Pharmaceutical and Analytical Standardization of Medopachak Vati

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[Find the meaning and references behind the names: Joshi, Ayu, Kalpana, Ayush, Med]

78 Journal of Ayurvedic and Herbal Medicine 2020; 6(2): 78-80 Research Article ISSN: 2454-5023 J. Ayu. Herb. Med. 2020; 6(2): 78-80 © 2020, All rights reserved www.ayurvedjournal.com Received: 11-05-2020 Accepted: 04-06-2020 *Corresponding author: Dr. Sayali Joglekar-Joshi Associate Professor, Department of Rasashastra and Bhaishajya Kalpana, Seth Chandanmal Mutha Aryangla Ayurved Mahavidyalaya, Satara, Maharashtra, India Email: sayalijoglekar[at]gmail.com Pharmaceutical and Analytical Standardization of “ Medopachak Vati ” Sayali Joglekar-Joshi 1 , Sarang Deshpande 2 1 Associate Professor, Department of Rasashastra and Bhaishajya Kalpana, Seth Chandanmal Mutha Aryangla Ayurved Mahavidyalaya, Satara, Maharashtra, India 2 Vice Principal and HOD, Dept of Rasashastra and Bhaishajya Kalpana, Vijayashree Ayurvedic medical college and Hospital, Jabalpur, M.P., India ABSTRACT In ancient Ayurvedic classics, many formulations are there like herbal, mineral and herbomineral in origin. These formulations are effective in many diseases depending upon their qualities and properties. In this study, we are dealing with medopachak vati which is herbal preparation. In Charak Samhita , Uttarsthana, Aacharya Charak mentioned Pachak Yoga in the treatment of Vishamjwara. “ Medopachak yoga ” which is useful in the Treatment of Medogatjwar . Many of the Ayurvedic paractitioners prescribe Medopachak yoga in various dosage forms like kashaya (Decoction), Churna (Powder) as per their convenience. Dosage form for administration plays an important role in the reaction and delivery of particular drug on a specific system. Tablets are easy to prepare, packing, transportation and administration to patients. Hence tablet form is the most accepted dosag e form amongst all. In this study, formulation of “ Medopachak Yoga ” is transformed to the tablet form by using modern equipments and analytical techniques. An effort is made to validate the pharmaceutical and analytical procedures to maintain the quality of product and to avoid batch to batch variation. Pharmacopeial standards are set for this Ayurvedic formulation in tablet form. All the 3 samples were prepared by this method show identical characteristics and analytical parameters do not show much significant difference. These set parameters may be used for the further pharmaceutical preparations. Keywords: Charak Samhita , Pachak Yoga , Medopachak Tablet (MPT), Pharmaceutical standard, Dosage form. INTRODUCTION Five Pachak Yoga mentioned in Treatment of “ Vishamjwara ” in Jwara Chikitsa Adhyaya [1] . They are RasaPachak, RaktaPachak, MansaPachak, MedoPachak and Asthimajja Pachak . Lack of exercise, sleeping at day time, excessive consumption of fatty, oily, junk food, excessive consumption of alcohol causes Medovah Strotodushti [2] . WHO have stated that 80% of populations are using herbs and other traditional medicines as their primary healthcare needs. Due to increased demands of herbal medicines worldwide, it is responsibility to provide the quality of product in standard dosage form is bestowed upon Ayurvedic industry. Dosage form plays an important role for specific action and their efficacy on the human body. Amongst all dosage forms, tablet is widely used like syrup, powder, injectable Tablets are easy to administer, delivers exact dose, more palatable, easy to transport, packaging. So Medopachak Yoga is transformed into tablet form. AYUSH, Govt. of India, is now working on development of S.O.P. for the manufacturing of Ayurvedic preparation to avoid batch to batch variations. This can be achieved by evaluating and analyzing herbal products using both Ayurvedic as well as modern techniques of standardization during and after preparation of finished product. In original reference, Medopachak Yoga/Kalp is nowhere mentioned as in Vati (Tablet) form. Here for proper administration of dosage and to avoid its bitter taste, the kalpa is modulated in Vati [3] (Tablet) form. The ingredients and Bhavana Dravya used were same as described in original reference. One of the major problems faced by the Ayurveda physician is the unavailability of unique pharmaceutical and analytical validation for herbal medicines and their formulations. In this study, standardization of Medopachak Yog in its vati [4] (tablet) form is an important step.

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[Find the meaning and references behind the names: Shri, June, Shree, Brown, Chandan, Market, April, Min]

