Significance of Volume of distribution
Volume of distribution, often denoted as Vd, is a key pharmacokinetic parameter. It quantifies how extensively a drug spreads throughout the body's tissues compared to its concentration in the plasma. Vd is a theoretical volume representing the drug's dispersion, influenced by factors like body weight and the drug's properties. A higher Vd suggests the drug is more widely distributed, reflecting its ability to move from the bloodstream into body compartments.
Synonyms: Distribution volume, Apparent volume of distribution, Volume of distribution at steady state, Vd
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The concept of Volume of distribution in scientific sources
Volume of distribution (Vd) is a pharmacokinetic parameter. It describes how a drug distributes throughout the body's tissues relative to its concentration in plasma. Vd indicates the extent of drug dispersion, reflecting the drug's ability to leave the bloodstream and enter other body compartments.
From: International Journal of Pharmacology
(1) Volume of distribution (Vß) is a pharmacokinetic parameter reflecting the extent to which a drug distributes throughout the body, and it was found to be significantly higher in infected goats.[1] (2) This pharmacokinetic parameter did not show a significant difference over the administered doses of gemfibrozil.[2] (3) Upon administration of antipyrine, there was a steady decrease in this and in the elimination half-life in the first three months of life.[3] (4) Volume of distribution is a measure of the apparent space in the body available to contain the drug.[4] (5) It refers to the apparent space in the body available to contain the drug, with values of 15 to 32 L m -2 described.[5]
From: Asian Journal of Pharmaceutics
(1) Since these parameters were not presented in this report, it was not possible to assess the differences of that parameter.[6] (2) A pharmacokinetic parameter that remained nearly the same with and without A. sativum treatment.[7] (3) Represented as V d , it is the apparent space in the body available to contain the drug.[8] (4) It is used in the dose calculation of the amount of drug to be incorporated in a patch.[9] (5) It is a pharmacokinetic parameter indicating drug distribution in the body.[10]
From: South African Family Practice
(1) To decrease the effective plasma concentration of these molecules, the best option is thus to increase their volume of distribution and to do this, the patient may be exposed to a dose of ILE, which acts as a “Lipid sink”.[11] (2) The volume of distribution, denoted as Vd, is the apparent volume of blood into which a drug has distributed, indicating how much drug remains in the blood after it gets there.[12]
From: The Malaysian Journal of Medical Sciences
(1) A pharmacokinetic parameter indicating the extent to which propranolol is distributed in the body's tissues relative to the plasma concentration.[13]