Significance of Therapeutic index
The therapeutic index is a crucial measure of a drug's safety, calculated as the ratio between the toxic dose and the therapeutic dose. It indicates the range of drug dosages that can effectively treat disease while remaining within safety limits. A higher therapeutic index suggests a safer drug, highlighting the importance of this ratio in dosing decisions. This measurement is particularly relevant for drugs with narrow therapeutic windows and can influence formulations for effective drug delivery while minimizing toxicity.
Synonyms: Therapeutic window, Therapeutic range, Safety margin, Therapeutic ratio, Dosage range
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The concept of Therapeutic index in scientific sources
The Therapeutic index is a crucial measure that differentiates drugs from poisons, comparing toxic doses to therapeutic doses, thus indicating a drug's safety margin, especially in contexts like anti-HIV activity.
From: World Journal of Pharmaceutical Research
(1) The therapeutic index refers to the effectiveness and safety of a therapeutic agent in treating diseases, particularly in increasing the efficacy of anticancer therapies.[1] (2) The ratio that compares the level of a drug that produces the desired effect to the amount that causes toxicity.[2] (3) A measure of a drug's safety margin, defined as the ratio between the toxic dose and the effective therapeutic dose.[3] (4) The ratio between the toxic and therapeutic doses of a drug, which can be improved through enhanced bioavailability using gastro-retentive systems.[4] (5) A value indicating the range of dosages that can treat disease effectively while staying within safety limits.[5]
From: Ancient Science of Life
(1) The therapeutic index is a ratio that compares the toxic and therapeutic doses of a drug, indicating its safety margin; GoA exhibits a high therapeutic index.[6]
From: International Ayurvedic Medical Journal
(1) The concept used to differentiate between a drug and a poison based on the dosage and its effects.[7]