“Role Of Guduchyadi Churna On Rajonivrutti Avastha With Special Reference To...

[Full title: “Role Of Guduchyadi Churna On Rajonivrutti Avastha With Special Reference To Postmenopausal Syndrome”- A Review Of Literature]

P a g e | 229 Review Article. IRJAY IS OFFICIAL JOURNAL OF BALA G PUBLICATION International Research Journal of Ayurveda & Yoga An International Peer Reviewed Journal for Ayurveda & Yoga “ROLE OF ICV-70.44 ISRA-1.318 VOLUME 4 ISSUE 1 JANUARY 2021 1 Assist. Professor, Deptt. Of Prasuti & StreeRoga , SSSB Ayurvedic College & Hospital, Renwal, Jaipur, Rajasthan 2 Associate Professor, Deptt. Of Samhita & Siddhant , SSSB Ayurvedic College & Hospital, Renwal, Jaipur, Rajasthan 3 Assist. Professor, Deptt. Of Rasashastra & Bhaishjya kalpana , Baba Hiradasji Ayurvedic college & Hospital, Badal, Muktsar, Punjab Article received on 23 th Dec 2020 Article Accepted 3 th Jan 2021 Article published 31 st Jan 2021 ABSTRACT Menopause is defined retrospectively as the time of the Final Menstrual Period (FMP), followed by 12 months of amenorrhea. Post menopause describes the period following the final menses. In Ayurveda, this phenomenon is considered as a natural process due to aging and not associated with any serious health problems. Menopause is a state of Vata predominance & Dhatukshaya (depletion of tissue) and it occurs at the age of 50 years. The menopause is permanent cessation of menstruation at the end of reproductive life due to loss of ovarian follicular activity. The age at menopause appears to be genetically determined and is unaffected by race, socioeconomic status, age at menarche, or number of prior ovulations. Factors that are toxic to the ovary often result in an earlier age of menopause; for example, women who smoke experience an earlier menopause. Women who have had surgery on their ovaries, have had a hysterectomy, despite retention of their ovaries, may also experience early menopause. In U.K. average age for menopause is 52 (National Health Service) while in the U.S.A, it is 51 (National Institute of Aging). About 1/5 th women in India experience menopause before the age in 41, but average age is 50 years and about 10% women seek medical advice during menopause. Premature ovarian failure is defined as menopause before the age of 40 years. It may be idiopathic or associated with toxic exposure, chromosomal abnormality, or autoimmune disorder. ‘ Guduchyadi Churna’ drug can be effective in the management of Postmenopausal Syndrome and can be an effective, safe, promising and cost effective remedy. Keyword:. Rajonivrutti, Postmenopausal Syndrome, Guduchyadi Churna. “Role Of Guduchyadi Churna On Rajonivrutti Avastha With Special Reference To Postmenopausal Syndrome”- A Review Of Literature Dr.Suresh Kumar 1 , Dr Dholaram Saini 2 , Dr Brijgopal 3 Corresponding author : Dr. Suresh Kumar 1 Assist. Professor, Deptt. Of Prasuti & StreeRoga, SSSB Ayurvedic College & Hospital, Renwal, Jaipur, Rajasthan E mail: drskpaliwal 08@gmail.com , Contact no. 8209849426

P a g e | 230 Review Article. IRJAY IS OFFICIAL JOURNAL OF BALA G PUBLICATION This work is licensed under a creative attribution -Non-commercial-No derivatives 4.0 International License commons How to cite this article: - Dr. Suresh Kumar, Dr Dholaram Saini, Dr Brijgopal, Role Of Guduchyadi Churna On Rajonivrutti Avastha With Special Reference To Postmenopausal Syndrome”- A Review Of Literature IRJAY, January: 2021 Vol- 4, Issue-1; 229-241; Doi: https://doi.org/10.47223/IRJAY.2021.4132 INTRODUCTION: The age at menopause appears to be genetically determined and is unaffected by race, socioeconomic status, age at menarche, or number of prior ovulations. Factors that are toxic to the ovary often result in an earlier age of menopause; for example, women who smoke experience an earlier menopause. Women who have had surgery on their ovaries, have had a hysterectomy, despite retention of their ovaries, may also experience early menopause 1 .In U.K. average age for menopause is 52 (National Health Service) while in the U.S.A, it is 51 (National Institute of Aging). About 1/5 th women in India experience menopause before the age in 41, but average age is 50 years 3 and about 10% women seek medical advice during menopause. Menopause is defined retrospectively as the time of the Final Menstrual Period (FMP), followed by 12 months of amenorrhea. Post menopause describes the period following the final menses 2 . In Ayurveda , this phenomenon is considered as a natural process due to aging and not associated with any serious health problems. Menopause is a state of Vata predominance & Dhatukshaya (depletion of tissue) and it occurs at the age of 50 years 4 ‘Guduchyadi Churna’ drug can be effective in the management of Postmenopausal Syndrome and can be an effective, safe, promising and cost-effective remedy MATERIALS AND METHODS: In order to determine in current body of scientific evidence supporting the therapeutic effect of ‘Guduchyadi Churna’ in case of Rajonivrutti (Postmenopausal Syndrome), the author performed thorough literature search focused on the ratification of the available peer reviewed literature that provide scientific evidence for the benefits of ‘Guduchyadi Churna’ in human subjects. REVIEW: Menopausal syndrome is a fact of multi-factorial etiopathogenesis with symptoms of varying degree from very mild to very severe and distressing, disturbing the routing life of the women. The women are running in the critical phase in their aging phenomenon i.e. late middle or early old age also. Single drug formulation may treat a fraction of symptoms but not the whole symptoms of menopause. Postmenopausal Syndrome or Rajonivrutti Avastha is comprises of several Lakshana (Signs and symptoms) of all Dhatukshaya . (depletion of tissue) Moreover there is vitiation of two Dosha along with Manasikdosha and Agni (digestive fire) is decreasing DRUG REVIEW 5-42 : Guduchyadi Churna : It is explained in Y.R. Uttarakandha 24, by Dr.Indradevatripati&D.S.Tripati,edition 1 st Chkambha series office ,Varanasi (P) p.No-892 Table: Contains of Guduchyadi Churna :

