Role of Ashwagandadhi Ksheera Paka and its influence on Maternal and Foetal...

[Full title: Role of Ashwagandadhi Ksheera Paka and its influence on Maternal and Foetal Weight during Pregnancy]

[Find the meaning and references behind the names: Sri, Ayu, Nil, Med, April]

Journal of Ayurveda and Integrated Medical Sciences 2025 Volume 10 Number 4 APRIL E-ISSN:2456-3110 Research Article Ashwagandadhi Ksheera Paka Publisher www.maharshicharaka.in Role of Ashwagandadhi Ksheera Paka and its influence on Maternal and Foetal Weight during Pregnancy Meghashree B 1* , Ramadevi G 2 DOI:10.21760/jaims.10.4.3 1* Meghashree B, Final Year Post Graduate Scholar, Dept of Prasuti Tantra and Stree Roga, Sri Dharmasthala Manjunatheshwara College of Ayurveda Hospital and Research Centre, Kuthpady, Udupi, Karnataka, India 2 Ramadevi G, Professor and HOD, Dept of Prasuti Tantra and Stree Roga, Sri Dharmasthala Manjunatheshwara College of Ayurveda Hospital and Research Centre, Kuthpady, Udupi, Karnataka, India Background: Ashwagandadhi Ksheera Paka, a traditional Ayurvedic preparation, which is rich in protein, is been used for its potential benefits during pregnancy. However, its impact on maternal and foetal weight gain has not been thoroughly studied Objective: This study aims to evaluate the effect of Ashwagandadhi Ksheera Paka administration on maternal and foetal weight gain in pregnant women during the 6 th and 7 th month of pregnancy along with the analytical study of Ashwagandadi Ksheerapaka Materials and Methods: Twenty pregnant women were given Ashwagandadhi Ksheera Paka for two months i.e., 6 th and 7 th month. Maternal weight gain was monitored every 15 th day, and fetal weight gain was estimated via ultrasound. Observations were recorded to assess the correlation between the administration of the Ksheera Paka and weight changes Results: The administration of Ashwagandadhi Ksheera Paka was associated with a statistically significant increase in both maternal and foetal weight over the two-month period. Analytical Study revealed the presence phytochemicals & presence of protein concentration higher in its hydroalcoholic extract Conclusion: The findings suggest that Ashwagandadhi Ksheera Paka may contribute positively to maternal and foetal weight gain during pregnancy. Further studies with larger sample sizes are recommended to confirm these results Keywords: Ashwagandadhi Ksheerapaka, Maternal health, Ayurveda Corresponding Author How to Cite this Article To Browse Meghashree B, Final Year Post Graduate Scholar, Dept of Prasuti Tantra and Stree Roga, Sri Dharmasthala Manjunatheshwara College of Ayurveda Hospital and Research Centre, Kuthpady, Udupi, Karnataka, India Email: Meghashree B, Ramadevi G, Role of Ashwagandadhi Ksheera Paka and its influence on Maternal and Foetal Weight during Pregnancy . J Ayu Int Med Sci 2025;10(4):10-13 Available From https://jaims.in/jaims/article/view/4199/ Manuscript Received Review Round 1 Review Round 2 Review Round 3 Accepted 2025-03-07 2025-03-17 2025-04-03 2025-04-15 2025-04-23 Conflict of Interest Funding Ethical Approval Plagiarism X-checker Note None Nil Yes 11.41 © 2025 by Meghashree B, Ramadevi G and Published by Maharshi Charaka Ayurveda Organization. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License https://creativecommons.org/licenses/by/4.0/ unported [CC BY 4.0] J Ayu Int Med Sci 2025 ; 10 ( 4 ) 10

[Find the meaning and references behind the names: Guna, Daya, Guru, Mala, Rasa, Sam]

