A Conceptual Study Of Kala And Its Applied W.S.R To Diseases Occurring In...

[Full title: A Conceptual Study Of Kala And Its Applied W.S.R To Diseases Occurring In Sharata Ritu]

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P a g e | 45 Research Article. ISSN NO. 2581-785 X IRJAY IS OFFICIAL JOURNAL OF BALA G PUBLICATION International Research Journal of Ayurveda & Yoga An International Peer Reviewed Journal for Ayurveda & Yoga ICV-70.44- ISRA-1.318 VOLUME 4 ISSUE 5 1 PG Scholar, P.G. Department of Ayurveda Samhita & Siddhanta, Govt. Ayurvedic College & Hospital, Balangir 2 Reader & Head, P.G. Department of Ayurveda Samhita & Siddhanta, Govt. Ayurvedic College & Hospital, Balangir 3 Reader, P.G. Department of Ayurveda Samhita & Siddhanta, Govt. Ayurvedic College & Hospital, Balangir 4 Professor & Head, P.G. Department of Roga Nidana Evum Vikriti Vgyana, Govt. Ayurvedic College & Hospital, Balangir Corresponding Author:- Dr. Saumyaleena Baral (Final yr, P.G. Scholar) P.G. Department of Ayurveda Samhita & Siddhanta Govt. Ayurvedic College & Hospital, Balangir, Odisha E-mail:- Saumyaleena.baral 1@gmail.com Mob. No- 7008168670, 9556598987 Article revised on 2 nd May 2021 Article Accepted 27 th May 2021 Article published 31 st May 2021 ABSTRACT: - Introduction- As per Ritu Kriyakala Pitta Prakopa occurs in Sharata Ritu , which results in Sharataritujanya Vikaras in human being. In order to pacify the aggravated Pitta, Samana therapy with Kakolyadigana drug in Hima form which is mentioned in Sushruta Samhita had been taken for study Aim and Objective- To study the efficacy of Kakolyadi Gana Hima in various Pitta-Rakta janya diseases occuring in Sharata Ritu Materials and methods- 100 no. of patients were selected and kept on ‘Kakolyadigana drugs in Hima form’ 30 ml twice daily in empty stomach for a period of 10 days. All patients were investigated for DC, TLC, ESR, Hb gm% before and after treatment. The collected data was distributed according to different demography and Prakriti Pareeksha . The assessment of the subjective and objective parameters were evaluated by statistical w-test & paired t-test. Observation and results:- It had been observed that, the trial drug is statistically significant at level of 5% (p<0.5) to reduce both parameters. Discussion and Conclusion- Finally it can be said that the trial drug could be the best means for management of Pitta Vikara in Sharata ritu . During the entire duration of therapy, there was no found any adverse effect of drug reaction. Keywords- Kala, Sharata Ritu, Paittik Vikara, Kakolyadigana Hima. A Conceptual Study Of Kala And Its Applied W.S.R To Diseases Occurring In Sharata Ritu Dr. Saumyaleena Baral 1 , Dr. Manoj Kumar Sahoo 2 , Dr. Sushil Kumar Meher 3 Prof. (Dr.) P.K. Panda 4