P a g e | 231 Review Article. IRJAY IS OFFICIAL JOURNAL OF BALA G PUBLICATION Sl.no. Ingredients Scientific name Useful parts 1. Guduchi Tinospora cordifolia Willd Stem 2. Apamarga Achyranthes aspera Linn Whole plant 3. Vidanga Embelia ribes Burm.f Fruit 4. Shankhapushpi Convovulus pluricaulis Chois Whole plant 5. Vacha Acorus calamus Linn Root 6. Haritaki Terminalia chebula Retz . Fruit 7. Sunthi Zingiber officinale Rosc . Stem 8. Shatavari Asparagus racemosus Willd . Root GUDUCHI Botanical name: Tinospora cordifolia Wild Natural order: Menispermaceae Classical name: Guduchi, Amrita, Giloy,Gulancha, Gulbel, Madhuparni, Chhinnaroha, Galu, Shindhilkudhi, Kondhalin, Vatsadhani, Tantrika. Vernacular name:Sanskrit : Amritavalli, Amrita English :Moonseed Hindi : Giloe, Gurcha Bengali : Gulancha Parts used: Stem Ayurveda properties: Rasa : Tikta, Kashaya • Guna :Guru, Snigdha • Virya : Usna • Vipaka : Madhura • Doshaghnata : Tridoasa shamaka • Rogaghnata: • Jwara (fever) , Vatarakta (gout) , Prameha (DM), Kushtha (skin disease) , Agnimandhya, Trishna (thirst) , Daha (burning sensation) , Kasa (cough) , Krimi (worms) , Chhardi (vomiting) , Arshas (piles) ,Netravikara (eye disorders) , Hridroga (Heart disorders) • Karma: Rasayana (Rejuvenation) , Tridosashamaka, Medhya (Nootropic ), Jvarahara (Antipyretic), Dahaprasamana (burning sensation) ,vedanasthapana (Pain killer) ,Kushthaghna ,Hridya (Heart tonic) ,Raktashodaka, Raktavardhaka, Jwaraghna (Antipyretic) mootrajanana , (Diuretic) Madhumeha , (DM) Deepana ,(Appetizer) Pachana (Digestive) , Chhardinigrahana ,(Antiemetic) Anulomana, Balya. (Tonic) Action and uses: Jwara (fever), Vataj jwara (fever because of vata), Vatarakta (gout), Amlapitta (hyper acidity), Prameha (diabetes), Trishna (thirst), Kustha, Pandu, Kamala. It is useful in burning sensation, hyperdipsia, helminthiasis, dyspepsia, vomiting, flatulence, acid gastritis, jaundice, haemorrhoids, meno-metrorrhagia, intermittent fever, asthma, filarial, diarrhoea and eye diseases Chemical constituents: A diterpenoid of columbin typetinosporin is isolated from plant ( sci. Cult. 26: p.140, 1960; Chem. Abstr.61:12331 b, 1964). Tinosporide and cordifolide (Sci.Res.1:177, 1964). Tinosporidine and beta- Sitosterol isolated stems; cordifol, heptacosanol and octacosanol reported from the leaves (Comp. Ind. Med. Plants vol.2 p.679).A new furanoid diterpenetinosporide from stems ( Ind. J. Chem; 16 B:317, 1978 & Chem. Abstr. 93.72009 c, 1980), 18- norclerodene glucosetinosporide-from stem wood is reported (phytochem. 28:273, 1989 & Chem. Abstr.112:211629; 1990).Five diterpene furan glycosider, viz., cordifolisides A-E and two phenyl propane glycosides are isolated from aq. Extracts (Gangan et al; 1994).Isocolumbin, tetrahydropalmatine, magnoflarine and palmatine

P a g e | 232 Review Article. IRJAY IS OFFICIAL JOURNAL OF BALA G PUBLICATION were isolated from roots (Sarma et al; 1998). Ref. Dravya Guna vijnana, Author Dr J.L.Sastry, Chaukhambha orientalia, Varanasi, edition:2015, page no. 39) Pharmacological activities: Hypoglycemic, CNS depressant, antibacterial, antimicrobial,Antipyretic, anti-inflammatory, antiaarthritic, antiallergic, hepatoprotective, analgesic, immunosuppressive, immunostimulant, antineoplastic, antistress, antidiabetic, antitumour, adaptogenic, antileishmanial, antioxidant, antiendotoxic, hypotensive, diuretic. Important formulation : Amritarisa, Amritottara Kvatha Churna, Guduchi Taila,Guducyadi Churna, Guduchi Sattva, Chinnobhavadi Kvatha Churna. APAMARGA Botanical name: Achyranthus aspera Linn. Natural order: Amaranthaceae Classical name: Apamarga, Shikhari, Adhashalya, Mayuraka, Aghata, Kharamanjari, Latajeera, Aapang, Utterana, Pratyakapushpa, Katalani, Durgraha, Kinihi,Markati. Vernacular name:Sanskrit : Mayura, Mayuraka English :Prickly Chaff Flower Hindi : Chirchita, Latjira Bengali : Apamarga Parts used: Whole plant Ayurveda properties: Rasa : Katu, Tikta • Guna : Laghu, Ruksha, Tikshna • Virya : Ushna • Vipaka : Katu • Doshaghnata : kaphavatahara • Rogagnata : Agnimandhya(weak digestion) , Adhmana,(Flatulence) Arsha(Piles) , Apachi, Kandu,(Itching) Dadru(Psorariasis), Chhardi(Vomiting), Udarashula(Abdominal pain), Hridruja(cardiac pain) , Udara, Mutrakriccha(Dysuria) ,Visucika(Cholera) , Nadivrana • Karma: Agnideepaka,(appetizer) Pittasharaka, Pachaka,(Digestive) Vamaka,(Emetic) Chhedana (excision), Shothahara ,(anti-inflammatory) Vedanasthapana (pain killer) , Lekhana,(scrapping), Kaphanissaraka, Mutrala ,(diuretic) Kushthaghna, Krimighna, Raktavardhaka, Raktashodhaka(blood purifier), Vishaghna, (anti-toxic)Rochan, Kandughna etc. Action and uses: Arsas (piles), Rakta arsas (bleeding piles), Visucika (diarrhoea), Nadivrana (sinus), Atyagi (bhasmaka), Sastraksata (wound), Shula,(pain) Udara Roga, Apaci, Kandu(itching) , Medoroga. Apamarga root taken with milk overcomes dysuria. Decoction of Apamarga, Kakajangha, Kokilaksha and Suparnika induces sleep (HS.3.15.6). A pair of leaves of Apamarga introduced into the vagina relieves pain instantaneously (GN.6.6.15. Application of the paste of the roots of Apamarga and Punarnava (Borrehevia diffusa) removes vaginal pain during puerperium Chemical constituents: Betaine, Achyranthine, hentriacontane, ecdysone, aldosterone, inocoterone, oleanolic acid, glycosides and Achyranthes saponins A, B, C,D Pharmacological Activities: Antihypertensive, Antidiabetic, Abortifacient, Diuretic, Antileprotic, Purgative, anti-implantation, vasodilator, cardiac stimulant (seed saponins), cardiac depressant (achyranthine), Spasmolytic, Hypoglycemic and Antifungal Important formulations: Apamargakshara, Apamargakshara Taila, Abhaya Lavana,Agastya haritaki,Gudhapippali, Jyotishmati Taila, Mahashankha vati.

