Comparative study between Patrangasava and Pradararipu Rasa in the treatment...

[Full title: Comparative study between Patrangasava and Pradararipu Rasa in the treatment of Leucorrhoea]

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ORIGINAL ARTICLE February 2024 Journal of Ayurveda and Integrated Medical Sciences | February 2024 | Vol. 9 | Issue 2 1 Comparative study between Patrangasava and Pradararipu Rasa in the treatment of Leucorrhoea Animesh Maiti HOD & Professor, Department of Prasuti Tantra & Stri Roga, Belley Sankarpur Rajib Gandhi Memorial Ayurvedic College and Hospital, Belley Sankarpur, Kushdanga, West Bengal, India. I NTRODUCTION Leucorrhoea is a common and major problem in each woman who suffers at least one time specially in her reproductive age. Leucorrhea is a combination of 2 words i.e., Leuco & Rrhoea . Leuco means White and Rrhoea means vaginal discharge. So, leucorrhoea means excessive white vaginal discharge [1] It is also known as Leukorrhoea or lukoria or likoria or leu.kor.rhea [2] In this study Gr-A was treated with Patrangasava and Gr-B was treated with Pradararipu Rasa. Address for correspondence: Dr. Animesh Maiti HOD & Professor, Department of Prasuti Tantra & Stri Roga, Belley Sankarpur Rajib Gandhi Memorial Ayurvedic College and Hospital, Belley Sankarpur, Kushdanga, West Bengal, India. E-mail: dr.animeshpupu@gmail.com Submission Date: 15/12/2023 Accepted Date: 23/01/2024 Access this article online Quick Response Code Website: www.jaims.in DOI: 10.21760/jaims.9.2.1 A IM AND O BJECTIVES To evaluate the role of both drugs that ware Patrangasava and Pradararipu Rasa in the treatment of Leucorrhoea. M ATERIALS AND M ETHODS The study was conducted in the department of Prasuti Tantra and Stri Roga, B.S.R.G.M.A.C & Hospital, West Bengal, in which 60 patients were selected and were divided in two equal groups. 30 patients were taken in Group-A and other 30 Patients were taken in Group-B. Study design Prospective and comparative and observative. Selection criteria 60 female patients were selected with some parameters that were white vaginal discharge, itching of vulva, burning pain in vagina, low back pain and general weakness of women specially during reproductive age. Exclusion criteria Patients who were suffering from Cervical Erosion, Genital Prolapse, Pregnancy, CA cervix, Uterine A B S T R A C T Leucorrhoea is a common and significant issue that affects women, particularly during their reproductive years, often experiencing it at least once. It manifests as a discharge of white fluid from the vagina. In this study, we evaluated the comparative efficacy of Patrangasava and Pradararipu Rasa in treating Leucorrhoea. Sixty patients with clinical symptoms including white vaginal discharge, vulva itching, vaginal burning pain, low back pain, and general weakness were selected and divided into two equal groups: Group A and Group B. Group A received treatment with Patrangasava for 3 months, while Group B received treatment with Pradararipu Rasa for the same duration. This prospective, comparative, observational study aimed to assess the effectiveness of these treatments in both groups. The study observed a significant reduction in mean scores of clinical symptoms, particularly white vaginal discharge, in both groups. Overall compliance with the treatment was good in both groups, with a highly significant p-value of < 0.001. Key words: Leucorrhoea, Patrangasava, Pradararipu Rasa.