79 Journal of Ayurvedic and Herbal Medicine|April-June|2020 For establishment of physiochemical profile, Pharmaceutical and Analytical validation of “given” herbal drug is done MATERIALS AND METHODS Medopachak Yoga contains total 4 ingredients viz. Kirattikta, Amruta, Chandan, Vishwabhshajam . Decoction of all these drugs was used to give Bhavana in order to increase the potency of the drug. The details of parts and quantity used are given below in Table No. 1 All the ingredients for this kalpa were collected from local authentic market and identified and authenticated at the quality control laboratory by using facilities of Shree Bramhachaitanya Ayurved, Nagpur, Maharashtra. All these herbal ingredients passed quality parameters described in API [5] . Table 1: Contents of the drug Sr. No. Sanskrit Name Latin Name Parts Used Quantity for batch size 1 kg 1 Kirattikta Swertia Chirayata Stem, bark 250 gm 2 Amruta Tinospora Cordifolia Stem, Root 250 gm 3 Rakt Chandan Pterocarpus Santalinus Stem, Bark 250 gm 4 Vishwabhaishaj Zingiber officinale Rhizomes 250 gm Pharmaceutical Procedure All the ingredients mentioned in above table were mixed together in equal quantity of 250 gm each. It was then processed in mass pulveriser and sifted in mass sifter using sieve no. 80 to obtain fine power from it. The obtained mass was uniformly mixed in mass mixture and triturated in end runner for three prahar (9 hr approx) with the decoction made of the same ingredients which are mentioned above. After trituration it was dried in electric dryer at temperature not more than 60 0 C. The excipients were added in dried mass in the quantity of MCC 30 gm, Starch 50 gm. Then the mass was passed through multimill with sieve no. 2 and granules were prepared. After that tableting was done using tableting machine each of size 250 mg. About 3800 to 4000 tablets were obtained from each batch. OBSERVATIONS AND RESULTS Physicochemical analysis was done at quality control lab by using facilities of Shree Bramhachaitanya Ayurved, Nagpur, Maharashtra. Table 2: Showing comparative physicochemical study. Sr. No. Test Name Sample A Sample B Sample C 1 Colour Reddish Brown coloured Dark Brown Brown 2 Average Weight 0.270 gm 0.248 gm 0.255 gm 3 Uniformity in Weight Not >5% Not >5% Not >5% 4 Diameter 8.20 mm 8.18 mm 8.24 mm 5 Thickness 3.59 mm 3.64 mm 3.55 mm 6 Hardness [6] 2.50 Kg/cm 2 2.54 kg/cm 2 2.49 kg/cm 2 7 Friability [7] 0.5%w/w 0.2%w/w 0.3%w/w 8 Disintegration [8] 12 min 11 min 14 min DISCUSSION Tablet is widely used dosage form. Exact dose can be delivered to the patient, easy for administration, palatable, easy to transport and packaging. This way tablets have more advantages over other dosage form. Pharmaceutical and Analytical validation of Medopachak Tablet(MPT) became possible by following every step in proper way and by modern Physicochemical analysis of finished product. Ingredients used in MPT are the same as mentioned in Charak Samhita . In order to increase the potency of these tablets bhavana with the kwath of same ingredients was given while manufacturing. The appropriate processing sequence was strictly followed as per GMP norms and changes were noted after each step from pulverization of raw material to packaging of finished product. Finished product was examined by both classical as well as modern parameters to check batch to batch variations and consistency. In all three sample batches quality control parameters for this drug doesn’t show significant difference in their value which means the operating manufacturing process is similar and could be standardized.

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[Find the meaning and references behind the names: Prakashan, Mishra]

80 Journal of Ayurvedic and Herbal Medicine|April-June|2020 The analytical parameters for Medopachak vati (tablet) which is prepared by the above said method may be set for SOP of this tablet as per table below. Table 3: Showing set parameters for Medopachak tablet Sr. Test Name Parameters 1 Description Reddish Brown, circular compressed, biconvex uncoated tablet 2 Average Weight 0.248 to 0.270 gm 3 Uniformity of weight Complies 4 Diameter 8 mm to 8.2 mm 5 Thickness 3.5 mm to 3.7 mm 6 Hardness 2.3 Kg/cm 2 to 2.5 Kg/cm 2 7 Friability NMT 1% 8 Disintegration NMT 30 min CONCLUSION The pharmaceutical and analytical process standardization of Ayurvedic formulation Medopachak Vati(tablet) has been validated by using both Ayurvedic as well as modern physiochemical parameters. The validated method can be used for the preparation of Medopachak Vati (tablet) by which we get an optimal efficacy of the finished product. There are no significant variations observed in all the three batches prepared. The above study reveals Medopachak Vati prepared by above method meets to the quality parameters. As there is no standard data published anywhere for this formulation, a comparison is not possible and current observations in this study may be referred for the future study. REFERENCES 1 Agnivesh, edited by Ravidatta Tripathi, Vidyadhar Shukla, Charak Samhita, Part 2, Delhi: Choukhamba Sanskrit Publication; 2013, Ch. No.3/201. Page No.99. 2 Charak samhita by Dr Brahmanand Tripathi,Part 1,Choukhamba Surbharati Publication; 2001, Ch.No.5/16.Page no.699. 3 Acharya Sharngdhar, Sharangdhar Samhita, Dr. Bramhanad Tripathi, 1 st edition, Varanasi: Choukhmba Surbharti Prakashan; 2011; M.K.Ch.7/11. Page. 195. 4 Acharya Sidhinandan Mishra, Bhishjyakalpana Vidnyan, Varanasi: Choukhamba Surbharti Prakashan; 2016. Page 178. 5 Ayurvedic Pharmacopoeia of India Part 1 Vol 7, 1 st edition, Delhi: The Controller of Publications; 2007; Ch 5.2.1; Page 342. 6 Lachman L and others, The theory and Practice of Industrial Pharmacy, 2 nd edition; Vargese Publishing House; 1987; Ch. 5 p. 159. 7 Lachman L and others, The theory and Practice of Industrial Pharmacy, 2 nd edition; Vargese Publishing House; 1987; Ch. 5 p. 162. 8 Lachman L and others, The theory and Practice of Industrial Pharmacy, 2 nd edition; Vargese Publishing House; 1987; Ch. 5 p. 176. HOW TO CITE THIS ARTICLE Joglekar-Joshi S, Deshpande S. Pharmaceutical and Analytical Standardization of “ Medopachak Vati ” . J Ayu Herb Med 2020;6(2):78-80.