P a g e | 233 Review Article. IRJAY IS OFFICIAL JOURNAL OF BALA G PUBLICATION VIDANGA Botanical name: Embelia ribes Burm . f Natural order: Myrsinaceae Classical name: Vayavidanga, Vidanga, Krimighna, Chitratandhula, Bhabhiranga, Viggala, Vella, Krimihara, Jantughna Vernacular name:Sanskrit : Jantughna, Krimighna, English :Embelia fruit Hindi : Vayavidanga, Bhabhiranga, Baberang Bengali : Vidang Parts used: Fruit Ayurveda properties: • Rasa : Katu, Kashaya • Guna : Laghu, Ruksha, Tikshna • Virya :Ushna • Vipaka : Katu • Doshaghnata : Kaphavata shamak • Rogagnata : Deepana (appetizer), Vishaghna(anti-toxic), Krimiroga, Udara roga, Adhman(Flautence), Shola(abdominal pain), Kushtha,(skin disease) Agnimandya, Ajirna, Vibandha(constipation), Aruci, Medoroga, Prameha(DM), Vaivarna(discoloration) • Karma: Krimighna, ,Pachana(digestive) , Anulumana, Mootrajanana,(Diuretic) Sulahara(pain killer), Adhmanahara, Vibandhahara, Vishaghna(anti toxic), Rucya, Medohara, Mehahara, Garbhanirodhaka, Varnya, Rasayana(rejunevation) and Kushthaghna. Action and uses: Krimi (worm infestation) , Kushtha (skin disease), Rasayana (rejuvenating), Visa roga,Shula, Udararoga, aadhmana. Water boiled with Vidanga and added with the same should be used as drink. It destroys worms and disorders caused thereby (BP.Ci.7.23). Those who take Vidanga, Bhallataka and Shunthi with ghee and honey cross over the turbulent stream of old age and diseases (A.H.U.39.152) Chemical constituents: Rruits yielded Embelin, Quercitol, Tannin, an alkaloid Christembine, Iodoembolin, Bromoembolin, Embelic acid, Fatty ingredients, Volatile oil, Vilangin Pharmacological activities: Estrogenic, antihelmintic, antigungal, antioxidant, hepatoprotective, Anticonvulsant, immunostimulant, antiimplantation, antiovulatory, hypotensive, antipyretic, diuretic, antispermatogenic, antiandrogenic, anticancer Important formulations: Vidangadi churna, Abhayarishta, Kasisadi ghrita, Vidanga taila, Kaishore guggulu,Vidangarishta, Vidanga Lauha, Vidagadi Lauha, Vayashadi guggulu. SHANKHAPUSHPI Botanical name: Convolvulus pluricaulis Chois Natural order:Convolvulaceae Classical name: Shankhapushpi, Kshirapushpi, Mangalyakusuma, Shankhahuli, Sangkhavel, Shankhavali, Vanvilasini, Tilaki, Shankhavya, Shankhakusuma. Vernacular name:Sanskrit : Shankapushpi English : Speed wheel Hindi : Shankhahuli Bengali: Shankhapushpi Parts used: Whole herb Ayurveda properties: • Rasa : Kashaya, Katu, Tikta • Guna : Snigdha,Pichila, Guru, Sara • Virya : Shita • Vipaka : Madhura • Doshaghnata : Tridoshagna • Rogaghnata: Vatapittavikara, Anidra (insomnia), Ajeerna (indigestion), Daha,(burning sensation) Shoukradourbalya, Manasika Vikaras(mental disorders) , Unmada,(insanity) Apasmara(epilepsy) ,

P a g e | 234 Review Article. IRJAY IS OFFICIAL JOURNAL OF BALA G PUBLICATION Dourbalya(debility) Kushtha(skin disease) , Krimi(worms), Visavikara,(toxinc effects) Kasa,(cough) Swarabheda(hoarshness of voice) , Pooyameha. • Karma: Rasayana (Rejuvenation) , Tridosashamaka, Medhya (Nootropic ), Jvarahara (Antipyretic), Dahaprasamana (burning sensation) ,vedanasthapana (Pain killer) ,Kushthaghna ,Hridya (Heart tonic) ,Raktashodaka, Raktavardhaka, Jwaraghna (Antipyretic) mootrajanana ,(Diuretic) Madhumeha ,(DM) Deepana ,(Appetizer) Pachana (Digestive) , Chhardinigrahana ,(Antiemetic) Anulomana, Balya. (Tonic) • Action and uses: Medhyarasayana (intellect promoter), Unmad (insanity), Apasmara (epilepsy) Vrisya(aphrodisiac) , Kantivardhaka, Balya(tonic) , Kushthagna, Krimighna, Visaghna(anti toxic) , Kasahara,(anti tussive) Swarya Shankhapushpi is rasayana (rejunevating) specially promoting intellect (CS.Ci.3.31). Ghee 10.24 kg should be cooked with three times juice of Shankhapushpi along with milk. By its regular use even the dull becomes sharp and intelligent (A.H.U.39.47). Old Ghee cooked with Brhmi juice, Vacha, Kushtha and Shankhapushpi alleviates insanity and epilepsy (CS.Ci.10.25) Chemical constituents : Shankhapushpine, 6- methoxy-7-hydroxycoumarin, n-hexacosanol, Carbohydrate-D-glucose, Maltose, Rhamnose, Glacial acetic acid, Scopoletin, Beta sitosterol, Esitosterols, Tropane alkaloids, Kaemferol, Convoline, Convolidine, Convolvine, Confoline, Convosine, Tetratriacontanoic acid Pharmacological activities: Sedative, hypotensive, hypolipidemic, antifungal, hypoglycaemic , anticonvulsant, anti-oxidant, anti-depresant and antiulcerogenic Important formulations : Guduchyadi Churna (YR), Brahmi Ghrita, Brahmi Vati, Brahma Rasayana, Saraswata Churna, Agastya Haritaki