Sharma refers to an author whose work contributed experimental findings discussed in the article. Mentioning his studies on 'Datura' highlights the significant scientific contributions that support traditional Ayurvedic practices to ensure safe use of toxic substances in therapeutic contexts.

33) Laghu:
'Laghu' denotes lightness and in the Ayurvedic context can refer to the quality of drugs affecting their dosage and toxic potential. The article discusses the necessity to consider such properties in the context of 'Sodhana' and drug safety in Ayurveda.

34) Ruksha (Rūkṣa):
'Ruksa' refers to the quality of dryness associated with certain drugs. The article suggests that recognizing this property in 'Visa' and 'Upavisa' substances can help in understanding their effects and necessity for 'Sodhana' to prevent undesirable outcomes.

35) Kara (Kārā, Kāra, Kaṟa, Kaṟā):
In this context, 'Kara' refers to those who compile and document knowledge, especially in classical pharmacological texts. The mentioning of various authors indicates the collaborative effort in building the foundational knowledge for Ayurvedic pharma practices focused on detoxification and safety.

36) Rasashastra (Rasa-shastra, Rasaśāstra):
'Rasa-shastra' is a branch of Ayurveda dealing with alchemical processes and the preparation of medicinal substances. The text underscores its significance in the study of 'Visa' and 'Upavisa' classifications, reinforcing their relevance in the purification processes presented.

37) Purification:
'Purification' is the central theme of the article, focused on detoxifying substances classified as 'Visa' through 'Sodhana.' Various methods and their importance in enhancing the safety and effectiveness of Ayurvedic drugs constitute the core discussion within the paper.

38) Vatakopana (Vātakopana, Vata-kopana):
'Vata-kopana' refers to aggravation of Vata dosha, which can be triggered by certain toxic substances. The discussions highlight the need to purify 'Visopavisa' drugs to avoid such aggravations and maintain balance within the body when undertaking Ayurvedic treatments.

39) Cintamani (Cintāmaṇi, Cintāmanī, Cinta-mani, Cimtamani):
Cintamani references historical Ayurvedic texts that contribute knowledge about drug purification processes. The article discusses such texts to illustrate the evolution of understanding regarding 'Visa' properties and the procedures necessary for their detoxification.

40) Substance:
'Substance' in this paper mostly refers to the various drugs or materials used in Ayurvedic formulations. The emphasis is on understanding their properties, especially the toxic ones, and the processes necessary for making them safe for medicinal use.

41) Karavira (Karavīra, Karavīrā, Kara-vira):
'Karavira,' a toxic plant discussed within the text, exemplifies one of the substances requiring 'Sodhana' for safe therapeutic use. The paper underscores the need for purification across toxic plants and emphasizes the ongoing need for careful processing before use in treatments.

42) Ahiphena (Ahipheṇa, Ahi-phena):
'Ahiphena' is another specific drug referenced as requiring purification due to its toxicity. The article elucidates methods of 'Sodhana' applied to this substance, further emphasizing the importance of safety and efficacy in the use of potent herbal materials.

43) Jayapala (Jayapāḷa, Jayapāla, Jaya-pala):
'Jayapala' also needs purification processes clarified within the article, focusing on its toxicity and consequently the methods necessary to prepare it for safe therapeutic administration in accordance with traditional Ayurvedic methods.

44) Bharjana:
'Bharjana', or frying, is mentioned as one of several methods applicable to the 'Sodhana' process. The article explains how this technique specifically aids in detoxifying certain herbal substances, enhancing their safety for therapeutic usage in a traditional medical setting.

45) Samhita (Saṃhitā, Saṃhita):
'Samhita' refers to collections of texts that compile Ayurveda's extensive knowledge on various subjects including 'Sodhana' processes. The article highlights how historical Samhitas inform contemporary practices surrounding the detoxification and safe usage of potentially toxic drugs.

46) Shastra (Śāstra):
'Shastra' indicates the comprehensive body of knowledge within Ayurveda. It encompasses various texts and treatises detailing the principles of 'Sodhana' and the management of toxic herbs, which the article extensively discusses regarding traditional herbal medicines.