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Animesh Maiti. Comparative study between Patrangasava and Pradararipu Rasa in the treatment of Leucorrhoea ISSN: 2456-3110 ORIGINAL ARTICLE February 2024 Journal of Ayurveda and Integrated Medical Sciences | February 2024 | Vol. 9 | Issue 2 2 Tumour, positive VDRL, carcinoma, positive pap smear, presence of other infective organism were excluded from the study. Selection and preparation of the drug A compound medicine ‘ Patrangasava’ has been mentioned in Bhaisajyaratnavali Pradara Roga Chikitsa Prakaranam Adhyaya , was selected for the study in Group-A. The ingredients of the Patrangasava [3] are - 1 Patranga ( vakam ) - 46 gm 2 Khadirakastha - 46 gm 3 Bark of Adusa plant - 46 gm 4 Flowers of silk cotton tree - 46 gm 5 Root of Bala - 46 gm 6 Purified Bhallatak - 46 gm 7 White and black varieties Sariva - 46 gm 8 Buds of Japakusuma plants - 46 gm 9 Stone of mango - 46 gm 10 Daruharidra - 46 gm 11 Kiratatikta - 46 gm 12 Opium fruits - 46 gm 13 Cumin seed - 46 gm 14 Lauha Bhasma - 46 gm 15 Rasanjana - 46 gm 16 Pulp of unripe Bilwa fruits - 46 gm 17 Bhringaraj - 46 gm 18 Cinnamon bark - 46 gm 19 Saffron - 46 20 Clove - 46 gm 21 Kalka of raisin fruit - 950 gm 22 Powder of Dhataki flowers - 750 gm 23 Water - 25 litres 24 Raw sugar - 4670 gm 25 Honey - 2340 gm Dissolve all of these drugs into water and add sugar & honey. Put the preparation into an earthen pot coated inside with ghee and fomented. Keep the pot beneath the earth for one month. Remove it thereafter and strain the drug into glass containers. Another compound medicine Pradararipu Rasa has been mentioned in Bhaisajyaratnavali Pradara Roga Chikitsa Prakaranam Adhyaya was selected for the study in Group-B. The ingredients of the Pradararipu Rasa [4] are - 1 Purified mercury - 1 part 2 Purified sulphur - 1 part 3 Sisak Bhasma - 1 part 4 Rasanjana - 3 parts 5 Lodhra - 6 parts 6 Decoction or juice of Adusa First of all, prepare Kajjali out of the mercury and sulphur. Mix rest of the drugs into the Kajjali and process the preparation through a hand mortar along with the decoction or juice of Adusa for one day. Prepare pill measuring 250 mg each. At the end the pills are stored in an air tight container. Study procedure Total patients were equally divided in to two groups i.e. Group-A & Group- B. Group-A - This group was treated with ‘ Patrangasava’ - 15 ml with equal quantity of warm water twice daily for 3 months. Group-B - This group was treated with ‘ Pradararipu Rasa’ - 1 pill (250 mg) with honey thrice daily for 3 months. All groups were similar with regard to the demographic data and baseline parameters. Total score was based on white vaginal discharge, itching of vulva, burning pain in vagina, low back pain and general weakness, in the same parameters. O BSERVATIONS AND R ESULTS Comparative study of the effectiveness between the Group-A and Group-B in same parameters with