Rasayana, Jeevaniya Ghrita, Shankhapushpi Panaka. VACHA Botanical name: Acorus calamus Linn . Natural order:Araceae Classical name: Vacha, Ugragandha, Swaragrantha, Golomee, Vekhandha, Vaja, Varcha, Varaja, Vaya, Karunaka, Vasambho, Kshudrapatra, Shataparvika,Mangalya. Vernacular name:Sanskrit : Ugragandha, Ugra, Shadh·grantha English : The Sweet Flag Hindi : Bach, Gora-bach Bengali : Bach Parts used: Rhizome Ayurveda properties: Rasa : Katu, Tikta • Guna : Laghu, Tikshna • Virya : Ushna • Vipaka :Katu • Doshaghnata : Kaphavatashamaka • Rogaghnata: Unmada(insanity) , Apasmara,(epilepsy) Sthoulya(obesity) , Murchha(syncope) , Agnimandya (weak digestion) , Ajirna(indigestion) , Arsas(piles), Krimi(worms) , Udarasula(abdominal pain), Jwara(fever), Adhmana,(flatulence)Vibandha(constipatio n) , Mukharoga, Swarasada, Atisara (diarrhea) and Mutradosha.(urine disorders) • Karma: Medhya (nootropic), Lekhana, (scrapper) Vamaka (emetic) , Dipana (appetizer) , vedanasthapana (Pain killer) ,Kushthaghna ,Hridya (Heart tonic) ,Raktashodaka, Raktavardhaka, Jwaraghna (Antipyretic) mootrajanana ,(Diuretic) Madhumeha , (DM) Deepana ,(Appetizer)

P a g e | 235 Review Article. IRJAY IS OFFICIAL JOURNAL OF BALA G PUBLICATION Pachana (Digestive) , Chhardinigrahana , (Antiemetic) Anulomana ,Bhutaghna, Action and uses: Rasayana (Rejuvenation), Apasmara ( Epilepsy), Sotha (oedema), Suryavarta, Visamajwara (malaria) Shula (pain), Shvasa (asthma) , Kasa (cough) , Vibandha (constipation), Unmada (insanity) , Aadhmana, Karna Srava, Smriti daurbalya (weak memory) By using for a month Vacha with milk or ghee or oil one becomes invincible for pathogenic agents and endowed with sharp intellect and sweet voice (AH.U.39.164). One who keeps the nodular piece of Vacha in mouth day and night gets rid of the diseases of mouth (HS.3.46.31) Chemical constituents: Rhizome of Vacha contains 1.5 to 3,5% of volatile oil, Starch, Resin (2.5%), and Tannin. Volatile oil contains asaradehyde, Asarone, and eugenol. Other constitutuents include beta asarone, Calamenol, Calamene, Calamenone, Methyle eugenol, alfa pinene and camphene Pharmacological activities: Vermifuse, carminative, tranquilizer, sedative, hypothermic, anticonvulsant, carcinogenic, antimicrobial, anthelmintic, insecticidal, antibacterial and CNS depressant Important formulations : Ashwagandharishta, Vachadi Taila, Vacha Lasunadi Taila, Sarasvata, Churna, Sarasvata Rista, Manasmitra Vataka, Candra Prabha Vati, Khadiradi Vati, Hinguvacadi Churna. HARITAKI Botanical name: Terminalia chebula Retz. Natural order:Combretaceae Classical name: Haritaki, Abhaya, Pathya, Chetaki, Rohini, Haimavati, Shiva, Hare, Halilaja, Karakkai, Putana, Vayastha, Kayastha Vernacular name:Sanskrit : Abhaya, Kayastha, Shiva, Pathya, Vijaya (Not Bhaaga) English : Myrobalan Hindi : Harre, Harad, Harar Bengali : Haritaki Parts used: Fruit Ayurveda properties: • Rasa : Kashaya pradhana, Pancharasa lavanavarjita • Guna : Laghu, ruksa • Virya : Usna • Vipaka : Madhura • Doshaghnata : Tridosahara, specially vatashamaka • Rogaghnata: Vatavyadhi, Shothavedanayukta vikara (inflammatory conditions) , Vrana (wound) , Mukharoga, Kantharoga, Nadi daurbalya, Mastishka daurbalya (brain disorders), Netrabhishyanda (conjunctivitis), Drishtimandya (diminution of vision.) Indryadaurbalya (diminished senses), Agnimandya, Shoola (pain) , Anaha, Gulma (abdominal tumour) , Vibandha, (constipation) Arsha (piles) , Kamala (jaundice) , Yakritpleeha vridhi (spleenliver enlargement), Krimiroga, Hriddaurbalya (cardiac inefficiency) , Vatarakta (gout) , Raktavikara, Shotha (inflammation) , Pratishyaya (sinusitis) , Kasa (cough) , Swarabedha, Hikka (hiccups) , Swasa,(asthma) Sukrameha, Shwetapradara (leucorrhea) , Mootrakrichchhra, (dysuria) Mootraghata, Ashmari (stone) , Kushtha (skin disease), Visarpa,(erysipelas) Vishama jwara,(malaria) Jeernajwara (chronic fever) • Karma: Rasayana (Rejuvenation) , Tridosashamaka, Medhya (Nootropic ), Jvarahara (Antipyretic), Dahaprasamana (burning sensation) ,vedanasthapana (Pain killer) ,Kushthaghna ,Hridya (Heart tonic) , Anulomana, Krimighna, Kaphaghna, Vrishya (aphorodiasic) , Grahi, Prajasthapana, Mootrala (diuretic) , Kushthaghna (antileprosy) , Mridurechana

