Some pharmacological studies on cardiospermum halicacabum linn

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Journal name: Ancient Science of Life
Original article title: Some pharmacological studies on cardiospermum halicacabum linn
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:

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Author:

N. R. Pillai, N. Vijayamma


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: Some pharmacological studies on cardiospermum halicacabum linn

Year: 1985

Copyright (license): CC BY-NC-SA


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Summary of article contents:

Introduction

Cardiospermum halicacabum, commonly known as Jyotishmati, is a plant referenced in Ayurveda for treating various ailments such as rheumatism, piles, bronchitis, and nervous disorders. Traditionally, its decoction is believed to possess diuretic, diaphoretic, and laxative properties. While previous studies have indicated its diuretic activity, limited research has focused on other pharmacological effects. The present study aimed to investigate the medicinal value of C. halicacabum through a series of pharmacological experiments using aqueous extracts derived from the whole plant.

Analgesic and Anti-Inflammatory Activities

The research revealed significant analgesic and anti-inflammatory activities associated with C. halicacabum. In the analgesic assessment, the decoction exhibited substantial effects, particularly at doses of 10 and 20 g/kg, which demonstrated maximum effectiveness 60 minutes post-administration, although acetylsalicylic acid was found to be comparatively superior. The anti-inflammatory effects were further substantiated through acute and chronic inflammation models, where the plant's decoction led to a notable reduction in edema and inflammatory exudates, thus affirming its traditional use in pain relief and inflammatory conditions.

Conclusion

The findings from this pharmacological study provide substantial support for the use of Cardiospermum halicacabum in Ayurvedic medicine. The plant's notable central nervous system effects, alongside its significant analgesic and anti-inflammatory properties, reinforce its traditional applications for treating pain and inflammatory disorders. Furthermore, the lack of acute toxicity at higher doses underscores its potential safety for therapeutic use. The research affirms C. halicacabum's relevance in contemporary medicinal practices, laying groundwork for further exploration and validation of its therapeutic benefits.

FAQ section (important questions/answers):

What is the scientific name of the plant studied?

The plant studied is Cardiospermum halicacabum, commonly referred to as Jyotishmati in Ayurveda. It is used for various medicinal purposes.

What pharmacological effects were observed in Cardiospermum halicacabum?

The studies revealed that the decoction showed sedative effects, significant analgesic and anti-inflammatory activities, and vasodepressor effects, supporting its use in traditional medicine.

Did Cardiospermum halicacabum show any acute toxicity in tests?

No acute toxicity or mortality was observed in mice at doses up to 50 g/kg. This suggests a level of safety for the tested decoction.

What effects did the plant have on inflammation?

The decoction significantly reduced inflammation in both acute and chronic models, inhibiting oedema and decreasing inflammatory exudate, comparable to the standard drug phenylbutazone.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Some pharmacological studies on cardiospermum halicacabum linn”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
The term 'Drug' refers to any substance that alters physiological functions in the body. In the context of the study, it specifically pertains to Cardiospermum halicacabum, which is investigated for its medicinal properties and pharmacological actions in various experimental models, showcasing its potential therapeutic uses.

2) Activity:
Activity relates to the specific effects that a substance, like a drug, exhibits in biological systems. The study emphasizes various pharmacological activities of Cardiospermum halicacabum, such as analgesic, anti-inflammatory, and CNS sedative effects, demonstrating how these activities validate its traditional usage in medicine.

3) Edema (Oedema):
Oedema signifies the swelling caused by excess fluid trapped in the body's tissues. In the study, the researchers assess the ability of Cardiospermum halicacabum to reduce oedema induced by xylol and croton oil, indicating its effectiveness as an anti-inflammatory agent in controlling swelling-related conditions.

4) Water:
Water serves as a universal solvent and medium for many pharmacological experiments, facilitating the administration of drug decoctions to experimental animals. The control groups in the study receive distilled water to set a baseline for comparing the effects of Cardiospermum halicacabum against a non-active substance during testing.

5) Pharmacological:
Pharmacological pertains to the study of the interactions between drugs and living systems. It encompasses the investigation of Cardiospermum halicacabum's effects on various physiological systems, aiding in understanding its medical applications, safety, and efficacy as a traditional remedy utilized in Ayurvedic practices.

6) Ayurveda (Āyurveda, Ayus-veda):
Ayurveda is a traditional system of medicine from India that emphasizes balance in bodily systems and uses natural substances for treatment. The study explores how Cardiospermum halicacabum aligns with Ayurvedic principles, targeting specific ailments like rheumatism and bronchitis, thereby validating its historical medicinal relevance.

7) Blood:
Blood is a vital fluid in the body responsible for transporting nutrients and oxygen. The study examines the effects of Cardiospermum halicacabum on blood pressure in anesthetized dogs, contributing to understanding its potential cardiovascular impacts and highlighting its implications for treating blood-related conditions in Ayurveda.

8) Pharmacology:
Pharmacology is the branch of medicine concerned with the study of drug action and effects. The article's focus on the pharmacology of Cardiospermum halicacabum involves rigorous experimentation to elucidate its therapeutic properties, thereby providing insights into its role in enhancing traditional healing practices.

9) Inflammation:
Inflammation is a biological response to harmful stimuli and is characterized by redness, swelling, and pain. The study investigates Cardiospermum halicacabum's anti-inflammatory properties through various tests, underscoring its importance as a natural remedy in treating conditions associated with chronic and acute inflammation.

10) Toxicity:
Toxicity refers to the degree to which a substance can harm living organisms. Investigating the toxicity of Cardiospermum halicacabum is crucial in determining its safety profile; the study reveals no significant toxic effects at high doses, which is essential for validating its use in medicinal applications.

11) Accumulation (Accumulating, Accumulate):
Accumulation indicates the build-up of a substance within biological systems. In the context of the study, it refers to the measurement of inflammatory exudate and changes in organ weights, helping assess the efficacy of Cardiospermum halicacabum in preventing excessive accumulation associated with inflammation in experimental models.

12) Jyotishmati (Jyotiṣmatī, Jyotirmatī, Jyotirmati):
Jyotishmati is the traditional name for Cardiospermum halicacabum in Ayurveda. This nomenclature reflects the plant's revered status in the Ayurvedic system, where it is valued for its therapeutic properties, promoting health and well-being, particularly regarding neurological and inflammatory conditions.

13) Discussion:
Discussion in the study provides a critical analysis of the results obtained from pharmacological tests. It interprets the significance of Cardiospermum halicacabum's effects on various physiological systems, correlating the findings with established Ayurvedic practices and reinforcing the plant's traditional medical utility.

14) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing disease. This study investigates Cardiospermum halicacabum's role within the medicinal sphere, bridging traditional Ayurvedic applications with modern pharmacological research to validate and expand its therapeutic uses for various health conditions.

15) Science (Scientific):
Science is the systematic study of the structure and behavior of the physical and natural world. The research on Cardiospermum halicacabum exemplifies the scientific approach to understanding herbal medicines, focusing on empirical evidence, experimentation, and knowledge expansion within pharmacology and traditional medicine.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Some pharmacological studies on cardiospermum halicacabum linn’. Further sources in the context of Science might help you critically compare this page with similair documents:

Cardiospermum halicacabum, Pain relief, Ayurvedic medicine, Central nervous system, Chronic inflammation, Anti-inflammatory activities, Acute toxicity, Pharmacological studies, Anticonvulsant activity, In vitro studies, Analgesic activities, Antifertility activity, Experimental Animal Model, Sedative effect, Arterial Blood Pressure.

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