Significance of Systemic circulation
Systemic circulation refers to the circulation of blood throughout the body. It plays a crucial role in delivering oxygen, nutrients, and therapeutic agents to tissues and organs, while also removing waste products. Various routes, including the gastrointestinal tract, nasal cavity, rectum, and skin, facilitate the entry of substances into this system. The liver filters blood from systemic circulation and bioavailability indicates the proportion of a drug that reaches this circulation.
Synonyms: Circulatory system, Systemic blood flow, Blood circulation, Cardiovascular circulation, General circulation
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
Hindu concept of 'Systemic circulation'
In Hinduism, systemic circulation denotes the body's circulatory system where absorbed substances like medicine, nutrients, and hormones are distributed. It's a key pathway for drug delivery, bypassing initial metabolism and influencing various bodily functions and areas.
From: Journal of Ayurveda and Integrated Medical Sciences
(1) From pharyngeal plexus it enters into.[1] (2) The portion absorbed from the lower rectum enters directly into this via the middle and inferior haemorrhoidal veins, while the portion absorbed from the upper rectal mucosa is carried by the superior haemorrhoidal vein into the portal circulation.[2] (3) It can be said that absorption is facilitated from the buccal mucosa and reaches here.[3] (4) When the drug is administered through the scalp, the first-pass metabolism can be avoided as it allows the drug to be absorbed directly into this.[4] (5) The liver receives both portal and these circulations and is important in host defense against micro-organisms.[5]
From: International Research Journal of Ayurveda and Yoga
(1) The process where the virus may enter and continue to spread in the body, from affected locations in the respiratory tract.[6] (2) The provided text says that the liver receives blood circulation from this, making it vulnerable to infections.[7] (3) These Srotas are anatomically structured with two ends – one of which is anchored in the gastrointestinal mucosa, allowing for the selective delivery of Ahara Rasa to the tissue level via systemic circulation and targeted Srotas entry.[8] (4) Mucosal layer inferior to the tongue is thin and vascular enough to permit the rapid absorption.[9] (5) Bioavailability is the fraction of administered medicine available in systemic circulation.[10]
From: Journal of Ayurvedic and Herbal Medicine
(1) According to the text, minerals or metals in the form of its ash become a lot easier to get absorbed into the systemic circulation after the Bhasmikarana process.[11] (2) The circulatory system through which drugs pass after being absorbed through the nasal cavity.[12] (3) The circulation of bacteria and endotoxins into deeper layers of the skin due to leaky gut syndrome.[13] (4) The text uses "systemic circulation" to indicate where glucose is absorbed after being broken down in the small intestine.[14]
The concept of Systemic circulation in scientific sources
Systemic circulation is the circulation of blood throughout the body, delivering oxygen, nutrients, and drugs to tissues. It's crucial for drug distribution and therapeutic effects, with various delivery methods influencing drug concentration.
From: Asian Journal of Pharmaceutics
(1) The circulation of blood throughout the body.[15] (2) The drug undergoes substantial hepatic firstpass metabolism and from the administered dose only about 50% of reaches this.[16] (3) Solubility is one of the important parameter to achieve the desired concentration of drug in this for pharmacological response to be shown.[17] (4) They conclude that the drug retention on the skin gives the best result in treatment without leading to therapeutic levels in the systemic circulation.[18] (5) It is the circulation of blood throughout the body, delivering drugs to their target sites.[19]
From: International Journal of Pharmacology
(1) After oral administration, amoxicillin is rapidly and well absorbed, a high fraction of the dose reaching this.[20] (2) Oligoarginie significantly improved delivery of insulin from the intestine to this without the requirement of interlinking.[21] (3) High BA loads or inadequate detoxification can lead to BA entering here and causing the release of adrenaline and noradrenaline.[22] (4) The generous blood flow from the hemorrhoidal veins in the distal part of the rectum allows absorbed drug to enter directly.[23] (5) Intranasal administration of therapeutics avoids this, enhancing the uptake of the therapeutic moiety to the brain.[24]
From: The Malaysian Journal of Medical Sciences
(1) The text mentions that IL-1β and TNF-α can be found abundantly in the synovial fluids and this of the RA patients.[25] (2) The blood flow throughout the body, where toxins released by the infection's microorganisms can lead to systemic inflammatory response syndrome and shock.[26] (3) This is where toxic products, such as hydroperoxides and aldehydes, can be introduced after consumption, affecting the gastrointestinal system.[27]
From: South African Family Practice
(1) Sympathetic nervous system activation results in an inotropic and chronotropic response which aims at stabilizing this, for patients who survive pulmonary embolism.[28] (2) Systemic circulation is a part of the circulation circuit that delivers blood to the body, and the single ventricle must supply this in cases of certain cardiac malformations.[29]
From: South African Journal of Physiotherapy
(1) The bronchial arteries are part of this circulation and their blood pressure is therefore more or less five times that of the pulmonary arteries, showing a difference in pressures.[30]
From: South African Journal of HIV Medicine
(1) The circulation of blood throughout the body, and HAART can effectively suppress viral replication in the systemic circulation.[31]
From: African Journal of Primary Health Care and Family Medicine
(1) This is the circulation of blood throughout the body, and drugs or fluids injected into the bone marrow cavity enter this system.[32]
From: International Journal of Environmental Research and Public Health (MDPI)
(1) is the network of blood vessels through which blood travels from the heart to all parts of the body and back to the heart, delivering oxygen and nutrients.[33] (2) In the absence of sufficient cytochrome action, the drug seems more bioavailable in this for a longer time, thus causing the difference in the populations.[34] (3) The part of the circulatory system that carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart.[35] (4) It is the main source of glucocorticoids, as breastmilk cortisol reflects diurnal variations related to maternal HPA axis activity.[36] (5) According to the provided information, "systemic circulation" refers to the circulation of blood throughout the body, and PAS is quickly removed from it, resulting in a low blood level.[37]
From: Sustainability Journal (MDPI)
(1) The spread of a virus throughout the body via the bloodstream, potentially affecting multiple organs and systems.[38]
From: International Journal of Pharmacology
(1) The network of blood vessels carrying blood throughout the body, into which liver enzymes are released when the liver is damaged.[39]