Indian Medicinal Plants

by Kanhoba Ranchoddas Kirtikar | 1918

A comprehensive work on Indian Botany including plant synonyms in various languages, habitat description and uses in traditional medicine, such as Ayurveda....

Notes on the alkaloid aporeine

By extraction of the seed capsules of Papaver dubium with light petroleum, a previously unknown alkaloid, aporeine, is obtained. The thick, yellow, amorphous extractive product amounting to 0.015 p. c yields with 10 p. c. hydrochloric acid, the hydrochloride, which forms glistening scales, melting at about 230°, and gives precipitates with silver nitrate and phosphomolybdic acid. The base forms microscopic leaflets after crystallisation from ether, light petroleum, or chloroform. When a solution of the trace of the alkaloid or its hydrochloride in a drop of nitric acid of sp. gr. 1.8 is dropped into concentrated sulphuric acid, a violet, brown, and finally yellow coloration is produced, a similar result being given by the base with strong sulphuric acid in which a crystal of potassium chlorate has been dissolved. The hydrochloride gives a greyish-blue, green, brown, and finally black coloration, with a solution of 2 or 3 drops of 40 per cent, formalin in 3 C C. of concentrated sulphuric acid; with strong sulphuric acid, especially in the presence of potassium nitrate, or with fuming nitric and sulphuric acids in the presence of potassium dichromate, a brown coloration.

The hydrochloride produces on the tongue at first a burning and then a numbing sensation. The alkaloid is a tetanus poison, similar to thebaine—(J. Ch. S. LXXXVIII, part I., p. 368).