Studies on dasamula – its chemistry, botany and biology part – i prisniparni
Journal name: Ancient Science of Life
Original article title: Studies on dasamula – its chemistry, botany & biology part – i prisniparni
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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K. K. Purushothaman, A. Sarada, E. Sasikala, Hamsaveni Gopal
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Studies on dasamula – its chemistry, botany & biology part – i prisniparni
Year: 1986
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
The article "Studies on Dasamula – Its Chemistry, Botany & Biology Part – I Prisniparni" provides an in-depth exploration of the medicinal herb Prisniparni, scientifically identified as Desmodium gangeticum. It is one of the components of a traditional Ayurvedic formulation known as Dasamula, which translates to "ten roots," although only nine are true roots. The authors, including K. K. Purushothaman and colleagues, outline the herb’s botanical, chemical, and biological characteristics and emphasize its importance in Ayurvedic medicine. The article serves as a foundational study on this plant, discussing its properties, uses in traditional practices, and its relevance in contemporary research.
Pharmacological Significance of Gangetin
A key compound derived from Desmodium gangeticum is Gangetin, a pterocarpan known for its notable biological activities. Gangetin has demonstrated significant anti-inflammatory effects during both exudative and proliferative phases of inflammation at oral doses of 50 and 100 mg/kg. Additionally, it showed analgesic properties but did not exhibit antifertility or antipyretic effects in albino rat models. The compound did not display acute toxicity levels even at 7 g/kg, indicating a relatively safe profile for therapeutic uses. Furthermore, pharmacological assessments suggest that Gangetin influences uterine biochemical markers without altering essential minerals, highlighting its potential therapeutic applications and warranting further investigation into its mechanisms and therapeutic efficacy.
Conclusion
The research presented on Prisniparni underscores the crucial role of Desmodium gangeticum in Ayurvedic medicine as a component of Dasamula. With its extensive range of identifiers and medical properties, the importance of this herb extends beyond traditional uses into promising fields of pharmacological research. The highlighted compound, Gangetin, exemplifies the potential for traditional herbs to yield significant bioactive molecules, which could lead to novel therapeutic options. Continued exploration of Dasamula and its constituents will enhance our understanding of their benefits and applications in modern healthcare practices.
FAQ section (important questions/answers):
What is Dasamula and what does it consist of?
Dasamula, meaning 'ten roots', is a group of Ayurvedic herbs, consisting of nine roots and one fruit. It is used in traditional medicine for various ailments, including fever and inflammation.
What is Prisniparni and its botanical classification?
Prisniparni, identified as Desmodium gangeticum Dc., is a member of the Leguminosae family. It is characterized as a common shrub found throughout India and is an ingredient in the Dasamula formulation.
What are the key phytochemical constituents of D. gangeticum?
D. gangeticum contains pterocarpans such as gangetin, gangetinin, and desmodin, along with several alkaloids. These compounds are studied for their potential biological activities.
What are the biological activities attributed to Gangetin?
Gangetin exhibits significant anti-inflammatory and analgesic activities. It also shows moderate anti-implantation effects in female rats, demonstrating its potential therapeutic applications in traditional medicine.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Studies on dasamula – its chemistry, botany and biology part – i prisniparni”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Dashamula (Dasha-mula, Daśamūla, Dashan-mula):
Dasamula refers to a significant group of Ayurvedic herbal formulations consisting of ten roots, primarily utilized for the treatment of various ailments including fever and inflammation. In traditional Ayurvedic medicine, it emphasizes the synergistic effects of the combined herbs, although technically it includes nine roots and one fruit.
2) Activity:
In the context of medicinal plants like Prisniparni, 'activity' refers to the pharmacological effects demonstrated by the plant's compounds. This includes anti-inflammatory, analgesic, and potential reproductive effects established through various biological evaluations, highlighting the importance of plant-based therapeutics in Ayurvedic medicine.
3) Drug:
In Ayurvedic terms, 'drug' signifies a plant or its extract impacted by nature, hypertension, and behavior, while also considering theoretical aspects of health restoration. The constituents found in Dasamula members, such as Desmodium gangeticum, showcase the modern understanding of herbal remedies as potential therapeutic agents.
4) Hrasva (Hrasvā):
Hrasva denotes the 'minor' category of roots in the Dasamula grouping. This classification emphasizes its therapeutic applications in treating diseases related to deranged Kapha, showcasing the Ayurvedic principle of individualized treatment based on Dosha imbalances, where certain combinations of herbs are preferred for specific ailments.
5) Desmodium gangeticum:
Desmodium gangeticum, identified as Prisniparni in Ayurveda, is a crucial component of Dasamula recognized for its therapeutic properties. This shrub contributes to several formulations for its anti-inflammatory and other pharmacological activities, underscoring its significance in holistic health practices.
6) Inflammation:
Inflammation is a critical physiological response relevant to numerous diseases treated in Ayurveda. The presence of anti-inflammatory compounds like Gangetin in herbs such as Desmodium gangeticum demonstrates the potential of these plants to modulate inflammatory processes and provide symptomatic relief.
7) Himalaya (Himālaya, Hima-alaya):
The Himalaya region represents a diverse habitat where many medicinal plants, including Desmodium gangeticum, thrive at varying altitudes. The unique climatic and ecological conditions contribute significantly to the biodiversity of medicinal species utilized in traditional medicine across India and neighboring regions.
