Significance of Toxicity studies
Toxicity studies, across Ayurveda, Science, and Health Sciences, involve assessing the harmful effects of substances on biological systems. These investigations, often conducted on animal models, evaluate safety profiles, permissible levels, and potential adverse effects. The research encompasses a broad range of substances, including herbal extracts, nanoparticles, and drugs, with a focus on understanding dosage-related impacts and ensuring safe usage. These studies are essential for determining the safety of substances before human use, often required prior to clinical trials.
Synonyms: Toxicity testing, Safety assessment, Hazard evaluation, Risk assessment, Toxicology studies, Hazard assessment, Safety evaluation, Exposure assessment, Chemical analysis
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
Hindu concept of 'Toxicity studies'
In Hinduism, toxicity studies are crucial for evaluating the safety of Bhasmas. They involve global standard assessments, determining permissible levels, and analyzing safety profiles. These studies, especially on Vanga Bhasma, investigate potential effects on organs like the gastrointestinal tract, liver, and pancreas.
From: Journal of Ayurvedic and Herbal Medicine
(1) Evaluations conducted on the most promising interacting chemical entities to determine their potential for causing harmful effects within a biological system, showing very little concern for these compounds.[1] (2) These investigations focus on Vanga Bhasma, specifically examining its potential effects on the body, particularly the gastrointestinal tract, liver, and pancreas, offering insights into its safety profile.[2]
From: Journal of Ayurveda and Integrated Medical Sciences
(1) Toxicity studies are carried out on Ayurvedic nanomedicine, such as Swarna Bhasma, as it is a main obstacle in exploring Bhasma preparations for broader use.[3] (2) To evaluate the safety of Bhasmas, these studies on global standards should be conducted, along with procedures to assess permissible levels and overall safety profiles.[4]
From: International Research Journal of Ayurveda and Yoga
(1) Evaluations conducted to assess the safety of Arogyavardhini Vati, showing no accumulation or toxic effects of mercury and copper on vital organs.[5]
The concept of Toxicity studies in scientific sources
Toxicity studies are research endeavors that evaluate the safety of substances by assessing their potential harmful effects on living organisms. These studies involve various methods, including observing physiological reactions, measuring toxic effects, and determining safe dosages, often using animal models and various extracts. They are crucial for determining safe usage.
From: International Journal of Pharmacology
(1) These investigations were performed for ethanolic and aqueous extracts in albino rats, following OECD guidelines.[6] (2) This text refers to the evaluation of organ weights for rodent and non-rodent toxicity studies.[7] (3) For toxicity studies, 12 (six male, six female) Sprague-Dawley rats (225-250 g) were divided into two groups with six rats in each group (three male and three female).[8]
From: Asian Journal of Pharmaceutics
(1) Conduct extensive in vitro and in vivo these to understand the potential adverse effects of nanomaterials.[9] (2) These are investigations conducted to assess the potential harmful effects of a substance on living organisms.[10] (3) These studies are needed using various experimental animals to evaluate the safety and efficacy of selected formulations.[11]
From: Onderstepoort Journal of Veterinary Research
(1) Diplodiatoxin was reported to account for only 10% of the total toxicity.[12]
From: Journal of Medicinal Plants for Economic Development
(1) These are investigations that assess the potential for a substance to cause harm, looking at the adverse effects in living organisms, and they are crucial for determining safe usage.[13] (2) These are investigations into the harmful effects of the plant or its components.[14] (3) These are scientific investigations that evaluate the adverse effects of a substance on living organisms, including determining safe dosages.[15]
From: Journal of Public Health in Africa
(1) This is the investigation of the adverse effects of a substance on a biological system, conducted to assess its potential harm, and is part of the regulatory requirements.[16]
From: Sustainability Journal (MDPI)
(1) Toxicity studies, including both cyto- and phytotoxicity assessments, are comprehensive risk evaluations that must be conducted to ensure the acceptance of nanoparticles and to properly identify their ultimate fate within the soil-plant environment.[17] (2) Toxicity studies are scientific investigations conducted to evaluate the harmful effects of substances on living organisms, which helps determine safe exposure levels.[18]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) Toxicity studies are performed using the bacterium Vibrio fischeri on samples of surface water and wastewater analyzed by liquid chromatography-mass spectrometry to evaluate potential harmful effects.[19] (2) The text mentions that the relative bioavailability factor is introduced to compare oral bioavailability of Pb in soils with bioavailability of Pb based on toxicity studies with food, liquids and suspensions.[20] (3) The text mentions that toxicity studies are important to conduct before a transgenic crop such as BT 799 is available on the market to ensure it is safe.[21]
From: International Journal of Pharmacology
(1) Investigations into the harmful effects of substances, conducted on animal models for hydrogels used in drug delivery.[22] (2) Investigations conducted to assess the safety of Strychnos potatorum Linn. seeds, which revealed them to be non-toxic up to a specific dosage level.[23] (3) Preliminary toxicity studies were conducted on a methanolic leaves extract.[24]