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P a g e | 46 Research Article. ISSN NO. 2581-785 X IRJAY IS OFFICIAL JOURNAL OF BALA G PUBLICATION This work is licensed under a creative attribution -Non-commercial-No derivatives 4.0 International License commons How to cite this article: Dr. Saumyaleena Baral, Dr. Manoj Kumar Sahoo, Dr. Sushil Kumar Meher, Prof. (Dr.) P.K. Panda “A Conceptual Study Of Kala And Its Applied W.S.R To Diseases Occurring In Sharata Ritu ” IRJAY, May: 2021, Vol-4, Issue-5;45-54 ; DOI: https://doi.org/10.47223/IRJAY.2021.4510 INTRODUCTION A living person is the product of Kala (Time). Diseases occurring in the persons are considered to be caused by Kala. Ayurveda has given great importance to the kala for the swastha purusha (healthy person) as well as atura purusha (ill person) [1] Kala (Season) is divided into two Ayanas i.e. Uttarayana and Dakshinayana [2] Each Ayana consists of 3 Ritus. Strength of the person is highest in Visarga Kala and lowest in Adana Kala . Sharata Ritu (Autumn) comes under middle part of the Visarga Kala, at that time strength of the person remains medium [3] On the basis of Kriyakala, Sharata Ritu (Autumn) is a time where aggravation of Pitta dosha takes place . [4] The body that is habituated to Shita guna of Varsha ritu , when suddenly get exposed to heat of the sun rays, the pitta which was accumulated in rainy season gets provoked by Ushna guna (hot) of this season. This result in the Prakopa (aggravation)of pitta dosha [5] As Rakta dhatu (blood) is the yoni of pitta dosha, diseases related to Rakta are also bound to occur. Shamana therapy (Pacification) with Madhura(sweet), Tikta(bitter), Kasaya rasa (astringent) with Sita Virya and Madhura Vipaka Dravya in Sharata ritu (Autumn) for preventing and controlling aggravated Pitta dosha [6] So for better and safety treatment Ayurvedic herbal preparation Kakolyadigana drugs in Hima form is selected for present research study [7] AIMS AND OBJECTIVE To study the concept of Kala (time) according to Ayurveda in detail. 1 To study the concept of time according to modern medical science in detail. 2 To explain the role of Kala in causation of diseases in Sharata Ritu (Autumn). 3 To find out and establish the diseases of aggravated Pitta and vitiated Rakta occuring in sharat ritu. 4 To study the efficacy of Kakolyadi Gana drugs in various pitta-Rakta janya diseases occuring in sharat ritu. MATERIALS AND METHODS CTRI Number- CTRI/2021/02/030931 IEC Number- 1249/G.A.C & H, Dt. 14/05/2019 Selection of Patients The total 100 patients had been selected by a special proforma covering demography along with both Subjective and Objective criteria’s from OPD of Govt. Ayurvedic College & Hospital, Balangir and Saradeswari Govt. Ayurvedic Hospital, Balangir. Before treatment consent of each patient was taken. Inclusion criteria:- • Common seasonal diseases occurring in Sharata Ritu related to pitta-rakta dusti . • Patients age between 12-70 yrs of either sex.

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P a g e | 47 Research Article. ISSN NO. 2581-785 X IRJAY IS OFFICIAL JOURNAL OF BALA G PUBLICATION Exclusion criteria:- • Age below 12 yrs. and above 70 yrs. • Patients having chronic systemic disorders like Diabetes, Hypertention, Ischemic heart disease, HIV, an infective and contaminated diseases etc. Criteria for Investigations DLC, TLC, ESR, Hb gm% were investigated before treatment and after treatment Selection of drug:- One drug formulation was selected i.e. “Kakolyadigana Drugs” in Shita Kasaya(Hima) form for Pittadustijanya Vikaras and Raktadustijanya Vikaras in Sharata Ritu . Each drugs of Kakolyadigana were identified by the experts of Dept. of Dravya guna, which were approved by DRC and IEC of college and Sambalpur University. Medicine was prepared as per GMP certified method in Govt. Ayurvedic Pharmacy, Balangir under supervision of expert Pharmacy Dose- Kakolyadigana Hima - 30 ml twice daily in empty stomach. Assessment Criteria- 100 no. of patients, satisfying the inclusion criteria, had been taken for the present study and the assessment had been made before and after treatment. The overall assessment was done considering the percentage relief of both parameters and statistical evaluation. OBSEVATION AND RESULTS - Different clinical features were observed during clinical study. Table No- 01 Table showing the distribution of 100 patients of Sharataritujanya Vikaras on the basis of the symptoms and percentage of improvement were observed. Name of the symptoms No. of Patients % of patients Total Score Percentage of relief BT AT Subjective Criteria Atisweda 40 40 % 78 23 70.51 Atidourgandhya 15 15 % 19 03 84.21 Twak daha 23 23 % 32 05 84.38 Tikta asyta 18 18 % 24 08 66.67 Lavana asyata 21 21 % 30 08 73.33 Putimukhata 07 07 % 13 05 60.00 Asyavipaka 04 04 % 08 04 50.00 Galapaka 02 02 % 03 01 66.66 Raktamandal 07 07 % 10 04 60 Atrupti 24 24 % 41 12 70.73 Trushna adhikya 48 48 % 93 34 63.44 Tamaprabesha 17 17 % 29 13 55.17 Vaibarnya 08 08 % 18 08 55.56 Agnisada 14 14 % 33 15 54.54 Kandu 25 25 % 51 20 60.78 Amlaudgirana 76 76 % 168 54 67.85 Haridra mutra 07 07 % 08 01 87.50

