Ayurvedic treatment protocol in the management of Diabetic Foot Ulcer - A...

[Full title: Ayurvedic treatment protocol in the management of Diabetic Foot Ulcer - A Single Case Report]

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CASE REPORT February 2023 Journal of Ayurveda and Integrated Medical Sciences | February 2023 | Vol. 8 | Issue 2 184 Ayurvedic treatment protocol in the management of Diabetic Foot Ulcer - A Single Case Report Riddhi J. Ganatra 1 , Tukaram S. Dudhamal 2 1 Ph.D. Scholar, Department of Shalya Tantra, Institute of Teaching & Research In Ayurveda, Jamnagar, Gujarat, India. 2 Associate Professor, Department of Shalya Tantra, Institute of Teaching & Research In Ayurveda, Jamnagar, Gujarat, India. I NTRODUCTION A diabetic foot ulcer is the outcome of peripheral neuropathy and peripheral arterial disease among individuals with diabetes. Out of 62 million diabetics in India, 25% are people affected with Diabetic foot ulcers (DFUs) [1] DFUS is one of the devasting complications of diabetes that usually fail to heal and leads to lower limb amputation. There are various precipitating factors for the development of DFUs such as calluses, blisters, cuts, burns, and ingrown toenails. A patient with diabetes may not be aware of these minor injuries due to peripheral neuropathy so, lack of awareness leads to Address for correspondence: Dr. Riddhi J. Ganatra Ph.D. Scholar, Department of Shalya Tantra, Institute of Teaching & Research In Ayurveda, Jamnagar, Gujarat, India. E-mail: ganatrariddhi 86@gmail.com Submission Date: 13/12/2022 Accepted Date: 18/01/2023 Access this article online Quick Response Code Website: www.jaims.in Published by Maharshi Charaka Ayurveda Organization, Vijayapur, Karnataka (Regd) under the license CC-by-NC-SA the development of ulcers and it’s enlarged before they are noticed [2] Among all DFUs literature identified that 90% are caused by neuropathy alone or with ischemia. Additionally, it has been demonstrated that foot deformities and gait instability increase plantar pressure, which can result in the development of callosity and corn in the foot letter on they are infected and result in a non-healing foot ulcer [3] The foremost goal for DFUs is to obtain wound closure as expeditiously as possible and prevent further complications. A multidisciplinary approach is needed in the management of DFUs as diabetes is a multiorgan systemic disease. All factors that affect wound healing must be considered while managing the DFUs. Based on research optimum control of blood sugar, antibiotics for managing infection, wound debridement, appropriate dressings, and offloading are basic and essential components in the management of DFUs. Advanced therapy such as hyperbaric oxygen therapy, negative pressure wound therapy (NPWT), bioengineered skin, and growth factors also plays a major role in the rapid healing of DFUs [4] Appropriate patient education and foot care are must in order to prevent DFUs and their complications. A B S T R A C T The most common debilitating complication of diabetes mellitus is nonhealing diabetic foot ulcers worldwide. This case report presents a complete wound healing of 4-months chronic nonhealing diabetic foot ulcer in 66 years old retired male. Complete wound healing was achieved in 15 days with help of local as well as systemic management of Ayurveda . Cleaning of the wound with Triphala Kwatha followed by dressing with Apamarga Kshara Taila was done regularly. Footwear modification was also done in the patient for faster healing of the wound. For systemic management, Punarnavashtak Kwatha 20 ml twice a day, Snjivani Vati 1 tab four times a day , and Haritaki Churna 5 gm HS with lukewarm water for 1 month were prescribed orally for 15 days. This is a single case report presenting complete healing of a diabetic foot ulcer with a positive outcome in short term through Ayurveda management. Key words: Apamarga Kshara Taila, Callus, Diabetic foot ulcer, Healing, Vrana,

