Significance of Tophi
Tophi are deposits of urate crystals that accumulate in the periarticular tissues of individuals suffering from chronic gout. These nodular formations can be found in and around joints, resulting from the prolonged presence of elevated uric acid levels in the body. Tophi are indicative of advanced gout and can lead to joint damage if not managed appropriately.
Synonyms: Gouty tophi, Urate crystals, Nodules
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The concept of Tophi in scientific sources
Tophi are nodular deposits of urate crystals that accumulate in and around joints, as well as in periarticular tissues, due to chronic gout, indicating advanced disease and potential joint damage from prolonged uric acid elevation.
From: International Ayurvedic Medical Journal
(1) Deposits of urate crystals found in the periarticular tissues of individuals with chronic Gout.[1]
From: World Journal of Pharmaceutical Research
(1) Nodular deposits of urate found in and around joints as a result of chronic gout.[2]