Significance of Single nucleotide polymorphism
Single nucleotide polymorphism (SNP) refers to a common type of genetic variation where a single nucleotide in the DNA sequence differs among individuals. This variation can impact disease susceptibility and response to treatments, such as medications. SNPs play a significant role in the development of various diseases, including type 2 diabetes and cardiovascular diseases, by influencing gene expression and protein production. They are vital for understanding individual differences in health and disease outcomes.
Synonyms: Genetic variation, Point mutation, Allelic variation, Genetic marker
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The concept of Single nucleotide polymorphism in scientific sources
Single Nucleotide Polymorphisms (SNPs) are genetic variations affecting individual dietary responses, obesity risk, and overall phenotype, making them the most prevalent genetic variations that also impact drug efficacy in humans.
From: World Journal of Pharmaceutical Research
(1) Small genetic variations that have been linked to increased risk for diseases such as T2DM and CVD.[1] (2) Single nucleotide polymorphisms (SNPs) are variations in a single base pair in the DNA that can affect how individuals respond to medications.[2] (3) A single nucleotide polymorphism (SNP) is a variation that involves a change in a single nucleotide in the DNA sequence, which can affect how individuals respond to drugs.[3] (4) A type of genetic variation that involves a change of one nucleotide in the genome, which can have implications for disease susceptibility.[4] (5) The most common type of genetic variation among people, which can have significant impacts on drug metabolism.[5]
From: Journal of Indian Society of Periodontology
(1) A variation at a single position in a DNA sequence among individuals that may contribute to a susceptibility to diseases like periodontitis.[6] (2) A type of gene polymorphism where a single base pair is altered in the DNA sequence, potentially impacting gene expression and disease risk.[7] (3) A variation in a single nucleotide that occurs at a specific position in the genome, which may impact gene function.[8] (4) Genetic variations that have been studied in relation to susceptibility to severe chronic periodontitis.[9] (5) A variation in a single nucleotide that occurs at a specific position in the genome, associated with different resistin levels and periodontal health.[10]
From: The Malaysian Journal of Medical Sciences
(1) A variation at a single position in a DNA sequence among individuals, which may impact an individual's susceptibility to disease or response to drugs.[11] (2) A variation at a single position in a genome that can affect how individuals respond to medications, such as statins.[12] (3) Genetic variations that may result in functional changes affecting enzyme activity.[13] (4) Genetic variations that occur at a single position in the DNA sequence among individuals.[14] (5) A variation at a single position in a DNA sequence among individuals, specifically referring to the rs2239670 variant investigated in the study.[15]
From: AYU (Journal of Research in Ayurveda)
(1) The most common genetic variation among humans, contributing to phenotypic differences and influencing drug response.[16]
From: Journal of Ayurveda and Integrative Medicine
(1) Variations in a single nucleotide in a genome that may contribute to an individual's susceptibility to diseases.[17]
From: Ayushdhara journal
(1) Single Nucleotide Polymorphism (SNP) is a common type of genetic variation where a single base pair within the DNA sequence differs among individuals, impacting their development and health.[18]