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P a g e | 48 Research Article. ISSN NO. 2581-785 X IRJAY IS OFFICIAL JOURNAL OF BALA G PUBLICATION Objective Criteria No. Of Patient % of Patient % relief Neutrophil 100 100% 0.31 Eosinophil 100 100% 28.86 Basophil 100 100% 50.00 Lymphocyte 100 100% 02.36 Monocyte 100 100% 68.85 TLC 100 100% 01.98 ESR 100 100% 03.46 Hemoglobin 100 100% 10.66 Table No- 02:-Showing Statistical Analysis of subjective criteria and Objective criteria.(n=100) Symptoms BT/AT Mean Median SD W- Value P-Value Result Atisweda BT 1.95 2.00 0.81 -5.719 0.000001 P<0.05 AT 0.58 0.50 0.64 Atidourgandhya BT 1.27 1.00 0.46 -3.771 a 0.000162 P<0.05 AT 0.20 0.00 0.41 Twak daha BT 1.39 1.00 0.66 -4.508 a 0.000007 P<0.05 AT 0.22 0.00 0.42 Tikta asyta BT 1.33 1.00 0.59 -3.771 a 0.000162 P<0.05 AT 0.44 0.00 0.62 Lavana asyata BT 1.43 1.00 0.60 -4.119 a 0.000038 P<0.05 AT 0.38 0.00 0.50 Putimukhata BT 1.88 2.00 0.35 -2.460 a 0.013874 P<0.05 AT 0.75 1.00 0.46 Asyavipaka BT 2.00 2.00 0.00 -1.732 a 0.033265 P<0.05 AT 1.00 1.00 0.00 Galapaka BT 1.50 1.50 0.71 -1.414 a 0.041573 P<0.05 AT 0.50 0.50 0.71 Raktamandal BT 1.43 1.00 0.53 -2.121 a 0.033895 P<0.05 AT 0.57 1.00 0.53 Atrupti BT 1.71 2.00 0.69 -4.284 a 0.000018 P<0.05 AT 0.50 0.00 0.59 Trushna adhikya BT 1.94 2.00 0.67 -5.938 a 0.000000 P<0.05 AT 0.71 1.00 0.68 Tamaprabesha BT 1.71 2.00 0.69 -3.557 a 0.000375 P<0.05 AT 0.76 1.00 0.83 Vaibarnya BT 2.25 3.00 1.04 -2.232 a 0.025597 P<0.05 AT 1.00 1.00 1.07 Agnisada BT 2.20 2.00 0.56 -3.448 a 0.000565 P<0.05 AT 1.00 1.00 0.76 Kandu BT 2.04 2.00 0.54 -4.206 a 0.000026 P<0.05 AT 0.80 1.00 0.71 Amlaudgirana BT 2.21 2.00 0.82 -7.559 a 0.000000 P<0.05 AT 0.71 1.00 0.80 Haridramutra BT 1.14 1.00 0.38 -2.530 a 0.011412 P<0.05 AT 0.14 0.00 0.38

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P a g e | 49 Research Article. ISSN NO. 2581-785 X IRJAY IS OFFICIAL JOURNAL OF BALA G PUBLICATION Assessment of subjective criteria Before treatment & After treatment. Objective Criteria PARAMETERS MEAN N S.D S.E tvalue pvalue % change Result Neutrophil BT 58.59 100 7.72 0.77 0.3259 0.7452 0.31 P>0.05 AT 58.41 100 5.06 0.51 Eosinophil BT 3.43 100 1.98 0.20 6.5381 0.0000 28.86 P<0.05 AT 2.44 100 0.90 0.09 Basophil BT 0.02 100 0.14 0.01 1.0000 0.3197 50.00 P>0.05 AT 0.01 100 0.10 0.01 Lymphocyte BT 38.09 100 7.79 0.78 - 1.5279 0.1297 02.36 P>0.05 AT 38.99 100 5.33 0.53 Monocyte BT 0.61 100 0.74 0.07 5.2919 0.0002 68.85 P<0.05 AT 0.19 100 0.49 0.05 TLC BT 9180.50 100 1399.06 139.91 3.9183 0.0002 01.98 P<0.05 AT 8998.80 100 1244.38 124.44 Hemoglobin BT 12.21 100 2.08 0.21 - 5.9806 0.0000 03.46 P<0.05 AT 12.64 100 1.68 0.17 ESR BT 16.00 100 6.82 0.68 7.7550 0.0001 10.66 P<0.05 AT 14.30 100 5.52 0.55 0 0.5 1 1.5 2 2.5 Atis wed a Atid our gan dhy a Twa k dah a Tikt a asya ta Lav ana asya ta Puti muk hat a Asy avip aka Gal apa ka Rak tam and al Atru pti Trus hna adhi kya Tam apr abe sha Vaib arn ya Agni sad a Kan du Aml audi ran a Hari dra mut ra Series 1 1.95 1.27 1.39 1.33 1.43 1.88 2 1.5 1.43 1.71 1.94 1.71 2.25 2.2 2.04 2.21 1.14 Series 2 0.58 0.2 0.22 0.44 0.38 0.75 1 0.5 0.57 0.5 0.71 0.76 1 1 0.8 0.71 0.14 A xi s Ti tle Chart No-01: Showing assessment of Subjective criteria Before treatment and After treatment