P a g e | 236 Review Article. IRJAY IS OFFICIAL JOURNAL OF BALA G PUBLICATION (soft purgatives) , Shonitasthapana, Garbhashayashothahara, (antiinflammatory), Yakrituttejaka. ( hepatic stimulants). Action and uses: Rasayana,Parinama sula (duodenal ulcer), Vatavyadhi (disorder of vata ), Atisweda (exssive sweating ), Vibandha (constipation), Chhardi (vomiting), Arsas (piles), Shotha, Arsha, Aruci,Hridroga, Kasa, Pandu, Prameha, Udavarta,Vibandha, Jirnajvara, Visamajvara, Siroroga, Tamaka svasa,Gulma, Udararoga, Haritaki fried in ghee should be taken followed by intake of ghee. It provides firm strength in the body (AH.U.39.148). In prameha, Haritaki powder should be taken with honey (As.Ci.14.5). Haritaki, Pippali and Shunthi is known as ‘trisama’, which promotes digestive power and prevents thirst etc Chemical constituents: Anthraquinone glycoside, chebulinic acid, chebulagic acid, tannic acid, terchebin, tetrachebulin, vitamin C (fruits); arachidic, behenic, linoleic, oleic, palmitic and stearic acids (fruit kernels); chebulin ( flowers ); 2- alpha-hydroxymicromeric acid, maslinic acid and 2- alpha hydroxyl ursoloic acid(leaves) Pharmacological activities: Antimicrobial, antifungal, antibacterial, antistress, antispasmodic, hypotensive, hypolipidemic, anthelmintic, purgative, cytoprotective, cardiotonic, antihelmintic, antihepatitis B virus activity, inhibitory activity against HIV-1 protease. Important formulations : Triphala churna, Triphaladi Taila, Abhayarishta, Agastya haritaki rasayana, Citraka Haritaki, Danti Haritaki, Dasamula Haritaki, Brahma Rasayana, Abhaya Lavana, Pathyadi Lepa . SHUNTHI Botanical name: Zingiber officinale Rosc Natural order:Zingiberaceae Classical name: Mahaushadha, Nagara, Sunthi, Visvabhesajya, Sringbera , Sonth, Janjavila , Katubhadra, ardrika, Ardraka Vernacular name:Sanskrit : Aushadha, Muhaushadha, English : Ginger root, Ginger Hindi : Sonth Bengali : Suntha, Sunthi Parts used: Dry rhizome Ayurveda properties: • Rasa : Katu • Guna : Laghu, Snighdha • Virya : Ushna • Vipaka : Madhura • Doshaghnata : Vatakaphashamaka • Rogaghnata : Ajirna,(indigestion) Amavata (Rheumatoid arthritis), Agnimanghya, Chhardi(vomiting), Anaha, Sula(pain) , Vibandha(constipation) , Slipada,(elephantiasis) Shool vatakaphahara, Shopha(inflammation), Kasa,(cough) Hikka,(hiccups) Grahani roga,(sprue) Sheet-pitta(urticaria) , Pandu jwara(Anemic fever) , Pratishyaya(sinusitis), Deepana(appetizer), Karnashoola.(ear pain) • Karma: Vatakaphashamaka, Anulomana, Deepana (appetizer), Pachana(digestives) , Rochana, Vrishya(Aphorodiasic) , Jwaraghna(antipyretic) ,Sothahara(antiinflammatory) , Hridya, Amadoshahara, Arshoghna, Vedanasthapana(pain killer) etc. Action and uses: Agnimandya (loss of appetite), Aruci (anorexia), Arsas (haemaroids), Sitapitta (urticaria), Parinamasula (duodenal ulcer), Sotha (oedema), Sira sula (headache), Visucika (diarroea) Shvasa, Adhmana, Aamavata, Pandu, Udararoga. Chemical constituents: Heptane, Octane, Isovaleraldehyde, nonanol, ethyl pinene, camphene, beta pinene, sabinene, myrecene, limonene, beta

P a g e | 237 Review Article. IRJAY IS OFFICIAL JOURNAL OF BALA G PUBLICATION phellandrane, 1,8 cineole, alfa-farnesene, betafarnesene, gingerol, hexahydrocucuromin, gingerone A, B & C,resin, starch, thiamine, riboflavin, niacin, vitamin C, carotone, Pharmacological activities: Anti-allergic activity, Anti inflammatory, hypolipidemic, antibacterial, antiemetic, antifungal, antipyretic, antiplatelet, antitumoral, hypourecemic, antidepressant, hepatoprotective, hypoglycaemic, inhibition of prostaglandin release, analgesic activity, antioxidative effect and bioavailability enhancing activity Important formulations: Trikatu, Erandapaka, Panchakola Churna, Abhayarishta, Ashwagandharishta, Shunthi Ghrita, Rasanadi Jwatha , Saubhagyshunthi, Saubhagya Vati, Vaishvanara Churna. SHATAVARI Botanical Name: Asparagus racemosus willd Natural Order:Liliaceae Classical Names : Shatapadi , Bahusuta, Atirasa, Mahodari, Narayani, Shataveerya, Shatamooli,Bhiru, Indivari, Vari, Urdhwakantika, Rishyaprokta, Pivari. Vernacular Names:Sanskrit : Shatavari English : Wild asparagus Hindi : Shatawar, Satamuli Bengali : Satavari Parts Used: Root Ayurveda Properties : Rasa : Madhura, Tikta Guna : Guru, Snigdha Virya : Sita Vipaka : Madhura Doshaghnata :Vatapittashamaka Rogaghnata : Rasayana (Rejuvenator) ,Dourbalya (Debility), Shukrakshaya (Oligozoospermia) , Stanyakhsaya ,(Decreased milk production) Mutrakrichchhra(Dysuria), Arsha(Piles), Vatavikara, grahani (Sprue) , Gulma (Abdominal tumour), Manasika vikara (Mental disorders), Hridaroga (Cardiac disorders) , Shotha (inflammation) ,Amlapitta, Raktapitta, Kshaya, Drishtimandya (diminished vision). Karma: Rasayana (Rejuvenator) , Pittashamaka, Grahi, Sukrala, Nadibaladayaka, Garbhaposhaka, Mootrala,(diuretic) Stanyajanana (galactogogue) , Balya (tonic) ,Medhya (nootropic) ,Vedanasthapana ,(pain killer) Chakshushya (promotion of Eye health), Raktapittashamaka, etc Action and Uses: Stanya vardhanartha (galactogogue) Rasayana (rejuvenative), Swarabheda (hoarseness of voice). In intrinsic haemorrhage and diarrhoea- Shatavaryadi ghrita , Shatavari in piles and diarrhoea, Shatavari juice mixed with honey in biliary colic, Shatavari powder with cold water in dysuria, Shatavari with milk as galactogogne, and Shatavari cooked with ghee and decoction as rasayana etc. The roots are bitter, sweet, emollient, cooling, nervine tonic, constipating, ophthalmic, anodyne, aphrodisiac, diuretic, carminative, appetiser, stomachic,antispasmodic and tonic. They are useful in nervous disorders, dysentery, tumours, inflammations, burning sensation, hyperdipsia, ophthalmopathy, nephropathy, hepatopathy, strangury, burning micturition, throat infections, tuberculosis, cough, bronchitis, gleet, gonorrhoea, cardiac debility, leucorrhoea, leprosy, epilepsy, fatigue, hyperacidity, haemorrhoids, hypertension, abortion, agalactia and general debility. Chemial Constituents: Sarsapogenin, Saponin A 4- A 7, glycosides of quercetin, rutin, hyperoside in flower and fruits, diosgenin, quercetin 3- glucoronide in leaves, sitasterol and stigmasterol along with their glucosides, two spirostanolic and furostanolic saponoins and sapogenin, 4 saponins, viz, Shatavarin I to IV, Polycyclic alkaloids, asparagamine A and disaccharide in roots are reported. Pharmacological activities: Antioxytotic (Shatavarin IV), diuretic, galactogogue, anticancer, antifungal, hypotensive, antiamoebic, nematicidal, gastric-sedative, antidysentric, spasmodic to uterus, anticoagulant, antiabortifacient (shatavarin I), enzymatic, hypoglycaemic and phagocytic Important formulations: Shatvaryadi Churna, Shatavaryadi Ghrita( CS.Ci.4.95-96), Puga

P a g e | 238 Review Article. IRJAY IS OFFICIAL JOURNAL OF BALA G PUBLICATION Khanda, Phalaghrita, Narayana Taila, Guduchyadi Taila, Shatamoolyadi Lauha, Brihatashwagandha Ghrita,Eranda paka,Shatavari Garbhachintamani Rasa,Brihatchagaladya Ghrita, Vishnu Taila. DISCUSSION: PROBABLE MODE OF ACTION OF ‘GUDUCHYADI CHURNA’: ACCORDING TO AYURVEDA CONCEPTS: Guduchyadi Churna ’ is having mainly Katu, Tikta, Kashaya Rasa (bitter-pungent-astringent taste) and 3 drugs are Katu Vipaka; Ushna Virya; Laghu, Snigdha, Tikshna Guna and Vata-Kaphashamaka effects. The drug is also having Rasayana (rejuvenator) , Dipana (appetizer), Pachana (digestive) Anulomana, Vayasthapana(anti-ageing) , Balya(tonic) and Medhya(nootropic) properties. In the ‘Guduchyadi Churna’ like Guduchi, Apamarga, Vidanga, Vacha, Haritaki and Shunthi which are having Usna Virya; Laghu, Ruksha Guna of Apamarga, Vidanga, Haritaki and Prabhava posses Dipana (appetizer), Pachana (digestive) and Vatanulomana properties in the drug helps in regulation of Agni and combating Agnivaishamaya . But in spite of Dipana (appetizer), Pachana (digestive) , Anulomana properties they have Tridoshahara activities like Guduchi, Shankhapushpi, Haritaki; and Shunthi, Vacha, Vidanga, Apamarga is Kapha-Vatashamaka and Shatavari is Vata-Pittashamaka . This ‘Guduchyadi Churna’ due to its properties like Madhura Rasa and Madhura Vipaka; Snigdha & Guru Guna ; Sita Virya of Shatavari and Sita Virya & Madhura Vipaka of Shankhapushpi ; Madhura Vipaka of Guduchi, Haritaki, Shunthi act as Rasayana, Balya , Vayasthapana , Medhya and Vata-Pitta Shamaka and helps in Dhatu formation & keeps the body free from Jara /aging. The ingredients of ‘Guduchyadi Churna’ like Shunthi, Vacha, Vidanga, Apamarga having Kapha-Vatashamaka due to their Katu Rasa & Ushna Virya properties . . Shankhapushpi shows Rasayana (rejuvenator) , Dipana (appetizer), Pachana (digestive) Anulomana, Vayasthapana(anti-ageing) , Balya(tonic) and Medhya (nootropic) properties Vrishya(aphorodiasic) , Nadibalya, Manashikavikaraka(mental disorders) , Hridya,(heart tonic) Nidrajanana, Tridoshahara properties and sedative, hypotensive, antidepresant, Anti-convulsant and antioxidant activities. Guduchi also possesses Rasayana (rejuvenator) , Dipana (appetizer), Pachana (digestive) Anulomana, Vayasthapana(anti-ageing) , Balya(tonic) and Medhya(nootropic) properties Vedanasthjapana Balya & Tridoshahara properties and CNS depressant, hypoglycemic, anti-stress, adaptogenic, diuretic, analgesic-anti-inflammatory, antimicrobial & anti-oxidant activity. All drugs present in ‘Guduchyadi Churna’ are Rasayana (rejuvenator) and act on Manovaha Srotas