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Riddhi J. Ganatra et al. Ayurvedic treatment protocol in the management of Diabetic Foot Ulcer ISSN: 2456-3110 CASE REPORT February 2023 Journal of Ayurveda and Integrated Medical Sciences | February 2023 | Vol. 8 | Issue 2 185 In Ayurveda DFUs more or less can be correlated with Madhumeha Janya Dushtavrana . Sushruta stated Shashti Upkrama for treating different types of wounds on the basis of their clinical presentation [5] Ayurveda as well as contemporary science described the management in-depth with their own limitation. However, previous studies reported the local application of Apamarga Kshara Taila in non-healing wounds along with systemic oral Ayurvedic medication gives better outcomes without any untoward effects. The purpose of this retrospective case study was to see the healing effect of Ayurvedic medication in DFU caused by callosity and it refers to cost-effective, OPD base treatment of DFU with a positive outcome. Patient information A 66-year-old, retired male approached our Shalya tantra OPD with a non-healing ulcer over the callosity at the lateral aspect of the right foot and watery discharge from the wound for 4 months along with bilateral foot swelling for 1 month. The patient was a known case of diabetes mellites and hypertension for the last 15 years. For this diseases patient-reported history of oral hypoglycaemic medication (tablet metformin 500 mg three times a day before meal TDS) and antihypertensive medication (Tablet Enalpril BD and tablet amlodipine 1 BD after meal). The patient was consulted at a government hospital 3 months ago and undergone for surgical debridement of the wound and continuous dressings with povidone-iodine solution for 2.5 months but he noticed no signs of improvement in healing then the patient came to Ayurveda hospital. Patient reported a history of leftside inguinal hernioplasty before 3 years along with bilateral cataract surgery before 8 months. Clinical findings On general examination, the patient was fit and well oriented with the absence of pallor and icterus. There were no enlarged inguinal lymph nodes. B/L foot pitting edema was present. All vitals of the patient were within normal range. Local examination Location – lateral aspect of 5 th tarsometatarsal joint of right foot, size – 2 cm x 2 cm, shape - spherical, discharge – absent, odour - absent, floor - mild slough, margin - poorly defined, edge - sloping, base - Muscle, surrounding skin - oedematous and thickened with blackish discoloration, tenderness - absent, pulsation - dorsalis pedis and posterior tibial artery well appreciated, peripheral sensation - completely lost. The clinical finding suggested a diabetic foot ulcer with grade I Wagner Maggit classification of the diabetic wound. [Figure 1] Blood investigations are reported in the table. (Table 1) There was no significant abnormality noted in the foot X-ray. Table 1: Investigations SN Investigations Before treatment After Treatment 1. Hb 13.3 gm% 13.4 gm% 2. RBCs 3.23 mill/c.mm 3.25 mill/c.mm 3. WBCs 6320/c.mm 7000/c.mm 4. ESR 56 mm 20 mm 5. FBS 220 mg/dl 180 m/dl 6. PPBS 252 mg/dl 200 mg/dl Fig. 1: Before treatment Fig. 2: After 7 days of treatment

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Riddhi J. Ganatra et al. Ayurvedic treatment protocol in the management of Diabetic Foot Ulcer ISSN: 2456-3110 CASE REPORT February 2023 Journal of Ayurveda and Integrated Medical Sciences | February 2023 | Vol. 8 | Issue 2 186 Fig. 3: After completion of treatment Therapeutic plan The treatment plan was established on the basis of Ayurvedic principles for wound management given by Acharya Sushruta . Parisheka with Triphala Kwatha for 5 minutes followed by local wound dressing with Apamarga Kshara Taila under aseptic precautions was done on regular basis up to complete wound healing. External treatment was done for wound cleansing, debridement of the wound and to improve wound healing. The patient was prescribed oral Ayurvedic medication such as Punarnavashtaka Kwatha 20 ml twice a day empty stomach, Haritaki Churna 5 gm at bedtime with lukewarm water, and Sanivani Vati (125 gm) 1 tablet four times a day after meal with lukewarm water. All these medicines were continued for 1 month and the patient was allowed to continue their oral antihypertensive and hypoglycaemic medications. During the complete course of treatment, the patient was advised Pathya - Apathya to fasten wound healing and prevent further complications. The patient was also told to replace footwear with diabetic micro cellular rubber (MCR) footwear. Outcome measurements and follow-up Local and systemic Ayurvedic approaches in the nonhealing diabetic foot ulcer caused by callosity help in complete wound healing after 15 days of treatment. On the first consultation, patient was presented with non-healing callus DFU at the lateral side of the right foot. After 7 days of external treatment with Triphala Kwatha Parisheka and dressing with Apamarga Kshara Tail along with internal medication exudation was completely ceased and the wound was covered with healthy granulations. The wound size was also reduced by upto half compared to before treatment. [Figure 2] After 15 days of treatment, the wound was completely healed and covered with pinkish skin. [Figure 3] By the time of the 1-month complete relief was observed in the patient. Follow-up The patient was living symptoms free for the last 12 months and there was no recurrence of the wound was reported. DISCUSSION The DFUs associated with neuropathy and ischemia need specialized care and appropriate treatment. The primary goal of this patient was to achieve complete wound healing along with maintaining the blood sugar level. The second aim was to prevent the further degradation of wound conditions as diabetes is vulnerable to infections. Parisheka is one of the Shashti Upkrama mentioned by Sushruta . In this case, Triphala Kwatha was used for Vrana Shodhan and Vrana Ropan effect. Triphala Kwatha is a well-known drug for decreasing microbial load and preventing further infection through its antimicrobial activity or antifungal activity. The active compounds of Triphala such as, Chebulinic acid, Flavonoids, Tannins, and Polyphenols are responsible for the stimulation of immunity which is further helpful in wound healing mechanisms [6] Apamarga Kshara Taila is evidence-based oil preparation having a potential effect on autolytic tissue debridement by its alkaline property and might help in the development of healthy granulation. In short Apamarga Kshara Taila perform multi-model actions which involved Chedan , Lekhana, and Ropan by virtue of their properties to promote wound healing [7] Haritaki Churna which was given orally works at the metabolic level in the body and thus it can also help in removing toxic catabolites ultimately improving cellular growth. Again, the active components of Haritaki i.e., phenolic acids, and flavonoids are known for their antioxidant effects and thus they help in improving immunity and directly or indirectly help in wound healing [8] Punarnavashtaka

