Significance of Swelling Index
The Swelling Index is a crucial parameter that gauges the extent to which tablets and other formulations swell when immersed in a liquid. It impacts drug release rates, evaluates mucoadhesive properties, and assesses the swelling capacity of buccal patches and microspheres. The index also indicates the hydrophilic nature of components like polymers and plant materials, influencing how effectively they absorb water and expand, which is vital for determining their drug release characteristics in pharmaceutical applications.
Synonyms: Expansion ratio
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The concept of Swelling Index in scientific sources
Swelling Index quantifies the degree of expansion in buccoadhesive tablets, Grevillea robusta gum, and films upon water immersion, influencing adhesion, release rates, and overall physical characteristics essential for various applications.
From: Asian Journal of Pharmaceutics
(1) This index was calculated using a specific formula involving wet and dry weights of the beads.[1] (2) This index is calculated using a formula involving the weight of the tablet at a specific time and the initial weight.[2] (3) This was calculated using the formula: (W g -W o ) / Wo × 100, where W o was the initial weight of beads and W g was the weight of beads in the swelling medium.[3] (4) This is a measurement which indicates the degree to which a material swells.[4] (5) Measured by the weight gain of a dosage unit in a dissolution apparatus.[5]
From: Sustainability Journal (MDPI)
(1) This index decreased to 0.037 (over 50% reduction compared to 0.2 CTS) after treatment with 1%, 2%, and 5% nZVI, and also showed a decreasing trend. This is calculated based on the void ratio at 400 kPa and 100 kPa during the rebound stage.[6] (2) Refers to the ratio of the volume occupied by the swollen starch granules to the original volume of the starch. It is used to measure the degree of swelling of starch in water.[7] (3) Swelling index (Cs) is a parameter obtained from the consolidation test, and the effect of adding rubber to this parameter was investigated.[8]