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P a g e | 50 Research Article. ISSN NO. 2581-785 X IRJAY IS OFFICIAL JOURNAL OF BALA G PUBLICATION Table No- 03:Showing Overall clinical assessment of Result in Paittik Vikaras. Clinical Assessment After Treatment No. of Patients % of Patient Marked Improvement (76- 100 %) 43 43% Moderate Improvement (50- 75%) 44 44% Mild Improvement (25- 49%) 10 10% Unsatisfactory (below 25%) 03 03% Table No- 04 Demography Incidence of Registered Patients.(n=100) Criteria Maximum % Category Age 91% Madhyama avastha (30- 60 yr) Sex 58 % Female Religion 94% Hindu Marital Status 76% Married Socio-economical Status 52% Middle class Occupation 63% House holder Desha 100% Jangala Mode of onset 97% Gradual Family History 77% Absent Dietary status 88% Mixed diet Dietary Habit 43% Samashana Dominant of Rasa 49%, 48%, 34% Katu, Amla, Lavana Agni 44% Teekshnagni Vyayama 63% Only routine work Sleep 65% Normal Addiction 71% Tea/Coffee Bowel habit 73% Normal 0 10 20 30 40 50 Unsatisfactory Mild Imp Moderate Imp Marked Imp 3% 10% 44% 43% Series 1

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P a g e | 51 Research Article. ISSN NO. 2581-785 X IRJAY IS OFFICIAL JOURNAL OF BALA G PUBLICATION Table No-05 Incidence of Dahsavidha Pariksha Prakriti of Registered Patients. (n=100) Criteria Maximum % Category Prakriti 44%, 34% Vata-Pittaja, Pitta-Kaphaja Vikriti 50% Alpabala Vikara Sara 66% Madhyama Sara Samhanana 56% Madhyama Pramana 48% Samasarira Sattwa 68% Madhyama Satmya 73% Madhyama Ahara Shakti 50% Pravara Ahara Shakti Vyayama Shakti 51% Madhyama Vyayama Shakti Vaya 91% Madhyama Vaya avastha Table No-06 Pharmacodynamic properties of Kakolyadigana drugs Name of Drugs Rasa Guna Virya Vipaka Doshaghna Aswagandha Madhura, Tikta,Katu Laghu, Snigdha Ushna Madhura Vata-Kapha Satavari Madhura, Tikta Guru, Snigdha Sita Madhura Vata-Pitta Guduchi Tikta, Kasaya Guru, Snigdha Ushna Madhura Tridosha Vidarikanda Madhura Guru, Snigdha Sita Madhura Vata-Pitta Barahikanda Madhura, Katu,Tikta Laghu, Snigdha Ushna Katu Tridosha Karkatsringi Kasaya, Tikta Laghu, Rukshya Ushna Katu Vata-Kapha Jeevanti Madhura Laghu, Snigdha Sita Madhura Vata-Pitta Surpaparni dwaya Madhura Laghu, Rukshya Sita Madhura Vata-Pitta Padmak Kasaya, Tikta Laghu Sita Katu Kapha-Pitta