Introduction Pregnancy is a critical period where the health and nutrition of the mother directly influence the growth and development of the fetus. During the second and third trimesters, especially in the 6 th and 7 th months, the fetus undergoes rapid growth, including substantial increases in weight and organ development [1] According to ACOG guidelines there is average of 3-4 grms per day weight gain in 6 th month, in 7 th month average fetal weight gain should be around 4-5 gms per day [2] Ksheerapaka helps improve maternal strength, digestion, and immunity, while supporting healthy fetal growth. Rich in essential nutrients, promotes opti. weight gain for both mother & baby, reducing risk of deficiencies during this critical stage [3 ] Objectives 1. To analyze the effect of Ashwagandadhi Ksheerapaka on the general health of pregnant women and fetal well-being during the 6 th and 7 th months of pregnancy. 2. Phytochemical screening and protein estimation of Ashwagandhadhi ksheerapaka Materials and Methods Study Design Sample - 20 pregnant patient Intervention - The administration of Ashwagandhadhi Ksheera Paka was advised to the patient, prepared as per classical references, with a recommended dosage of 50 ml in the morning and evening after food Duration - 8 weeks Method of preparation The patient was instructed to take 6 grams of Ashwagandhadi Churna , add 50 ml of milk and 200 ml of water, boil the mixture, and reduce it to 50 ml. The prepared Ksheerapaka was advised to be consumed twice daily, 50 ml each in the morning and at night after food [4 ] Drug Review Dravya is Panchabauthika these are the physicochemical basis of the material objects These Dravya work on Panchamahabhutha and Tridosha Sidhantha contributing to balance state of Dosha, Dhathu, Mala and Agni . Dravya is again classified into Ahara Dravya and Aushada Dravya , where in food or diet which we consume daily also have got medicinal property hence at most care must be given to daily diet especially in pregnancy Criteria for selection of Madhura Dravyas for the study Ayurveda emphasizes importance of consuming Madhura (sweet) Ahara (food) and Madhura Auṣada (medicine) during pregnancy. The intake of milk and medicines from Madhura Gana is recommended throughout pregnancy. These Madhura substances are anabolic, promoting mother’s health and foetus’s growth and development. In light of significance of Madhura Auṣadha during pregnancy, as described in Caraka Saṃhita , Susruta Saṃhita, Aṣṭanga Saṃgraha , and Aṣṭanga Hṛdaya , study has been planned. The selection also considered availability of drugs, their action, potency, and shelf life in their pharmaceutical form, particularly as Churna (powder) which is used for Ksheerapaka. Study contains 5 drugs which are taken from Vidarigandadi Gana and Madhura Skanda , they are given in table no 1 Table 1: Ashwagandhadi Churna Drugs Rasa Guna Virya Vipaka Karma Ashwagandha [5] Kashaya Madhura Laghu Snigdha Ushna Madhura Dipana Yashtimadhu[6] Madhura Guru Sheeta Madhura Rasayana Punarnava[7] Madhura Ruksha Ushna Madhura Pandugna Sariva[8] Madhura Thiktha Guru Snigdha Sheeta Madhura Ruchya Vidarikanda[9] Thiktha Madhura Guru Ushna Madhura Tridoshashamaka Image 1: Ashwagandhadi Churna Meghashree B et al. Ashwagandadhi Ksheera Paka and its influence on Maternal J Ayu Int Med Sci 2025 ; 10 ( 4 ) 11

[Find the meaning and references behind the names: Bala, Heart]

Inclusion Criteria 1. Primi and multi gravida 2. Subjects limited to the age group of 20-35 years Exclusion Criteria 1. Pregnancy complicated by anaemia, Multiple Pregnancy, APH, GDM, PIH, pre-eclampsia, Eclampsia, co-existing fibroid, Thyroid disfunction, Hyperemesis gravidarum and other Systemic diseases. 2. Diagnosed cases of IUGR, Oligohydramnios, Polyhydramnios Subjective Parameter 1. Appetite, General weakness, Headache, Back ache, Constipation, Flatulence, Giddiness, Heart Burn, Palpitation, Vomiting, Pedal oedema, Sleep 2. Assessment done based on scoring Objective Parameter 1. Maternal Weight assessment 2. Haemoglobin 3. Foetal weight assessment Results This study was statistically tested with Wilcoxson test for subjective parameter and for objective parameter paired ‘t’ test is used Subjective Parameter Graph 1 In subjective parameters there was marked difference observed before and after treatment, percentage of improvement in each subjective parameter is been given in graph no 1. Extremely statistical and clinical significance was noted in appetite, leg cramps, fatigue, headache, backache, Heart burn, sleep. pedal oedema and constipation there was no statistical significance noted Objective Parameter Mean of before treatment and after treatment in given in table no 4. haemoglobin, serum protein, maternal weight, estimated foetal weight there was statistical significance noted Table 4 Parameters Mean BT Mean AT Haemoglobin 10.52 10.83 Serum protein 7.36 8.51 Maternal weight 64.75 67.98 Estimated foetal weight 354.3 1424.5 Analytical Study Results obtained for qualitative screening of phytochemicals in Ashwagandhadi Churna are presented in table no. 5. The qualitative phytochemical analysis of both aqueous and hydroalcoholic extract revealed the presence of key bioactive compounds including carbohydrates, phytosterols, tannins, reducing sugar, proteins Table 5 SN Phytochemicals Ashwagandhadi Churna Aqueous extract Hydroalcoholic extract 1. Alkaloid + - 2. Carbohydrates + + 3. Phytosterols + + 4. Glycosides - - 5. Tannins + + 6. Saponins + + 7. Reducing sugar + + 8. Flavonoids - - 9. Proteins + + Estimation of protein concentration by Biuret Method The hydroalcoholic extract of Ashwagandhadi at a 1:10 dilution had an exceptionally high protein concentration of 12739.25 µg BSAE/mg of extract, making it the most protein-rich sample among all tested groups Discussion Weakness, fatigue, depletion in maternal Bala & Varṇa, backpain, leg cramps, constipation, palpitation are anticipated due to the growing fetus, especially in the 6 th and 7 th month of pregnancy Meghashree B et al. Ashwagandadhi Ksheera Paka and its influence on Maternal J Ayu Int Med Sci 2025 ; 10 ( 4 ) 12

