Significance of Solid-phase extraction
Solid-phase extraction is a versatile method used for isolating specific compounds from complex mixtures, particularly in biological samples. The technique involves passing a liquid sample through solid adsorbents that selectively retain target analytes, facilitating their concentration and purification. This technique is valuable in various analytical applications, including the determination of drugs like Isoniazid and Acetyl-isoniazid in serum, and is commonly used in preparation for liquid chromatography and mass spectrometry, streamlining the sample analysis process.
Synonyms: Solvent extraction
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The concept of Solid-phase extraction in scientific sources
Solid-phase extraction is a purification technique that isolates and concentrates analytes from liquid media using solid adsorbents, often serving as a preparatory method for subsequent analysis by techniques like liquid chromatography or mass spectrometry.
From: World Journal of Pharmaceutical Research
(1) A method to separate and concentrate compounds from a mixture using a solid material.[1] (2) The method of isolating Tenofovir and Lamivudine from their mixtures before analysis, ensuring accurate measurement of their concentrations.[2] (3) A method used to extract compounds from a mixture by passing the mixture through a solid adsorbent.[3] (4) A sample preparation technique used prior to the liquid chromatography process for the quantification of quetiapine in human serum.[4] (5) A specific process referenced for its importance in obtaining purified phthalate samples from complex mixtures.[5]
From: AYU (Journal of Research in Ayurveda)
(1) A method used to isolate and purify analytes from a mixture, often utilized before liquid chromatography or mass spectrometry.[6]