Significance of Therapeutic target
A therapeutic target is a specific molecule or pathway within the body that drugs or treatments aim to affect to treat diseases. These targets are identified across various fields, including Ayurveda, Science, Psychiatry, Health Sciences, and Environmental Sciences. They can range from specific proteins and enzymes to pathways like Nrf2, TNF, and PI3K, with the goal of modulating them to alleviate symptoms, slow disease progression, or achieve desired health outcomes.
Synonyms: Treatment target, Therapeutic aim, Pharmacological target, Intervention target, Treatment goal, Intervention focus, Treatment objective
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
Hindu concept of 'Therapeutic target'
In Hinduism, a therapeutic target involves identifying specific points within disrupted molecular pathways caused by harmful substances. This knowledge aids in developing effective treatments by focusing on these vulnerabilities.
From: Journal of Ayurveda and Integrated Medical Sciences
(1) These are the targets that are identified by molecular pathways and networks that are perturbed by toxicants, which can help in the development of treatments.[1]
The concept of Therapeutic target in scientific sources
Therapeutic target refers to a specific molecule or pathway in the body, like a protein or receptor, that can be modified by drugs or treatments to alleviate disease symptoms or progression. This can include pathways, molecules, and biological components for intervention.
From: International Journal of Pharmacology
(1) A specific molecule or process within a disease that can be targeted by drugs or treatments to achieve a therapeutic effect, such as metastasis in cancer.[2] (2) These are specific molecules or pathways that can be targeted by drugs, such as regulators of g-protein signaling in the heart.[3] (3) A previous study suggested that ITGB 1 could be applied as a therapeutic target for the treatment of cancers, offering a potential avenue for developing new cancer therapies.[4]
From: The Malaysian Journal of Medical Sciences
(1) EDHF represents potential novel points of intervention for pharmacological strategies aimed at modulating vascular function and treating cardiovascular conditions.[5] (2) The text mentions hypoxia inducible factor-1 as a therapeutic target in ischemic stroke, indicating a focus on the molecular mechanisms of hypoxia.[6] (3) Furthermore, biomarkers may guide researchers in identifying potential therapeutic targets for intervention and developing novel treatments specifically targeting the underlying pathophysiological processes.[7]
From: South African Family Practice
(1) Aiming for these is one way to achieve successful ageing.[8] (2) A biological molecule or pathway that can be acted upon by medications to treat a disease, such as lipoprotein-associated phospholipase A2 in heart disease.[9] (3) These should be discussed with the patient, and one hundred per cent satisfaction with proton-pump inhibitors may not be an achievable target in all patients.[10]
From: Asian Journal of Pharmaceutics
(1) Glioblastoma multiforme is an area where emerging examples of these are being explored.[11] (2) Among the classes of drugs for HTN in modern medicine, ACE is considered crucial and had received considerable attention as this.[12] (3) A potential role of Pavetta bioactives, moving closer to this due to advanced techniques, such as molecular docking and computational research, describing how compounds connect to proteins.[13]
From: South African Journal of HIV Medicine
(1) DC-SIGN and DC-SIGNR may be potential new therapeutic targets for preventing vertical transmission of HIV, and disrupting the interaction represents a potential new therapeutic approach for preventing HIV transmission.[14]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) Therapeutic targets are specific points in biological pathways that can be modulated to treat diseases, and exploring them is important for optimizing mitochondrial health.[15] (2) Therapeutic targets for diabetes and other conditions can be found within the multifaceted roles of adipose tissue.[16] (3) A substance like adiponectin is considered this for conditions including obesity, diabetes, and endothelial dysfunction.[17]
From: Sustainability Journal (MDPI)
(1) The findings from the literature seem to suggest that mindfulness combined with endurance exercise can cause muscle expression of KATs and the detoxification of kyn accumulation in the brain, thereby offering potential therapeutic targets of antidepressant drugs.[18]
From: International Journal of Pharmacology
(1) Inhibitors of cytokine production are being studied for their potential to reduce post-ischemic brain damage, in an effort to identify these.[19]
From: International Journal of Pharmacology
(1) The Nrf2 pathway has become a novel therapeutic target for Alzheimer's disease due to its protective role against oxidative stress.[20] (2) Based on its protective effects, TBK1 is proposed as a potential target for developing new treatments to reduce RGC apoptosis in glaucoma.[21] (3) A goal for developing new treatments for glaucoma, with the p53/AMPK/mTOR pathway being explored in this study.[22]
From: South African Journal of Psychiatry
(1) A specific area or focus for interventions and treatments, which may include addressing family conflict and providing support to single-parent households, as well as mentoring parents who have substance use issues.[23]