Significance of Trimethoprim-Sulfamethoxazole
Trimethoprim-Sulfamethoxazole, or TMP-SMZ, is a commonly used antibiotic effective against various bacterial infections, including S. maltophilia and Nocardia species. It is the drug of choice for Pneumocystis jirovecii, displaying universal sensitivity. However, resistance can be high in some strains, like CA-MRSA. Studies explore its use in prophylaxis, while hypersensitivity reactions are a potential concern. Research indicates varying effectiveness, with some studies showing lower efficacy compared to other antibiotics.
Synonyms: Tmp-smx, Co-trimoxazole
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Trimethoprim-Sulfamethoxazole in scientific sources
Trimethoprim-Sulfamethoxazole is a commonly used antibiotic with varying effectiveness. It's the preferred treatment for S. maltophilia, potentially effective against CA-MRSA, and used for Nocardia. Resistance varies, and hypersensitivity reactions are possible.
From: South African Journal of HIV Medicine
(1) It is a medication that the patient was commenced on, in high doses, and it is also a medical therapy for pulmonary pneumocystis.[1] (2) Pneumocystic jirovecii is universally sensitive to this, and antibiotic resistance is unknown.[2] (3) This is a medication mentioned alongside nevirapine and efavirenz, which may cause a very similar hypersensitivity reaction.[3]
From: The Malaysian Journal of Medical Sciences
(1) This is one of the medications used in the successful treatment of Nocardia species, alongside meropenem, imipenem, ceftriaxone, moxifloxacin, and linezolid, demonstrating the range of treatments.[4] (2) An antimicrobial agent that remains the drug of choice for treating S. maltophilia infections with high susceptibility rates.[5]
From: Journal of Public Health in Africa
(1) This is the least effective antibiotic, according to the results of the study, as mentioned in the provided document.[6] (2) This is an antibiotic, and the text provides information on the resistance rates of various bacteria to this antibiotic, indicating resistance patterns.[7]
From: South African Family Practice
(1) This is a drug, also known as TMP-SMZ, and the text mentions a study comparing dose escalation versus direct rechallenge for its use in prophylaxis.[8]
From: Onderstepoort Journal of Veterinary Research
(1) Genes conferring resistance to sulfamethoxazole were detected in most Salmonella isolates that exhibited resistance to this.[9]
From: Asian Journal of Pharmaceutics
(1) It is being tested versus vancomycin for severe infections caused by methicillin resistant Staphylococcus aureus.[10]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) The study also wants to highlight the resistance values obtained for trimethoprim-sulfamethoxazole (38.7%), which is a significant finding regarding antibiotic susceptibility.[11]