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P a g e | 52 Research Article. ISSN NO. 2581-785 X IRJAY IS OFFICIAL JOURNAL OF BALA G PUBLICATION DISCUSSION:- (Table No- 01) Study revels Paittik Vikaras (Subjective Parameter) and (Objective Parameter) were taken into consideration. (Table No-01, 02) in Subjective Parameter, it had been observed that, In case of Atisweda , before treatment the mean score was 1.59 which reduced to 0.58 with 70.51 % mean percentage of improvement after treatment. Atidourgandhya , Initial mean score was 1.27 which reduced to 0.20 with 84.21 % mean percentage of improvement after treatment. Twak daha , before treatment mean score was 1.39 which reduced to 0.22 with 84.38% mean percentage of improvement after treatment. Tikta asyata , the mean score was 1.33 before treatment which reduced to 0.44 with 66.67% mean percentage of improvement after treatment. Lavana asyata , before treatment the mean score was 1.43 which reduced to 0.38 with 73.33% mean percentage of improvement after treatment. Putimukhata , before treatment the mean score was 1.88 which reduced to 0.75 with 60.00% mean percentage of improvement after treatment. Asyavipaka , before treatment the mean score was 2.00 which reduced to 1.00 with 50% mean percentage of improvement after treatment. Galapaka , the mean score was 1.50 which reduced to 0.50 with 66.67% mean percentage of improvement after treatment. Raktamandal , before treatment the mean score was 1.43 which reduced to 0.57 with 60% mean percentage of improvement after treatment. Atrupt i, before treatment the mean score was 1.71 which reduced to 0.50 with 70.73% mean percentage of improvement after treatment. Trushna adhikya , before treatment the initial mean score was 1.94 which reduced to 0.71 with 63.44% mean percentage of improvement after treatment. Tamaprabesha , before treatment the mean score was 1.71 which reduced to 0.76 with 55.17% mean percentage of improvement after treatment. Vaibarnya, mean score was 2.25 before treatment which reduced to 1.00 with 55.56% mean percentage of improvement after treatment. Agnisada, before treatment the mean score was 2.20 which reduced to 1.00 with 54.55% mean percentage of improvement after treatment. Kandu, before treatment the mean score was 2.04 which reduced to 0.80 with 60.78% mean percentage of improvement after treatment. Amlaudgirana, before treatment the initial mean score was 2.21 which reduced to 0.71 with 67.865 mean percentage of improvement after treatment. In Objective Parameter , it had been observed that, TLC , before treatment the mean score was 9180.50/cumm which reduced to 8998.80/cumm with 1.98% of mean percentage of improvement after treatment. Hemoglobin , before treatment the initial mean score was 12.21 which increased to 12.64 with

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P a g e | 53 Research Article. ISSN NO. 2581-785 X IRJAY IS OFFICIAL JOURNAL OF BALA G PUBLICATION 3.46% of mean percentage improvement after treatment. ESR , before treatment the mean score was 16.00 which reduced to 14.30 with 10.66% of mean percentage of improvement after treatment. More than 80 % relief was noticed in the symptoms like Haridramutra (87.50%) Atidourgandhya (84.21%) and Twak daha (84.38%). More than 70 % relief was noticed in the symptoms like Atisweda (70.51%), Lavana asyata (73.33%) and Atrupti (70.73%).More than 60 % relief was observed in the symptoms like Tikta asyata (66.67%), Raktamandal (60%), Trushna adhikya (63.44%), Kandu (60.78%), Amlaudgirana (67.86%), Galapaka (66.67%) and Putimukhata (60%).The symptoms like Tamaprabesha (55.17), Vaibarnya (55.56%), Agnisada (54.55%), Asyavipaka (50%) have shown alleviation to the extent of more than 50 %.It had been observed that there were mild changes in objective parameters after treatment. Overall effect of Kakolyadigana drugs in Shita Kasaya (Hima) form on Paittik Vikaras was 66.55 %. (Table No- 03) – It had been observed that, as per after treatment procedure 43% (43) had got marked improved, 44% (44) had got moderate recovered, 10% (10) had got mild recovered and only 03% (03) had shown unchanged result. (Table No-04) – It had been observed on Demography incidence that both male and female of middle age group, belongs to Jangala desha, middle class family, married, mix diet with Samashana habit, addiction of taking tea & coffee and having normal bowel habit were prone to Paittik Vikaras. (Table No-05) – Individual Dashavidha- Pariksha (ten-fold examination) was covered and observed that the Vata – Pittaja and Pitta- Kaphaja patients having Madhyama- Sara- Samhanana- Satwa- Satmya- Pramana- Vyayama Shakti and Pravara Ahara Shakti were manifested with Paittik Vikara patients. (Table No- 06)- The drugs of Kakolyadigana Hima were the predominance of Madhura (sweet), Tikta, (bitter) Kashaya Rasa (astringent) and Sita Virya with Madhura Vipaka. Madhura rasa suppress hyper activity (Teekshna guna) of vitiated pitta whereas Tikta & Kasaya rasa absorbs liquid form (Drava guna ) of vitiated pitta 8 . Ushna Virya(hot) where sheeta Virya is opposite to Ushna and Teekshna guna of pitta hence it helps in pacify the aggravated pitta. Hima kalpana is also a Shita kalpana which has opposite character of Pitta doshsa . So this mode of application of drug also suppresses the vitiated Pitta doshsa and diseases related with the aggravated pitta 9 . CONCLUSION Sanchaya and Prakopa (aggravation) of doshas occur in our body according to Ritu and get subsided accordingly in presiding Ritu . If someone take the support of medicine in Prakopa (aggravation) stage of dosha in particular ritu (season) then it gets cured in that ritu itself. So in this research study Kakolyadigana drugs in Hima form had been chosen for 10 days for pitta samana in Sharata ritu as pitta Prakopa (aggravation) takes place in Sharata ritu( autumn). Finally, it can be said that the formulation i.e. Kakolyadigana drugs in Hima form could be the best means for management of Pitta vikara in Sharata ritu . Results of this work have undoubtedly established the efficacy of trial drug. Forth coming researchers may pursue further study in a large sample size over a period of longer duration. No side effect was noticed during clinical trial.