for which vitiated Manas Doshas are returns back to its normal condition and helps in reducing psychological symptoms associated with Postmenopausal Syndrome. Presents of Shankhapushpi, Haritaki and Shunthi in ‘Guduchyadi Churna’ may helps in Sexual problems as they are having Rasayana (rejuvenator) & Vrishya (aphrodisiac) activity and further research is needed to get the Significant result in Postmenopausal Syndrome statistically. Due to all these properties together ‘Guduchyadi Churna’ is able to relieve symptoms of Dhatukshaya, vitiated Vata-Pitta-Kapha , Agnivaishamya and Manovahasrotas (psychological). ACCORDING TO MODERN SCIENCE: Mode of action of ‘Guduchyadi Churna’ also depends upon properties and pharmacological action of their ingredients of the drug. The pharmacological actions of the ingredients are – 1 Guduchi: Hypoglycemic, CNS depressant, antibacterial, anti-microbial, Anti-pyretic, anti-inflammatory, anti-arthritic, antiallergic, hepato-protective, analgesic, immunosuppressive, immune-stimulant, anti-neoplastic, anti-stress, anti-tumour, adaptogenic, antileishmanial, antioxidant, anti-endotoxic, hypotensive, diuretic

P a g e | 239 Review Article. IRJAY IS OFFICIAL JOURNAL OF BALA G PUBLICATION 2 Apamarga: Antihypertensive, Anti-diabetic, Abortifaecient, Diuretic, Anti-leprotic, Purgative, anti implantation, vasodilator, cardiac stimulant (seed saponins), cardiac depressant ( achyranthine), Spasmolytic, Hypoglycaemic and Antifungal 3 Vidanga: Estrogenic, antihelmintic, antifungal, antioxidant, hepato-protective, Anticonvulsant, immune-stimulant, antiimplantation, antiovulatory, hypotensive, antipyretic, diuretic, antispermatogenic, anti-androgenic and anticancer 4 Shankhapushi: Sedative, hypotensive, hypolipidemic, antifungal, hypoglycaemic , anti-convulsant, anti-oxidant, anti-depresant and anti-ulcerogenic 5 Vacha: Vermifuse, carminative, tranquilizer, sedative, hypothermic, anticonvulsant, carcinogenic, antimicrobial, anthelmintic, insecticidal, antibacterial and CNS depressant 6 Haritaki: Antimicrobial, antifungal, antibacterial, antistress, antispasmodic, hypotensive, hypolipidemic, anthelmintic, purgative, cytoprotective, cardiotonic, antihelmintic, antihepatitis B virus activity, inhibitory activity against HIV-1 protease 7 Shunthi: Anti-allergic activity, Anti inflammatory, hypolipidemic, antibacterial, antiemetic, antifungal, antipyretic, antiplatelet, antitumoral, hypourecemic, antidepressant, hepatoprotective, hypoglycaemic, inhibition of prostaglandin release, analgesic activity, antioxidative effect and bioavailability enhancing activity. 8 Shatavari: Antioxytotic (Shatavarin IV), diuretic, galactogogue, anticancer, antifungal, hypotensive, antiamoebic, nematicidal, gastric-sedative, antidysentric, spasmodic to uterus, anticoagulant, antiabortifacient (shatavarin I), enzymatic, hypoglycaemic So, the drug ‘Guduchyadi Churna’ can be effective on somatopsychological and other symptoms of Postmenopausal Syndrome by its various pharmacological actions CONCLUSION: ‘ GuduchyadiChurna’ would be better choice in Postmenopausal Syndrome with osteoporosis. the drug can be used in the management of Postmenopausal Syndrome with Diabetes Mellitus. ‘GuduchyadiChurna’ is an effective, safe, promising and cost effective remedy REFERENCE: 1 Indian J Psychiatry,2015 jul; 57(Suppl 2):s 222-s 232.Postmenopausal syndrome, by Pronobk.Dalal and Manu Agarwal 2 Kravitz HM, JoffeH.Sleep during the perimenopause: a SWAN story, ObstetGynecolClin North Am.2011;38:567-586. 3 D C Dutta’s Textbook of Gynecology, edited by Hiralalkonar, edition 7, published by JaypeeThe Health Science of India, new Delhi, page no.46. 4 Su. S. Su. 14/6 & Su. S. Sha. 3/11 . 5 Y.R.Uttarakandha 24, by Dr.Indradevatripati&D.S.Tripati,edition 1 st Chkambha series office ,Varanasi (P) p.No-892. 6 Dravyaguna-Vijnana,vol-2 by Prof. P.V.Sharma,published by Chaukhambha