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Animesh Maiti. Comparative study between Patrangasava and Pradararipu Rasa in the treatment of Leucorrhoea ISSN: 2456-3110 ORIGINAL ARTICLE February 2024 Journal of Ayurveda and Integrated Medical Sciences | February 2024 | Vol. 9 | Issue 2 3 laboratory investigation before and after treatment (Table no. 1 and 2). Table 1: Result of the treatment in Group - A Sign & symptoms Mean ± S.D df ‘t’ value P value Effectiveness BT AT White vaginal discharge 2.35 ± 0.5 0.60 ± 0.5 24 9.35 <0.001 87.56 Itching of vulva 2.1 ± 0.7 0.68 ± 0.5 24 11.85 <0.001 75.00 Burning pain in vagina 1.10 ± 0.3 0.5 ± 0.12 14 2.88 <0.05 57.06 Low back pain 1.33 ± 0.5 0.45 ± 0.1 15 10.06 <0.001 62.62 General weakness 2.65 ± 0.3 1.1 ± 0.3 14 6.76 <0.001 65.00 Table 2: Result of the treatment in Group - B Sign & Symptoms Mean ± S.D df ‘t’ value P value Effectiveness BT AT White vaginal discharge 2.23 ± 0.5 0.60 ± 0.5 24 9.12 <0.001 85.95 Itching of vulva 2.2 ± 0.5 0.40 ± 0.6 24 11.80 <0.001 77.15 Burning pain in vagina 1.19 ± 0.1 0.33 ± 0.11 14 5.89 <0.001 68.59 Low back pain 1.33 ± 0.4 0.42 ± 0.12 15 10.01 <0.001 63.15 General weakness 2.55 ± 0.35 0.46 ± 0.42 14 10.60 <0.001 64.00 P = <0.001 (Highly Significant) From the statistical point of view it was observed that out of 30 patients in Group-A,20(66.66 %) patients were cured,6(19.8 %) patients were maximum improved, 3 (9.9 %) patients were moderately improved, 1(3.3%) patients were mildly improved and out of 30 patients in Group-B, 19 (62.7 %) patients were cured,6(19.8%) patients were maximum improved, 3 (9.9%) patients were moderately improved, 2(6.6 %) patients were mildly improved (Table no. 3). Table 3: Overall clinical assessment of the treatment. Result Group - A Group - B No. of pt % of pt No. of pt % of pt Cured 20 66.66 % 19 62.7 % Maximum improved 6 19.8 % 6 19.8 % Moderately improved 3 9.9 % 3 9.9% Mildly improved 1 3.3 % 2 6.6% CONCLUSION The study observed a highly significant reduction in the mean of white vaginal discharge and significant reduction in the mean of itching of vulva, burning pain in vagina, low back pain and general weakness. The overall compliance to the treatment was excellent in both group and the p value of <0.001 was considered highly significant. Hence, it can be concluded that the both drugs more or less are having same effect. So, we can recommend any one of the drugs for satisfactory management of Leucorrhoea . REFERENCES 1 CS DAWN. Textbook of Gynaecology and Contraception. 10 th edition. Calcutta: DAWN BOOKS; 1990. p. 487. 2 Merriam-Webster [Internet]. Available from: https://www.merriam-webster.com/dictionary.

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Animesh Maiti. Comparative study between Patrangasava and Pradararipu Rasa in the treatment of Leucorrhoea ISSN: 2456-3110 ORIGINAL ARTICLE February 2024 Journal of Ayurveda and Integrated Medical Sciences | February 2024 | Vol. 9 | Issue 2 4 3 Shri Gobinda Dasji. Bhaisajya Ratnavali. Vol III. 1 st edition. Varanasi: Chaukhambha Sanskrit Bhawan; 2006. Pradara Roga Chikitsa Prakaranam, Chap 66. p. 359. 4 Shri Gobinda Dasji. Bhaisajya Ratnavali. Vol III. 1 st edition. Varanasi: Chaukhambha Sanskrit Bhawan; 2006. Pradara Roga Chikitsa Prakaranam, Chap 66. p. 349. ******************************* How to cite this article: Animesh Maiti. Comparative study between Patrangasava and Pradararipu Rasa in the treatment of Leucorrhoea. J Ayurveda Integr Med Sci 2024;2:1-4. http://dx.doi.org/10.21760/jaims.9.2.1 Source of Support: Nil, Conflict of Interest: None declared. Copyright © 2024 The Author(s); Published by Maharshi Charaka Ayurveda Organization, Vijayapur (Regd). This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc-sa/4.0), which permits unrestricted use, distribution, and perform the work and make derivative works based on it only for non-commercial purposes, provided the original work is properly cited

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Bhaishajyaratnavali, Study, Vagina, Treatment, Leucorrhoea, Reproductive age, Highly significant, Group A, Cured, Exclusion criteria, Moderately improved, P Value, Selection criteria, Study design, General weakness, Low Back Pain, Mean score, Overall compliance, Clinical symptom, White vaginal discharge, Group B, Key-word, Patrangasava, Pradararipu Rasa, Mildly improved.