8) Botany:
Botany plays a significant role in understanding the medicinal properties of plants mentioned in Ayurvedic texts. The study of Desmodium gangeticum's morphology, classification, and distribution helps in identifying its key characteristics and potential applications in phytotherapy and holistic health.
9) Water:
Water assists in extraction processes for medicinal properties from plants like Prisniparni. It is an important solvent used in Ayurveda for decoctions (like Dasamula-kvatha) to release soluble constituents from herbs, affirming its necessity in preparing therapeutic formulations.
10) Dashamulakvatha (Daśamūlakvātha, Dashamula-kvatha):
Dasamula-kvatha is a traditional Ayurvedic decoction constituted from the Dasamula group, recognized for its potency in treating various ailments. This formulation capitalizes on the synergistic properties of its combined ingredients, aiming to restore balance among the body's Doshas.
11) Gitanaram (Gitānaram):
Gitanaram is one of the regional names for Desmodium gangeticum. The diversity in nomenclature across different cultures emphasizes the widespread acknowledgment and integration of this plant into traditional medicinal practices, indicative of its universal relevance.
12) Vidaryadi (Vidāryādi):
Vidaryadi refers to another Ayurvedic formulation that may incorporate Desmodium gangeticum or similar herbs. These formulations are designed for specific health benefits, reinforcing the importance of integrated approaches in holistic health through the combination of various herbal constituents.
13) Ayurveda (Āyurveda, Ayus-veda):
Ayurveda is the ancient system of medicine that emphasizes balance within the body. Knowledge of plants such as Desmodium gangeticum contributes to Ayurvedic practices, enabling treatment through herbs categorized by their properties and functions, thus promoting overall wellness.
14) Tridosha (Tridoṣa, Tri-dosha):
Tridosha is a foundational Ayurvedic concept describing the three fundamental bodily energies—Vata, Pitta, and Kapha—that govern physiological and psychological functions. Herbal combinations like those found in Dasamula are utilized to balance these doshas, promoting health and preventing disease.
15) Gokshura (Gokṣura, Go-kshura):
Gokshura, one of the ten ingredients in Dasamula, is crucial for understanding the formulation's comprehensive benefits. Its inclusion underscores the complexity and balance of traditional Ayurvedic remedies that target multiple health conditions through diverse herbal synergism.
16) Toxicity:
Toxicity refers to the potential harmful effects of various compounds found in plants. Studies on Desmodium gangeticum reveal low toxicity levels, making it a preferred choice in herbal medicine while indicating the importance of safety in therapeutic applications.
17) Pulladi (Pullādī):
Pulladi is another regional name for Desmodium gangeticum, showcasing the widespread recognition of this herb. Such regional terms reflect the cultural significance and integration of specific plants in local medicinal practices, reinforcing their popularity and efficacy.
18) Habitat:
Habitat refers to the natural environment where Desmodium gangeticum grows. Understanding its habitat is essential for conservation efforts and sustainable harvesting practices, aligning with traditional principles of ecological balance recognized in Ayurveda.
19) Science (Scientific):
The study of medicinal plants such as Desmodium gangeticum blends traditional knowledge with modern scientific inquiry. Understanding their chemical constituents and biological activities fosters advancements in pharmacology and validates the efficacy of Ayurvedic medicine through empirical evidence.
20) Kvatha (Kvātha):
Kvatha refers to a traditional decoction preparation method in Ayurveda, where plant materials are boiled in water. This method is significant for extracting active compounds, as seen in the preparation of Dasamula-kvatha, where efficacy in treating ailments is achieved.
21) Kalashi (Kalaśī, Kalaśi, Kalasī):
Kalasi is one of the many synonyms associated with Desmodium gangeticum. The existence of multiple names reflects the plant's traditional use across different regions and languages, showcasing the shared cultural heritage in medicinal practices.
22) Sharada (Śāradā, Śārada, Śaradā, Sāradā, Sārada, Sarada, Sara-da):
Sarada may refer to one of the researchers or contributors in the study pertaining to Dasamula. Recognizing their role highlights the collaborative effort in documenting and analyzing traditional medicinal plants within scientific frameworks, contributing to the ongoing exploration of Ayurvedic medicine.
23) Bitter:
Bitter is a flavor profile often attributed to many Ayurvedic medicines, including those from Dasamula. This characteristic taste is known to stimulate digestion and appetite, indicating the Ayurveda principle of utilizing flavors to balance bodily doshas.
24) Kapha:
Kapha represents one of the three doshas in Ayurveda, associated with qualities such as heaviness and moisture. Herbal formulations, like Dasamula identified for their Kapha-balancing properties, are essential in treating conditions arising from Kapha imbalances, emphasizing holistic treatment.
25) Sugar:
Sugar refers to various carbohydrates that play roles in metabolism. In the study of medicinal plants, like Desmodium gangeticum, understanding the effects on substances such as sugar in terms of biochemistry aids in recognizing their health applications and potential benefits in dietary contexts.
26) Vata (Vāṭa, Vaṭa, Vāta, Vaṭā):
Vata is another of the three Ayurveda doshas, characterized by qualities like lightness and dryness. Herbal formulations, particularly those aimed at balancing Vata, play a crucial role in managing conditions associated with Vata imbalances, reinforcing the holistic nature of Ayurvedic treatments.
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