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P a g e | 54 Research Article. ISSN NO. 2581-785 X IRJAY IS OFFICIAL JOURNAL OF BALA G PUBLICATION ACKNOWLEDGEMENT I am very much grateful and thankful to Principal Prof. (Dr.) Arun Kumar Das, Prof.(Dr.) P.K. Panda, H.O.D RNVV, Dr. G.B. Acharya, H.O.D Dravya guna, Dr. S.B. Behera, H.O.D Rasashastra & Bhaisajya Kalpana, Dr. Nabin Ku. Behera, Lecturer, Samhita & Siddhanta for their proper guidance and grateful blessings. I am also thankful to Dr. Neetu Jha, Dr. Dusmanta Kumar Majhi, Dr. Madhusmitarani Sethi and Dr. Anamika Das, all my P.G. Scholars friends, juniors, seniors, Hospital Staff for their constant helping attitude to complete the research work with a full satisfaction and belief. Financial Support: Nil. Conflict of Interest: Nil REFERENCES 1 Charaka Samhita of Agnivesha, Edited with the Vidyotini Hindi Commentary, Sutra Sthana, Tasyashiitiya Adhyaya (Ch. Su. 6/2) Chuakhambha Orientalis Varanasi 2005,pp-676 2 Charaka Samhita of Agnivesha, Edited with the Vidyotini Hindi Commentary, Sutra Sthana, Tasyashiitiya Adhyaya (Ch. Su. 6/4) Chuakhambha Orientalis Varanasi 2005,pp-675 3 Charaka Samhita of Agnivesha, Edited with the Vidyotini Hindi Commentary, Sutra Sthana, Tasyashiitiya Adhyaya (Ch. Su. 6/8) Chuakhambha Orientalis Varanasi 2005,pp-564 4 Charaka Samhita of Agnivesha, Edited with the Vidyotini Hindi Commentary, Sutra Sthana, Tasyashiitiya Adhyaya (Ch. Su. 6/41) Chuakhambha Orientalis Varanasi 2005,pp-675 5 Charaka Samhita of Agnivesha, Edited with the Vidyotini Hindi Commentary, Sutra Sthana, Tasyashiitiya Adhyaya (Ch. Su. 6/41) Chuakhambha Orientalis Varanasi 2005,pp-647 6 Charaka Samhita of Agnivesha, Edited with the Vidyotini Hindi Commentary, Sutra Sthana, Tasyashiitiya Adhyaya (Ch. Su. 6/42) Chuakhambha Orientalis Varanasi 2005,pp-345 7 Sushruta Samhita Edited with Ayurveda Tattwa Sandipika by Kaviraja Ambikadatta Shastri, Sutra Sthana, Mishraka Gana Adhyaya (Su. Su. 38/35- 36) Chuakhambha Orientalis Varanasi 2005,pp-670 8 Kumar, D. V., Verma, D. S., & Khatri, D. S. (2019). A Treatment Protocol of Jwara in the Perspective of examination of Kala (Time). International Research Journal of Ayurveda & Yoga, 2(3), 07-15. 9 Dravya guna Vigyan, Part-2, by Acharya Priyabarta Sharma. Chuakhambha Orientalis Varanasi 2005,pp-345

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