Significance of Therapeutic concentration
Therapeutic concentration refers to the specific plasma levels of a drug, such as levofloxacin, necessary to achieve effective treatment of infections without causing toxicity. It encompasses the minimum effective level needed in the bloodstream to ensure desired antimicrobial effects. Maintaining the right drug concentration allows for effective treatment while minimizing side effects, crucial in medical therapies, including those targeting specific infections in the body, such as in periodontal therapy.
Synonyms: Therapeutic level, Effective concentration, Treatment concentration
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The concept of Therapeutic concentration in scientific sources
Therapeutic concentration is the optimal level of a drug in plasma that effectively treats infections while minimizing toxicity, achieved at a specific concentration (0.125 µg/ml) to ensure efficacy and safety in treatment.
From: World Journal of Pharmaceutical Research
(1) The level of medication in the bloodstream that is sufficient to achieve the desired therapeutic effect.[1] (2) The effective dose of a medication achieved within a specific area to treat a disease.[2] (3) The plasma level of a drug that is effective for treatment.[3] (4) The drug concentration range that provides the desired therapeutic effect without causing toxicity.[4] (5) The minimum effective level of an antibiotic in the body required to achieve the desired antimicrobial effect.[5]
From: Journal of Indian Society of Periodontology
(1) The effective levels of a drug in a specific area, such as the gingival crevicular fluid, achieved through the methods of local delivery systems used in this study.[6] (2) The drug concentration required to effectively inhibit the growth of gram-negative bacteria like P. gingivalis.[7]