47) Kritrima (Kṛtrima, Kritrama):
'Krtrima' refers to artificial or synthesized substances in Ayurvedic terminology. This category is noted for potentially being harmful and thus requires 'Sodhana' to detoxify before utilization, which is a theme stressed throughout the article on purification processes.

48) Avipaki (Avipākī):
Avipaki pertains to the quality of food or substances that can be troublesome for digestion. The article links this concept to toxic drugs, emphasizing the necessity of 'Sodhana' to counteract these digestive challenges when administering potent 'Visa' substances.

49) Science (Scientific):
'Science' in the context of Ayurveda emphasizes the empirical study and validation of traditional practices. The article underlines the importance of collaborating contemporary scientific insights with Ayurvedic knowledge, particularly in the purification and therapeutic applications of toxic herbs.

50) Dravya:
'Dravya' translates to substance or material and is a fundamental concept in Ayurveda that encompasses herbs, minerals, and metals. The discussions emphasize understanding their properties, particularly in their toxic forms, and highlight the significance of rigorous 'Sodhana' processes.

51) Kupilu (Kupīlu):
'Kupilu' refers to Strychnos Nux-vomica, a highly toxic plant. The article highlights methods for its detoxification through 'Sodhana', stressing its pharmacological properties and therapeutic use while emphasizing the safety measures necessary for such potent drugs.

52) Pitta (Pītta, Piṭṭā):
'Pitta' represents one of the three doshas in Ayurveda, associated with heat and metabolism. Understanding how toxic herbs can interact with or affect 'Pitta' balance underlines the need for careful 'Sodhana' processes to prevent aggravation upon administration.

53) Marma:
'Marma' points to vital points in the body, the disturbance of which can lead to significant health issues. The article emphasizes that substances classified as 'Visa' could endanger these points; thus, 'Sodhana' is crucial for minimizing risks when preparing these drugs.

54) Rakta (Raktā):
'Rakta' reflects the blood tissue according to Ayurvedic principles. The paper discusses how toxic substances may disrupt 'Rakta' and how 'Sodhana' can help mitigate these effects, ensuring a balanced state when used therapeutically.

55) Gunja (Guñjā, Gumja):
'Gunja' refers to Abrus precatorius, a toxic plant whose qualities necessitate purification. The article discusses its detoxification processes under 'Sodhana,' emphasizing the role of traditional knowledge and methods in mitigating the dangers of compounds with known toxicity.

56) Bhava (Bhāva):
'Bhava' relates to the inherent qualities or nature of substances in Ayurveda. The article illustrates how understanding and recognizing various 'Bhava' can inform the need for purification processes when dealing with potentially toxic drugs.

57) Ghrita (Ghṛta):
'Ghrta', or clarified butter, is highlighted for its importance in Ayurvedic formulations. The text outlines various ways ghee is used in 'Sodhana' to enhance the pharmacological properties of drugs while minimizing toxicity, showcasing its dual role in traditional medicine.

58) Kshira (Kṣīra):
'Ksira' refers to milk in the Ayurvedic context, noted for its nutritional and therapeutic benefits. Its relevant properties in purification processes are highlighted, particularly in studies demonstrating improved safety of toxic herbs when treated with milk.

59) Shauca (Śauca):
'Sauca' signifies purity and cleanliness in Ayurvedic practices. The importance of 'Sauca' can be seen in how 'Sodhana' processes aim to achieve this necessary state in 'Visa' substances before they can safely be used in medicinals.

60) Water:
'Water' in Ayurvedic practices symbolizes purification and cleansing. Its application in various 'Sodhana' procedures, such as washing or boiling substances, is emphasized in the article as essential for detoxifying drugs before they enter therapeutic contexts.

61) Tvak:
'Tvak' refers to the bark of certain trees used in Ayurvedic texts, with properties oftentimes requiring purification. The discussions highlight how 'Sodhana' plays a vital role in preparing such materials for safe medicinal usage.

