Significance of Thermal hyperalgesia
Thermal hyperalgesia is characterized by increased sensitivity to pain from thermal stimuli, often evaluated in conditions such as neuropathic pain and inflammatory pain. It manifests as heightened responses to normally non-painful heat, with assessments conducted using various methods, including the hot plate test and immersion tests with cold and hot water. This condition is frequently observed in diabetic rats, where treatments can alleviate symptoms. Thermal hyperalgesia serves as a significant indicator of altered pain perception in various medical contexts.
Synonyms: Thermal sensitivity, Pain sensitivity, Heat sensitivity, Temperature sensitivity
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The concept of Thermal hyperalgesia in scientific sources
Thermal hyperalgesia is characterized by heightened sensitivity to painful heat stimuli, commonly seen in neuropathic pain conditions, where typically non-painful heat sensations are perceived as painful, worsening the individual's discomfort.
From: The Malaysian Journal of Medical Sciences
(1) The introduction of NR2B subunit antagonist, Ro 25-6981 into the PAG region of the brain effectively alleviated this of CFA-induced peripheral inflammatory pain in a rat model.[1]