P a g e | 240 Review Article. IRJAY IS OFFICIAL JOURNAL OF BALA G PUBLICATION Bharati Academy, Varanasi,edition 1999, page no.761-763. 7 Illustrated Dravyaguna Vijnana, by Dr. J.L.N.Sastry, forwarded by Prof. K.C,Chunekar, Published by Chukhambha Orientalia, Varanasi, edition 2015, page no.33-49. 8 A text book of Dravyaguna vijnana,Vol-2 by Dr. Prakash L.Hegde and Dr Harini A,Published by Chaukhambha Publications, new Delhi, edition 2017, page no.309-318. 9 Bhavaprakasa Nighantu commentary by Padmashri Prof. K.C.Chunekar,edited by Late Dr. G.S.Pandey, Published by Chaukhambha Bharati Academy, Varanasi, edition 2015, Guducyadi varga Page no. 258-259. 10 Database on Medical Plants used in Ayurveda,e dition 2005, vol-3, published by Docomentation and Publication Division, CCRAS, New Delhi, page no.256. 11 Dravyaguna-Vijnana, Vol-2 by Prof. P.V.Sharma,published by Chaukhambha Bharati Academy, Varanasi,edition 1999, page no.542-544. 12 Illustrated Dravyaguna Vijnana, by Dr. J.L.N.Sastry, forwarded by Prof. K.C,Chunekar, Published by Chukhambha Orientalia, Varanasi, edition 2015, page no.443-447. 13 A text book of Dravyaguna vijnana, Vol-2 by Dr. Prakash L.Hegde and Dr Harini A,Published by Chaukhambha Publications, new Delhi, edition 2017, page no.41-49. 14 Bhavaprakasa Nighantu commentary by Padmashri Prof. K.C.Chunekar,edited by Late Dr. G.S.Pandey, Published by Chaukhambha Bharati Academy, Varanasi, edition 2015, Guducyadi varga Page no.400-401. 15 Database on Medical Plants used in Ayurveda, edition 2005, vol-1, published by Docomentation and Publication Division, CCRAS, New Delhi, page no. 11. 16 Classical Uses of Medicinal Plants by P.V Sharma,edition 2004, published by Chaukhambha Viswabharati, Varanasi-1 , page no. 12-13. 17 Dravyaguna-Vijnana,vol-2 by Prof. P.V.Sharma,published by Chaukhambha Bharati Academy, Varanasi,edition 1999, page no.503-506. 18 Illustrated Dravyaguna Vijnana, by Dr. J.L.N.Sastry, forwarded by Prof. K.C,Chunekar, Published by Chukhambha Orientalia, Varanasi, edition 2015, page no.318-320. 19 A text book of Dravyaguna vijnana,Vol-2 by Dr. Prakash L.Hegde and Dr Harini A,Published by Chaukhambha Publications, new Delhi, edition 2017, page no.887-894. 20 Bhavaprakasa Nighantu commentary by Padmashri Prof. K.C.Chunekar,edited by Late Dr. G.S.Pandey, Published by Chaukhambha Bharati Academy, Varanasi, edition 2015, Guducyadi varga Page no. 51- 52. 21 Database on Medical Plants used in Ayurveda, edition 2005, vol-5, published by Docomentation and Publication Division, CCRAS, New Delhi, page no.478. 22 Dravyaguna-Vijnana, Vol-2 by Prof. P.V.Sharma,published by Chaukhambha Bharati Academy, Varanasi,edition 1999, page no.9-11. 23 Illustrated Dravyaguna Vijnana, by Dr. J.L.N.Sastry, forwarded by Prof. K.C,Chunekar, Published by Chukhambha Orientalia, Varanasi, edition 2015, page no.359-362. 24 A text book of Dravyaguna vijnana, Vol-2 by Dr. Prakash L.Hegde and Dr Harini A,Published by Chaukhambha publications, new delhi, edition 2017, page no.764-770. 25 Bhavaprakasa Nighantu commentary by Padmashri Prof. K.C.Chunekar,edited by Late Dr. G.S.Pandey, Published by Chaukhambha Bharati Academy, Varanasi,

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Ayurveda, Haritaki, Vidanga, Rasayana, Shatavari, Shankhapushpi, Vrishya, Apamarga, Shunthi, Vacha, Guduchi, Dhatukshaya, Madhuravipaka, Tridoshahara, Madhurarasa, Manodosa, Agnivaishamya, Digestive fire, Medicinal plant, Antibiotic, Natural order, Natural process, Menstrual period, Therapeutic effect, Signs and symptoms, Modern science, Anthelmintic, Purgative, Diabetes mellitus, Botanical name, Review of Literature, Parts used, Medical advice, Other symptoms, Sedative, Ayurvedic College, Pharmacological activities, Hepato-protective, Galactogogue, Anti-inflammatory, Hypolipidemic, Anti oxidant activity, Analgesic activity, Tissue Depletion, Manovaha srotas, Scientific evidence, Anti-allergic activity, Rajonivrutti, Autoimmune disorder, Antioxidant, Diuretic, Hepatoprotective, Antimicrobial, CNS depressant, Anticancer, Anti pyretic, Antifungal, Vata Predominance, Health problem, Menopause, Scientific name, Post menopause, Premature ovarian failure, Anticoagulant, Vata-Pittashamaka, Anti stress, Antipyretic, Analgesic, Carminative, Immune stimulant, Vasodilator, Chemical constituent, Postmenopausal Syndrome, Cardiotonic, Ayurveda properties, Guduchyadi Churna, Katu-Tikta-Kashaya-Rasa, Antiplatelet, Anti diabetic, Toxic exposure, Insecticidal, Anti-microbial, Antispasmodic, Cytoprotective, Anticonvulsant, Cardiac stimulant, Important formulation, Antiemetic, Anti-arthritic, Antihypertensive, Anti-tumour, Anti-neoplastic, Action and uses, Antihelmintic, Useful part, Hypotensive, Anti-ulcerogenic, Spasmolytic, Antioxidative effect, Hypoglycemic, Sexual problem, Carcinogenic, Antiallergic, Anti-convulsant, Antileishmanial, National Health Service, Ovary, Cardiac depressant, Kapha Vatashamaka, Anti-implantation, Reproductive life, Ovarian follicular activity, Adaptogenic, Anti leprotic, Tranquilizer, Immunosuppressive, Inhibition of prostaglandin release, Single drug formulation, Antiamoebic, Classical name, Estrogenic, Enzymatic.