Anti-ovulayor effect of different crude drug combinations in female albino rats
Journal name: Ancient Science of Life
Original article title: Anti-ovulayor effect of different crude drug combinations in female albino rats
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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M.Krishna Reddy, C.K. Kokate, N. Chari
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Anti-ovulayor effect of different crude drug combinations in female albino rats
Year: 1984
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
The rapid increase in population has triggered the need for effective contraceptive methods, prompting research into potential antifertility drugs derived from natural sources. Ayurvedic texts have documented various plant-based substances that claim to possess antifertility properties with minimal side effects. This study focuses on the antifertility effects of specific plant extracts and their combinations in female albino rats, particularly emphasizing the extracts from Azadirachta indica, Piper longum, and Embelia ribes. Previous research has indicated the antifertility properties of these substances, yet studies combining different extracts systematically to analyze their synergistic effects remain limited.
Synergistic Antifertility Effects of Extract Combinations
The experimental investigation revealed significant findings regarding the effects of various crude drug combinations on the estrous cycle in female albino rats. Specifically, two combinations, I (petroleum ether extracts of A. indica) and III (benzene extract of A. indica alongside P. longum and E. ribes), demonstrated a noteworthy ability to prolong the diestrous phase of the estrous cycle by 11 and 7 days, respectively. Both combinations also delayed the time frame within which rats allowed copulation after drug administration ceased, with some animals from combination I taking up to 15 days post-treatment to mate. In contrast, combination II (alcoholic extracts of A. indica) showed no extension of the diestrous phase, indicating the importance of the specific constituents and extraction methods used in achieving antifertility effects.
Conclusion
This study underscores the efficacy of certain combinations of crude drug extracts in prolonging the diestrous phase of the estrous cycle in female albino rats, suggesting potential pathways for developing natural contraceptive methods. The findings highlight the importance of analyzing plant extract combinations in pharmacological research, providing insights into their potential synergistic effects against fertility. Further research is warranted to explore the underlying mechanisms of these extracts and their applicability in contraceptive strategies, potentially contributing to innovative approaches in managing population growth through safe and effective means.
FAQ section (important questions/answers):
What was the objective of the study on crude drug combinations?
The study aimed to investigate the anti-ovulatory effects of various crude drug combinations on female albino rats, particularly focusing on their potential to prolong the diestrous phase of the estrous cycle.
Which crude drugs were used in the combinations tested?
The study utilized extracts from Azadirachta indica (A. indica), Piper longum (P. longum), and Embelia ribes (E. ribes), prepared using different solvents for their antifertility properties.
What were the results of using Combination I and III?
Combination I effectively prolonged the diestrous phase by 11 days, while Combination III resulted in a prolongation of 7 days, demonstrating significant anti-ovulatory effects compared to the control groups.
How was the effectiveness of the drug combinations measured?
The effectiveness was assessed by observing the prolongation of the diestrous phase of the estrous cycle and the time it took for the rats to allow copulation after drug withdrawal.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Anti-ovulayor effect of different crude drug combinations in female albino rats”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
The term 'Drug' refers to substances used for medical purposes, including preventive and therapeutic capabilities. In this context, the focus is on the antifertility properties of certain herbal combinations tested on female albino rats. Understanding the efficacy of these drugs is crucial for exploring contraceptive options in Ayurvedic medicine.
2) Activity:
In this research, 'Activity' pertains to the biological responses elicited by the crude drug combinations. The study measures their anti-ovulatory effects and impact on the estrous cycle of female albino rats, highlighting the drugs' potential reproductive influence and significance in the field of contraceptive development.
3) Science (Scientific):
'Science' represents the systematic study and application of knowledge through observation and experimentation. This investigation exemplifies scientific inquiry as it assesses the effects of herbal drug combinations on reproduction, contributing to the understanding of antifertility mechanisms and enhancing our knowledge of natural contraceptive agents.
4) Azadirachta indica:
'Azadirachta indica', commonly known as neem, is a tree with numerous medicinal properties. Its extracts were one of the key components in this study. The research explored its antifertility effects, reinforcing the relevance of traditional plants in modern pharmacology and their role in developing contraceptive measures.
5) Piper longum:
'Piper longum', known as long pepper, is another herbal component examined in this research. Its fruit extracts were tested for fertility modulation. The study underscores its potential benefits in traditional Ayurvedic medicine, highlighting the importance of such plants in exploring natural antifertility options.
6) Embelia ribes:
'Embelia ribes' is a plant known for its various health benefits, including antifertility properties. This research focused on its berries, assessing their role in the drug combinations tested. By identifying effective natural substances, this study contributes to broader understanding of herbal medicine and reproductive health.
7) Phytochemical:
'Phytochemical' refers to chemical compounds produced by plants, often linked to health benefits. This research emphasizes the significance of the phytochemicals extracted from various herbs used in the study, as they possess the potential to alter reproductive activities, showcasing the importance of plant compounds in medical research.
8) Discussion:
'Discussion' in this paper entails an analytical evaluation of the findings, interpretation of results, and implications for future research. It provides insights into the efficacy of different drug combinations tested for their anti-ovulatory effects, fostering dialogue within the scientific community about herbal contraceptives.
9) Medicine:
'Medicine' encompasses the science and practice of diagnosing, treating, and preventing illness. The study investigates traditional herbal medicines for their ability to affect fertility, contributing to the field of reproductive health. This focus on natural remedies underlines the importance of integrating traditional practices with modern medicine.
10) Krishna (Kṛṣṇā, Kṛṣṇa):
'Krishna' refers to M. Krishna Reddy, one of the authors involved in this study. His contribution is pivotal in exploring the anti-ovulatory effects of herbal drug combinations, signifying the importance of individual researchers in advancing knowledge within the fields of pharmacology and reproductive health.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Anti-ovulayor effect of different crude drug combinations in female albino rats’. Further sources in the context of Science might help you critically compare this page with similair documents:
Population explosion, Female albino rats, Estrous cycle, Percentage yield, Carboxy Methyl Cellulose, Antifertility properties, Maceration technique, Vaginal smear, Successive solvent extraction.