[Find the meaning and references behind the names: Kalpana, Surendran, Carolina, Prakashan, Jan]

The drugs selected for the study belonging to Madhura Rasa Gana, which overcomes these hindrances efficiently in this phase of pregnancy Madhura Rasa is considered to be Ajanma Satmya It could be administered irrespective of age limit and time. Supplementing Madhura Rasa through maternal diet, may facilitate the fetus in the womb to gain all the superior qualities and effects of it Conclusion Study showed statistically significant results in the subjective parameters-appetite, leg cramps, fatigue, general weakness, backache, constipation, heart burn, palpitation & sleep. Hemoglobin, serum protein, EFW, Maternal weight showed statistically significant results. Analytical study proved that, higher concentration of protein in Ashwagandhadi Churna in 1:10 dilution References 1. Myer ML, Bullard L, Beasley VL, Gentile D. Embryonic and fetal development. Columbia (SC): South Carolina Department of Health and Environmental Control; 2015. [Meeting the requirements of the SC Women’s Right to Know Act]. [Crossref][PubMed][Google Scholar] 2. American College of Obstetricians and Gynecologists. Committee Opinion No. 548: Weight gain during pregnancy. Obstet Gynecol 2020;135(2):e 44-e 52. doi: 10.1097/AOG.0000000000003664 [Crossref] [PubMed][Google Scholar] 3. Meghna PP, Surendran E, Sumedhan V, Sinimol T. A critical review of Garbhini Ksheerapakas mentioned in Ayurvedic texts of Kerala. J Ayurveda Integr Med Sci. 1970 Jan 1. [Crossref][PubMed] [Google Scholar] 4. Angadi R. Bhaishajya Kalpana Vigyan. Varanasi: Chaukambha Surbharati Prakashan; 2016. p. 105- 106 [Crossref][PubMed][Google Scholar] 5. Shastry JLN. Illustrated Dravya Guna. Vol II. Varanasi: Chaukhambha Orientalia; 2012. p. 375- 380 [Crossref][PubMed][Google Scholar] 6. Shastry JLN. Illustrated Dravya Guna. Vol II. Varanasi: Chaukhambha Orientalia; 2012. p. 152- 155 [Crossref][PubMed][Google Scholar] 7. Shastry JLN. Illustrated Dravya Guna. Vol II. Varanasi: Chaukhambha Orientalia; 2012. p. 437- 442 [Crossref][PubMed][Google Scholar] 8. Vaidya BG, editor. Nighantu Adarsha. Vol 1, Arka Varga. 1 st ed. Varanasi: Chaukhambha Publication; 2007. p. 19-21 [Crossref][PubMed][Google Scholar] 9. Vaidya BG, editor. Nighantu Adarsha. Vol 1, Palashadi Varga. 1 st ed. Varanasi: Chaukhambha Publication; 2007. p. 398-403 [Crossref][PubMed] [Google Scholar] Disclaimer / Publisher's Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of Journals and/or the editor(s). Journals and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content Meghashree B et al. Ashwagandadhi Ksheera Paka and its influence on Maternal Thereby may improve the Dhatu, Ojas, Vīrya, Bala, Varṇa of the fetus from the very beginning itself and thus it can attain Ayuṣhya, Tarpaṇa, Jivana and Balya qualities Ksheerapaka of Ashwagandhadhi Churna , promotes maternal and foetal weight gain by enhancing nourishment and vitality due to its Balya, Rasayana Guna. Ashwagandha and Vidarikanda boost tissue growth and muscle strength, while Yashtimadhu supports healthy weight gain and immune function Punarnava regulates fluid balance, maintains the Hb and Sariva improves blood circulation and digestion, ensuring proper nutrient absorption The milk-based preparation ( Ksheerapaka ) enhances the bioavailability of these herbs, maximizing their nutritive benefits for both mother and foetus J Ayu Int Med Sci 2025 ; 10 ( 4 ) 13

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Ayurveda, Pregnant women, Analytical study, Rapid growth, Critical period, Inclusion criteria, Exclusion criteria, Statistical Significance, Maternal weight gain, Maternal Diet, Weight gain, Muscle Strength, Study design, Subjective parameter, Objective parameter, Ayurvedic preparation, Hydroalcoholic extract, Maternal health, Bioactive compound, Foetal weight, Protein concentration, Maternal weight, Immune function, Tissue growth, Pregnant patient, Essential nutrient, Fetal well-being, Maternal and foetal.