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Riddhi J. Ganatra et al. Ayurvedic treatment protocol in the management of Diabetic Foot Ulcer ISSN: 2456-3110 CASE REPORT February 2023 Journal of Ayurveda and Integrated Medical Sciences | February 2023 | Vol. 8 | Issue 2 187 Kwatha helps in wound healing through its antiinflammatory, antioxidant, and immunomodulatory actions [9] Sanjivani Vati works on all Agni thus it works at a metabolic level which helps in producing good quality Dhatu formation in the body through their anabolic and catabolic activities at the cellular level and helps in improving nutrition in the body by their systemic effect and increasing granulations of tissue at the wound site and fastens the wound healing through their localized effect [10] CONCLUSION This case report shows a significant effect of systemic as well as localized Ayurveda treatment in the management of diabetic foot ulcers. REFERENCES 1 Sorber R, Abularrage CJ. Diabetic foot ulcers: Epidemiology and the role of Multidisciplinary Care Teams. Seminars in Vascular Surgery. 2021; 34(1):47 – 53. Available from: doi: 10.1053/j.semvascsurg .2021.02.006 2 Arosi I, Hiner G, Rajbhandari S. Pathogenesis and treatment of callus in the diabetic foot. Current Diabetes Reviews. 2016;12(3):179 – 83. Available from: doi:10.2174/1573399811666150609160219. 3 Boada A. Skin lesions in the diabetic foot. Actas Dermo- Sifiliográficas (English Edition). 2012;103(5):348 – 56. Available from: https://doi.org/10.1016/j.ad.2011.08.005. 4 Brocco E, Ninkovic S, Marin M, Whisstock C, Bruseghin M, Boschetti G, et al. Diabetic foot management: Multidisciplinary approach for advanced lesion rescue. The Journal of Cardiovascular Surgery. 2018;59(5)670- 84. Available from: https://doi.org/10.23736/S 0021- 9509.18.10606-9. 5 Acharya YT, editor. Sushruta Samhita Varanasi:Chaukhamba Surbharati Prakashana; 2005. p. 99 6 Peterson CT, Denniston K, Chopra D. Therapeutic uses of triphala in Ayurvedic Medicine. The Journal of Alternative and Complementary Medicine. 2017;23(8):607 – 14. Available from: https://doi.org/10.1089/acm.2017.0083. 7 Joshi F, Dudhamal TS. Wound healing effect of Apamarga Kshara Taila and adjuvant drugs in the management of diabetic foot ulcer - a case report. Annals of Ayurvedic Medicine. 2020;9(4):320-27. Available from doi: 10.5455/aam.110195. 8 Singh D, Singh D, Choi SM, Zo SM, Painuli RM, Kwon SW, et al. Effect of extracts of terminalia chebula on proliferation of keratinocytes and fibroblasts cells: An alternative approach for wound healing. Evidence- Based Complementary and Alternative Medicine. 2014;2014:1 – 13. Available from: https://doi.org/10.1155/2014/701656. 9 Sharma V. Anti-inflammatory and analgesic activity of Punarnavashtak Kwath, an Ayurvedic formulation. BLDE University Journal of Health Sciences. 2017;2(1):38. Available from: 10.4103/bjhs.bjhs_45_16 10 Tiwari T et al. 2018 A Scientific Review on Sanjivani Vati with special reference to its Pharmacological Actions, Therapeutic Indications and Pharmaceutics. Int J Ayu Pharm Chem. 2018;9(3):82-92. Available from: http://ijapc.com. ******************************* How to cite this article: Riddhi J. Ganatra, Tukaram S. Dudhamal. Ayurvedic treatment protocol in the management of Diabetic Foot Ulcer - A Single Case Report. J Ayurveda Integr Med Sci 2023;02:184-187. Source of Support: Nil, Conflict of Interest: None declared. Copyright © 2023 The Author(s); Published by Maharshi Charaka Ayurveda Organization, Vijayapur (Regd). This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc-sa/4.0), which permits unrestricted use, distribution, and perform the work and make derivative works based on it only for non-commercial purposes, provided the original work is properly cited

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