62) Dosha (Dosa, Doṣa, Dosā, Doṣā, Ḍosā):
'Dosa' encapsulates the concept of imbalance caused by the three humors in Ayurveda. The article discusses the importance of managing the effects of toxic substances on 'Dosa' balance, advocating for 'Sodhana' practices to maintain overall health.

63) Vata (Vāṭa, Vaṭa, Vāta, Vaṭā):
'Vata' represents one of the three doshas governing bodily functions. The text emphasizes how some 'Visa' substances can disturb 'Vata' balance, underlining the necessity of 'Sodhana' to prevent potential aggravation and health issues arising from using toxic herbs.

64) Internal purification:
'Internal purification' refers to the processes aimed at cleansing substances before they interact with the body. The article illustrates this necessity particularly in the case of 'Visopavisa' drugs, detailing methods to reduce intrinsic toxicity.

65) Rasendracudamani (Rasendracūḍāmaṇi, Rasendra-cudamani):
'Rasendra-cudamani' is an Ayurvedic text focused on the properties of therapeutic drugs, including those with toxic characteristics. Its mention reflects the historical and scholarly context informing current practices regarding drug safety and purification processes in Ayurveda.

66) Caraka-samhita (Caraka-saṃhitā):
'Caraka-samhita' is a foundational text in Ayurveda that discusses numerous aspects of health. Its relevance is cited for outlining essential principles and processes like 'Sodhana' that guide the safe use of drugs with toxic potential in Ayurvedic remedies.

67) Rasaratnakara (Rasaratnākara, Rasa-ratnakara):
'Rasa-ratnakara' refers to a classical text known for its exploration of metals and minerals, including their medicinal uses. The article acknowledges its contribution to the evolving understanding of toxic substances and the methods needed for their detoxification in traditional practices.

68) Gunantaradhana (Guṇāntarādhāna):
'Gunantaradhana' refers to the enhancement of properties of drugs in Ayurveda. This concept is pivotal in discussing how 'Sodhana' not only reduces toxicity but may also serve to optimize the therapeutic effects through careful processing methods.

69) Anirdeshyarasa (Anirdeśyarasa):
'Anirdesyarasa' denotes an undefined or indeterminate taste property that can be linked to potent drugs. The article explores how better understanding of these properties through detoxification processes can ensure more precise therapeutic applications in Ayurveda.

70) Jangamavisha (Jaṅgamaviṣa, Jangama-visha, Jamgamavisha):
'Jangama-visa' refers to poisons originating from the animal kingdom. The need for 'Sodhana' for these substances is notable in the context of their potent toxicities and the emphasis on methods for effective purification before their use in treatments.

71) Avyaktarasa (Avyakta-rasa):
Avyakta-rasa relates to an indeterminate taste or essence in Ayurvedic classifications. The article discusses the importance of recognizing such qualities in drugs to ensure appropriate detoxification measures through 'Sodhana' for safe therapeutic uses.

72) Kaphakopana (Kapha-kopana):
'Kapha-kopana' indicates the aggravation of the Kapha dosha, which can result from improper use of potent drugs. This notion underscores the necessity of 'Sodhana' to preemptively mitigate any potential disruptions to bodily balance following treatment with 'Visa' drugs.

73) Kritrimavisha (Kṛtrimaviṣa, Kritrima-visha):
Krtrima-visa indicates poisons formed through artificial combinations of substances. The article's inclusion of this classification emphasizes the importance of purification processes like 'Sodhana' to ensure these created substances do not adversely impact health when used therapeutically.

74) Pittakopana (Pitta-kopana):
'Pitta-kopana' refers to an aggravation of Pitta dosha often linked to the properties of certain toxic drugs. This notion is crucial in the article's argument for the necessity of purification measures to avoid exacerbating conditions linked to Pitta imbalance.

75) Kalpasthana (Kalpasthāna, Kalpa-sthana):
Kalpasthana is a part of the classic Ayurvedic texts that address preparations and formulations. The mention of 'Kalpasthana' in the article illustrates the traditional framework used to develop understanding and guidelines for 'Sodhana' processes and drug safety.

[Note: The above list is limited to 75. Total glossary definitions available: 121]

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